Alexander Bertrand

• Ph.D.
• Professor (Associate) at KU Leuven

An adaptive distributed noise reduction algorithm for speech enhancement is considered, which operates in a wireless acoustic sensor network where each node collects multiple microphone signals. In previous work, it was shown theoretically that for a stationary scenario, the algorithm provides the same signal estimators as the centralized multi-cha...

Objective. The electroencephalogram (EEG) is an essential neuro-monitoring tool for both clinical and research purposes, but is susceptible to a wide variety of undesired artifacts. Removal of these artifacts is often done using blind source separation techniques, relying on a purely data-driven transformation, which may sometimes fail to sufficien...

This tutorial article introduces the utility metric and its generalizations, which allow for a quick-and-dirty quantitative assessment of the relative importance of the different input variables in a linear estimation model. In particular, we show how these metrics can be cheaply calculated, thereby making them very attractive for model interpretat...

Objective: Concealable, miniaturized electroencephalography ('mini-EEG') recording devices are crucial enablers towards long-term ambulatory EEG monitoring. However, the resulting miniaturization limits the inter-electrode distance and the scalp area that can be covered by a single device. The concept of wireless EEG sensor networks (WESNs) attemp...

Canonical correlation analysis (CCA) is a widely-used data analysis tool that allows to assess the correlation between two distinct sets of signals. It computes optimal linear combinations of the signals in both sets such that the resulting signals are maximally correlated. The weight vectors defining these optimal linear combinations are referred...

Selective attention enables humans to efficiently process visual stimuli by enhancing important elements and filtering out irrelevant information. Locating visual attention is fundamental in neuroscience with potential applications in brain-computer interfaces. Conventional paradigms often use synthetic stimuli or static images, but visual stimuli...

Objectives Auditory Attention Decoding (AAD) is a technique utilizing brain signals to decode on which sound the listener focuses the attention. In most current studies, the effect of type of speech materials used and sex of the listener is not considered. We investigated the effect on AAD performance of factors related to the speaker (such as the...

We propose a fully unsupervised algorithm that detects from encephalography (EEG) recordings when a subject actively listens to sound, versus when the sound is ignored. This problem is known as absolute auditory attention decoding (aAAD). We propose an unsupervised discriminative CCA model for feature extraction and combine it with an unsupervised...

Correlation-based auditory attention decoding (AAD) algorithms exploit neural tracking mechanisms to determine listener attention among competing speech sources via, e.g., electroencephalography signals. The correlation coefficients between the decoded neural responses and encoded speech stimuli of the different speakers then serve as AAD decision...

Objective: Selective auditory attention decoding (AAD) algorithms process brain data such as electroencephalography to decode to which of multiple competing sound sources a person attends. Example use cases are neuro-steered hearing aids or communication via brain-computer interfaces (BCI). Recently, it has been shown that it is possible to train...

In a recent paper, we presented the KU Leuven audiovisual, gaze-controlled auditory attention decoding (AV-GC-AAD) dataset, in which we recorded electroencephalography (EEG) signals of participants attending to one out of two competing speakers under various audiovisual conditions. The main goal of this dataset was to disentangle the direction of g...

Selective attention enables humans to efficiently process visual stimuli by enhancing important locations or objects and filtering out irrelevant information. Locating visual attention is a fundamental problem in neuroscience with potential applications in brain-computer interfaces. Conventional paradigms often use synthetic stimuli or static image...

Various new brain-computer interface technologies or neuroscience applications require decoding stimulus-following neural responses to natural stimuli such as speech and video from, e.g., electroencephalography (EEG) signals. In this context, generalized canonical correlation analysis (GCCA) is often used as a group analysis technique, which allows...

italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective: Building large-scale data bases of biomedical signal recordings for training artificial-intelligence systems involves substantial human effort in data processing and annotation. In the case of event detection, experts need to exhaustively sc...

Objective. In this study, we use electroencephalography (EEG) recordings to determine whether a subject is actively listening to a presented speech stimulus. More precisely, we aim to discriminate between an active listening condition, and a distractor condition where subjects focus on an unrelated distractor task while being exposed to a speech st...

