Alessandro Martini

Alessandro Martini
University of Padova | UNIPD · Department of Neurosciences

About

483
Publications
67,215
Reads
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7,575
Citations
Citations since 2016
93 Research Items
3968 Citations
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20162017201820192020202120220100200300400500600700
20162017201820192020202120220100200300400500600700
20162017201820192020202120220100200300400500600700
Additional affiliations
January 2011 - present
January 2008 - present
Italian National Research Council
January 2007 - December 2008

Publications

Publications (483)
Article
Full-text available
The conjugation of drugs with nanoparticles represents an innovative approach for controlled and targeted administration of therapeutic agents. Nanoparticle-based systems have been tested for the inner ear therapy, increasing the drug diffusion and being detected in all parts of the coch-lea when locally applied near the round window. In this study...
Poster
Introduction An adequate surgical access to the internal auditory canal (IAC) fundus is a crucial aspect of retro-labyrinthine meatotomy in retrosigmoid approaches for vestibular schwannoma hearing preservation surgery. To maximize surgical exposure while preserving labyrinthine structures, an adequate surgical corridor passing through an appropri...
Poster
Full-text available
The poster describes an ongoing research aiming at understanding the electrophysiological neural correlates of audiovisual speech comprehension in deaf people with cochlear implant by manipulating the visibility of the mouth of the speaker and sentence constraint regulating target word predictability.
Article
Background Impedance is a basic parameter registered at any cochlear implant (CI) fitting section. It is useful in monitoring electrode functioning and the status of the surrounding anatomical structures. Purpose The main aim of this study is to evaluate the 5-year impedance-value trend in patients affected by congenital genetically determined prof...
Article
Full-text available
The biocompatibility and the antioxidant activity of barium titanate (BaTiO3) and lithium niobate (LiNbO3) were investigated on a neuronal cell line, the PC12, to explore the possibility of using piezoelectric nanoparticles in the treatment of inner ear diseases, avoiding damage to neurons, the most delicate and sensitive human cells. The cytocompa...
Article
Full-text available
Purpose To describe our institutional experience in cochlear implantation after vestibular schwannoma (VS) resection, and compare the audiological outcomes between sporadic and neurofibromatosis type 2 (NF2) VS sub-cohorts of patients, and in relation to preoperative contralateral hearing. Methods Seventeen patients (8 sporadic and 9 NF2-associate...
Article
Objective: To investigate the prevalence-rate of oval window bulging in the common cavity and its association with bacterial meningitis. Patients: CT and clinical files of 29 children with preliminary diagnosis of common cavity deformity were collected from 13 Italian centers. Intervention: A retrospective case review study was conducted with...
Article
Full-text available
Hearing loss is one of the most common congenital sensory disorders. It can be associated with several comorbidities, in particular developmental disabilities (DD). In Emilia-Romagna (ER), a region in Northern Italy, Child and Adolescent Mental Health Services (CAMHS) provide the diagnostic framework and treatment for these conditions. The aim of t...
Conference Paper
Razionale: Anche se negli ultimi anni si è assistito ad un miglioramento nell’ambito della diagnosi e del trattamento dello schwannoma vestibolare sporadico, non esistono tuttora dei fattori in grado di predirne la crescita. L’endoglina (CD105) è una proteina espressa dalle cellule endoteliali, associata all’angiogenesi e rappresenta un promettente...
Article
The “spirit” of a scientific journal is determined by mul- tiple factors, such as being promoted by an association of professionals or by addressing specific scientific fields of interest, but ultimately it is up to the editors to shape the style and the content of a journal. So, in this editor- ial we will discuss the “spirit” of the Hearing, Bala...
Article
Introduction: In the ENT community, auditory deprivation is frequently considered as a negative prognostic factor for a good hearing outcome of cochlear implantation (CI), even if a growing literature suggests that this is not completely true. The purpose of this study is to evaluate the results of CI in patients with hearing deprivation, to compa...
Article
Full-text available
Purpose To assess preoperative features that could predict the audiological outcome after cochlear implantation in the elderly, in terms of pure tone audiometry, speech audiometry, and speech perception performance. Methods All available records of patients with cochlear implants aged 65 or more at the time of their implantation at our Institution...
Article
Full-text available
Plain-language-summary The concept of auditory restoration after cochlear implant (CI) in prelingual deafness is well described by a synaptic network model, whose development depends on sensory experience. The aim of this work was to study the associative networks activated by the CI in a population of prelingually deaf patients. In particular, the...
Article
Although the diagnosis and treatment of sporadic vestibular schwannoma has improved in recent years, no factors capable of predicting its growth have been identified as yet. Endoglin (CD105) is a proliferation-associated protein expressed in angiogenic endothelial cells, and a potential prognostic indicator for several solid tumors. The aim of the...
