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Alexander N Shikov

Alexander N Shikov
Saint Petersburg State Chemical Pharmaceutical University · Technology of Pharmaceutical formulations

Professor

About

187
Publications
54,438
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2,613
Citations
Additional affiliations
September 2016 - present
St. Petersburg State Chemical Pharmaceutical University
Position
  • Professor
March 2007 - July 2019
Saint Petersburg Institute of Pharmacy
Saint Petersburg Institute of Pharmacy
Position
  • Professor (Full)

Publications

Publications (187)
Preprint
Brown seaweeds due to their wide range of bioactive compounds have a high ability to inhibit free radicals and protect against ultraviolet rays. In the present study, the ethyl acetate fraction was isolated from the Padina boergesenii brown alga. Antioxidant activity (by inhibition DPPH free radical method) and cytotoxicity against UVB-induced cyto...
Article
Full-text available
Phlorotannins are polyphenolic compounds in brown algae and can be used as a natural UV filter in sunscreen formulations. The aim of the present study was to characterize the biological activities of phlorotannins-rich fractions from the brown alga Polycladia myrica and to validate the protective effect as well as stability of cream formulation wit...
Article
Full-text available
In recent years, natural deep eutectic solvents (NADES) have been widely investigated for the extraction of food and medicinal plants as well as seaweeds. However, the ability of NADES for trace elements co-extraction from natural sources is not well investigated. The aim of this study was to investigate the ability of common NADES for trace elemen...
Article
Full-text available
Fucus vesiculosus is one of the most prominent brown algae in the shallow waters of the seas of the Arctic region (Barents (BS), White (WS), Norwegian (NS), and Irminger (IS)). The aim of this study was to determine the biochemical composition of F. vesiculosus from the Arctic at different reproductive phases, and to evaluate the antioxidant proper...
Chapter
The extraction of raw plant material is an initial stage in the preparation of herbal medicinal products (HMP). In this chapter, specific factors playing a crucial role in the efficacy of the recovery of active metabolites from medicinal plants are discussed. Based on the definition of HMP in regulatory documents, the main parameters for the qualif...
Article
Full-text available
Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoidan-based cream formulation and to investigate its...
Article
Modern-day regulatory systems governing conditions for how health products enter national markets constitute a barrier of access for traditional herbal medicines on an international level. Regulatory intentions are focused on ensuring consumers are being provided with safe, efficacious and high-quality products that, however, collaterally limit opp...
Article
Full-text available
Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine ( Tripterygium wilfordii Hook.f.), has shown remarkable potency against obesi...
Article
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Background: Polyherbal mixtures called “medical species” are part of traditional and officinal medicine in Russia. This review aimed to analyze medical species used in Russia for the treatment of diabetes and related disorders. The information relevant to medical species, diabetes, and obesity was collected from local libraries, the online service...
Article
Full-text available
The impact of the composition of natural deep eutectic solvents (NADES) and extraction conditions on the simultaneous extraction of hydrophilic ascorbic acid (AA), phlorotannins (TPhC), and lipophilic fucoxanthin (FX) from Fucus vesiculosus was investigated for the first time. In biological tests, the NADES extracts showed the promising ability to...
Article
Ethnopharmacological relevance Eleutherococcus senticosus (Rupr. et Maxim.) Maxim (ES) (syn. Acanthopanax senticosus (Rupr. & Maxim.) Harms) is a medicinal plant used in traditional medicine of Russian Far East and East Asia and known as an adaptogen – a category of herbal medicinal products which have non-specific inter-system anti-stress effects...
Article
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The roots of Glycyrrhiza spp. have been utilized in Traditional Chinese medicine (TCM) for thousands of years. Non-traditional (aerial) parts constitute a large portion of the biomass of Glycyrrhiza plants and are mostly discarded after harvesting the roots and rhizomes. Through comparative phytochemical and anti-inflammatory activity analyses, thi...
Article
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Herbal teas or herbal drinks are traditional beverages that are prevalent in many cultures around the world. In Traditional Chinese Medicine, an herbal drink infused with different types of medicinal plants is believed to reduce the ‘Shang Huo’, or excessive body heat, a status of sub-optimal health. Although it is widely accepted and has a very la...
