Alexander Vizel

Alexander Vizel
Kazan State Medical University · Department of Phthisis Pulmonology

About

136
Publications
8,396
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
5,006
Citations

Publications

Publications (136)
Chapter
Третий том руководства охватывает интерстициальные, неопластические, профессиональные заболевания органов дыхания, а также болезни легких сосудистого генеза. В частности, значительно обновлены главы об идиопатических интерстициальных пневмониях, идиопатическом легочном фиброзе и о гиперчувствительных пневмонитах. Переработан и дополнен раздел, посв...
Article
Sarcoidosis is a systemic epithelioid cell granulomatosis of unknown origin. The specialized commission on pulmonology of the Russian Ministry of Health recommended creating a register for sarcoidosis in the beginning of 2023. The aim of the study was to assess the main characteristics of newly identified patients with sarcoidosis according to the...
Article
The purpose of publishing the resolution of the Interdisciplinary Council of Experts in the fields of pulmonology, allergology, pediatrics, and clinical pharmacology was to discuss the effectiveness and safety of a new short-acting β 2 -adrenergic receptor agonist in the Russian Federation – levosalbutamol. The Interdisciplinary Council of Experts...
Article
The review analyzes publications devoted to the formation of phenotypes in sarcoidosis patients. It has been noted that there is a certain difficulty in phenotyping the disease that can affect all human organs and systems. The article demonstrates the trend to shift from Scadding radiographic stages of intrathoracic sarcoidosis, based on radiograph...
Article
Introduction. During the COVID-19 pandemic, the first experience was gained in managing patients with sarcoidosis in the face of a dangerous viral infection, a combination of two diseases and vaccination against COVID-19. Publications on this issue remain ambiguous, which made it relevant to assess the management of patients with sarcoidosis during...
Article
Chronic broncho-obstructive pulmonary diseases – bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) – are a serious clinical problem and an economic burden for practical healthcare. The purpose of the scientific review is to track the evolution of views on the use of bronchodilators and inhaled corticosteroids (ICS) in these dis...
Article
The treatment of sarcoidosis remains uncertain despite 70 years of studies. The conventional approach is to initiate corticosteroids in individuals who require treatment. However, to date, there are no strict dosing regimens for systemic corticosteroids (SСS), and patients who were treated with SСS develop relapses more frequently than those who ha...
Article
The objective: to compare the correct use of different types of inhalers in patients with COPD and bronchial asthma. Subjects and Methods. 100 patients with COPD and 108 patients with BA were examined. Nine devices were evaluated – a metered dose inhaler (MDI), Rapihaler, Respimat, Breezhaler, CDM, Turbuhaler, Genuair, Spiromax, and Ellipta. The ap...
Article
In respiratory medicine, the correct inhaler technique determines the clinical efficacy of inhaled medications.
Article
The COVID-19 pandemic was accompanied at different times by the prescription of various drugs. The prescription of antibacterial drugs was regarded differently, and even the term “pneumonia” was the subject of discussion. The frequency of antibiotic use during the pandemic varied widely across countries, with a general trend towards overprescribing...
Article
Chronic obstructive pulmonary disease (COPD) is a progressing disease. Each exacerbation impairs the patient’s prognosis and increases burden for the healthcare system. The most common maintenance treatment options for COPD include long-acting bronchodilators – β2-agonists (LABA) and long-acting antimuscarinic agents (LAMA), and inhaled glucocortic...
Article
Chronic obstructive pulmonary disease (COPD) is a progressing disease. Each exacerbation impairs the patient’s prognosis and increases burden for the healthcare system. The most common maintenance treatment options for COPD include long-acting bronchodilators – β2-agonists (LABA) and long-acting antimuscarinic agents (LAMA), and inhaled glucocortic...
Article
Sarcoidosis is a multi-organ granulomatosis of unknown origin. Modern diagnostic methods allow detecting this disease at an early stage. The absence of specific markers requires a comprehensive approach to diagnosis based on comparison of radiation, clinical, morphological and functional data. The course of sarcoidosis without damage to the respira...
Article
Full-text available
COVID-19 is a viral infection and its prevalence requires investigation of different co-morbid conditions including tuberculosis, as well as operation of temporary infectious diseases hospitals (TIDH) for the treatment of COVID-19 deployed on the facilities of anti-tuberculosis institutions. The objective : analysis of follow-up and treatment of pa...
Article
Introduction. Sarcoidosis and COVID-9 are diseases in which the response of the human immune system plays a significant role in the pathogenesis. Descriptions of cases of a combination of these diseases and the development of a granulomatous reaction in those who have undergone COVID-19 make it relevant to study these two diseases. Aim. The aim of...
Article
