Alexander Hemprich

• Md, DDS, PhD,
• CEO at Leipzig University

Background: Patients with cleft palate often suffer from recurrent otitis media chronica with effusion during infancy. The consecutive binaural conductive hearing loss is seen as a risk factor for developing auditory processing disease. Since there are just a few studies examining auditory processing in this population this study aimed to investig...

Background: Surgical treatment of endocrine orbitopathy can be performed by way of resecting orbital walls, which effectively releases superfluous tissue from the surgically enlarged orbital space allowing the eyeballs to move back. Existing approaches aim to select an optimal surgical strategy based on statistical correlations between the extent...

Since the middle of the 1990s distraction osteogenesis has been introduced into maxillofacial surgery. Its advantage in comparison to single-step movements of mandible or maxilla lies in the simultaneous augmentation not only of bone but also of soft tissues. Thus it can be applied to cases where long distances (n > 10 mm) have to be overcome and/o...

The purpose of this study was to determine whether tooth extraction for patients with ventricular assist devices (VADs) could be performed without interruption of anticoagulant and/or antiplatelet therapy and whether treatment with von Willebrand factor concentrates and desmopressin is required. The study consisted of three groups of patients under...

Zusammenfassung Im Rahmen dieser Übersichtsarbeit sollen exemplarisch typische interdisziplinäre Behandlungsschritte bei Patienten mit Kraniosynostosen (Crouzon-Syndrom) sowie die abschließende zahnärztliche Versorgung und Weiterbetreuung durch den Hauszahnarzt als Beispiele für komplexe Rehabilitationen und Nachsorgestrategien vorgestellt werden....

Trotz aller Fortschritte in der Behandlung von Lippen-Kiefer-Gaumen-Spalten gibt es auch heute noch bei etwa 10 % der Patienten eine behandlungsbedürftige velopharyngeale Insuffizienz. Im besten Fall handelt es sich dabei um eine Stimmklangveränderung, schlimmstenfalls resultiert eine zentripetal verlagerte Lautbildung. Die Diagnostik dieses Proble...

Background and study aims Patients with malignant tumors of the upper gastrointestinal tract are at risk of weight loss. Early supportive nutrition therapy is therefore recommended and usually requires placement of a percutaneous endoscopic gastrostomy (PEG). The aim of this study was to compare adverse events and usage characteristics of the direc...

Objectives This study aims to describe morphological peculiarities of maxillary and mandibular first molars in Europeans, Asians and Europeans with cleft lip and palate. Material and methods Reflex microscopy was used to obtain three-dimensional morphometric landmarks from 40 models (11 Europeans and 13 Asians without cleft lip and palate, 16 Euro...

Patient characterization based on orthodontic metrics. (CSV)

Traditional morphometry mandible. (CSV)

Coordinates PAST maxilla. (CSV)

Traditional morphometry maxilla. (CSV)

Centroid size mandible. (CSV)

Coordinates PAST mandible. (CSV)

Centroid size maxilla. (CSV)

Nonsyndromic cleft palate only (nsCPO) is a facial malformation that has a livebirth prevalence of 1 in 2,500. Research suggests that the etiology of nsCPO is multifactorial, with a clear genetic component. To date, genome-wide association studies have identified only 1 conclusive common variant for nsCPO, that is, a missense variant in the gene gr...

Einleitung: Bei Karzinomen des oberen Gastrointestinaltraktes (oGIT) werden bei eingeschrankter Fahigkeit zur oralen Nahrungsaufnahme die Fadendurchzugsmethode (FDM) oder – bei endoskopisch nicht passierbaren Stenosen – das Direktpunktionsverfahren (DPV) angewandt. Neben infektiosen Komplikationen besteht bei der FDM in ca. 1% der Falle das Risiko...

Orthognathic surgery has always been a classical focus of maxillofacial surgery. Since more than 100 years, various surgical techniques for mandibular repositioning have been developed and clinically tested. Since the establishment of plate and screw osteosynthesis, orthognathic surgery became more stable and safe. Nowadays, different surgical meth...