Article
Ethnopharmacological relevance Herbal medicine in Russia has a long history starting with handwritten herbalist manuscripts from the Middle Ages to the officinal Pharmacopoeia of the 21st century. The "herbophilious" Russian population has accumulated a lot of knowledge about the beneficial effects of local medicinal plants. Yet, for a long time, R...
Article
Modern-day regulatory systems governing conditions for how health products enter national markets constitute a barrier of access for traditional herbal medicines on an international level. Regulatory intentions are focused on ensuring consumers are being provided with safe, efficacious and high-quality products that, however, collaterally limit opp...
Article
Full-text available
Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern...
Article
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Marine organisms represent an excellent source of innovative compounds that have the potential for the development of new drugs. The pharmacokinetics of marine drugs has attracted increasing interest in recent decades due to its effective and potential contribution to the selection of rational dosage recommendations and the optimal use of the thera...
Article
Introduction Les remèdes phytothérapiques associent souvent plusieurs composés censés potentialiser leurs propriétés intrinsèques. En Belgique, il est probable que les patientes ayant développé une néphropathie aux acides aristolochiques (AA) aient ingéré des racines broyées d’Aristolochia mais aussi des écorces de Magnolia officinalis dont certain...
Article
The discovery and development of drugs that can compete in effectiveness with direct anticoagulants is a critical problem. Fucoidan is a complex branched heteropolysaccharide with anticoagulant and antithrombic activity. Fucoidan drug substance is hygroscopic and possesses poor technological properties. This study was aimed at development of the op...
Article
Full-text available
Rhodiola rosea L. (roseroot) is an adaptogen plant belonging to the Crassulaceae family. The broad spectrum of biological activity of R. rosea is attributed to its major phenyletanes and phenylpropanoids: rosavin, salidroside, rosin, cinnamyl alcohol, and tyrosol. In this study, we compared the content of phenyletanes and phenylpropanoids in rhizom...
Article
Full-text available
Introduction . In recent years, substances extracted from plant materials have been widely used in the pharmaceutical, cosmetic and food industries. Such substances are used as solutions, dry extracts for the manufacture of medicines, dietary supplements, cosmetic creams, food additives in various forms – tablets, capsules, solutions, granular powd...
Article
Full-text available
The aim of this study was to elucidate some mechanisms of radical scavenging and the anti-inflammatory, anti-hyperglycemic, and anti-coagulant bioactivities of high molecular weight fucoidan from Fucus vesiculosus in several in vitro models. Fucoidan has displayed potent 1, 1-diphenyl-2-picryl hydrazil radical scavenging and reduction power activit...
Article
Full-text available
The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett–Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters teste...
Article
Full-text available
Fucoidan, a fucose-rich polysaccharide from brown algae, has been used for transdermalformulations targeting inflammatory skin conditions, for the treatment of thrombosis, vascularpermeability diseases, subcutaneous wounds, and burns. However, the pharmacokinetics offucoidan after topical application has not been described. In this study, an ointme...
Article
Ethnopharmacological relevance: Aqueous autolysate from the snake Eryx miliaris (SNA) has been used in traditional medicine of Uzbekistan as anti-inflammatory, hepatoprotective and immunomodulatory agent. However, little is known about the chemical composition and its mechanisms of activity. Aim of the study: This is our first attempt to analyse...
Article
Full-text available
A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i/n) administration over the cou...
Article
Full-text available
Natural deep eutectic solvents (NADES) are promising green solvents for extracting biologically active compounds from plant raw material. This is the first study in which NADES were used to extract phlorotannins from brown algae Fucus vesiculosus L. and Ascophyllum nodosum (L.) Le Jolis. The extraction efficiency of polyphenols was evaluated using...
Article
Full-text available
Природные глубокие эвтектические растворители (ПГЭР) являются перспективными «зелеными» растворителями для экстракции биологически активных веществ из растительного сырья. Это первое исследование, в котором ПГЭР использованы для извлечения флоротанинов из бурых водорослей Fucus vesiculosus L. и Ascophyllum nodosum (L.) Le Jolis. На основе холина хл...
