Alex Boye

Alex Boye
University of Cape Coast | UCC · Medical Laboratory Science

BSc., MPhil., Ph.D

About

77
Publications
35,125
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518
Citations
Introduction
Alex Boye (BSc, Mphil., Ph.D) is a natural product scientist, pharmacologist and a Science reader. Dr. Boye has multi-disciplinary biomedical background spanning Biological Sciences, Pharmacology, Toxicology, and Cancer Biology. Research and Teaching have been his preoccupation for the past eight years at University of Cape Coast, Ghana and Anhui Medical University, China. Since 2011, Dr. Boye has taught undergraduate students who major in: nursing, human biology, biomedical science and medical laboratory science. Some of the courses taught by Dr. Boye include Human Physiology, Pharmacology, Drug Metabolism & Toxicology, and Medical Genetics. At the postgraduate level, Dr. Boye has taught courses such as Advanced Pharmacology, Advanced toxicology and Drug target identification
Additional affiliations
July 2011 - October 2013
University of Cape Coast
Position
  • Lecturer, teaches pharmacology

Publications

Publications (77)
Article
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Background: Polyscias fruticosa (L.) Harms is used as a folk medicine across Afro-Asian regions of the world. Safety of P. fruticosa use in pregnancy remains completely unknown despite its extensive usage. Objective: The study assessed maternal and post-implantation loss in pregnant rats gestationally exposed to P. fruticosa leaf extract (PFE). Met...
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The transforming growth factor (TGF)-β/Smad signaling pathway is involved in hepatocellular carcinoma development. Smad2 and Smad3 are phosphorylated following TGF-β1 stimulation and subsequently oligomerize with Smad4 to form the Smad2/3/4 complex, which translocates into the nucleus and regulates target genes, including plasminogen activator inhi...
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Background: Polyscias fruticosa is used widely as food, disease remedy and as an ornamental across Afro-Asian countries. For instance, P. fruticosa is used traditionally as an anti-asthma, anti-tussive, and a muco-suppressant herbal remedy for asthmatics in Ghana. Although many studies have investigated the pharmacological basis of the ethnobotanic...
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MicroRNAs 21 and 145 exhibit inverse expression in Hepatocellular carcinoma (HCC), but how they relate to Smad3 C-terminal and Link region phosphorylation (pSmad3C and pSmad3L) downstream of TGF-β/MAPK signaling, remains inconclusive. Our results suggest microRNA-145 targets Smad3 in HepG2 cells. Decreased tumor volume and increased apoptosis were...
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In Ghana, uncomplicated malaria and sickle cell disease (SCD) is common, hence comorbidity is not farfetched. However, the extent of oxidative stress and the array of clinical manifestations in this comorbidity (presence of both malaria and SCD) has not been fully explored. This study highlights the impact of uncomplicated malaria on SCD. The level...
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Tangeretin is one of the many polymethoxyflavones (PMFs) mostly found in fruits and fruit peels of citrus plants. In view of its importance as a nutraceutical it has received extensive scientific scrutiny with regards to its suspected diverse bioactivities including anti-oxidant, anti-diabetes, anti-inflammatory, neuroprotection, efflux pump inhibi...
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Background. Ethnodentistry is the use of indigenous oral cleansing agents such as plant parts by local folks not only to maintain oral hygiene but also to treat oral infections. Mostly, ethnodentistry is inspired by traditions and belief systems of local communities. Musa paradisiaca is extensively cultivated and used in many cultures for its nutri...
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Background. Abrus precatorius is used in folk medicine across Afro-Asian regions of the world. Earlier, glucose lowering and pancreato-protective effects of Abrus precatorius leaf extract (APLE) was confirmed experimentally in STZ/nicotinamide-induced diabetic rats; however, the underlying mechanism of antidiabetic effect and pancreato-protection r...
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Background: Despite the enrollment of new small molecules such as Sorafenib for the treatment of hepatocellular carcinoma (HCC), HCC still remains a significant contributor to cancer-related mortality and morbidity globally. Zanthoxylum zanthoxyloides is long suspected of possessing anticancer bioactive compounds that may hold the prospect of adju...