The purpose of this work was to analyse early upper-jaw development in patients with unilateral cleft lip and palate (UCLP) treated using two different concepts and to compare shape and size developments between these two groups and a group of noncleft patients. A total of 204 maxillary casts available for this study from 50 UCLP patients were anal...

Zusammenfassung Lippen-Kiefer-Gaumen-Spalten gehören zu den häufigsten Fehlbildungen des menschli-chen Körpers. Sie nehmen die zweite Stelle nach dem Klumpfuß ein. Die Behandlung erfolgt am besten interdisziplinär in einem Spaltzentrum in engster Zusammenarbeit zwischen Mund-, Kiefer- und Gesichtschirurgie, Kieferorthopädie, Hals-Nasen-Ohren-Heilku...

Zusammenfassung Frakturen des Gesichtsschädels sind im Kindesalter relativ selten, Jungen sind dabei häufiger betroffen als Mädchen. Nasengerüstfrakturen stellen die häufigste Gruppe dar, gefolgt von Unterkiefer- und lateralen Mittelgesichtsfrakturen. Mit zunehmendem Alter steigt das Frakturrisiko, und das Ursa-chenspektrum verändert sich hierbei v...

Objective Primary cleft lip closure can be achieved by use of different types of surgery. The procedures of Millard, Veau, and Delaire are among the techniques most frequently performed worldwide. The factors which affect development of the columella have not been studied, however. Setting University Hospital of Leipzig, Germany, Department of O...

Naso-orbitoethmoid fractures account for 5% of all facial fractures. We used data derived from a white 34-year-old man to make a transient dynamic finite element model, which consisted of about 740 000 elements, to simulate fist-like impacts to this anatomically complex area. Finite element analysis showed a pattern of von Mises stresses beyond the...

Negative pressure wound therapy (NPWT) has been used for a broad range of indications and wound types. However, it can be difficult to maintain an airtight dressing seal when the wound is located in an anatomically challenging area or environment. To address this problem, medical silicone, used to create intraoral vacuum dressings, was used in five...

Paget´s disease of bone is a common, progressive disorder with uncertain etiology. It results in the replacement of normal skeletal areas with highly vascularized, low density bone. The most frequent symptom is bone pain, which is a result of periostal irritation due to increased metabolic activity. However, the disease may run without any symptoms...

Nonsyndromic orofacial clefting (nsOFC) is a common, complex congenital disorder. The most frequent forms are nonsyndromic cleft lip with or without cleft palate (nsCL/P) and nonsyndromic cleft palate only (nsCPO). Although they are generally considered distinct entities, a recent study has implicated a region around the FOXE1 gene in both nsCL/P a...

Perception of the facial appearance of cleft patients has, until now, been evaluated on the basis of photographs of the patients. Research based on photographs generated by use of a morphing technique has not yet been reported. The purpose of this study was to investigate female and male raters' panel perception with regard to the following: (1) pa...

Columellar cartilage graft helps improve esthetic results in secondary cleft rhinoplasty for patients presenting with cleft lips. However, inadequate skin coverage of the cartilaginous graft can result in columellar necrosis and graft loss. Moreover, the scar after Millard's primary cheiloplasty may not be esthetic. The aim of this article was to p...

Fibular free flap is considered as an "old dog" in reconstructive surgery because it was first described by Taylor and his colleagues in 1975, and was then introduced for mandibular reconstruction by Hidalgo in 1989. There are some "tricks" for fibular free flap that have been used and recognized in many European maxillofacial surgical units over t...

Patients. Between May 1998 and May 2002, 38 patients suffering from severe midfacial retrusion and atrophy were treated by way of midfacial distraction osteogenesis. Diagnoses included cleft lip and palate (32 patients) and one case of Crouzon’s disease. Ages ranged from 6–65 years. A total of 28 patients presented a velopharyngeal flap and nine pa...

