Alet H Wijga

Alet H Wijga
National Institute for Public Health and the Environment (RIVM) | RIVM · Centre for Nutrition, Prevention and Health Services (VPZ)

About

292
Publications
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Introduction

Publications

Publications (292)
Article
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Pure fruit juice is comparable to sugar-sweetened beverages (SSBs) with respect to its sugar and fructose content. However, it also contains favorable components like polyphenols. From this perspective, pure fruit juice is more comparable with whole fruit. SSBs have been associated with higher asthma risk, while whole fruit consumption has been ass...
Article
Full-text available
Allergies are major noncommunicable diseases associated with significant morbidity, reduced quality of life, and high healthcare costs. Despite decades of research, it is still unknown if early-life exposure to indoor allergens plays a role in the development of IgE-mediated allergy and asthma. The objective of this study is to contribute to the id...
Article
Background Green space, air pollution and traffic noise exposure may be associated with mental health in adolescents. We assessed the associations of long-term exposure to residential green space, ambient air pollution and traffic noise with mental wellbeing from age 11 to 20 years. Methods We included 3059 participants of the Dutch PIAMA birth co...
Article
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The incidence of childhood overweight and obesity is rising. It is hypothesized that infections in early childhood are associated with being overweight. This study investigated the association between the number of symptomatic infections or antibiotic prescriptions in the first 3 years of life and body mass index (BMI) in adolescence. The current s...
Article
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Green space, air pollution, and traffic noise exposure may be associated with stress levels in children. A flattened diurnal cortisol slope (the decline in cortisol concentrations from awakening to evening) is an indicator of chronic stress. We examined associations of green space, ambient air pollution, and traffic noise with the diurnal cortisol...
Article
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PurposeIt is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts.Methods We searched https://www....
Article
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Objective: Dietary guidelines on pure fruit juice differ between countries regarding the question whether pure fruit juice (without added sugars) is an acceptable substitute for fruit or should be avoided because its comparable sugar content to that of sugar-sweetened beverages (SSBs). We modelled whether substituting pure fruit juice for fruit or...
Article
Full-text available
Objective To assess whether adolescents with asthma experience a lower mental wellbeing and lower general health than their non-asthmatic peers. Study design Data from the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study were used. At the ages of 11, 14, 17 and 20 years, respectively 2651, 2522, 2094 and 2206 participants complete...
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Introduction The adolescent years represent a key period for the development of musculoskeletal complaints (MSC) and the differences between boys and girls. We evaluated the prevalence and course of MSC and factors associated with MSC while growing up from age 11 to age 20. Methods Questionnaire‐based data at age 11 (n=2638), age 14 (n=2517), age...
Article
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We aimed to obtain reliable reference charts for sleep duration, estimate the prevalence of sleep complaints across the lifespan and identify risk indicators of poor sleep. Studies were identified through systematic literature search in Embase, Medline and Web of Science (9 August 2019) and through personal contacts. Eligible studies had to be publ...
Article
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The striking difference between men and women in headache prevalence is suggested to develop in adolescence. Although headaches are common and affect quality of life and daily functioning, the evidence needed to develop effective counselling and preventive approaches is still limited.Using data collected at age 11, 14, 17 and 20 years in the Dutch...
Article
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Background: Whether long-term air pollution exposure has effects on allergic sensitization is controversial. Objective: To investigate associations of air pollution exposure at birth and at the time of later biosampling, with IgE sensitization against common food/inhalant allergens, or specific allergen molecules, in children up to 16 years. Me...
Article
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Background House dust endotoxin may have beneficial effects on allergic sensitization and asthma in children. Evidence is scarce for adolescents and most studies so far have been cross‐sectional and limited to a single exposure measurement. Objective We assessed associations of house dust endotoxin with asthma and allergic sensitization from birth...
Article
Full-text available
House dust mites area worldwide major source of allergens, with Dermatophagoidespteronyssinus (Der p) being the most allergenicand frequently implicated in respiratory allergy. Determining the sources of exposure to Der p in infants may be particularly important in view of the accumulating evidence of an early life window of susceptibility for long...
