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Alexander Veselov

Alexander Veselov
Smolensk State Medical University · Institute of Antimicrobial Chemotherapy

MD, PhD

About

57
Publications
37,895
Reads
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500
Citations
Citations since 2017
15 Research Items
167 Citations
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2017201820192020202120222023051015202530
Introduction
Alexander Veselov currently works at the Institute of Antimicrobial Chemotherapy, Smolensk State Medical University.
Additional affiliations
October 2007 - present
Institute of Antimicrobial Chemotherapy
Position
  • Managing Director
Education
September 1994 - June 2000
Smolensk State Medical Academy
Field of study
  • Internal medicine

Publications

Publications (57)
Article
Full-text available
Invasive fungal infections in various categories of patients remain one of the most urgent problems of modern medicine. This is complicated by the imperfection of diagnostic methods, as well as a small range of antimycotics for systemic use. The market launch in 2005 of posaconazole, a second-generation systemic antimycotic from the group of triazo...
Article
Full-text available
Invasive fungal infections are one of the main causes of morbidity and mortality in pediatric oncohematological patients. The incidence of invasive mycoses in children and adolescents generally ranges from <5% to >10%, depending on a variety of risk factors; early diagnosis and early initiation of effective antifungal therapy are critical componen...
Article
Full-text available
The SARS-CoV-2 pandemic has highlighted a clear need to find ways to prevent this infection, primarily through the creation of effective and safe vaccines; so, efforts in this direction have been made by a number of pharmaceutical and biotechnology companies with varying degrees of success. If classical vaccines did not raise questions about the me...
Article
Full-text available
Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality. For the treatment of invasive mycoses, a few number of drugs are currently available, which include polyenes, azoles, echinocandins, allylamines and flucytosine. Among these groups, echi...
Article
Full-text available
Posaconazole is a broad-spectrum triazole antifungal agent with potent activity against various fungi, including yeast and molds, including Mucorales, what makes a key difference with itraconazole and voriconazole. Clinical studies have demonstrated his efficacy for prophylaxis against invasive fungal infections in hematological patients at high ri...
Article
Full-text available
Posaconazole is a broad-spectrum triazole antifungal agent with potent activity against various fungi, including yeast and molds, including Mucorales, what makes a key difference with itraconazole and voriconazole. Clinical studies have demonstrated his efficacy for prophylaxis against invasive fungal infections in hematological patients at high ri...
Article
Full-text available
Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida glabrata is becoming an increasingly relevant species, especially in oncohematology patients who hav...
Article
Full-text available
Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality. For the treatment of invasive mycoses, a few number of drugs are currently available, which include polyenes, azoles, echinocandins, allylamines and flucytosine. Among these groups, echi...
Article
Full-text available
Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida glabrata is becoming an increasingly relevant species, especially in oncohematology patients who hav...
Article
Full-text available
P. aeruginosa is not only intrinsically resistant to many groups of antimicrobials, but is also extremely capable in acquiring resistance to almost all antibacterial agents that are used for the therapy of infections caused by this pathogen, making the choice of treatment regimens very complicated. In this article we review the guidelines by the Sp...
Article
Full-text available
Patients undergoing cytotoxic chemotherapy and hematopoietic stem-cell transplantation are at risk for infection. The risk of infections increases with the depth and duration of neutropenia, with the greatest risk occurring in patients who experience profound, prolonged neutropenia after chemotherapy, which is most likely to occur in the period bef...
Article
Full-text available
An update on 2010 clinical practice guideline on Clostridium difficile infection (CDI) by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) was published in March 2018. This new version of guideline not only includes significant changes in the management of this infection and reflects the ev...
Article
Full-text available
Objective. To determine susceptibility of C. glabrata isolates to anidulafungin, caspofungin and micafungin using the SensititreTM YeastOneTM system. Materials and Methods. C. glabrata isolates were taken prospectively from clinical specimens or from strains collections in the participating sites. Susceptibility determination was performed using Se...
Article
Full-text available
Invasive infections caused by Candida species are the most common invasive fungal infections in children of different age groups. Premature neonates, especially newborns with low and extremely low birth-weight, have very high mortality rates, with the highest numbers in case of the central nervous system impairment. Among older children, by analogy...
Article
Full-text available
Posaconazole is a second generation triazole with a broad spectrum of activity, which first appeared on the market in 2005 in the form of a suspension for oral administration. Despite some progress made in the framework of clinical trials, the problems associated with both the features of the pharmacokinetics of an oral suspension, and with the ina...
Article
Full-text available
Invasive candidiasis is one of the main infectious complications in patients with impaired immunity, and severely ill patients in intensive care units, including premature neonates. High rates of morbidity and mortality in patients who have risk factors for invasive candidiasis, changes in the spectrum of pathogens in favor of the non-albicans spec...
Article
Full-text available
The resistance of the systemic Candida infections causative agents is a cornerstone of the selection of an effective therapy. But if before the problem was limited to resistance to azole antifungals, then by now we have enough data about cases of treatment failures with echinocandins, which for today are the drugs of choice for treating most clinic...
Article
Full-text available