Objective The purpose of this cross-sectional study was to assess the prevalence of dental caries in children with cleft lip, alveolus, and/or cleft palate living in central Germany between 1996 and 2010. Participants A total of 295 children 1 to 6 years of age from three birth cohorts (BC) with clefts from central Germany were included in the stu...

Investigations of cone beam computed tomography (CBCT) for bisphosphonate-related osteonecrosis of the jaw (BRONJ) imaging are rare. The purpose of this study was to investigate the prevalence of typical radiological findings of BRONJ in CBCT. Twenty-seven CBCTs of BRONJ sites were assessed on the basis of the radiological findings (cancellous bone...

Objectives: Principles and workflow are described to prevent bisphosphonate-related osteonecrosis of the jaw (BRONJ) when oral surgery is necessary in patients taking bisphosphonates. Material and method: A total of 117 surgical procedures were performed on 68 patients taking bisphosphonates. The basis of the treatment was (1) use of perioperati...

Background: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all congenital anomalies, and has a multifactorial etiology involving both environmental and genetic factors. Recent genome-wide association studies (GWAS) identified strong association between a locus on chromosome 10q25.3 and NSCL/P in European...

We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date. We confirmed associations with all previously identified loci and identified six additional susceptibility regions (1p36, 2p21, 3p11.1, 8q21.3, 13q31.1 and 15q2...

Inverted papilloma is an uncommon primary nasal tumor. Despite its benign nature, this tumor represents three typical characteristics: a high propensity of recurrence, local aggressiveness and association with malignancy. Inverted papilloma can reduce the patient's quality of life due to compromised nasal function, extension to the orbit and brain....

Distraction osteogenesis is an established procedure to cope with marked skeletal retrusion or deficiency. A principal theoretical problem with this method is the given length of the distractor unit. Regarding mandibular distraction, some devices allow reactivation of the distractor. 1 For maxillary and midfacial distraction osteogenesis, to date,...

As the biomechanical mechanisms of orbital wall fractures are still under research, three different fracture mechanisms were tested in a finite element based investigation. In contrast to earlier studies, a finer skeletal model and a transient dynamic simulation were used to test pure hydraulic, pure buckling and a mixed force transmission. Results...

Midfacial fractures rank first concerning maxillofacial traumatology. Collisions of two heads or head to object are the main causes for these fractures. An investigation based on a transient simulation using the finite element method was performed. A biomechanical head model was created and tested. A transient collision of two heads was simulated....

In 2009, a study group of three Saxon hospitals set up a Saxon register with the aim of including all patients with bisphosphonate (BP) medication. In addition, specific concepts for surgical approach were developed. The target is to define relevant treatment and prevention strategies of bisphosphonate-related osteonecrosis of the jaws (BRONJ) base...

BACKGROUND: German animal terms have been used to name oral cleft deformity for centuries. However, their contemporary use and influence on cleft patients remain unstudied. OBJECTIVE: The main aim of this study was to evaluate the current use of German animal terms for oral cleft and their influence on the perception of cleft patients. METHODS: We...

Die Distraktionsosteogenese des Oberkiefers stellt eine anerkannte Methode in der Behandlung ausgeprägter Oberkieferrücklagen dar. Haupteinsatzgebiete sind Verlagerungen über 10 mm bzw. vernarbte Weichgewebssituationen. Im Vergleich intra- und extraoraler Distraktoren erscheinen halobogen-verankerte externe Systeme vielfältiger einsetzbar zu sein....

Cleft-lip nasal deformity alters patient's self-image, as well as posing unique challenges for the rhinoplastic surgeon. The main purpose of this study was to compare the panel perceptions of nasal aesthetics following secondary cleft rhinoplasty with versus without caudal septal extension grafting (columella grafting). We also investigated whether...