Article
Neurofibromatosis type 2 (NF2) is an autosomal dominant, multiple neoplasia syndrome characterized by bilateral vestibular schwannomas (VSs). Endoglin is a proliferation-associated protein expressed in angiogenic endothelial cells. The aim of this study was to investigate endoglin expression in a series of NF2-associated VSs, as compared with a gro...
Article
Full-text available
Disregarding the widely used division of skull base into anterior and lateral, since the skull base should be conceived as a single anatomic structure, it was to our convenience to group all those approaches that run from the antero-lateral, pure lateral and postero-lateral side of the skull base as “Surgery of the lateral skull base”. “50 years of...
Article
An example of aggressive eosinophilic polyposis can be found in eosinophilic granulomatosis with polyangiitis (EGPA). Intercellular adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule-1 (vCAM-1) play a part in mediating the recruitment and adhesion of leukocytes to the vessel wall, and their blood-to-tissue migration under inflammatory...
Article
Full-text available
Case-control studies on malignant sinonasal tumors and occupational risk factors are generally weakened by non-occupational confounders and the selection of suitable controls. This study aimed to confirm the association between sinonasal malignant tumors and patients’ occupations with consideration for sinonasal inverted papillomas (SNIPs) as a con...
Article
Radiological imaging can reveal crucial information when dealing with single-side deafness. In early childhood, this condition is a challenging task for any clinician due to poor reliability of the patient at audiological testing. Moreover, clinical symptoms of unilateral hearing loss are blurred, even if it can severally affect quality of life, es...
Article
Importance Common cavity deformity is a rare congenital inner ear malformation associated with profound hearing loss and attributed to an early developmental arrest of the cochlear-vestibular structures. This narrative review highlights the need to identify reliable indicators of hearing rehabilitation outcome. Observations Despite its relatively...
Article
Cochlear implants, the only way to recover from severe/profound hearing loss, may cause adverse effects, among which reactions to silicone materials coating implant electrodes, leading to apoptosis and necrosis of spiral ganglion cells. Our aim was to evaluate whether three polydimethylsiloxane (PDMS) compounds (hexadimethylsiloxane, octamethyltris...
Article
Introduction: Some aspects of the natural history of vestibular schwannoma (VS) remain unsettled. A better understanding of the pathophysiology of the disease would improve its diagnostic workup and therapeutic management, as VS often requires surgery, which carries the risk of severe complications. This paper discusses the significance of ultrastr...
Article
Objectives: Children can well detect and respond to odours in order to have information about food and environment. Rapid Maxillary Expansion seems to improve dental and skeletal crossbite and increase nasal patency correcting oral respiration in children. A previous pilot study suggested that Rapid Maxillary Expansion may lead to improved N-Butano...
Article
Full-text available
The current treatment options for acoustic neuromas (AN) - observation, microsurgery and radiotherapy - should assure no additional morbidity on cranial nerves VII and VIII. Outcomes in terms of disease control and facial function are similar, while the main difference lies in hearing. From 2012 to 2016, 91 of 169 patients (54%) met inclusion crite...
Conference Paper
RAZIONALE Sebbene la diagnosi ed il trattamento dello schwannoma dell’ottavo nervo cranico [VIII N.C.] siano migliorati nel corso degli anni, non sono stati ancora identificati fattori in grado di predire la crescita tumorale. Questa è un’indagine preliminare riguardante l’espressione delle proteine citoplasmatiche YAP (Yes-associated protein), TA...
Conference Paper
Razionale: nel processo di transizione epitelio-mesenchimale (EMT), le cellule epiteliali perdono le loro caratteristiche tipiche, acquisendo fenotipo simil-mesenchimale. La proteina NM23-H1 è correlata al potenziale metastatico delle cellule tumorali e la sua ridotta espressione nei carcinomi è spesso correlata a prognosi infausta. Questo studio o...
Article
Background: Sinonasal inverted (schneiderian) papilloma (IP) is histologically benign but shows a propensity for malignant transformation. Survivin, a member of the inhibitor of the apoptosis family of proteins that controls cell division, apoptosis, metastasis, and, probably, also neoangiogenesis, is overexpressed in essentially all human cancers...
Article
Background: In epithelial-to-mesenchymal transition (EMT), epithelial cells lose their features, acquiring a mesenchymal-like phenotype. NM23-H1 protein relates to tumor cells’ metastatic potential, its low expression in carcinomas often meaning a poor prognosis. This study newly investigated the role of nuclear NM23-H1 in laryngeal carcinoma (LSCC...
