Alex Buoite Stella

Alex Buoite Stella
University of Trieste | UNITS · Department of Medicine, Surgery and Health Sciences

PhD

About

67
Publications
8,834
Reads
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626
Citations
Citations since 2016
65 Research Items
625 Citations
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Introduction
My main focus is clinical integrative and translational physiology, and environmental physiology, with particular interest into human thermoregulation and hydration. I currently work at prof. Paolo Manganotti's lab at the Clinical Unit of Neurology of Cattinara University Hospital - University of Trieste, using integrative and translational physiology to help clinicians in the diagnosis and evaluation of neurological diseases. Winner of the Merck Prize in Neurology 2019.
Additional affiliations
November 2013 - January 2014
University of Primorska
Position
  • Lecturer
Description
  • Assistant of prof. Pietro Enrico di Prampero at the M.Sc. in Applied Kinesiology course "Training Circulation, Oxygen Consumption and Muscle Force Development", giving lectures and managing lab experiences.
Education
January 2013 - December 2015
University of Udine
Field of study
  • Biomedical Sciences and Biotechnologies - Physiology
November 2010 - September 2012
University of Primorska
Field of study
  • Applied Kinesiology - Exercise Physiology and Ergonomics
October 2007 - July 2010
University of Udine
Field of study
  • Sports Science

Publications

Publications (67)
Article
Full-text available
Strength and power asymmetries have been observed in different sports, including soccer. Such asymmetries, as well as the bilateral deficit (BLD), can be assessed during different tasks, static or dynamic, and with different methods and devices, in order to detect the possible different aspects, as well as the association with physical performance...
Article
Full-text available
There is a growing research interest in wireless non-invasive solutions for core temperature estimation and their application in clinical settings. This study aimed to investigate the use of a novel wireless non-invasive heat flux-based thermometer in acute stroke patients admitted to a stroke unit and compare the measurements with the currently us...
Article
Full-text available
Objective: The objective of this study was to evaluate skin wetness perception and thermal sensitivity in people with migraine and similar healthy controls. Background: Environmental triggers, such as cold and humidity, are known triggers for pain in people with migraine. Sensory inputs might be implicated in such heightened responses to cold-hu...
Article
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Background and aim: The Mediterranean is one of the major gateways of human migratory fluxes from Northern Africa, the Middle East, and Central Asia to Europe. Sea accidents have become an urgent humanitarian crisis due to the high number of migrants on the move, but data on the physiological effects to sudden cool water immersion are not as exten...
Article
New findings: What is the central question of this study? Ageing impairs the skin's thermal and tactile sensitivity: does ageing also induce loss of skin wetness sensitivity? What is the main finding and its importance? Older adults show an average 15% loss of skin wetness sensitivity, with this sensory deficit being mediated by a combination of r...
Article
Full-text available
Background: Enteral nutrition is often prescribed in acute stroke to meet energy and fluid needs in patients with dysphagia. Tubes clogging represent a common complication of enteral formula delivery, requiring substitution and influencing nutrition administration. Frequent water flushes are recommended as one of the most effective procedures to p...
Article
Context: Unlike palpable lumps, a large number of nonpalpable testicular lesions found incidentally at ultrasound in asymptomatic postpuberal males are either benign tumours or non-neoplastic lesions. The prevalence of malignancy, however, is appraised based on small case series. Dedicated studies report a large number of patients, and systematic...
Article
We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD during SARS-CoV-2 co-infection. Our case report describes a fulminant CJD evolution associated with SARS-CoV-2 infection, which led to patient death after 15 days from admission. First EEG presented continuou...
Article
“Long-COVID” is a clinical entity that consists of persisting post-infectious symptoms that last for more than three months after the onset of the first acute COVID-19 symptoms. Among these, a cluster of neurological persisting symptoms defines Neuro-Long-COVID. While the debate about the pathogenesis of Long-COVID is still ongoing, sex differences...
Conference Paper
Full-text available
Climate change is becoming a crucial factor to consider within human activities and the building sector is particularly influenced for both internal comfort and energy aspects. In recent times in Italy great attention has been posed on energy refurbishment of buildings, mainly thanks to tax deduction policies like the Superbonus 110%. However , suc...
Chapter
Full-text available
Outcome prediction in wake-up ischemic stroke (WUS) is important for guiding treatment strategies, in order to improve recovery and minimize disability. We aimed at producing an interpretable model to predict a good outcome (NIHSS 7-day<5) in thrombolysis treated WUS patients by using Classification and Regression Tree (CART) method. The study enco...
