Alexander V Latanov

Alexander V Latanov
Lomonosov Moscow State University | MSU · Neurobiology

Professor

About

106
Publications
4,850
Reads
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758
Citations
Citations since 2017
42 Research Items
288 Citations
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201720182019202020212022202301020304050
201720182019202020212022202301020304050

Publications

Publications (106)
Article
Full-text available
Parkinson’s disease (PD) is characterized by slow progression with a long prodromal stage and the gradual evolution of both neuropsychological symptoms and subtle motor changes, preceding motor dysfunction. Thus, in order for animal models of PD to be valid, they should reproduce these characteristics of the disease. One of such models, in which ne...
Article
Full-text available
Background: Eye movement parameters are often used during cognitive functioning assessments of patients with psychotic spectrum disorders. It is interesting to compare these oculomotor parameters with cognitive functions, as assessed using psychometric cognitive tests. A network analysis is preferable for understanding complex systems; therefore, t...
Chapter
Full-text available
Visual cognition relies on a distinct type of eye movements called saccades. The cerebellum is important for all types of eye movements and gaze fixation stability and is involved in cognitive functions. In our previous research, we reported oculomotor deficits in cerebellar patients: unstable gaze fixation, incorrect hypermetric (‘overshooting’) s...
Chapter
Interest as a positive emotion is closely related to the ability to process new information and/or better consolidate the information which has already been perceived, increase in attention to what one is interested in, and indicators of processing, learning, and motivation [1]. Here we aim to identify oculomotor and electroencephalographic correla...
Chapter
We investigated dependence of eye movement parameters on musical notation complexity and performance quality. 29 students of piano classes of Tchaikovsky Moscow State Conservatory and The Gnesins Russian Academy of Music were enrolled in the study. The participants were asked to sight-read three two-staves fragments of classical music works of diff...
Chapter
Full-text available
Children who survived cerebellar tumor occur with atactic motor dis-orders. These disorders could be represented in postural, locomotor and oculomotor domains. The gait efficiency depends on visual information acquired from saccadic eye movements. The aim of the study was to establish the relationships between measures of tandem gait and saccades a...
Article
The cerebellum plays an important role in controlling saccadic eye movements and fixing gaze. Cerebellar lesions produce a variety of impairments to oculomotor behavior and associated psychophysiological processes. Such impairments have significant influences on the effectiveness of rehabilitation measures in patients treated for cerebellar tumors....
Article
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The existence of niches of stem cells residence in the ventricular–subventricular zone and the subgranular zone in the adult brain is well-known. These zones are the sites of restoration of brain function after injury. Bioengineered scaffolds introduced in the damaged loci were shown to support neurogenesis to the injury area, thus representing a s...
Article
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This review addresses approaches to modeling impairments to brain function assessed in adulthood by targeted treatments during the perinatal period. Models of neuromental disorders linked with impairments to the dynamics of brain development are considered, along with models of diseases characteristic of older people. Pharmacological actions on the...
Article
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Objective: To determine the network connections between clinical, cognitive, speech and oculographic parameters in patients with schizophrenia. Material and methods: The study included 104 patients with schizophrenia and schizophrenia spectrum disorders and 70 healthy subjects. Clinical assessment of the patients was performed using a number of...
Article
This study summarizes results from studies of behavior and visuomotor functions in monkeys (rhesus macaques) during development of parkinsonism-like syndrome induced by chronic administration of small doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). An operant conditioned reflex method was used to study the amplitude-tim...
Article
The link between the subjective perception of time and the functioning of the top-down and bottom-up visual attention subsystems was studied on performance of visual tasks using the Go/No Go and Go/No Go Change paradigms (with changes in the relevant stimulus) by sportsmen with different skill levels. Eye movements were recorded during task perform...
Article
Depression in the biological models considered here can be split into two opposite patterns of changes in serotonin and dopamine levels, corresponding to passive and active stress response tactics [Selye, 1979] – ↑5HT, ↓DA and ↓5HT, ↑DA. Unavoidable pain stimulation, chronic moderate aversive stimulation, unavoidable social suppression, and learned...
Article
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The closeness of the evolutionary origin, physiology, and structure of the brain with humans makes lower primates the preferred experimental animals for biomedical research. Many brain diseases induce degradation of cognitive capacities. Various aspects of impairments to cognitive functions are studied in model experiments in monkeys. In the presen...
Poster
Full-text available
In this poster we present a proof of concept for non-invasive anatomically customized monkey head immobilization system. Monkey was trained to execute saccades to peripheral stimuli and respond by pressing an ipsilateral lever, receiving reward (juice). Eye movements were recorded using IR camera (200 and 500 fps), FastVideoLab software and hardwar...
