Alexander Veselov

Smolensk State Medical University · Institute of Antimicrobial Chemotherapy

The steadily increasing incidence of invasive fungal infections, influenced to some extent by the COVID-19 pandemic, caused by both yeast and molds makes it necessary to improve the antifungal therapies used. Historically, azoles have held a key position with respect to a range of clinical forms and patient populations. Isavuconazole is the newest...

Invasive fungal infections in various categories of patients remain one of the most urgent problems of modern medicine. This is complicated by the imperfection of diagnostic methods, as well as a small range of antimycotics for systemic use. The market launch in 2005 of posaconazole, a second-generation systemic antimycotic from the group of triazo...

Invasive fungal infections are one of the main causes of morbidity and mortality in pediatric oncohematological patients. The incidence of invasive mycoses in children and adolescents generally ranges from <5% to >10%, depending on a variety of risk factors; early diagnosis and early initiation of effective antifungal therapy are critical componen...

The SARS-CoV-2 pandemic has highlighted a clear need to find ways to prevent this infection, primarily through the creation of effective and safe vaccines; so, efforts in this direction have been made by a number of pharmaceutical and biotechnology companies with varying degrees of success. If classical vaccines did not raise questions about the me...

Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality. For the treatment of invasive mycoses, a few number of drugs are currently available, which include polyenes, azoles, echinocandins, allylamines and flucytosine. Among these groups, echi...

Posaconazole is a broad-spectrum triazole antifungal agent with potent activity against various fungi, including yeast and molds, including Mucorales, what makes a key difference with itraconazole and voriconazole. Clinical studies have demonstrated his efficacy for prophylaxis against invasive fungal infections in hematological patients at high ri...

Posaconazole is a broad-spectrum triazole antifungal agent with potent activity against various fungi, including yeast and molds, including Mucorales, what makes a key difference with itraconazole and voriconazole. Clinical studies have demonstrated his efficacy for prophylaxis against invasive fungal infections in hematological patients at high ri...

Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida glabrata is becoming an increasingly relevant species, especially in oncohematology patients who hav...

Invasive fungal infections continue to show steady growth among various patient populations, accompanied by high rates of both morbidity and attributive mortality. For the treatment of invasive mycoses, a few number of drugs are currently available, which include polyenes, azoles, echinocandins, allylamines and flucytosine. Among these groups, echi...

Invasive candidiasis is a common, severe and often difficult to treat complication in various categories of patients. Despite the fact that in most cases Candida albicans retains a leading position as an etiological cause, a pathogen such as Candida glabrata is becoming an increasingly relevant species, especially in oncohematology patients who hav...

P. aeruginosa is not only intrinsically resistant to many groups of antimicrobials, but is also extremely capable in acquiring resistance to almost all antibacterial agents that are used for the therapy of infections caused by this pathogen, making the choice of treatment regimens very complicated. In this article we review the guidelines by the Sp...

Patients undergoing cytotoxic chemotherapy and hematopoietic stem-cell transplantation are at risk for infection. The risk of infections increases with the depth and duration of neutropenia, with the greatest risk occurring in patients who experience profound, prolonged neutropenia after chemotherapy, which is most likely to occur in the period bef...

An update on 2010 clinical practice guideline on Clostridium difficile infection (CDI) by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) was published in March 2018. This new version of guideline not only includes significant changes in the management of this infection and reflects the ev...

Objective. To determine susceptibility of C. glabrata isolates to anidulafungin, caspofungin and micafungin using the SensititreTM YeastOneTM system. Materials and Methods. C. glabrata isolates were taken prospectively from clinical specimens or from strains collections in the participating sites. Susceptibility determination was performed using Se...

An update on 2010 clinical practice guideline on Clostridium difficile infection (CDI) by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) was published in March 2018. This new version of guideline not only includes significant changes in the management of this infection and reflects the ev...

Invasive infections caused by Candida species are the most common invasive fungal infections in children of different age groups. Premature neonates, especially newborns with low and extremely low birth-weight, have very high mortality rates, with the highest numbers in case of the central nervous system impairment. Among older children, by analogy...

Posaconazole is a second generation triazole with a broad spectrum of activity, which first appeared on the market in 2005 in the form of a suspension for oral administration. Despite some progress made in the framework of clinical trials, the problems associated with both the features of the pharmacokinetics of an oral suspension, and with the ina...

Invasive candidiasis is one of the main infectious complications in patients with impaired immunity, and severely ill patients in intensive care units, including premature neonates. High rates of morbidity and mortality in patients who have risk factors for invasive candidiasis, changes in the spectrum of pathogens in favor of the non-albicans spec...

The resistance of the systemic Candida infections causative agents is a cornerstone of the selection of an effective therapy. But if before the problem was limited to resistance to azole antifungals, then by now we have enough data about cases of treatment failures with echinocandins, which for today are the drugs of choice for treating most clinic...

АМ для системного применения по праву могут быть отнесены к категории жизнеспасающих препаратов. Возрастание числа ИМ требует от клинициста не только грамотных диагностических действий, но и своевременного назначения адекватной по клинико-фармакологическим характеристикам противогрибковой терапии. Несмотря на небольшое число доступных АМ для систем...