Article
Full-text available
Swallowing disorders are common in neurological diseases, with dysphagia representing one of the most prevalent complications that may cause poor quality of life, reduce independence, and increase mortality. Rapid identification of dysphagia is necessary to reduce the risk of penetration and aspiration, and to early start rehabilitation protocols....
Article
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Objective Orthostatic hypotension (OH) represents a frequent but under-recognized phenomenon in Parkinson’s disease (PD). During COVID-19 pandemic, Information and Communication Technologies (ICT) have become pivotal in the management of chronic diseases like PD, not only to assess motor impairment, but also for vital signs monitoring. This pilot s...
Article
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Background The COVID-19 lockdown has influenced people lifestyle, behaviour, physical activity (PA), and working habits as well as, possibly, migraine. The aim of the study was to assess the impact of lockdown on the burden of migraine attacks during COVID-19 lockdown. Methods Patients were interviewed, and data about demographics, PA, daily behav...
Article
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The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS function may be also impaired. The Composite Autonom...
Chapter
Neural networks are dynamic, and the brain has the capacity to reorganize itself. This capacity is named neuroplasticity and is fundamental for many processes ranging from learning and adaptation to new environments to the response to brain injuries. Measures of brain plasticity involve several techniques, including neuroimaging and neurophysiology...
Article
Full-text available
Background During the first COVID-19 lockdown in Italy, it was observed a reduction in emergency department (ED) attendances due to non-SARS-COV-2-related acute/chronic conditions.Objective To analyze the impact of the COVID-19 lockdown on patients reporting headache as the principal presenting symptom on admission to the ED of the tertiary care Un...
Article
Full-text available
Neurological manifestations may be common in COVID-19 patients. They may include several syndromes, such as a suggested autoimmune abnormal response, which may result in encephalitis and new-onset refractory status epilepticus (NORSE). Quickly recognizing such cases and starting the most appropriate therapy is mandatory due to the related rapid wor...
Article
Full-text available
Purpose The fear of COVID-19 infection may discourage patients from going to the hospital even in case of sudden onset of disabling symptoms. There is growing evidence of the reduction of stroke admissions and higher prevalence of severe clinical presentation. Yet, no studies have investigated the perfusion pattern of acute strokes admitted during...
Article
Space analogues, such as bed rest, are used to reproduce microgravity-induced morphological and physiological changes and can be used as clinical models of prolonged inactivity. Nevertheless, non-uniform decreases in muscle mass and function have been frequently reported, and peripheral nerve adaptations have been poorly studied, although some of t...
Article
Full-text available
This case series describes three patients affected by SARS‐CoV‐2 who developed polyradiculoneuritis as a probable neurological complication of COVID‐19. A diagnosis of Guillain Barré syndrome was made on the basis of clinical symptoms, cerebrospinal fluid analysis and electroneurography (ENG). In all of them therapeutic approach included the admini...
Article
Full-text available
Brain electrical activity in acute ischemic stroke is related to the hypoperfusion of cerebral tissue as manifestation of neurovascular coupling. EEG could be applicable for bedside functional monitoring in emergency settings. We aimed to investigate the relation between hyper-acute ischemic stroke EEG changes, measured with bedside wireless-EEG, a...
Article
Background and purpose: Diagnosis of posterior circulation stroke may be challenged. National Institutes of Health Stroke Scale (NIHSS) and brain imaging (non-contrast brain computed tomography-CT) are used for diagnosis; evaluation on posterior circulation stroke remains a limit of NIHSS, and the value of non-contrast CT (NCCT) is limited due to...
Article
Hypohydration may be associated with vascular diseases, poor prognosis and worse outcomes in stroke. The underlying mechanisms have not yet been completely investigated, although some studies suggested potential associations with brain perfusion and collaterals status. Despite the potentially different mechanisms promoting serum or urine biomarkers...
Article
Full-text available
There is growing research interest on identification of CT Perfusion (CTP) parameters that predict the outcome in acute ischemic stroke patients. The aim of this study is to produce the model, based on core-penumbra related parameters assessed by CTP processing and commonly used clinical prediction factors, to predict the final infarct volume in th...
Article
Changes in physiological functions after spaceflight and simulated spaceflight involve several mechanisms. Microgravity is one of them and it can be partially reproduced with models, such as head down bed rest (HDBR). Yet, only a few studies have investigated in detail the complexity of neurophysiological systems and their integration to maintain h...