Article
Cancer remains one of the debilitating health threats to mankind in view of its incurable nature. Many factors are complicit in the initiation, progression and establishment of cancers. Early detection of cancer is the only window of hope that allows for appreciable management and possible limited survival. However, understanding of cancer biology...
Preprint
Abstract Background: Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality globally, however, available treatments are expensive and associated with adverse effects or poor treatment outcomes in advanced disease. Meanwhile, plants like Carica papaya have demonstrated hepatoprotective effects, and further studies may lead to...
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Objective: Automobile mechanics are exposed to a wide range of chemicals contained in brake fluids, detergents, lubricants, paints, metal cleaners, solvents and fluids. Constant exposure to these chemicals puts mechanics at risk. This study aimed to assess the diverse hazards in working environment of automobile mechanics in Cape Coast Metropolis,...
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Introduction Artemether-Lumefantrine (A-L) remains the drug of choice for the treatment of uncomplicated malaria in Ghana. However, the pharmaco-activity of A-L has not been assessed on various Plasmodium falciparum Kelch 13 and Pfmdr1 genes. Therefore, this study sought to determine the therapeutic efficacy of A-L on P. falciparum parasites isolat...
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The severe form of COVID-19 has significant sex disparities, with high fatalities commonly reported among males than females. The incidence of COVID-19 has also been higher in males compared with their female counterparts. This trend could be attributed to a better responsive and robust immune system in females. Cytokine storm is one of the pathoph...
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Background: Thymol, a natural monoterpene phenol is not only relevant clinically as an anti-microbial, antioxidant and anti-inflammatory agent but also holds the prospect as a natural template for pharmaceutical semisynthesis of therapeutic agents. It is a major component of essential oils from many plants. Evidence abound linking overall bioactivi...
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Since the emergence of the pandemic in December 2019 in Wuhan, China, as of 10:00 CEST, June 6, 2020, there have been nearly 6,663,304 confirmed cases of COVID-19 including 392,802 deaths worldwide. In Africa, as of June 2, 2020, a total of 152,442 COVID-19 cases and 4334 deaths have been reported. The five countries with the highest commutative nu...
Article
Ethnopharmacological relevance Abrus precatorius (L.) leaves are used as folk medicine by the local communities in the western region of Ghana to treat diabetes mellitus; however, this health claim remains unverified scientifically. Objective The study investigated glucose lowering and pancreato-protective effects of Abrus precatorius leaf extract...
Article
Full-text available
Background Thymol, a natural monoterpene phenol is not only relevant clinically as an anti-microbial, anti-oxidant and anti-inflammatory agent but also holds the prospect as a natural template for pharmaceutical semi-synthesis of therapeutic agents. It is a major component of essential oils from many plants. Evidence abound linking overall bioactiv...
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Background: Benign prostatic hyperplasia (BPH) is a common urological disorder reported among ageing men. Objective: The study assessed histoprotective effect of lime essential oil (LEO) in a rat model of testosterone-induced benign prostatic hyperplasia (BPH) and evaluated its ability to reverse testosterone-mediated changes in the testis, kidn...
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Background: Undesirable consequences of donor Plasmodium falciparum parasitaemia on stored donor blood have been reported. Therefore, it is imperative that all prospective blood donors are screened for P. falciparum infections using sensitive techniques. In this study, the sensitivities of microscopy, rapid diagnostic test (RDT), loop-mediated iso...
Article
Ethnopharmacological relevance Compound Astragalus and Salvia miltiorrhiza extract (CASE), containing astragalosides, astragalus polysaccharide extracted from Astragalus membranaceus (Fisch.) Bge. and salvianolic acids from Salvia miltiorhiza Bge., has been found to inhibit hepatocarcinogenesis via mediating transforming growth factor-β (TGF-β)/Sma...
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Background: In most African countries, including Ghana, treatment of the Neisseria gonorrhoeae infection is based on syndromic management owing to lack of laboratory equipment and resources in primary care facilities where most patients first visit. Aim: The aim of this study was to determine the prevalence of Neisseria gonorrhoeae and evaluate its...