Rising incidence of invasive fungal infections caused by both yeast and filamentous micromycetes, making it necessary for the improvement of the applied therapy of antifungal drugs. Among them triazoles occupies a key position. Problems associated with secondary resistance, tolerability, drug-drug interactions, as well as availability of certain fo...

ANIDULAFUNGIN: SHORT CLINICO-PHARMACOLOGICAL REVIEW Veselov A. Institute of Antimicrobial Chemotherapy, Smolensk, Russia Abstract Invasive fungal infections are an actual problem of the modern medicine. This is due to the widening population of the affected patients and the increasing number of fungal strains that are resistant to the previously e...

Onychomycosis is a fungal infection of nails of fingers of the hands or feet, resulting in thinning, and the subsequent destruction, discoloration and desquamation of the nail plate from the nail bed. The etiology of onychomycosis in most cases are dermatomycetes, Candida species and non-dermatomycetes filamentous fungi. The prevalence of onychomyc...

The high prevalence of invasive candidiasis (IC) in intensive care units (ICU) is one of the major problems of medical mycology and the modern medicine in general. More than 10% of all infections in ICU are caused by Candida spp. Infections caused by Candida species are associated with the high mortality, including patients in ICUs. The high rates...

Candida krusei is well known as a fungal pathogen for patients with hematologic malignancies and for transplant recipients. Using the ARTEMIS Antifungal Surveillance Program database, we describe geographic and temporal trends in the isolation of C. krusei from clinical specimens and the in vitro susceptibilities of 3,448 isolates to voriconazole a...

Invasive mycoses are the substantial cause of morbidity and mortality in immunocompromised children. The prevalence of invasive mycoses in this population is around 25% and the mortality rates are run up to 55-60%. Invasive candidiasis is a major clinical form of systemic fungal infections, and in approximately 60% of all cases in children C. albic...

Invasive fungal infections are an existent and growing problem of modern medicine. The prevalence of invasive fungal infections significantly grew during the last few decades concurrently with the increasing number of immunocompromised patients. The number of available and approved systemic antimycotics is not too big, and a progress in development...

Discovery and implication to the clinical practice of macrolide antibiotics became one of the most significant achievements in the history of antimicrobial therapy. The most prescribe macrolide, e.g. in the USA, is azithromycin, which is closely connected with unique pharmacokinetic and pharmacodynamic properties of the drug. These allowed azithrom...

Roxithromycin is one of the most common semi-synthetic 14-membered macrolides. High activity against gram-positive flora, a number of gram-negative pathogens, as well as intracellular and atypical pathogens makes it possible to use it in a wide range of diseases, primarily respiratory and urogenital infections. An important feature of roxithromycin...

Fluconazole in vitro susceptibility test results for 140,767 yeasts were collected from 127 participating investigators in 39 countries from June 1997 through December 2003. Data were collected on 79,343 yeast isolates tested with voriconazole from 2001 through 2003. All investigators tested clinical yeast isolates by the CLSI (formerly NCCLS) M44-...

Purpose of the study. To assess the susceptibility of clinically significant Candida glabrata (Cg) and Candida krusei (Ck) isolates to fluconazole (FLU) and voriconazole (VOR) using disk diffusion method (DDM). Methods. These data are interim data of the global antifungal surveillance study ARTEMIS Disk, sponsored by Pfizer, Inc. Candida isolates...

Discovery and implication to the clinical practice of macrolide antibiotics became one of the most significant achievements in the history of antimicrobial therapy. The most prescribe macrolide, e.g. in the USA, is azithromycin, which is closely connected with unique pharmacokinetic and pharmacodynamic properties of the drug. These allowed azithrom...

Invasive mycoses year by year becomes more and more actual problem of the practical medicine. This is due to increasing number of immunocompromised patients population. Despite the fact that the main causative agents remains Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, the number of cases of systemic fungal infection due to...

Моксифлоксацин - новый 8�метоксихинолон широкого спектра действия с высокой активнос� тью в отношении как грам(+) и грам(-) аэробов, так и внутриклеточных возбудителей и анаэро� бов. Обладает активностью в отношении микро� организмов, резистентных к другим классам ан� тибактериальных препаратов, включая пеницил� лино� и макролидорезистентные пневмо...

1 НИИ детской гематологии МЗиСР РФ, Москва, Россия 2 Гематологический научный центр РАМН, Москва, Россия 3 НИИ антимикробной химиотерапии, Смоленск, Россия Комментарии к обзору Поражения, вызванные грибами рода Aspergillus, известны очень давно, однако инвазивный аспер-гиллез (ИА) возник в качестве важнейшей проблемы медицины сравнительно недавно,...

2 Городская клиническая больница №2, Краснодар 3 Гематологический научный центр РАМН, Москва 4 Областная детская клиническая больница, Иркутск 5 НИИ медицинской микологии, СанкттПетербург 6 Онкологический научный центр РАМН, Москва 7 Областная клиническая больница, Новосибирск 8 Городской центр лабораторной диагностики, Екатеринбург В 2003 г. восем...