Alex Barnes

Alex Barnes
Flinders Medical Centre · Gastroenterology

MD MPH FRACP

About

30
Publications
574
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31
Citations

Publications

Publications (30)
Article
Full-text available
Background The thiopurine medications are well established in the treatment of inflammatory bowel disease (IBD). There is significant variation in levels of toxic and therapeutic metabolites. Current data from small or short-term studies support therapeutic drug monitoring (TDM) in assessing azathioprine (AZA) and 6-mercaptopurine (6MP). TDM of thi...
Article
Full-text available
Background Poor sleep quality has been associated with active inflammatory bowel disease (IBD) in several studies. This review examines sleep quality in people with active IBD and in those in remission, with meta-analyses performed, considering subjective and objective sleep quality and IBD activity. Methods Electronic databases were searched from...
Article
Full-text available
Background and Aim Medication nonadherence is common in patients with inflammatory bowel disease (IBD) and has been associated with worse outcomes. The coronavirus disease 2019 (COVID‐19) pandemic led to significant consumer and medical concern regarding the possible risks of immunosuppressive medications during the pandemic. This study aimed to ex...
Article
Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old female who developed odynophagia and bloody diarrhea following treatment with ocrelizumab. This was characterized endoscopically by ulce...
Article
Introduction Steroid exposure has been associated with poorer outcomes following colectomy in acute severe ulcerative colitis (ASUC). Our centre aimed to examine the effect of prolonged oral corticosteroid therapy immediately prior to admission on the likelihood of requiring rescue therapy along with predictors of intravenous corticosteroid failure...
Conference Paper
Colonoscopy findings after a low‐risk adenoma in patients with and without inflammatory bowel disease A Barnes1,2, R Mountifield1,2, P Spizzo1 and E Symonds1,2 1Flinders Medical Centre, Adelaide, South Australia, Australia; 2Flinders University, Adelaide, South Australia, Australia Background and Aim: Australian guidelines suggest that the colon...
Presentation
Medication non‐adherence among patients with inflammatory bowel disease during the COVID‐19 pandemic is associated with increased disease activity and corticosteroid usage A Barnes1,2, P Spizzo1, J Andrews3,4 and R Mountifield1,2 1Flinders Medical Centre, Adelaide, South Australia, Australia; 2Flinders University, Adelaide, South Australia, Austr...
Conference Paper
Corticosteroid exposure before admission and predicting need for rescue therapy in patients with acute severe ulcerative colitis A Barnes1,2, P Spizzo1 and R Mountifield1,2 1Flinders Medical Centre, Adelaide, South Australia, Australia; 2Flinders University, Adelaide, South Australia, Australia Background and Aim: Steroid exposure has been assoc...
Conference Paper
Incidence of adenoma in patients with inflammatory bowel disease undergoing surveillance colonoscopy A Barnes1, R Mountifield1,2, P Spizzo1 and E Symonds1,2 1Flinders Medical Centre, Adelaide, South Australia, Australia; 2Flinders University, Adelaide, South Australia, Australia Background and Aim: Inflammatory bowel disease (IBD) colitis‐associ...
Article
Introduction: Faecal calprotectin is a highly sensitive non-invasive marker of intestinal inflammation that has evidence-based roles in outpatient diagnosis and management of inflammatory bowel disease. This study aimed to examine indications for faecal calprotectin (FCP) in a tertiary inpatient population, and its role in inpatient management and...
Article
Background Steroid exposure has been associated with poorer outcomes following colectomy in acute severe ulcerative colitis. Current treatment algorithms suggest three days of high dose intravenous steroid before the decision to commence rescue therapy. We aimed to look at medium-term outcomes in acute severe ulcerative colitis and their predictors...
Article
Background and aims: Palliative care referral for end stage liver disease (ESLD) is uncommon and usually occurs late. We aimed to review the rate of early palliative care referral (EPCR) in ESLD patients, its associations, and its impacts on resource utilisation and survival. Methods: A retrospective review of all patients with ESLD admitted to...
Article
Guidelines suggest that carefully selected patients with neutropenic fever (NF) may be suitable for early discharge on oral antibiotics. Despite these recommendations, many centres manage NF with intravenous antibiotic protocols and inpatient care. We have conducted a retrospective audit of patients with NF, and found that 12 of 40 (30%) patients w...
Article
The syndrome of inappropriate antidiuretic hormone (SIADH) is reported as the most common cause of hyponatraemia. This retrospective cross-sectional study evaluated the diagnosis of SIADH in 110 hospitalised patients in an Australian tertiary hospital with reference to recently published clinical guidelines. Investigation of SIADH was incomplete in...

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