Article
Full-text available
Owing to the large inter-subject variability, early post-stroke prognosis is challenging, and objective biomarkers that can provide further prognostic information are still needed. The relation between quantitative EEG parameters in pre-thrombolysis hyper-acute phase and outcomes has still to be investigated. Hence, possible correlations between ea...
Article
COVID-19 may increase the risk of heat-related symptoms during hot weather since vulnerable populations, including the elderly and those with neurological disabilities, must continue to self-isolate, often indoors. Within the chronic neurological patient population, indoor conditions in summer months present a hazard because of impaired and/or alte...
Article
Full-text available
PurposeHeat sensitivity is a common contraindication in people with Multiple Sclerosis (pwMS), and physical fatigue is one of the most frequently reported symptoms that can affect quality of life. Increases in body temperature may exacerbate fatigue and heat-related symptoms. Decreasing body temperature via cooling devices may mitigate disease symp...
Article
Background: The worldwide lockdown in response to COVID-19 pandemics has often led to physical inactivity and social distancing. When combined, these factors may affect quality and life and increase the risk of different diseases. Therefore, assessment of physical activity levels should be encouraged to monitor and identify those at a higher risk...
Chapter
Prognosis in Wake-up ischemic stroke (WUS) is important for guiding treatment and rehabilitation strategies, in order to improve recovery and minimize disability. For this reason, there is growing interest on models to predict functional recovery after acute ischemic events in order to personalize the therapeutic intervention and improve the final...
Article
COVID-19 pandemics required a reorganisation of social spaces to prevent the spread of the virus. Due to the common presence of fever in the symptomatic patients, temperature measurement is one of the most common screening protocols. Indeed, regulations in many countries require temperature measurements before entering shops, workplaces, and public...
Article
Full-text available
The microclimate of an airline cabin consists of dry, recirculated, and cool air, which is maintained at lower pressure than that found at sea level. Being exposed to this distinctive, encapsulated environment for prolonged durations, together with the short-term chair-rest immobilization that occurs during long-haul flights, can trigger distinct a...
Article
Full-text available
We report a case series of 5 patients affected by SARS‐CoV‐2 who developed neurological symptoms, mainly expressing as polyradiculoneuritis and cranial polyneuritis in the two months of COVID‐19 pandemic in a city in the north east of Italy. A diagnosis of Guillain Barré syndrome was made on the basis of clinical presentation, cerebrospinal fluid a...
Article
Objective: Advanced neuroimaging has proved to be pivotal in the management of acute ischemic stroke. The use of CT perfusion (CTP) core and penumbra parameters to predict the outcome in wake-up stroke (WUS) patients in everyday clinical scenarios has not yet been investigated. The aim of our study was to investigate the predictive power of CTP pa...
Article
This case report describes the clinical characteristics of a 50-year-old woman that developed SARS-CoV-2 pneumonia and was admitted at the COVID-19 dedicated unit where she developed neurological symptoms 10 days after admission. After neurological examination, including a panel of blood cerebrospinal fluid biomarkers, a diagnosis of Miller Fisher...
Article
Purpose Crossed cerebellar diaschisis (CCD) is a common finding in hyper-acute ischemic stroke, related to supratentorial dysfunction of the contralateral hemisphere. Several studies investigated a possible relationship between CCD and clinical outcomes but still no evidence emerged. We used a novel quantitative whole cerebellum analysis using CT p...
Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) is rapidly spreading worldwide, and the WHO declared its pandemic nature on 11th March 20201. The outbreak has hit Europe and, as of April 19, 2020, Italy has the third largest number of confirmed cases, namely a total of 175,925 cases and 23,227 deaths according to the John Hopkins Unive...
Article
Background The COVID-19 pandemics required several changes in stroke management and it may have influenced some clinical or functional characteristics. We aimed to evaluate the effects of the COVID-19 pandemics on stroke management during the first month of Italy lockdown. In addition, we described the emergency structured pathway adopted by an Ita...
Article
Full-text available
Backgrounds Wake-Up Stroke (WUS) patients are generally excluded from thrombolytic therapy (rTPA) due to the unknown time of stroke onset. This study aimed to investigate the effects of rTPA in WUS patients during every day clinical scenarios, by measuring ischemic lesion volume and functional outcomes compared to non-treated WUS patients. Methods...
Article
Full-text available
Comfortable walking speed and energy cost of walking are physiological markers of metabolic activity during gait. People with multiple sclerosis are characterized by altered gait biomechanics and energetics, related to the degree of disability and spasticity, which lead to an increased energy cost of walking. Several studies concerning the energy c...