Eosinophils play a protective role and are involved in the pathogenesis of exacerbations in chronic obstructive pulmonary disease (COPD). The study of the role of eosinophils in pathogenesis of COPD, especially during exacerbations, is relevant to selecting the optimal therapy. The aim was to analyze literature data and compare them with the result...
Article
Full-text available
The article analyzes 46 publications on the use of ICS for COVID-19. Both research results and their discussion by specialists are presented. The expediency of continuing basic therapy, including ICS, has been demonstrated in the event of COVID-19 in patients with bronchial asthma and chronic obstructive pulmonary disease. The risk of local immunos...
Article
Introduction. The novel coronavirus infection COVID-19, caused by SARS-COV-2, has been a global health problem for three years now. A new challenge is virus mutations that change clinical manifestations and response to therapy. Aim. The aim of the workwas to assess the condition of patients with COVID-19 treated in a temporary infectious diseases h...
Article
Study Objective: To assess the efficacy and safety of the use of leflunomide (LF) in chronic present and/or refractory sarcoidosis. Study Design: Retrospective observational non-interventional analysis. Materials and Methods. We studied the use of LF (20 mg daily) in 15 out of 1470 (1.0%) patients included into the State Sarcoidosis Clinical Databa...
Article
Aim. To assess the prevalence of fatigue in bronchial asthma patients by using the FAS (Fatigue Assessment Scale) questionnaire, and to evaluate the status of patients with bronchial asthma who experience fatigue. Material and methods. We examined 458 patients with bronchial asthma: 312 (68,81%) female and 146 (31,9%) males, aged 18 to 87 years, wh...
Article
Full-text available
Introduction . The natural course of some interstitial lung diseases (ILD) is characterized by progressive fibrosing phenotype resembling idiopathic pulmonary fibrosis (IPF). Until recently, the antifibrotic drug nintedanib was approved for treatment of the only fibrosing ILD which was IPF. A new indication for this drug which has been registered i...
Article
Achieving the control of bronchial asthma (BA) in real clinical practice remains an unresolved problem, despite the expansion of therapeutic options in this area. Guidelines about when and for whom should a particular treatment be used continue to develop. Increasing of inhaled corticosteroid dose (ICS) in combination with a long-acting β 2 -agonis...
Article
Aim of study. To carry out a comparative analysis of a population of patients with bronchial asthma under observation of pulmonologists and allergists. Material and methods. A total of 377 cases of bronchial asthma were studied and analysed. Th e non-interventional, observational, comparative study was carried out in the setting of actual clinical...
Article
Full-text available
Background: Sarcoidosis is a granulomatous disease with no established etiology. The prevalence of sarcoidosis is growing, there are changes in the clinic of the disease depending on geolocation and the environment.Aim: To analyze the database (register) of sarcoidosis patients registered with this disease in the Republic of Tatarstan.Materials and...
Article
Full-text available
The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair princip...
Article
A literature review of the combination of sarcoidosis and the novel COVID-19 infection is presented. In mild forms of sarcoidosis, without a decrease in lung function and without requiring immunosuppressive therapy, no additional risks have been identified in the context of a new COVID-19 pandemic. However, at the stage of diagnosis, one should be...
Article
Sarcoidosis is epithelioid cell granulomatosis of unknown etiology. All the schemes of its treatment are of a recommendatory nature. Methotrexate (MTT) is considered a second-line drug in the treatment of sarcoidosis. Methods . A retrospective observational study of patients with progressive sarcoidosis (n = 104), treated with MTT once a week, was...
Article
Full-text available
The main goals of COPD therapy are to achieve clinical stability with minimal clinical manifestations and low risk of relapse. The proposed COPD control concept by analogy with asthma has not been quite well characterized yet. COPD control is defined as "the long - term maintenance of a clinical situation with a low impact of symptoms on the patien...
Article
Full-text available
The use of a combination of the inhaled glucocorticosteroid budesonide and beta2-selective long-acting adrenergic agonist formoterol is recommended for both bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD), however, indications for their use have changed significantly over the past 20 years. In BA, there was a transition from...
Article
Full-text available
Chronic obstructive pulmonary disease (COPD) is a chronic, environmentally mediated disease manifested by broncho-obstructive syndrome, which is not completely reversible. The purpose of this review was to summarize the latest changes in the management of these patients, which occurred in international and domestic guidelines. Methods . The analysi...
Article
The objective of this study was to compare demographic, clinical, functional, laboratory data, and therapy in patients with chronic obstructive pulmonary disease (COPD) and asthma who seek for medical aid at medical institutions of Kazan’. Methods. The study involved 153 patients with COPD aged 33 to 89 years and 229 patients with asthma aged 18 to...
Article
Full-text available