Article
Recent publication evidenced about rationality and efficacy of combinatory therapy of antibiotic resistance, diabetes, obesity, cancer, viral infections, inflammatory bowel disease, etc. The combination of nutrients and pharmaceuticals has a good chance of contributing to a modern strategy of multi-target drug discovery. Different approaches and me...
Article
Full-text available
Due to their wide distribution, chemical diversity and scientifically confirmed pharmacological properties, sea urchin pigments have evoked renewed interest as a promising source material for the development of drugs that might be useful in clinical practice for the treatment of various human diseases. This review discusses advances in the chemistr...
Article
Full-text available
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharm...
Article
The pharmacokinetics of ubiquinol in a new dosage form for intravenous injection were studied for the first time. Biexponential kinetic curves were found using HPLC with electrochemical detection in 48-h experiments in rats. The main pharmacokinetic parameters, i.e., area under the kinetic curves, elimination half-life, and total clearance, were ca...
Article
Full-text available
Introduction. Polysaccharide-based polymers have a great potential of using in pharmaceutical industry and biotechnology. The advantages of agar versus other gelling agents are its higher stability at low pH values and elevated temperatures. Plasticizers increase the flexibility of the film and prevent its crack during processing and storage. Objec...
Article
Full-text available
Впервые изучена фармакокинетика убихинола в инновационной лекарственной форме для внутривенного введения. В эксперименте на крысах продолжительностью 48 ч с использованием метода ВЭЖХ с электрохимическим детектированием выявлен биэкспоненциальный характер кинетических кривых и рассчитаны основные фармакокинетические параметры: площадь под кинетичес...
Article
Full-text available
The lipids from gonads and polyhydroxynaphthoquinone pigments from body walls of sea urchins are intensively studied. However, little is known about the body wall (BW) lipids. Ethanol extract (55 °C) contained about equal amounts of saturated (SaFA) and monounsaturated fatty acids (MUFA) representing 60% of total fatty acids, with myristic, palmiti...
Article
Full-text available
Historically Russia can be regarded as a “herbophilious” society. For centuries the multinational population of Russia has used plants in daily diet and for self-medication. The specificity of dietary uptake of medicinal plants (especially those in the unique and highly developed Russian herbal medical tradition) has remained mostly unknown in othe...
Preprint
Full-text available
The pharmacokinetics of ubiquinol in a new dosage form for intravenous injection were studied for the first time. Biexponential kinetic curves were found using HPLC with electrochemical detection in 48-h experiments in rats. The main pharmacokinetic parameters, i.e., area under the kinetic curves, elimination half-life, and total clearance, were ca...
Article
Introduction. Fucoidans combine the properties of anticoagulants, thrombin inhibitors, and fibrinolytic drugs. They are promising for clinical use and are an alternative to heparin. When procedures are developed for quality control of herbal medicines, it is necessary to follow the principles of through standardization. Objective: to develop and va...
Article
Extraction of lipophilic substances from shells and spines of green sea urchins (Strongylocentrotus droebachiensis) was studied. It was found that the extraction time had the greatest influence on the yield of lipophilic substances whereas temperature and extraction modulus had insignificant effects. Ethanol (95%) was chosen as the extractant affor...
Article
Some features of the HPLC determination of two hydrophilic substances that poorly absorb in the UV spectral region (chondroitin sodium sulfate and glucosamine hydrochloride), associated with the absorption in the near UV region (195 nm) of components of buffer solutions with different pH values (1.2, 4.5, and 6.8), are considered. Such solutions ar...
Article
Full-text available
Изучен процесс экстракции липофильных веществ из панциря с иглами зеленого морского ежа. Установлено, что наибольшее влияние на выход липофильных веществ оказывает время экстракции, в то время как температура и модуль экстракции оказывают незначительное влияние. В качестве экстрагента, извлекающего максимальное количество липофильных веществ, выбра...
Article
Introduction. Preclinical studies using laboratory animals are one of the most important stages of drug registration. When using an object in the carrier, its homogeneity, concentration, and stability in this medium should be established in accordance with the regulatory document «Principles of Good Laboratory Practice» [1]. Thus, organizations inv...