Article
Objective A very high-resolution (70 MHz) ultrasound device (VHRUS) has recently been approved for use in humans. The aim of this study was to use VHRUS to collect data on healthy subjects to propose some reference values for the digital branches of the median nerves of the hand. Methods A VHRUS with 70 MHz linear array transducer was used to meas...
Chapter
Full-text available
Management of Type 1 Diabetes (T1D) in the context of exercise or sports competition still represents a great challenge for athletes living with this disease, due to the wide excursions in blood glucose level with increased risk of life threatening hypoglycemia. Recently, an algorithm called ECRES has been developed to estimate patient-exercise tai...
Article
Hypohydration has been suggested increasing the risk of vascular diseases, and it is associated with poor prognosis and worse functional outcome in stroke. Most studies have used blood parameters to determine patients' hydration status. The aim of this study was to measure urine osmolality (uOsm) and its influence on stroke severity and independenc...
Article
The present study investigated the effect of a 3% rapid weight loss (RWL) procedure on neuromuscular performance in elite, Olympic-style boxers. Nine boxers were randomly assigned to two experimental procedures (RWL and control, in a randomized counterbalance order) to perform 5-s maximum isometric voluntary contractions (MVC) of the dominant leg k...
Article
Full-text available
Background: Care partners of stroke survivors are often characterized by high burden levels and depression. Passive and active interventions have been proposed to help reduce burden and depression. The aim of this quality improvement report was to evaluate the effects of a single passive intervention on reported burden and depression in carers of...
Article
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Abstract: l'immersione in acqua fredda rappresenta uno dei metodi più utilizzati per accelerare il recupero dopo lo sforzo fisico. Questa breve revisione della letteratura propone un'analisi di alcuni tra i principali lavori dedicati allo studio dell'immersione in acqua fredda (CWI) applicata a diversi sport. Negli sport di squadra l'immersione in...
Article
Proper hydration and nutrition have been found to be contributing factors to a better recovery in patients after stroke. A better knowledge of factors influencing fluid and energy intake may contribute to a better care of the acute stroke patient. Aim of this study was to describe hydration status, fluid intake, and energy intake of stroke patients...
Poster
Full-text available
ABSTRACT: Introduction: Cold water immersion (CWI) is one of the most used strategies to enhance recovery in soccer players. However, clear demonstration of the efficacy of CWI on fatigue perception and sprint-performance after strenuous exercises is still lacking. Therefore, the aim of this study was to determine the effectiveness of CWI on muscle...
Article
Full-text available
Background/aims: Hyperglycemia may influence the hydration status in diabetic individuals. During exercise, type 1 diabetes mellitus (T1DM) individuals may be challenged by a higher risk of dehydration due to a combination of fluid losses from sweat and increased urine output via glycosuria. So far, no study has characterised spontaneous fluid int...
Article
Full-text available
Elderly and patients affected by chronic diseases face a high risk of muscle loss and impaired physical function. Omega 3 fatty acids (FA) attenuate inflammation and age-associated muscle loss, prevent systemic insulin resistance and improve plasma lipids, potentially impacting on sarcopenia. This paper aims to review recent randomized clinical stu...
Article
BACKGROUND: Hydration habits during training may differ depending on sports mode and individual characteristics. The aim of this study was to assess fluid intake behaviour in a wide sample of Italian athletes during their regular training. METHODS: Data on hydration habits during training were collected from a random sample of competitive athletes....
Article
Objectives: The preferred countermeasure to avoid exercise-related hypoglycemia was investigated in a group of patients with type 1 diabetes participating in a stressful event, a 24×1-hour relay marathon. The carbohydrates actually consumed were compared to those estimated for each patient by applying a customizable algorithm, Exercise Carbohydrat...
Conference Paper
Full-text available
This paper presents a review of the scientific literature about thermoregulation and hydration during exercise in young athletes. Many sports events are performed in environmental conditions in which thermal strain could represent a threatening situation for health and performance of the young participants. Growth and maturation produce several ana...
Conference Paper
Full-text available
Introduction: In Type 1 Diabetes Mellitus (T1DM) physical activity helps to maintain better metabolic control, enhancing patients quality of life (Riddell et al., 2013). However, the risk of hypoglicemia during or after physical activity represents one of the most important factors limiting voluntary exercise in T1DM (Dubé et al., 2006). To prevent...