Sarcoidosis is systemic granulomatosis of an unknown nature, the course of which varies from spontaneous remission to progression resulting in failure of organs and systems. The article presents a review of current approaches to treatment of sarcoidosis putting special emphasis on the use of the anti-rheumatic drug of leflunomide (LEF). LEF is a pr...
Article
Full-text available
The article presents the literature review devoted to establishment of the definition of chronic obstructive pulmonary disease and its components – chronic bronchitis and pulmonary emphysema.
Article
Full-text available
Sarcoidosis is a systemic epithelioid cell granulomatous disease of unknown etiology, which prevalence has increased over the past three decades. The objective of this work was to analyse the register of patients with sarcoidosis, in which the patients from the Republic of Tatarstan were entered for the period from 1969 until now. Methods. A patien...
Article
Full-text available
The article presents an analytical review of the use of aclidinium, formoterol, and combination of aclidinium and formoterol to treat chronic obstructive pulmonary disease (COPD) using a metered-dose dry powder inhaler Genuair® to administer a fixeddose combination. It is noted that twelve hours’ double bronchodilating effect has some advantages in...
Article
An impact of acute exacerbation of COPD (AECOPD) on the course and the prognosis of chronic obstructive pulmonary disease depends on severity of the exacerbation. Moderate and severe exacerbations are considered as clinically significant events. Clinical studies investigating a role of inhalational therapy for the risk of AECOPD differed significan...
Article
The aim of this review was to summarize recently published data on dual bronchodilation in patients with chronic obstructive pulmonary disease (COPD). Four fixed combinations of long-acting β2-agonists (LABA) and long-acting muscarinic receptor agonists (LAMA), vilanterol/umeclidinium, olodaterol/tiotropium, glycopyrronium/indacaterol, and formoter...
Article
The article is based on the resolution of the Expert Council, including experts from Russian Association of Allergists and Clinical Immunologists (RAACI) and Russian Respiratory Society (RRS) dated November 20, 2016, and the review of clinical studies results and publications on the biomarker-based diagnosis and biological treatment of severe uncon...
Article
Full-text available
Relevance of work. Chronic obstructive pulmonary disease (COPD) is a subject of many international studies, which leads to permanent renewal of clinical recommendations and standards of diagnostics and therapy of this disease. The objective included evaluation of the clinical state of COPD patients, functional evaluation of data and peculiarities o...
Article
Full-text available
Combination therapy with long-acting β2-agonists (LABA) and long-acting muscarinic antagonists (LAMA) can reduce symptoms of chronic obstructive pulmonary disease (COPD) and the risk of future exacerbations. To date, the only fixed combination of long-acting bronchodilators, indacaterol/glycopyrronium, has demonstrated a significant reduction in dy...
Article
Full-text available
Late diagnosis of chronic obstructive pulmonary disease (COPD) at advanced stage, high risk of exacerbations, low compliance of patients, and adverse effects of treatment have been still unresolved problems in the treatment of COPD despite the development of new drugs. The personalized medicine needs distinct indications and predictors of efficacy...
Article
Full-text available
Data of the most recent achievements in diagnostics and therapy of chronic obstructive pulmonary disease (COPD) from positions of division by phenotypes and global initiative GOLD-2015.
Article
A review of efficacy of budesonide/formoterol fixed combination in obstructive lung diseases has been done in the article. The efficacy of this combination in chronic obstructive pulmonary disease (COPD) and asthma has been supported by high-level evidence. Clinical effect of inhalation therapy depends on proper use of the inhaler. Information on a...
Article
BACKGROUND: Agents that target pro-inflammatory cytokines and decreased oxidative stress may be useful in pulmonary sarcoidosis. OBJECTIVE: To determine effectiveness of a non-selective cyclic nucleotide phosphodiesterase inhibitor, pentoxifylline (POF). At the same time POF is known to markedly reduce the release of TNF-alpha. PURPOSE: To conduct...
Article
The purpose of the study was to evaluate efficacy and safety of systemic corticosteroids (SCS) in 245 patients with sarcoidosis in a real clinical practice. Methods. This was a retrospective analysis of outpatients with pulmonary sarcoidosis who visited a pulmonologist in 2000 to 2015. The analysis involved 166 females and 79 males, mean age, 44.9...
Article
Full-text available
Aim. To evaluate the effectiveness of different management regimens in patients with sarcoidosis in clinical practice settings. Methods. A retrospective analysis of condition of 530 patients with sarcoidosis at baseline and at the end of follow-up (at least 6 months) was conducted. The patients were divided into subgroups according to the treatment...
Article
The most important symptoms of chronic obstructive pulmonary disease are dyspnea, cough and sputum production. According to results of sever-Al studies, 50% - 70% of COPD patients under regular therapy continue to experience dyspnea. Dyspnea has a great prognostic importance, it often correlates to exacerbation rate and the patients' survival. Symp...