Article
Full-text available
The visually driven instrumental conditioning on a one monkey (Macaca mulatta) was conducted after single-dose cranial irradiation with high-energy protons. The monkey executed saccades toward the visual stimuli and then performed the movement with ipsilateral hand correspondingly to their location in a right or left visual hemifield. The rate of c...
Article
The visually driven instrumental conditioning of a single monkey (Macaca mulatta) was conducted after single-dose cranial irradiation with high-energy protons. The monkey executed saccades toward the visual stimuli and then responded by manually pressing right or left lever for stimuli in right or left half-field, respectively. The percentage of co...
Code
The review considered approaches to the modeling of brain function impairment, evaluated in the adult state, by the method of directed action in the perinatal period. We considered the models of neurodevelopment disorders and models of adult diseases. It has been shown that pharmacological impact to the developing brain induces delayed behavioral s...
Chapter
We have analysed the basic characteristics of music playback at sight-reading of three two-line classic music selections of varying textures and complexity: a two-voice polyphonic musical piece, a theme and a variation of homophonic-harmonic musical piece. These characteristics serve as objective indicators of the musicians’ skill of sight-reading,...
Conference Paper
Принятие решения – проблема, которая волнует исследователей начиная со времен Античности до наших дней и которая занимает одно из ключевых мест в психологии и в других областях знаний (Greco, Figueira, 2005). Особый интерес принятие решения представляет собой в экономической науке (Saaty, 2008). Прежде чем принять решение о выборе потребитель произ...
Conference Paper
Full-text available
Introduction: A decrease of blood oxygen saturation level is observed in athletes in conditions of natural hypobaric hypoxia at high altitudes. This leads to corresponding shifts in functional state of athletes, in particular, in the cardiovascular system and its autonomic regulation. We used biofeedback (BF) method for correcting the functional st...
Article
Nowdays modern commercials presented to consumers in mass media contain a lot of text that carries key information for understanding the features of the product or service. However, this information cannot always be perceived and understood by consumers. Unique fact of viewing a text does not mean that consumer has perceived and comprehended the me...
Poster
Full-text available
The aim of this study was to investigate the EEG-correlates of subjective estimation of time spent. We have studied the dynamics of EEG power (10/20 standard electrode positions: O1, O2, P3, P4, C3, C4, F3, F4) during Go/No go task performance. Our participants performed four blocks of Go/No go task trials. They gave verbal time estimation of block...
Poster
Full-text available
The aim of this study was to investigate specificity of eye movement’s parameters during mixed facial emotion recognition task. We analyzed the fixation numbers in lower (L) and upper (U) part of emotional face stimuli during emotion recognition task performance. We used morphed emotional faces. Source stimuli were images of basic emotions and neut...
Article
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The aim of the work was the approbation of a method for correcting the functional state of participants in a high-altitude expedition using biofeedback (BF) technologies. Methods. A study of the dynamics of heart rate (HR) variability during the sessions of biofeedback training in the highlands (F. F. Konyuhov Everest expedition) was carried out. T...
Conference Paper
Full-text available
The cerebellar lesions inevitably provoke oculomotor impairments in patients of different age. Symptoms of subtentorial tumors, particularly medullobastomas, include static and dynamic coordination disorders (ataxia, asynergia, imbalance), hypo-muscle tonus, disruption of the cranial nerves, and within the oculomotor system-nystagmus (fine or gross...
Poster
Full-text available
Aim Nowdays modern commercials presented to consumers in mass media contain a lot of text that carries key information for understanding the features of the product or service. However, the comprehension of issues depends of many factors including volume of verbal and nonverbal information, physical features of the text and the background and also...
Article
Full-text available
We investigated the relationship between subjective time perception and functioning of top-down and bottom-up subsystems of visual attention. We studied the engagement of focal and ambient vision during visual tasks performance in athletes with different skill level. They performed Go/No go task and Go/No go task with stimuli relevance replacement...
Poster
Full-text available
The aim of this study was to investigate whether there is a relationship between subjective time perception and visual attention. We have studied the engagement of focal and ambient vision during visual tasks performance. Our participants were athletes with different skill level. They performed Go/No go task and Go/No go task with stimuli relevanc...
Article
Full-text available
We studied the basic characteristics of the music playback while sight-reading of three two-line musical selections of classic music of different textures and complexity–two-voice polyphonic musical piece, the theme and variation of homophonic-harmonic musical piece. The tempo of play and the number of errors depend on the texture of a musical sele...
Conference Paper
Eye movements relate to the content that consumer see. A logo is one of the most important features of advertisement that we see every day on the billboards, on TV, and in the world wide web. Differences in fixation numbers, fixation durations, and saccade amplitudes were revealed in an analysis of visual cover during viewing the logos.