Object recognition and categorization are essential cognitive processes which engage considerable neural resources in the human ventral visual stream. However, the tuning properties of human ventral stream neurons for object shape and category are virtually unknown. We performed large-scale recordings of spiking activity in human Lateral Occipital...

italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective: Finding events of interest is a common task in biomedical signal processing. The detection of epileptic seizures and signal artefacts are two key examples. Epoch-based classification is the typical machine learning framework to detect such s...

Objective. Electroencephalography (EEG) is a widely used technology for recording brain activity in brain-computer interface (BCI) research, where understanding the encoding-decoding relationship between stimuli and neural responses is a fundamental challenge. Recently, there is a growing interest in encoding-decoding natural stimuli in a single-tr...

Objective. Spatial auditory attention decoding (Sp-AAD) refers to the task of identifying the direction of the speaker to which a person is attending in a multi-talker setting, based on the listener’s neural recordings, e.g. electroencephalography (EEG). The goal of this study is to thoroughly investigate potential biases when training such Sp-AAD...

More than 5% of the world’s population suffers from disabling hearing loss. Hearing aids and cochlear implants are crucial for improving their quality of life. However, current hearing technology does not work well in cocktail party scenarios, where several people talk simultaneously. This is mainly because the hearing device does not know which sp...

Objective In this study, we use electroencephalography (EEG) recordings to determine whether a subject is actively listening to a presented speech stimulus. More precisely, we aim to discriminate between an active listening condition, and a distractor condition where subjects focus on an unrelated distractor task while being exposed to a speech sti...

A bstract Objective Electroencephalography (EEG) is a widely used technology for recording brain activity in brain-computer interface (BCI) research, where understanding the encoding-decoding relationship between stimuli and neural responses is a fundamental challenge. Recently, there is a growing interest in encoding-decoding natural stimuli in a...

The goal of change point detection (CPD) is to identify abrupt changes in the statistics of signals or time series that reflect transitions in the underlying system’s properties or states. While many statistical and learning-based approaches have been proposed to address this task, most state-of-the-art methods still treat this problem in an unsupe...

Object recognition and categorization are essential cognitive processes which engage considerable neural resources in the human ventral visual stream. However, the tuning properties of human ventral stream neurons for object shape and category are virtually unknown. We performed the first large-scale recordings of spiking activity in human Lateral...

We propose a dynamic sensor selection approach for deep neural networks (DNNs), which is able to derive an optimal sensor subset selection for each specific input sample instead of a fixed selection for the entire dataset. This dynamic selection is jointly learned with the task model in an end-to-end way, using the Gumbel-Softmax trick to allow the...

p>Auditory attention decoding (AAD) algorithms process brain data such as electroencephalography (EEG) in order to decode to which of multiple competing sound sources a person attends. Example use cases are neuro-steered hearing aids or brain-computer interfaces (BCI) for patients with severe motor or cognitive impairments. Recently, it has been sh...

p>Auditory attention decoding (AAD) algorithms process brain data such as electroencephalography (EEG) in order to decode to which of multiple competing sound sources a person attends. Example use cases are neuro-steered hearing aids or brain-computer interfaces (BCI) for patients with severe motor or cognitive impairments. Recently, it has been sh...

Objective Spatial auditory attention decoding (Sp-AAD) refers to the task of identifying the direction of the speaker to which a person is attending in a multi-talker setting, based on the listener’s neural recordings, e.g., electroencephalography (EEG). The goal of this study is to thoroughly investigate potential biases when training such Sp-AAD...

Object recognition and categorization are essential cognitive processes which engage considerable neural resources in the human ventral visual stream. However, the tuning properties of human ventral stream neurons for object shape and category are virtually unknown. We performed the first large-scale recordings of spiking activity in human Lateral...

Objective. The goal of this paper is to investigate the limits of electroencephalography (EEG) sensor miniaturization in a set-up consisting of multiple galvanically isolated EEG units to record interictal epileptiform discharges (IEDs), referred to as ‘spikes’, in people with epilepsy. Approach. A dataset of high-density EEG recordings (257 channe...

This paper studies the convergence conditions and properties of the distributed adaptive signal fusion (DASF) algorithm, the framework itself having been introduced in a ‘Part I’ companion paper. The DASF algorithm can be used to solve linear signal and feature fusion optimization problems in a distributed fashion, and is in particular well-suited...