Article
Objective: Methotrexate (MTX) is a cytotoxic agent that is commonly employed as an alternative to corticosteroids to treat sarcoidosis, although the proper use and efficacy of MTX as a single agent remain unclear. Our objective was to evaluate the efficacy and safety of monotherapy with MTX in chronic sarcoidosis patients. Methods: Between 2000 and...
Article
We estimated the effectiveness and safety of methotrexate monotherapy of sarcoidosis in 63 patients refractory to the previous treatment. Methotrexate was given weekly at a dose of 5-20 mg. 54% of the patients reported improvement of their condition. Parameters of spirogram and the ray picture improved in 63.2 and 54% of the cases respectively. Met...
Article
Full-text available
to compare respiratory function and laboratory data with the radiographic stages of intrathoracic sarcoidosis. Three hundred and eleven patients (70.4% for women and 29.6% for men; mean age, 44.7±0.6 years) with histologically verified sarcoidosis underwent X-ray computed tomography, spirography, estimation of carbon monoxide diffusing capacity (DL...
Article
Comparison of the state of 83 patients with histologically confirmed sarcoidosis observed with a 10 year interval revealed remission in 47% of the cases. The main factors having negative effect on prognosis of the disease included extrapulmonary symptoms, the use ofcorticosteroids (at all stages, especially at stage I and in Lofgren syndrome) and a...
Article
Full-text available
The history of the Russian tuberculosis (TB) program, dating from the second part of the 19th century until today, is presented, and its achievements and failures are analyzed. The epidemiology of TB is described, and the effects of the TB program initiatives are described and analyzed. Multidrug-resistant TB and HIV coinfection represent severe th...
Article
Full-text available
BACKGROUND: Nintedanib (formerly known as BIBF 1120) is an intracellular inhibitor that targets multiple tyrosine kinases. A phase 2 trial suggested that treatment with 150 mg of nintedanib twice daily reduced lung-function decline and acute exacerbations in patients with idiopathic pulmonary fibrosis. METHODS: We conducted two replicate 52-we...
Article
Full-text available
Background: Nintedanib (formerly known as BIBF 1120) is an intracellular inhibitor that targets multiple tyrosine kinases. A phase 2 trial suggested that treatment with 150 mg of nintedanib twice daily reduced lung-function decline and acute exacerbations in patients with idiopathic pulmonary fibrosis. Methods: We conducted two replicate 52-week...
Article
The aim of the work was to compare the quality of medical care provided to patients with severe community-acquired pneumonia (CAP) and its different outcomes. (complete recovery, or death--25 patients in either group). In the latter group, the patients did not undergo adequate clinical and instrumental examination at the pre-hospital stage). Most r...
Article
The natural history of sarcoidosis was analyzed in 279 patients with its history of as long as 2 years among the 832 with this disease registered in the Republic of Tatarstan in 1999 to 2002. The patients were divided into 3 groups: (1) 79 (28.3%) receiving systemic glucocorticosteroids (SGS); (2) 146 (52.3%) patients having therapy without SGS; (3...
Article
We conducted a simple prospective trial studied influence of pentoxifylline on the course of active pulmonary sarcoidosis in 70 patients. This drug decreasing TNF-α (tissue necrosis factor-α) level was given orally in the dose of 600 mg 3 times a day in combination with α-to copherol in the dose of 400 IU twice a day. Fourteen patients stopped trea...
Article
Three hundred and thirty-five patients with bronchial asthma (BA) and 534 patients with chronic obstructive lung disease (COLD) were examined. Before and after tests using salbutamol, phenoterol, ipratropium bromide and a fixed combination of phenoterol and ipratropium bromide, the forced expiratory flow-volume curve was recorded in the patients on...
Article
The paper analyzes the literature on sarcoidosis and pregnancy, available from the MedLine bases and Russian journals. It also presents a clinical case of sarcoidosis developed and recurred in a female after the first and repeated pregnancy. It is concluded that pregnancy in sarcoidosis may be preserved in most cases. Life-threatening rhythm and co...
Article
Due to the increasing interest in studies of apoptosis (programmed cell death) in the pathogenesis of many diseases and to the emergence of data on the direct impact of apoptotic disorders on the course of bronchial asthma and the magnitude of the obstructive syndrome, this study was undertaken to investigate apoptosis in patients with new-onset pu...
Article
A hundred thirty eight patients with pulmonary sarcoidosis were examined for the status of the respiratory and cardiovascular systems. There is a trend for external respiratory parameters to decrease as the X-ray stage increases (by 30-50% in Stage IV). The revealed cardiovascular changes in patients with different X-ray stages did not differ signi...
Article
Two hundred patients with sarcoidosis were interviewed by a questionnaire in the global Internet. For comparison, the same questionnaire was used in the interviews of 60 patients in Kazan. Among international responders, patients from the USA were prevalent. The age of 30-39 years was predominant in both groups, females were three fourths. Predomin...

Network

Cited By