Article
Full-text available
The review relates to modern point of view on the role of cerebellar structures in eye movement control. The review dedicates todisorders of all types of eye movements involving participating cerebellum in oculomotor and vestibular systems which are supported by experimental results. Revealing the mechanisms of eye movement disorders, especially wh...
Conference Paper
Full-text available
Available on: http://elib.cspu.ru/xmlui/handle/123456789/1086
Conference Paper
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The aim of this study was to find out EEG-correlates of mental activity in different semantic content in alpha-subbands. We have studied the dynamics of EEG power (10/20 standard electrode positions: O1, O2, P3, P4, C3, C4, F3, F4) during interesting (dedicated) and uninteresting (undedicated) task solving. Our participants were upper-form pupils w...
Article
Full-text available
This paper gives an overview of the published data on eye movement parameters while reading sentences in different languages with both local and global syntactic ambiguity. A locally ambiguous sentence contains a syntactically problematic phrase that leads to only one interpretation, while a globally ambiguous sentence has more than one distinct in...
Article
The saccadic eye movements declining given the development of Parkinson’s disease (PD) still deserves thorough analysis. Recent studies confirmed that PD patients show poor saccadic control in visuomotor tasks. The purpose of this study was to investigate the dynamics of saccades parameters at the development of 1-methyl-4-phenyl-1,2,3,6-tetrahydro...
Conference Paper
Full-text available
The monitoring of involuntary autonomic activity in particular due to the adaptation procedure is important to understand the physiological basis of biofeedback correction. In our study we recorded the autonomic indicators in the baseline condition and after 20 minutes of watching of the favorite cartoons (at the choice of the subjects, without bio...
Article
Full-text available
We studied the eye movement parameters during reading of syntactically ambiguous sentences with feminine relative clause in Russian language. A priori difficulties of sentence structural analysis results in increase of time spent on reading as opposed to reading control sentences (unambiguous). Such a delay is caused by an increase of frequency of...
Article
Full-text available
The main obstacle for investigating vocal interactions in vertebrates is the difficulty of discriminating individual vocalizations of rapidly moving, sometimes simultaneously vocalizing individuals. We developed a method of recording and analyzing individual vocalizations in free-ranging animals using ultraminiature back-attached sound and accelera...
Article
Three Macaca mulatta were tested in two different tasks. In the naturalistic behavioral experiment, a monkey had to grasp a piece of food from a hollow cube with an asymmetric position of an aperture. The preferable hand was determined. In the second experiment, a monkey performed a more difficult instrumental task: it pulled the lever by the right...
Article
Full-text available
We compared the alpha band EEG depression (event-related desynchnization, ERD) level in two tasks, involving activation of different attentional processes: visual search for a deviant relevant stimulus among many similar ones and visual oddball. Control data for the visual search task consisted of simple viewing of several stimuli being of the same...
Article
Full-text available
Comparative analysis of the EEG amplitude depression in the α band has been performed in two paradigms varying in the degree of involvement of functionally different attention processes: visual search for the relevant stimulus (RS) among many irrelevant stimuli (iRS) and oddball. Simple visual examination of several identical stimuli was used as a...
Article
An original method of EEG recording in combination with eye tracking was developed. Due to the precise synchronization (which can include any amount of various recording devices), it is now possible to record short-time electrophysiological patterns evoked by some visual stimulus. The key feature of the method is the possibility to study not only s...
Article
Full-text available
Studies in 47 right-handed subjects with right and left leading eyes addressed the latent periods of visually-evoked saccades in the horizontal, vertical, and diagonal directions within the field of vision. Visual environments with three levels of temporospatial complexity and two standard time protocols of visual stimulation, with "gap" and "overl...
Article
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The latencies of visually-guided saccades of 47 right-handed subjects (32 with right leading and 15 with left leading eyes) were studied. Stimulation paradigm was spatially bidimentional, and stimuli were presented along horizontal, vertical and oblique axes. Three levels of visual space complicity and two traditional single-step GAP and OVERLAP te...
Article
Full-text available
Summary Background: GPS analysis of flight trajectories of pigeons can reveal that topographic features influence their flight paths. Recording electrical brain activity that reflects atten- tional processing could indicate objects of interest that do not cause changes in the flight path. Therefore, we investi- gated whether crossing particular vis...
Article
GPS analysis of flight trajectories of pigeons can reveal that topographic features influence their flight paths. Recording electrical brain activity that reflects attentional processing could indicate objects of interest that do not cause changes in the flight path. Therefore, we investigated whether crossing particular visual landmarks when homin...
Article
Full-text available
Long-term electrophysiological experiments were carried out with rats with chronically implanted electrodes into dopaminergic brain structures. Within 4 weeks after surgery, the relative spectral power of electrical activity in the delta1 and delta2 frequency bands decreased, while the relative spectral power in the alpha, beta1 and beta2 bands inc...