In this paper, we describe a general algorithmic framework for solving linear signal or feature fusion optimization problems in a distributed setting, for example in a wireless sensor network (WSN). These problems require linearly combining the observed signals (or features thereof) collected at the various sensor nodes to satisfy a pre-defined opt...

Change point detection (CPD) refers to the problem of detecting changes in the statistics of pseudo-stationary signals or time series. A recent trend in CPD research is to replace the traditional statistical tests with distribution-free autoencoder-based algorithms, which can automatically learn complex patterns in time series data. In particular,...

Ultrasound contrast agents (UCAs) have broadened the scope of ultrasound imaging and therapeutic applications. One of the parameters of interest when measuring the response of UCAs to ultrasound is their frequency-dependent attenuation coefficient. The estimation of this parameter is relevant for sensing and therapeutic applications, as well as for...

The goal of change point detection (CPD) is to find abrupt changes in the underlying state of a time series. Currently, CPD is typically tackled using fully supervised or completely unsupervised approaches. Supervised methods exploit labels to find change points that are as accurate as possible with respect to these labels, but have the drawback th...

Wireless sensor networks consist of sensor nodes that are physically distributed over different locations. Spatial filtering procedures exploit the spatial correlation across these sensor signals to fuse them into a filtered signal satisfying some optimality condition. However, gathering the raw sensor data in a fusion center to solve the problem i...

Computing the optimal solution to a spatial filtering problems in a Wireless Sensor Network can incur large bandwidth and computational requirements if an approach relying on data centralization is used. The so-called distributed adaptive signal fusion (DASF) algorithm solves this problem by having the nodes collaboratively solve low-dimensional ve...

In brain-computer interface or neuroscience applications, generalized canonical correlation analysis (GCCA) is often used to extract correlated signal components in the neural activity of different subjects attending to the same stimulus. This allows quantifying the so-called inter-subject correlation or boosting the signal-to-noise ratio of the st...

In this paper, we describe a conceptual design methodology to design distributed neural network architectures that can perform efficient inference within sensor networks with communication bandwidth constraints. The different sensor channels are distributed across multiple sensor devices, which have to exchange data over bandwidth-limited communica...

Neurologists are often looking for various "events of interest" when analyzing EEG. To support them in this task various machine-learning-based algorithms have been developed. Most of these algorithms treat the problem as classification, thereby independently processing signal segments and ignoring temporal dependencies inherent to events of varyin...

In this paper, we describe a general algorithmic framework for solving linear signal or feature fusion optimization problems in a distributed setting, for example in a wireless sensor network (WSN). These problems require linearly combining the observed signals (or features thereof) collected at the various sensor nodes to satisfy a pre-defined opt...

This paper studies the convergence conditions and properties of the distributed adaptive signal fusion (DASF) algorithm, the framework itself having been introduced in a `Part I' companion paper. The DASF algorithm can be used to solve linear signal and feature fusion optimization problems in a distributed fashion, and is in particular well-suited...

Many problems require the selection of a subset of variables from a full set of optimization variables. The computational complexity of an exhaustive search over all possible subsets of variables is, however, prohibitively expensive, necessitating more efficient but potentially suboptimal search strategies. We focus on sparse variable selection for...

The goal of auditory attention decoding (AAD) is to determine to which speaker out of multiple competing speakers a listener is attending based on the brain signals recorded via, e.g., electroencephalography (EEG). AAD algorithms are a fundamental building block of so-called neuro-steered hearing devices that would allow identifying the speaker tha...

Quantitative ultrasound methods aim to estimate the acoustic properties of the underlying medium, such as the attenuation and backscatter coefficients, and have applications in various areas including tissue characterization. In practice, tissue heterogeneity makes the coefficient estimation challenging. In this work, we propose a computationally e...

div> The performance of most array signal processing tasks relies on the presence of correlation between sensor signals. In a wireless sensor network, where sensor nodes are spread out over a relatively large area, it is useful to identify nodes observing similar sensor signals and hence common phenomenons, for example to partition the network acco...

div> The performance of most array signal processing tasks relies on the presence of correlation between sensor signals. In a wireless sensor network, where sensor nodes are spread out over a relatively large area, it is useful to identify nodes observing similar sensor signals and hence common phenomenons, for example to partition the network acco...

div> The performance of most array signal processing tasks relies on the presence of correlation between sensor signals. In a wireless sensor network, where sensor nodes are spread out over a relatively large area, it is useful to identify nodes observing similar sensor signals and hence common phenomenons, for example to partition the network acco...