Article
Full-text available
The data of possibilities to use biologically active compounds, peptides and polysaccharides in particular, from sea urchins as potent sources of drugs are represented in the article. Their ability to act on the main chains of pathogenesis of the respiratory viral infections has been shown. So peptides and polysaccharides possess anti-inflammatory...
Article
Ultraviolet–visible spectroscopy and UPLC–DAD–MS were used for analysis of stability of ethanol solutions of ethylidene-6,6′-bis(2,3,7-trihydroxynaphthazarin) (ENZ), spinochrome dimer (SDM) and spinochrome D (SD) that were isolated from Strongylocentrotus droebachiensis. In the freshly prepared solution, the concentration of ENZ at pH 6.0 was at 6...
Article
Combination offish oil with herbal oil extract can extend functional properties of the products. A new functional food of salmon oil with oil extract of motherwort (8:2) was developed and studied. Qualitative profiling was evidenced about presence of flavonoids and iridoids. Quantification of vitamins A (210±3 IU/g), E (2.8±0.1 mg/g), D3 (12.2±0.4...
Article
Full-text available
We performed the study of the anti-inflammatory activity of glycosylated polypeptide complex (GPC) extracted from sea urchins Strongylocentrotus droebachiensis in the model of acute bronchitis induced by endotracheal administration of 1% formalin solution in male Wistar rats. Animals of experimental groups were inhaled by GPC solution at 25, 50 and...
Article
Full-text available
Pharmacokinetics of ketoprofen nanosystem was studied in outbred rats after single endotracheal administration. Ketoprofen was analyzed in blood serum and tissues by HPLC with UV detection. After endotracheal administration of the nanosystem, ketoprofen rapidly appears in systemic blood flow and its concentration in blood serum reaches maximum afte...
Article
Background and objectives: Betulin is a triterpene extracted from the cork layer of the outer bark of Betula spp. It has a wide spectrum of pharmacological activities, including being lung protective; however, its bioavailability is low. To increase its bioavailability, betulin was entrapped in a nanosystem (BN). In this study, we investigated the...
Article
Brown alga (Phaeophyta) lipids that have a broad range of pharmacological activity are promising compounds. Two brown alga species, such as Fucus vesiculosus and Ascophyllum nodosum, are most common in the seas of the North-Western Region. Instrumental high-performance thin layer chromatography was performed to comparatively investigate lipid extra...
Article
Background. Fucoidans are sulfated homo- and heteropolysaccharides synthesized by the cells of brown algae (Phaeophyta) of different species. Fucoidan extracted from bladderwrack (Fucus vesiculosus L.) is promising for designing novel anticoagulants [3]. Objective: to choose conditions for preparing samples to quantify fucoidan in the bladderwrack...
Article
Pharmacokinetics of ketoprofen nanosystem was studied in outbred rats after single endotracheal administration. Ketoprofen was analyzed in blood serum and tissues by HPLC with UV detection. After endotracheal administration of the nanosystem, ketoprofen rapidly appears in systemic blood flow and its concentration in blood serum reaches maximum afte...
Article
The anti-inflammatory activity of glycosylated polypeptide complex (GPC) extracted from sea urchin Strongylocentrotus droebachiensis was studied in the model of acute bronchitis induced by formalin in rats. The experiment was performed in Wistar male rats. All animals were divided into six groups: four experimental, one control and one intact group...
Article
Full-text available
Fish oil is reach natural source of vitamins А, Е, D and polyunsaturated fatty acids (PUFA) which are useful for supplementation, prophylaxis and therapy in food industry, medicine and veterinary. The analysis of regulatory documents for the quality of fish oil (based on concentration of main nutrients) leads to conclusion that content of vitamins...
Article
The effects of ultrasound treatment on the chemical composition and anticoagulant properties of a dry extract of bladderwrack (Fucus vesiculosus) (DFE) prepared by complex processing of thalli were studied. Ultrasound treatment at the stage of extracting Fucus meal was fond to affect the composition of sugars and the quantitative contents of fucoid...
Article
Full-text available
In the experimental pre-clinical study on spontaneously hypertensive rats, it was established for the first time that the standard extract of green sea urchin go-nads in doses of 0.37 and 0.74 mg/kg after peroral administration for 34 days decreases the blood glucose concentration (to almost the base level) more effecti-vely than does the reference...