Article
Introduction: Hearing loss is considered the most common congenital disease and the prevalence of neonatal deafness can be estimated between 1 and 2 cases per 1000 live births. Infant deafness must be diagnosed as early as possible and an effective therapeutic intervention needs to be carried out in order to avoid the serious consequences of heari...
Article
Background: The etiology of age-related olfactory loss is still unclear, but it has been claimed that polypharmacotherapy may contribute to olfactory dysfunction, particularly in the elderly, who are more likely to need multiple drugs. The present pilot study investigated the relationship between smell and the number and type of drugs taken in a gr...
Article
An innovative approach to improve drug delivery is the use of glycerol monooleate nanoparticles. Numerous studies describe their high versatility, low toxicity and ability to carry relatively high loads of conjugated compounds including scarcely soluble ones, providing sustained drug release and increasing drug diffusion and half-life. Despite a gr...
Article
Full-text available
Background: Feeding and swallowing impairment are present in up to 80% of oculo-auriculo-vertebral spectrum (OAVS) patients. Salivary gland abnormalities have been reported in OAVS patients but their rate, features, and relationship with phenotype severity have yet to be defined. Material and methods: Parotid and submandibular salivary gland hyp...
Chapter
Hearing loss in older adults is associated with both cognitive impairment and aging. Consequently, the auditory rehabilitation of the elderly should not be limited to restore hearing function and should take into careful consideration the effects, causes, and consequences of the sensorial deprivation on central processes in terms of speech percepti...
Article
Objective: Skull base osteomyelitis (SBO) is an unusual complication of malignant otitis externa (MOE), a potentially life-threatening invasive infection defined as “malignant” due to the high mortality rate it is associated with. It must be diagnosed and treated promptly. The aim of this study was to analyse various aspects of SBO diagnosis and tr...
Article
Background: Kanamycin, mainly used in the treatment of drug-resistant-tuberculosis, is known to cause irreversible hearing loss. Using the xeno-transplant model, we compared both in vitro and in vivo characteristics of human mesenchymal stromal cells (MSCs) derived from adult tissues, bone marrow (BM-MSCs) and adipose tissue (ADSCs). These tissues...
Article
Objectives: Dental infections can cause deep neck infections. There are still no widely-accepted prognostic factors for the rational diagnosis and treatment of deep neck infections (DNIs) of dental origin. The nature of the risk factors for DNIs of dental origin and their contributions to the outcome were analysed using univariate and multivariate...
Article
Full-text available
Although individuals categorize odors according to their pleasantness, experience may also influence odor perception—a phenomenon that partially explains why different populations perceive odors differently. Italy, which comprises 20 regions, is characterized by very different cultures. In the present study, we investigated for the first time how I...
Article
Full-text available
Background: Human unilateral nasal airflow shows spontaneous changes over a period of hours due to the alternating congestion and decongestion of the venous sinuses within the nasal turbinates and nasal septum. The aim of the present study was to compare PNIF and unilateral PNIF with nasal resistances measured by means of AAR in the evaluation of...
Article
Full-text available
Endolymphatic sac tumour (ELST) is infrequent, as emerges from small series reported in the literature. It is a slow-growing malignancy with local aggressiveness and a low risk of distant metastases. It is often misdiagnosed because of the late onset of symptoms and difficulty in obtaining a biopsy. Its frequency is higher in von Hippel-Lindau (VHL...
Article
Full-text available
In the Introduction, the sentence "The Q-TER® is obtained by terclatration, a patented solid-state physical procedure (WO/2003/097012, Actimex Srl, Piacenza, Italy) in which the coen-zyme (10% w/w) is added to a carrier and a catalyst [34]," the word “Piacenza” should be replaced with "Trieste." In the Drugs sub-section of the Materials and Methods...
Article
Objectives: Congenital Aural Atresia (CAA) is a deformity of the external ear and it is commonly associated with malformations of middle and inner ear and, in some cases, with other facial deformities. Very few assessment measures exist for evaluating the functional impairment in children with CAA. Purpose of this study is to introduce and describ...
Article
Deafness, with its personal and social burden, has certainly accompanied mankind since the beginning of its existence, meaning that various natural aids to hearing, the cupped human hand the first among them, have assuredly been in use since antiquity. Ear trumpets were essentially the first totally artificial type of hearing aid. The actual histor...
Article
BACKGROUND: In a recent preliminary study, eosinophil and basophil counts were calculated in chronic rhinosinusitis with nasal polyps (CRSwNP) using conventional histologic and immunohistochemical methods. The tissue eosinophil-to-basophil ratio differed in the CRSwNP endotypes considered. OBJECTIVE: To compare the blood eosinophil-to-basophil ra...
Article
Full-text available
In the last 20 years, neonatal survival has progressively increased due to the constant amelioration of neonatal medical treatment and surgical techniques. Thus, the number of children with congenital malformations and severe chronic pathologies who need rehabilitative care has progressively increased. Rehabilitation programs for paediatric patient...