Objective. We present a framework to objectively test and compare stimulation artefact removal techniques in the context of neural spike sorting. Approach. To this end, we used realistic hybrid ground-truth spiking data, with superimposed artefacts from in vivo recordings. We used the framework to evaluate and compare several techniques: blanking,...

The goal of auditory attention decoding (AAD) is to determine to which speaker out of multiple competing speakers a listener is attending based on the brain signals recorded via, e.g., electroencephalography (EEG). AAD algorithms are a fundamental building block of so-called neuro-steered hearing devices that would allow identifying the speaker tha...

The performance of most array signal processing tasks relies on the presence of correlation between sensor signals. In a wireless sensor network, where sensor nodes are spread out over a relatively large area, it is useful to identify nodes observing similar sensor signals and hence common phenomenons, for example to partition the network according...

Objective. Unobtrusive electroencephalography (EEG) monitoring in everyday life requires the availability of highly miniaturized EEG devices (mini-EEGs), which ideally consist of a wireless node with a small scalp area footprint, in which the electrodes, amplifier and wireless radio are embedded. By attaching a multitude of mini-EEGs at relevant po...

Objective: Noise and disturbances hinder effective interpretation of recorded ECG. To identify the clean parts of a recording, free from such disturbances, various quality indicators have been developed. Previous instances of these indicators focus on human-defined desirable properties of a clean signal. The reliance on human-specified properties...

Objective. To develop an efficient, embedded electroencephalogram (EEG) channel selection approach for deep neural networks, allowing us to match the channel selection to the target model, while avoiding the large computational burdens of wrapper approaches in conjunction with neural networks. Approach. We employ a concrete selector layer to jointl...

Objective. Spike sorting is the process of extracting neuronal action potentials, or spikes, from an extracellular brain recording, and assigning each spike to its putative source neuron. Spike sorting is usually treated as a clustering problem. However, this clustering process is known to be affected by overlapping spikes. Existing methods for res...

People suffering from hearing impairment often have difficulties participating in conversations in so-called cocktail party scenarios where multiple individuals are simultaneously talking. Although advanced algorithms exist to suppress background noise in these situations, a hearing device also needs information about which speaker a user actually...

Change point detection (CPD) aims to locate abrupt property changes in time series data. Recent CPD methods demonstrated the potential of using deep learning techniques, but often lack the ability to identify more subtle changes in the autocorrelation statistics of the signal and suffer from a high false alarm rate. To address these issues, we empl...

The ultrasonic attenuation and backscatter coefficients of tissues are relevant acoustic parameters due to their wide range of clinical applications. In this paper, a linear least-squares method for the estimation of these coefficients in a homogeneous region of interest based on pulse-echo measurements is proposed. The method efficiently fits an u...

Many problems require the selection of a subset of variables from a full set of optimization variables. The computational complexity of an exhaustive search over all possible subsets of variables is, however, prohibitively expensive, necessitating more efficient but potentially suboptimal search strategies. We focus on sparse variable selection for...

The trace ratio optimization (TRO) problem consists of finding an orthonormal basis for the discriminative subspace that maximizes the ratio of two trace operators on two covariance matrices corresponding to two distinctive classes or signal components. The TRO problem is encountered in various signal processing problems such as dimensionality redu...

In a multi-speaker scenario, the human auditory system is able to attend to one particular speaker of interest and ignore the others. It has been demonstrated that it is possible to use electroencephalography (EEG) signals to infer to which speaker someone is attending by relating the neural activity to the speech signals. However, classifying audi...

When multiple speakers talk simultaneously, a hearing device cannot identify which of these speakers the listener intends to attend to. Auditory attention decoding (AAD) algorithms can provide this information by, for example, reconstructing the attended speech envelope from electroencephalography (EEG) signals. However, these stimulus reconstructi...

Feature selection techniques are very useful approaches for dimensionality reduction in data analysis. They provide interpretable results by reducing the dimensions of the data to a subset of the original set of features. When the data lack annotations, unsupervised feature selectors are required for their analysis. Several algorithms for this aim...