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Compound Astragalus and Salvia miltiorrhiza extract (CASE) is a Chinese herbal formula consisting of astragalosides, astragalus polysaccharide and salvi-anolic acids extracted from Astragalus membranaceus and Salvia miltiorhiza. Previous studies by our group have demonstrated that CASE effectively suppresses diethylinitrosamine (DEN)-induced hepato...
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With the development of the society, the xenobiotics have brought high potential risk to human and animal. The study focused on the adverse health effect of xenobiotics which plays an important role in addressing public health challenge. The special issue has focused on the toxicity of xenobiotics. We call for manuscripts describing recent findings...
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Hepatitis B viral load is directly related to the risk of disease progression. Studies reporting outcomes and indication for treatment a to determine the relationship between viral load and obstetric and neonatal outcomes in hepatitis B virus (HBV) infected mothers. Two hundred and sixty two pregnant women whose H determined by PCR and HBsAg were r...
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ARTICLE INFO ABSTRACT Both symptomatic and asymptomatic chronic Hepatitis B viral infections in pregnancy have been found to be associated with adverse comparative study compared maternal and perinatal outcomes of pregnancy between mothers with symptomatic HBV infection and those who were asymptomatic. infected pregnant wome likely to be symptomati...
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Chinese herbal medicine (CHM) is an integral component of complementary/alternative medicine and it is increasingly becoming the preferred therapeutic modality for the treatment of liver fibrosis and hepatocellular carcinoma (HCC) worldwide. Accordingly, the World Health Organization (WHO) has attested to the popularity and efficacy of indigenous h...
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Combretum dolichopetalum Engl. & Diels (Combretaceae) is a medicinal plant used in the Kpando Traditional Area for treating wounds. However, it has received little attention by the scientific world. The study was designed to evaluate the wound healing potential and antioxidant activities of the plant to confirm its folkloric use. Excision wound mod...
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Background: Schistosoma haematobium co-infection with S. mansoni and soil-transmitted helminthes afflict most-at-risk populations in endemic communities in the developing world. Aim: This study investigated S. haematobium co-infection with soil-transmitted helminthes, and host risk factors in two communities in the central region of Ghana. Methods:...
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Asymptomatic bacteriuria (ASB) is a major risk factor for urinary tract infections in most-at-risk populations. This study determined ASB positivity, common uropathogens, antimicrobial resistance (AMR) and risk factors of ASB among tertiary female students. A cross-sectional study was conducted on randomly recruited resident female students (n = 15...
Article
Ethnopharmacological relevance: The seeds of Parkia clappertoniana Keay (Family: Fabaceae) are extensively used in food in the form of a local condiment called 'Dawadawa' in Ghana and consumed by all class of people including sensitive groups such as pregnant women and children. Also, crudely pounded preparations of P. clappertoniana seeds are use...
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Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of the liver by initiating complex pathological events characterized by steatosis, steatohepatitis, hepatic fibrosis and cirrhosis. Subsequently, these initial pathological events are sustained and ushered into a more complex and progressive liver disease, incre...
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Foodborne illnesses pose serious public health threat globally, but requisite data to inform proper planning and prioritizing food safety interventions especially in developing countries is lacking. This study investigated microbiological quality of serving utensils (serving plates or bowls) for enteric pathogens from food vending and serving outle...
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Context: Polyscias fruticosa (L.) Harms (Araliaceae) is used as a traditional remedy for asthma in Ghana. Objective: The objective of this study is to establish the anti-asthmatic property and a possible mode of activity of an ethanol leaf extract of P. fruticosa (PFE). Materials and methods: The time (min) for pre-convulsive dyspnea, and time...
Article
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Background: Polyscias fruticosa is been used in Ghanaian folkloric medicine for the management of asthma and its related complications. Aim: This study evaluated the muco-suppressant, anti-tussive, and safety profile of an ethanolic leaf extract of Polyscias fruticosa in its use as an anti-asthmatic. Place and Duration of Study: Department of Pha...