Article
Full-text available
Three Macaca rhesus monkeys were used for studies of the performance of visually evoked saccades in single-step changes in the position of a stimulus using standard schemes for presentation of GAP-OVERLAP stimuli. Two spatial schemes were used: presentation of stimuli along the horizontal meridian (one-dimensional) and presentation of stimuli withi...
Article
Full-text available
Parameters of saccadic eye movements were studied in patients with Parkinson's disease and control subjects. In parkinsonian patients, the number of slow regular saccades was shown to be increased, and the number of express saccades was shown to be decreased. As a result the mean of saccade latency in patients was longer than in the control group....
Article
Full-text available
Saccadic latencies of visually-guided saccades of 10 right-handed subjects with right-leading eyes were studied. Stimulation paradigm was spatially bidimentional, and stimuli were shown along horizontal and vertical meridians. Three traditional single step GAP - NO DELAY - OVERLAP temporal paradigms were used. In the first experiment, each paradigm...
Article
Full-text available
To study the neurophysiology of large-scale spatial cognition, we analyzed the neuronal activity of navigating homing pigeons. This is not possible using conventional radio-telemetry suitable for short distances only. Therefore we developed a miniaturized data logger ("neurologger") that can be carried by a homing pigeon on its back, in conjunction...
Article
Full-text available
The properties of visually-guided saccades were studied in three monkeys (Macaca rhesus). Traditional single-step GAP-OVERLAP temporal paradigms were used. Target stimuli were presented in accordance with two spatial stimulation schemes: (i) along the horizontal meridian (one-dimensional scheme) and (ii) within rectangle part of the visual field (t...
Article
Mismatch negativity (MMN) is an auditory event-related potential (ERP) that provides an index of auditory sensory memory and has become an important tool to investigate auditory sensory memory in cognitive neuroscience and disorders such as schizophrenia and dyslexia. The development of a mouse model of human MMN would permit to investigate the mol...
Article
Midlatency event-related potentials (ERPs) reflect early stages in processing of modality specific information. In humans, the auditory midlatency ERPs most investigated are the P1, N1 and P2. Abnormalities of these ERPs in neuropsychiatric disorders such as schizophrenia point to deficits in information processing at early stages. Investigations o...
Article
Full-text available
Changes in the amplitude and dynamic parameters of purposive saccades were studied in monkeys with MPTP-induced Parkinson-like syndrome. Lengthening of saccade latency, decreased maximum velocity of eye movements, and impaired saccade accuracy were observed at the early stages MPTP-syndrome. Different disturbances of large- and small-scale saccades...
Article
A search-coil method for two-dimensional chronic registration of eye and head movements is described. The method is based on the analysis of the electromotive force induced by a magnetic field in a search coil. The output parameters of the original dual system were measured using both the standard search coil and that implanted into monkey's eye. T...
Article
A search-coil method for two-dimensional chronic registration of eye and head movements is described. The method is based on the analysis of the electromotive force induced by a magnetic field in a search coil. The output parameters of the original dual system were measured using both the standard search coil and that implanted into monkey's eye. T...
Article
Full-text available
The brain NA deficit was produced by bilateral injection of 6-OHDA into the locus coeruleus. Three weeks later amygdala hyperactivation was initiated by local penicillin injection (1% solution, 0.5 mcl). Saline in the same volume was used in control groups in both cases. It was shown that the decrease in NA level facilitated the development of epil...
Article
Full-text available
The brain NA deficit was produced by bilateral injection of 6-OHDA into the Locus coeruleus. Three weeks later amygdala hyperactivation was initiated by local penicillin injection (1% solution, 0.5 mcl). Saline in the same volume was used in control groups in both cases. It was shown that the decrease in NA level facilitated the development of epil...
Article
Full-text available
Three weeks after implantation of the electrodes for EEG recording, hyperactivation of the basal nucleus of rat's amygdala was produced by a local injection of penicillin (0.5 mcl, 1% solution). Saline injection of the same volume served as control. The hyperactivation of the amygdala resulted in a long-lasting (at least for 3 weeks) increase in th...
Article
Full-text available
Three weeks after implantation of the electrodes for EEG recording, hyperactivation of the basal nucleus of rat's amygdala was produced by a local injection of penicillin (0.5 mcl, 1% solution). Saline injection of the same volume served as control. The hyperactivation of the amygdala resulted in a long-lasting (at least for 3 weeks) increase in th...
Article
Full-text available
Operant differentiation was used to study black/white stimulus intensity discrimination (over the range 1-37 cd/m2; CIE-31 coordinates X = 0.340, Y = 0.304) in two monkeys (rhesus macaques). Confusion matrices were constructed from the probabilities that animals would make operant responses when required to select from pairs (a conditioned stimulus...