АМ для системного применения по праву могут быть отнесены к категории жизнеспасающих препаратов. Возрастание числа ИМ требует от клинициста не только грамотных диагностических действий, но и своевременного назначения адекватной по клинико-фармакологическим характеристикам противогрибковой терапии. Несмотря на небольшое число доступных АМ для систем...
Article
Full-text available
Rising incidence of invasive fungal infections caused by both yeast and filamentous micromycetes, making it necessary for the improvement of the applied therapy of antifungal drugs. Among them triazoles occupies a key position. Problems associated with secondary resistance, tolerability, drug-drug interactions, as well as availability of certain fo...
Article
Full-text available
ANIDULAFUNGIN: SHORT CLINICO-PHARMACOLOGICAL REVIEW Veselov A. Institute of Antimicrobial Chemotherapy, Smolensk, Russia Abstract Invasive fungal infections are an actual problem of the modern medicine. This is due to the widening population of the affected patients and the increasing number of fungal strains that are resistant to the previously e...
Article
Full-text available
Onychomycosis is a fungal infection of nails of fingers of the hands or feet, resulting in thinning, and the subsequent destruction, discoloration and desquamation of the nail plate from the nail bed. The etiology of onychomycosis in most cases are dermatomycetes, Candida species and non-dermatomycetes filamentous fungi. The prevalence of onychomyc...
Article
Full-text available
The high prevalence of invasive candidiasis (IC) in intensive care units (ICU) is one of the major problems of medical mycology and the modern medicine in general. More than 10% of all infections in ICU are caused by Candida spp. Infections caused by Candida species are associated with the high mortality, including patients in ICUs. The high rates...
Article
Full-text available
Candida krusei is well known as a fungal pathogen for patients with hematologic malignancies and for transplant recipients. Using the ARTEMIS Antifungal Surveillance Program database, we describe geographic and temporal trends in the isolation of C. krusei from clinical specimens and the in vitro susceptibilities of 3,448 isolates to voriconazole a...
Article
Full-text available
Invasive mycoses are the substantial cause of morbidity and mortality in immunocompromised children. The prevalence of invasive mycoses in this population is around 25% and the mortality rates are run up to 55-60%. Invasive candidiasis is a major clinical form of systemic fungal infections, and in approximately 60% of all cases in children C. albic...
Article
Full-text available
Invasive fungal infections are an existent and growing problem of modern medicine. The prevalence of invasive fungal infections significantly grew during the last few decades concurrently with the increasing number of immunocompromised patients. The number of available and approved systemic antimycotics is not too big, and a progress in development...
Article
Full-text available
Discovery and implication to the clinical practice of macrolide antibiotics became one of the most significant achievements in the history of antimicrobial therapy. The most prescribe macrolide, e.g. in the USA, is azithromycin, which is closely connected with unique pharmacokinetic and pharmacodynamic properties of the drug. These allowed azithrom...
Article
Full-text available
Roxithromycin is one of the most common semi-synthetic 14-membered macrolides. High activity against gram-positive flora, a number of gram-negative pathogens, as well as intracellular and atypical pathogens makes it possible to use it in a wide range of diseases, primarily respiratory and urogenital infections. An important feature of roxithromycin...
Article
Full-text available
Fluconazole in vitro susceptibility test results for 140,767 yeasts were collected from 127 participating investigators in 39 countries from June 1997 through December 2003. Data were collected on 79,343 yeast isolates tested with voriconazole from 2001 through 2003. All investigators tested clinical yeast isolates by the CLSI (formerly NCCLS) M44-...
Conference Paper
Full-text available
Purpose of the study. To assess the susceptibility of clinically significant Candida glabrata (Cg) and Candida krusei (Ck) isolates to fluconazole (FLU) and voriconazole (VOR) using disk diffusion method (DDM). Methods. These data are interim data of the global antifungal surveillance study ARTEMIS Disk, sponsored by Pfizer, Inc. Candida isolates...
Article
Full-text available
Discovery and implication to the clinical practice of macrolide antibiotics became one of the most significant achievements in the history of antimicrobial therapy. The most prescribe macrolide, e.g. in the USA, is azithromycin, which is closely connected with unique pharmacokinetic and pharmacodynamic properties of the drug. These allowed azithrom...
Article
Full-text available
Invasive mycoses year by year becomes more and more actual problem of the practical medicine. This is due to increasing number of immunocompromised patients population. Despite the fact that the main causative agents remains Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, the number of cases of systemic fungal infection due to...
Article
Full-text available
Моксифлоксацин - новый 8�метоксихинолон широкого спектра действия с высокой активнос� тью в отношении как грам(+) и грам(-) аэробов, так и внутриклеточных возбудителей и анаэро� бов. Обладает активностью в отношении микро� организмов, резистентных к другим классам ан� тибактериальных препаратов, включая пеницил� лино� и макролидорезистентные пневмо...
Article
Full-text available
1 НИИ детской гематологии МЗиСР РФ, Москва, Россия 2 Гематологический научный центр РАМН, Москва, Россия 3 НИИ антимикробной химиотерапии, Смоленск, Россия Комментарии к обзору Поражения, вызванные грибами рода Aspergillus, известны очень давно, однако инвазивный аспер-гиллез (ИА) возник в качестве важнейшей проблемы медицины сравнительно недавно,...
Article
Full-text available
2 Городская клиническая больница №2, Краснодар 3 Гематологический научный центр РАМН, Москва 4 Областная детская клиническая больница, Иркутск 5 НИИ медицинской микологии, СанкттПетербург 6 Онкологический научный центр РАМН, Москва 7 Областная клиническая больница, Новосибирск 8 Городской центр лабораторной диагностики, Екатеринбург В 2003 г. восем...

Questions

Question (1)
Question
Hi! Do we have any comprehensive review of the data regarding prevention/prophylaxis of fungal foot infections (Athlete's foot) in different categories of patients, including antifungal agents, certain devices, etc.? Thanks.

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