Article
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Background Primary prevention of overweight is to be preferred above secondary prevention, which has shown moderate effectiveness. Objective To develop and internally validate a dynamic prediction model to identify young children in the general population, applicable at every age between birth and age 6, at high risk of future overweight (age 8). M...
Article
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Human milk contains proteins and/or protein fragments that originate from nonhuman organisms. These proteinaceous molecules, of which the secretion might be related to the mother’s allergy status, could be involved in the development of the immune system of the infant. This may lead, for example, to sensitization or the induction of allergen-specif...
Article
Background Air pollution is associated with asthma development in children and adults, but the impact on asthma development during the transition from adolescence to adulthood is unclear. Adult studies lack historical exposures and consequently cannot assess the relevance of exposure during different periods of life. We assessed the relevance of ea...
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Background: It is well known that maternal smoking during pregnancy and maternal pre-pregnancy overweight have opposite effects on the infants' birth weight. We report on the association of the combination between both risk factors and the infants' birth weight. Methods: We studied 3241 infants born at term in the PIAMA birth cohort. Maternal sm...
Article
Targeted screening for childhood high blood pressure may be more feasible than routine blood pressure measurement in all children to avoid unnecessary harms, overdiagnosis or costs. Targeting maybe based e.g. on being overweight, but information on other predictors may also be useful. Therefore, we aimed to develop a multivariable diagnostic predic...
Article
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Background: Dietary guidelines on pure fruit juice consumption vary from country to country regarding the inclusion of pure fruit juice in the recommendations as an acceptable alternative for fruit. Current epidemiological evidence on the association between pure fruit juice consumption and diabetes risk is scarce. Objective: We studied the asso...
Article
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Background: Most previous studies that investigated associations of surrounding green, air pollution or traffic noise with mortality focused on single exposures. Objectives: The aim of this study was to evaluate combined associations of long-term residential exposure to surrounding green, air pollution and traffic noise with total non-accidental...
Article
Background The relevance of timing of exposure in the associations of secondhand tobacco smoke (SHS), pets, and dampness or mould exposure with lung function is unclear. We investigated the relevance of timing of these exposures for lung function in adolescence. Methods We used data from participants of the Dutch Prevention and Incidence of Asthma...
Article
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Background: Green space has been hypothesized to improve cardiometabolic health of adolescents, whereas air pollution and traffic noise may negatively impact cardiometabolic health. Objectives: To examine the associations of green space, air pollution and traffic noise with cardiometabolic health in adolescents aged 12 and 16 years. Methods: W...
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Introduction To understand the puberty-related sex shift in the prevalence of asthma and rhinitis as single entities and as respiratory multimorbidities, we investigated if there is also a sex-specific and puberty-related pattern of their incidences. Methods We used harmonised questionnaire data from 18 451 participants in five prospective observa...
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Self-perceived general health (SGH) is one of the most inclusive and widely used measures of health status and a powerful predictor of mortality. However, only a limited number of studies evaluated associations of combined environmental exposures on SGH. Our aim was to evaluate associations of combined residential exposure to surrounding green, air...
Article
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Background: There is growing evidence for a protective effect of breastfeeding against overweight and diabetes. It is less clear though, whether breastfed infants also have a more favorable cardiometabolic profile in childhood. Objective: We investigated whether children who were breastfed in infancy had more favorable cardiometabolic markers at...
Article
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Background: Evidence is emerging that poor mental health is associated with the environmental exposures of surrounding green, air pollution and traffic noise. Most studies have evaluated only associations of single exposures with poor mental health. Objectives: To evaluate associations of combined exposure to surrounding green, air pollution and...
Article
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Background: Surrounding green, air pollution, and noise have been associated with cardiometabolic diseases, but most studies have assessed only one of these correlated exposures. Objectives: We aimed to evaluate associations of combined exposures to green, air pollution, and road traffic noise with cardiometabolic diseases. Methods: In this cr...
Article
