Alexandra Aube

Alexandra Aube
Université de Montréal | UdeM · Department of Chemistry

PhD candidate

About

8
Publications
5,656
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120
Citations

Publications

Publications (8)
Article
Full-text available
Correction for ‘Ultra-low fouling methylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysates’ by Alexandra Aubé et al. , Analyst , 2017, 142 , 2343–2353.
Article
Full-text available
The clinical success of Escherichia coli l-asparaginase II (EcAII) as a front line chemotherapeutic agent for acute lymphoblastic leukemia (ALL) is often compromised because of its silent inactivation by neutralizing antibodies. Timely detection of silent immune response can rely on immobilizing EcAII, to capture and detect anti-EcAII antibodies. H...
Article
We synthesized novel ultra-low fouling ionic liquids and demonstrated their use with surface plasmon resonance (SPR) sensing for the analysis of HER2 in breast cancer cell lysates. Whilst biomarkers are commonly detected in serum, this remains challenging for cancer diagnosis due to their low concentrations in circulation and in some cases, there i...
Article
Monitoring the response of patients undergoing chemotherapeutic treatments is of great importance to predict remission success, avoid adverse effects and thus, maximise the patients’ quality of life. In the case of leukemia patients treated with E. coli L-asparaginase, monitoring the immune response by the detection of specific antibodies to L-aspa...
Article
Therapeutic drug monitoring (TDM) is required for pharmaceutical drugs with dosage limitations or toxicity issues where patients undergoing treatment with these drugs require frequent monitoring. This allows for the concentration of such pharmaceutical drugs in a patient's biofluid to be closely monitored in order to assess the pharmacokinetics, wh...
Article
Non-specific adsorption of the molecular components of biofluids is ubiquitous in the area of biosensing technologies, severely limiting the use of biosensors in real-world applications. The surface chemistries developed to prevent non-specific adsorption of crude serum are not necessarily suited for sensing in other biosamples. In particular, the...
Article
Nonspecific adsorption of the molecular components of biofluids is ubiquitous in the area of biosensing technologies, severely limiting the use of biosensors in real-world applications. The surface chemistries developed to prevent nonspecific adsorption of crude serum are not necessarily suited for sensing in other biosamples. In particular, the di...

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