Article
Hearing loss, or deafness, affects 360 million people worldwide of which about 32 million are children. Deafness is irreversible when it involves sensory hair cell death because the regenerative ability of these cells is lost in mammals after embryo development.The therapeutic strategies for deafness include hearing aids and/or implantable devices....
Article
Full-text available
Introduction: Intracranial vascular, bone, and brain abnormalities might be observed in oculo-auriculo-vertebral spectrum (OAVS) patients even though these structures do not derive embryologically from the first and second pharyngeal arches. This neuroimaging study investigated their type, frequency and phenotype correlations among OAVS patients....
Article
Local drug delivery based on nanoparticles (NP) represents a novel strategy to improve inner ear treatments. The intratympanic delivery of NP may be suitable to treat or prevent hearing loss originating from damage to hair cells and spiral ganglion neurons in the cochlea. Numerous experimental studies support in vitro and in vivo the biocompatibili...
Article
It is unusual for a parapharyngeal abscess (PA) to occur late after an adenotonsillectomy. We report here on a 13-year-old female patient who developed a PA a year after an uneventful adenotonsillectomy. The patient underwent 2 surgical explorations and was given intravenous antibiotic treatment. She was discharged in good general condition after...
Article
Purpose: Cortactin is a multidomain protein engaged in several cellular mechanisms involving actin assembly and cytoskeletal arrangement. Cortactin overexpression in several malignancies has been associated with increased cell migration, invasion, and metastatic potential. Cortactin needs to be activated by tyrosine or serine/threonine phosphoryla...
Article
Background Predicting which patients are at a higher risk for recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. A direct association between CRSwNP recurrence rates and serum eosinophil and basophil counts was reported. This study aimed to identify best-fitting cutoffs for bin...
Article
A growing interest in cognitive effects associated with speech and hearing processes is spreading throughout the scientific community essentially guided by evidence that central and peripheral hearing loss is associated with cognitive decline. For the present research, 125 participants older than 65 years of age (105 with hearing impairment and 20...
Article
Full-text available
Temporal bone squamous cell carcinoma (TBSCC) is an uncommon, aggressive malignancy with a poor prognosis in advanced cases. The dismal outcome is partially related to: the lack of reliable clinical or pathological prognostic factors and the largely unstandardized surgical and integrated treatments adopted. There is an undeniable need for novel dia...
Article
Full-text available
Cisplatin (Cpt) is known to induce a high level of oxidative stress, resulting in an increase of reactive oxygen species damaging the inner ear and causing hearing loss at high frequencies. Studies on animal models show that antioxidants may lower Cpt-induced ototoxicity. The aim of this study is to evaluate the ototoxic effects of two different pr...
Article
Full-text available
Aim: Prognostic factors, rational management, and the ongoing investigations regarding temporal bone squamous cell carcinoma (TBSCC) have been critically reviewed. Background: TBSCC is an uncommon, aggressive malignancy. Although some progress has been made in treating this aggressive tumor, the prognosis in advanced cases remains poor. Materia...
Article
Full-text available
Background and aims: Sinonasal cancers (SNCs) are rare neoplasms, accounting for about 3 % of head and neck cancers, with squamous cell carcinoma (SCC) and adenocarcinoma (ADC) as the most common subtypes. ADCs present strong associations with occupational wood dust exposure. Preventive measures have progressively reduced wood dust concentrations...
Article
BACKGROUND: Most authors agree that radical surgery for advanced, aggressive temporal bone squamous cell carcinoma (SCC) should be followed by postoperative radiotherapy (PORT). The purpose of this study was to identify clinical and/or conventional pathological parameters capable of pinpointing patients with temporal bone SCC at higher risk of rec...
Article
Full-text available
Background: Nasal obstruction is correlated with a decreased quality of life. An easy way to evaluate nasal patency is the peak nasal inspiratory flow (PNIF) measurement. Normal PNIF values have been published by many authors. However, some authors evaluated volunteers in a sitting position, while others have measured PNIF values in standing volunt...
Conference Paper
Background In the management of Granulomatosis with Polyangiitis (GPA), is critical to assess correctly the disease activity in each organ to define the better therapeutic approach and follow up strategy. This statement is also valid for ENT involvement, that we decide to assess with two different organ specific disease activity scores, the already...
Article
Background: When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptidic hormone associated with cancer quite recently. It can induce human osteoclast differentiation and activation, suggesting a role for it in tumor-driven osteolysis....
Article
Background: When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptidic hormone associated with cancer quite recently. It can induce human osteoclast differentiation and activation, suggesting a role for it in tumor-driven osteolysis....