Purpose Despite the physical benefits of protons over conventional photon radiation in cancer treatment, range uncertainties impede the ability to harness the full potential of proton therapy. While monitoring the proton range in vivo could reduce the currently adopted safety margins, a routinely applicable range verification technique is still lac...

Measurement of neural tracking of natural running speech from the electroencephalogram (EEG) is an increasingly popular method in auditory neuroscience and has applications in audiology. The method involves decoding the envelope of the speech signal from the EEG signal, and calculating the correlation with the envelope of the audio stream that was...

Many electroencephalography (EEG) applications rely on channel selection methods to remove the least informative channels, e.g., to reduce the amount of electrodes to be mounted, to decrease the computational load, or to reduce overfitting effects and improve performance. Wrapper-based channel selection methods aim to match the channel selection st...

Spike sorting is the process of retrieving the spike times of individual neurons that are present in an extracellular neural recording. Over the last decades, many spike sorting algorithms have been published. In an effort to guide a user towards a specific spike sorting algorithm, given a specific recording setting (i.e., brain region and recordin...

Channel selection or electrode placement for neural decoding is a commonly encountered problem in electroencephalography (EEG). Since evaluating all possible channel combinations is usually infeasible, one usually has to settle for heuristic methods or convex approximations without optimality guarantees. To date, it remains unclear how large the ga...

Objective: Noise reduction algorithms in current hearing devices lack informationabout the sound source a user attends to when multiple sources are present. To resolve this issue, they can be complemented with auditory attention decoding (AAD) algorithms, which decode the attention using electroencephalography (EEG) sensors. State-of-the-art AAD a...

Auditory attention decoding (AAD) algorithms decode the auditory attention from electroencephalography (EEG) signals which capture the neural activity of the listener. Such AAD methods are believed to be an important ingredient towards so-called neuro-steered assistive hearing devices. For example, traditional AAD decoders allow to detect to which...

Channel selection or electrode placement for neural decoding is a commonly encountered problem in electroencephalography (EEG). Since evaluating all possible channel combinations is usually infeasible, one usually has to settle for heuristic methods or convex approximations without optimality guarantees. To date, it remains unclear how large the ga...

The authors have withdrawn their manuscript because they discovered an error in the analysis code after publication of the preprint, which turns out to have a major impact on the main results in the paper. The results on the imagination data become non-significant after correcting for the mistake. Significant results on the perception data are pres...

Change point detection (CPD) aims to locate abrupt property changes in time series data. Recent CPD methods demonstrated the potential of using deep learning techniques, but often lack the ability to identify more subtle changes in the autocorrelation statistics of the signal and suffer from a high false alarm rate. To address these issues, we empl...

Advances in electroencephalography (EEG) equipment now allow monitoring of people with epilepsy in their daily-life environment. The large volumes of data that can be collected from long-term out-of-clinic monitoring require novel algorithms to process the recordings on board of the device to identify and log or transmit only relevant data epochs....

Objective. A hearing aid’s noise reduction algorithm cannot infer to which speaker the user intends to listen to. Auditory attention decoding (AAD) algorithms allow to infer this information from neural signals, which leads to the concept of neuro-steered hearing aids. We aim to evaluate and demonstrate the feasibility of AAD-supported speech enhan...

People suffering from hearing impairment often have difficulties participating in conversations in so-called `cocktail party' scenarios with multiple people talking simultaneously. Although advanced algorithms exist to suppress background noise in these situations, a hearing device also needs information on which of these speakers the user actually...

Objective Noise reduction algorithms in current hearing devices lack information about the sound source a user attends to when multiple sources are present. To resolve this issue, they can be complemented with auditory attention decoding (AAD) algorithms, which decode the attention using electroencephalography (EEG) sensors. State-of-the-art AAD al...

In a multi-speaker scenario, the human auditory system is able to attend to one particular speaker of interest and ignore the others. It has been demonstrated that it is possible to use encephalography (EEG) signals to infer to which speaker someone is attending by relating the neural activity to the speech signals. However, classifying auditory at...

Objective: A hearing aid's noise reduction algorithm cannot infer to which speaker the user intends to listen to. Auditory attention decoding (AAD) algorithms allow to infer this information from neural signals, which leads to the concept of neuro-steered hearing aids. We aim to evaluate and demonstrate the feasibility of AAD-supported speech enhan...