Cleft-lip nasal deformity (CLND) affects the overall facial appearance and attractiveness. The CLND nose shares some features in part with the aging nose. This questionnaire survey examined: 1) the panel perceptions of the role of secondary cleft rhinoplasty in nasal rejuvenation; and 2) the influence of a medical background in cleft care, age and...

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) seems resistant to conventional treatment approaches. We report a study with a surgical concept characterized by resection of the necrotic bone followed by sufficient wound closure. In a clinical study of 24 patients with 33 sites of BRONJ, the surgical basis of the treatment was as follows: (...

Organogallium(III) dinuclear (1-9) and tetranuclear (10) complexes present potential therapeutic agents for the treatment of various types of cancer. The antiproliferative activity of 1-10 was evaluated with cell lines of head and neck squamous cell carcinomas, e.g. HN (soft palate), Cal27, Cal33 (tongue) and FaDu (hypopharynx) cell lines. The acti...

Background: Mucous cysts of the nose are a rare complication of rhinoplasty. They may develop as a result of implantation or herniation of mucosa. The entrapped epithelium may proliferate, forming a subcutaneous cyst. Patients and methods: Two patients with unilateral cleft lip nose deformity had previously undergone corrective rhinoplasty. Year...

Studies in mice and humans have suggested that SUMO1, which codes for the small ubiquitin-related modifier 1 (SUMO1), is a promising candidate gene for non-syndromic cleft lip with or without cleft palate (NSCL/P). To investigate the possible involvement of this gene in NSCL/P patients from Central Europe, we performed: (i) a case control associati...

Objectives: To review outcomes and complications of endoscope-assisted submandibular sialadenectomy (EASS) and to analyze this innovative technique with regard to ethical issues. Methods: We used a systematic review study design to identify clinical studies on EASS, published in English, French, German, and Thai. The last electronic search was c...

Ethical standards of biomedical publications are associated with editorial leadership, such as contents of instructions to authors and journal's mechanisms for research and publication ethics. To compare ethical issues in the guidelines for authors in oral-craniomaxillofacial/facial plastic surgery (OCM-FPS) journals with those in plastic surgery a...

Since the spring of 2009, there have been a considerable number of infected as well as fatal cases by virologically confirmed swine-origin H1N1 influenza A virus (S-OIV). The virus continues to spread globally. The World Health Organization (WHO) has now raised the level of S-OIV influenza pandemic alert to phase 6 ('the pandemic phase') because of...

We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.8...

Orofacial clefts are among the most common of all congenital disorders. Nonsyndromic cases of cleft lip with or without cleft palate (NSCL/P) and cleft palate only (NSCPO) are considered to have a multifactorial etiology which involves both genetic and environmental factors. We present the results of a genome-wide linkage scan in 91 families of cen...

Variants in the interferon regulatory factor 6 (IRF6) gene have repeatedly been associated with non-syndromic cleft lip with or without cleft palate (NSCL/P). A recent study has suggested that the functionally relevant variant rs642961 is the underlying cause of the observed associations. We genotyped rs642961 in our Central European case-control s...

Publication bias (PB) diminishes the full distribution of research, distorts and discredits the scientific record, and thus compromises evidence-based practice. The objective of this study was to analyse published controlled trials with regard to PB in leading oral and maxillofacial surgery (OMS) journals. All controlled trials published in the Int...

The aim of this study was to compare the craniofacial morphology of a group of orthognathic adults to adult patients with unilateral cleft lip and palate who had undergone delayed cleft closure. Lateral cephalograms of 38 adult patients with unilateral cleft lip and palate (cleft group) were submitted for cephalometric analysis with Onyx Ceph((R))...

In contrast to the multitude of investigations regarding aesthetic changes in nasal surgery, few data are available concerning nasal function. This is especially important for cleft patients with a compromised nasal respiration.In this prospective study, 68 cleft patients, who underwent nasal surgery, were evaluated concerning aesthetic and respira...