Article
Mitogen-activated protein kinase (MAPK) pathway-dependent linker phosphorylation of Smad2/3 and subsequent formation of Smad2/3/4 complex and its nuclear translocation are crucial for dysregulated transforming growth factor beta (TGF)-β/Smad signaling in liver fibrosis. Abrogation of this critical step of TGF-β/Smad signaling leading to liver fibro...
Article
Ethnopharmacological relevance: Astragalus membranaceus Bunge (Leguminosae) and Salvia miltiorrhiza Bunge (Lamiaceae) are two important Chinese herbs with a long history of extensive ethnobotanical usage in the treatment of liver-related diseases over many centuries. Presently, these two herbs are being used either as a single herbal formulation o...
Article
The aim of this study was to investigate the mitogen-activated protein kinase (MAPK) pathway, which crosstalk with TGF-β/Smad signaling via linker phosphorylation of Smad2/3 to promote hepatocarcinogenesis. After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-β...
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A preliminary study had shown that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. The study was a follow up work to evaluate the anti-nociceptive effects and other possible mechanisms of action of an aqueous leaf extract of C. olitorius (COE) using formalin-induced nociception test. COE was screened for its analg...
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Aim: To assess the nephroprotective and curative effects of an aqueous seed extract of Parkia clappertoniana on gentamicin-induced renal damage (GIRD) in Sprague-Dawley rats. Aim: To assess the nephroprotective and curative effects of an aqueous seed extract of Parkia clappertoniana on gentamicin-induced renal damage (GIRD) in Sprague-Dawley rats.
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Helminthiasis is one of the most common and widespread parasitic infections of humans, contributing to poor nutritional status, anemia, and low birth weight (LBW) in pregnancy. We investigated the possible association between helminthiasis and anemia in pregnancy and their combined effect on day zero birth weights (DZBW). A total of 83 pregnant wom...
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Background: Polyscias fruticosa is a plant used in the traditional management of asthma in Ghana. Aim: This study evaluated the anti-inflammatory property of an ethanolic leaf extract of Polyscias fruticosa and safety for use in ovalbumin-induced asthma. Methodology: The total and differential white blood cell counts, C-reactive protein level, and...
Article
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2014). Preliminary phytochemical screening, antimicrobial examination and wound healing potential of the root extract of amaranthus spinosus. Journal of Basic & Applied Sciences, 1 (2), 84-95 Abstract Amaranthus spinosus is traditionally acclaimed to be effective in treating infectious wounds in man and animals. It is also used medicinally in the t...
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Background: Hypertrophic scar is a fibro-proliferative disease. Our previous studies demonstrate that compound Astragalus and Salvia miltiorrhiza extract (CASE) inhibits proliferation and invasion in keloid fibroblasts. Objective: To investigate the effects of CASE on hypertrophic scar. Methods: Rabbits were divided into the control, model and...
Article
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MicroRNAs are evolutionary conserved single stranded non-coding RNAs with immense ability to posttranscriptionally regulate gene expression via complementary base pairing with mRNAs of more than 50% protein encoding genes. They play diverse roles in physiological and pathophysiological processes such as normal development and cancer pathogenesis re...
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Daniellia oliveri stem bark is used traditionally by the people of Northern Ghana to manage pain. This study therefore sought to validate the antinociceptive property of an aqueous stem bark extract of Daniellia oliveri (DOE) using murine hot plate and paw pressure pain models as well as its antioxidant property. Groups of ICR mice were pre-treated...
Article
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Background: The need for new antimalarial agents with a transcriptional mode of action but fewer side effects compared with artemisinin-based combination therapy for malaria has been the preoccupation of scientists in areas where malaria is a menace. Stem bark extracts of Plumeria alba, used traditionally for the treatment of malaria in Ghana, were...
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Wound healing disorders present a serious clinical problem of medical health care in Africa and in Ghana; most of these disorders lead to complications, high morbidity and mortality rates. However, most of the synthetic drugs currently used for the treatment of wounds are not only expensive but also pose problems such as allergy and drug resistance...