Background: Pet and dampness or mould exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence. Objective: We investigated the role of timing of pet and dampness or mould exposure in asthma and sensit...
Article
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Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births...
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Adolescents with high educational attainment generally have better outcomes across the lifespan than adolescents with lower educational attainment. This study investigated how three measures of socioeconomic status (SES)–maternal education, paternal education, and neighbourhood SES–combined to predict adolescent educational attainment (track level...
Data
Associations of gestational weight gain with the risk of overweight/obesity assessed by 2-stage IPD meta-analysis. (PDF)
Data
Associations of maternal pre-pregnancy BMI and gestational weight gain clinical categories with childhood BMI SDS: Complete case analysis. (PDF)
Data
Country-specific PARs of maternal overweight, maternal obesity, and excessive gestational weight gain for mid childhood overweight/obesity. (PDF)
Data
Cohort-specific description of available covariates. (PDF)
Data
Associations of maternal pre-pregnancy BMI clinical categories with the risk of childhood overweight/obesity, additionally adjusted for gestational diabetes. (PDF)
Data
Associations of maternal pre-pregnancy BMI clinical categories with the risk of childhood overweight/obesity, additionally adjusted for gestational hypertensive disorders. (PDF)
Data
Associations of maternal pre-pregnancy BMI and gestational weight gain clinical categories with the risk of childhood underweight. (PDF)
Data
Contact information for data requests per cohort. (PDF)
Data
Plan for analysis for invitation of cohorts. (PDF)
Data
Country-specific description of exposures and outcomes. (PDF)
Data
Associations of maternal pre-pregnancy BMI with the risk of childhood overweight/obesity assessed by 2-stage IPD meta-analysis. (PDF)
Data
Cohort-specific methods of data collection. (PDF)
Data
Sources of funding/support per cohort. (PDF)
Data
Associations of maternal pre-pregnancy BMI clinical categories with the risk of childhood overweight/obesity, additionally adjusted for gestational-age-adjusted birth weight. (PDF)
Data
Associations of maternal pre-pregnancy BMI and gestational weight gain clinical categories with the risk of childhood overweight/obesity: Complete case analysis. (PDF)
Article
Observational studies suggest that breastfeeding is associated with a more favorable BMI and cardio-metabolic markers, but potential underlying mechanisms are unclear. As serum adiponectin has an important function in adults for glucose and lipid metabolism, we assessed in 251 participants of the PIAMA birth cohort whether breast milk adiponectin i...
Article
Full-text available
Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the se...
Article
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Objectives: To develop a dynamic prediction model for high blood pressure at the age of 9–10 years that could be applied at any age between birth and the age of 6 years in community-based child healthcare. Design, setting and participants: Data were used from 5359 children in a population-based prospective cohort study in Rotterdam, the Netherland...
Article
Full-text available
Dietary guidelines for pure fruit juice consumption differ between countries, regarding the question whether pure fruit juice is an acceptable alternative for fruit. Currently, little is known about pure fruit juice consumption and the risk of CVD. In this prospective cohort study, we studied the association of pure fruit juice and fruit consumptio...
Article
Full-text available
Atherosclerotic changes can be measured as changes in common carotid intima media thickness (CIMT). It is hypothesised that repeated infection-associated inflammatory responses in childhood contribute to the atherosclerotic process. We set out to determine whether the frequency of infectious diseases in childhood is associated with CIMT in adolesce...
Article
Background: Air pollution, traffic noise and absence of green space may contribute to the development of overweight in children. Objectives: To investigate the combined associations of air pollution, traffic noise and green space with overweight throughout childhood. Methods: We used data for 3680 participants of the Dutch PIAMA birth cohort....
Article
Full-text available
International collaborations among birth cohorts to better understand asthma and allergies have increased in the last years. However, differences in definitions and methods preclude direct pooling of original individual participant data. We harmonized data from 14 birth cohorts, with three to 20 follow-ups, from nine European countries, as part of...
Article
Background: It has been suggested that children who are exposed to agricultural pesticides have an increased risk of asthma, but evidence for associations betweeen residential pesticide exposure and childhood asthma is inconsistent. Objectives: To investigate the associations of residential pesticide exposure with the prevalence of asthma and re...
Article
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood. T...
Article
Full-text available
Evidence for the effects of air pollution exposure on lung function growth into adolescence is scarce. We investigated associations of air pollution exposure with lung function and lung function growth until age 16. We conducted both longitudinal (n=915) and cross-sectional (n=721) analyses of associations of air pollution exposure with forced expi...