Alessia Butera

Alessia Butera
Istituto Superiore di Sanità | ISS · National Center for Drug Research and Evaluation

Immunological, Haematological And Rheumatological Sciences (PhD Student)

About

28
Publications
1,864
Reads
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327
Citations
Citations since 2016
15 Research Items
208 Citations
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201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
Education
November 2017 - February 2019
Sapienza University of Rome
Field of study
  • Immunology
November 2014 - September 2016
Sapienza University of Rome
Field of study
  • Biotechnologies
November 2009 - September 2012
Sapienza University of Rome
Field of study
  • Biology

Publications

Publications (28)
Article
Full-text available
Background and Aims Intestinal fibrosis is a common complication of inflammatory bowel diseases. Medical treatment of intestinal fibrosis is an unmet therapeutic need. CD147 overexpression can induce myofibroblast differentiation associated with extracellular matrix deposition, favouring the development of fibrosis. To understand whether CD147 may...
Article
Full-text available
Systemic sclerosis (SSc) is characterized by skin/internal organ fibrosis, vasculopathy and autoimmunity. Chemokine (C-X-C motif) ligand 4 (CXCL4) is an SSc biomarker, predicting unfavorable prognosis and lung fibrosis. CXCL4 binds DNA/RNA and favors interferon (IFN)-α production by plasmacytoid dendritic cells (pDCs), contributing to the type I IF...
Article
Full-text available
LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In systemic lupus erythematosus (SLE), LL37 also triggers IFN-I in pDCs and is target of pathogenic autoantibodies. Howev...
Article
Autism Spectrum Disorders (ASD) are neurodevelopmental disorders characterized by social communication deficits and repetitive/stereotyped behaviours. We evaluated the effects of a chronic treatment with the immunomodulator drug Fingolimod (FTY720 - a non-selective Sphingosine 1-Phosphate Receptor ligand) in an ASD model, the BTBR T⁺tf/J (BTBR) mou...
Article
Background and aim: A personalized approach to therapy has great promise to improve disease outcomes. To this end, the identification of different subsets of patients according with the prevalent pathogenic process might guide in the choice of therapeutic strategy. We hypothesize that UC patients might be stratified according to distinctive cytoki...
Article
Full-text available
Background and Aims: In ulcerative colitis (UC), inflammation begins in the rectum and can extend proximally throughout the entire colon. The extension of inflammation is an important determinant of disease course, and may be limited by the action of regulatory T cells (Tregs). In this cross-sectional study, we evaluated the relationship between UC...
Article
Full-text available
Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn's Disease. In previous studies, we have shown that Nod2-/- mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3- regulatory cells, when compared with Nod2+/+ mice, while CD4+ Foxp3 + regulatory cells were not affe...
Article
Background: A personalized approach to therapy has great promise to improve disease outcomes. Selection of patients as candidates for the early introduction of highly effective therapy can both maximize treatment efficiency and prevent long-term complications. Ulcerative Colitis (UC) has been associated with an atypical Th2 cell response mediated i...
Article
Full-text available
Background: A CD4+CD25- regulatory T cell population expressing the surface TGF-β in its latent form LAP+ (Latency Associated Peptide) cells was proved to be protective in experimental colitis and be suppressive of human peripheral blood (PB) T proliferation. We investigated the frequency and function of lamina propria (LP) CD4+LAP+ T cells in inf...
Article
Full-text available
Human serum IgM Abs are composed of heavily glycosylated polymers with five glycosylation sites on the μ (heavy) chain and one glycosylation site on the J chain. In contrast to IgG glycans, which are vital for a number of biological functions, virtually nothing is known about structure-function relationships of IgM glycans. Natural IgM is the earli...
Article
Full-text available
On the basis of previous studies demonstrating that a breach of the colonic epithelial barrier is associated with a microbiota-dependent increase in lamina propria (LP) regulatory cells, we investigated if the lack of spontaneous intestinal inflammation observed in nucleotide-binding oligomerization domain 2 (Nod2)-/- mice was due to enhanced intes...
Data
Unsupervised PCA analysis of changes in gene expression in wt and Mutyh−/− mice exposed to DSS. (0.11 MB TIF)
Article
Full-text available
The Mutyh DNA glycosylase is involved in the repair of oxidized DNA bases. Mutations in the human MUTYH gene are responsible for colorectal cancer in familial adenomatous polyposis. Since defective DNA repair genes might contribute to the increased cancer risk associated with inflammatory bowel diseases, we compared the inflammatory response of wil...
Article
Full-text available
Immune homeostasis at mucosal level results from controlled response to intestinal luminal antigens. Recent insights into the nature of inflammatory bowel diseases, derived mainly from studies of experimental models of colonic inflammation, strongly suggest that they can result from a loss of immune tolerance to antigens in the bacterial microflora...
Article
Previous studies have indicated that a defective epithelial barrier leads to inflammation of the underlying lamina propria. Nevertheless, it is likely that physiologic breaks in the barrier must occur for homeostatic regulatory T cells to develop. We determined the effect of agents that disrupt epithelial tight junctions (ethanol and AT1002, a Vibr...

Questions

Question (1)
Question
Dear all,
i a question. I have the need to measure soluble collagen from colon mouse tissue but i do not have freezing colon samples but only the protein extract for wester blot analysis (- Hepes pH 7,9 -EDTA pH 8,0 -KCl -Nonidet; DTT, PMSF, Aprotinin , Leupeptin, Na3VO4). Do you think that I can quantified collagen in this protein extracxt?
thank you all
bye

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