Alessandro Marcon

Alessandro Marcon
University of Verona | UNIVR · Department of Diagnostics and Public Health

PhD in Biosciences

About

182
Publications
23,841
Reads
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5,820
Citations
Citations since 2016
103 Research Items
4425 Citations
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20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
Additional affiliations
December 2015 - present
University of Verona
Position
  • Researcher
Description
  • Researcher at University of Verona from December 2015. This 3-year position is funded by the H2020 programme – SC1 Health (project “ALEC - Ageing Lungs in European Cohorts”) (http://www.alecstudy.org/).
May 2015 - June 2015
University of Verona
Position
  • Contract professor
Description
  • Short course in Environmental Epidemiology for Ph.D. students
March 2015 - May 2015
University of Verona
Position
  • Contract professor
Description
  • Epidemiological methods: Applied analysis using STATA, Ph.D. students and MSc in Biotechnology and Bioinformatics
Education
January 2006 - April 2009
University of Verona
Field of study
  • Biosciences
October 1997 - June 2003
University of Padova
Field of study
  • Pharmaceutical Chemistry and Technology

Publications

Publications (182)
Article
Full-text available
Background: A higher risk for COVID-19 infection and severity for men compared to women has been described since the beginning of the pandemic. The role of androgens has been recently highlighted as they control two key steps of coronavirus infection mediated through the transmembrane protease serin 2 (TMPRRS2) and the angiotensin-converting enzyme...
Article
Full-text available
Parental socioeconomic position (SEP) is a known determinant of a child’s health. We aimed to investigate whether a low parental education, as proxy of SEP, has a direct effect on physician-diagnosed asthma, current asthma and current allergic rhinitis in children, or whether associations are mediated by exposure to other personal or environmental...
Article
Full-text available
Mortality related to chronic obstructive pulmonary disease (COPD) during the COVID-19 pandemic is possibly underestimated by sparse available data. The study aimed to assess the impact of the pandemic on COPD-related mortality by means of time series analyses of causes of death data. We analyzed the death certificates of residents in Veneto (Italy)...
Article
Background/aim Daily air pollution has been linked with mortality from urban studies. Associations in rural areas are still unclear and there is growing interest in testing the role that air pollution has on other causes of death. This study aims to evaluate the association between daily air pollution and cause-specific mortality in all 8092 Italia...
Article
Full-text available
Background: Despite mounting evidence for the powerful influence of smell and taste substances in experimental pain, our knowledge of their effects in the clinical context is scarce, especially for patients with chronic oral burning pain. To fill this gap, we investigated the effect of olfactory and gustatory stimuli on pain perception in patients...
Article
Full-text available
Background: Co-exposures and polysensitization to several pollen species are very common in real life practice. However, little information exists on allergic symptoms and airway inflammation related to natural pollen exposure in large general population samples. Objective: To assess the combined effect of sensitization and/or exposure to one or...
Article
Full-text available
Background: a number of studies highlighted increased mortality associated with hospital admissions during weekends and holidays, the so-call "weekend effect". In this retrospective study of mortality in an acute care public hospital in Italy between 2009 and 2015, we compared inpatient mortality before and after a major organizational change in 2...
Article
Background and Aims Communication of personalised disease risk can motivate smoking cessation. We assessed whether routine implementation of this intervention by general practitioners (GPs) in England is cost-effective or whether we need further research to better establish its effectiveness. Design Cost-effectiveness analysis (CEA) with value of...
Article
Full-text available
Background Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant. Objective We aimed to see if there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma...
Article
Full-text available
Mortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multiple cause of death analyses, and to describe the imp...
Article
Full-text available
Chipboard production is a source of ambient air pollution. We assessed the spatial variability of outdoor pollutants and residential exposure of children living in proximity to the largest chipboard industry in Italy and evaluated the reliability of exposure estimates obtained from a number of available models. We obtained passive sampling data on...
Article
Full-text available
Background Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. Objectives To study the association between FeNO and...
Article
Background: There are increasing evidences of the influence of the oropharyngeal stimulations on the autonomic nervous system and an easy approach to evaluate the balance between parasympathetic and sympathetic system is the measurement of the pupil diameter. The aim of this analytic observational study is to define the effects of clenching and sw...
Article
Full-text available
Rationale Patients with concomitant features of asthma and chronic obstructive pulmonary disease (COPD) have a heavy disease burden. Objectives Using data collected prospectively in the European Community Respiratory Health Survey, we compared the risk factors, clinical history, and lung function trajectories from early adulthood to the late sixti...
Conference Paper
Full-text available
Introduction: We assessed the association between long term exposure to outdoor air pollution and asthma incidence in European adults using two exposure assessment models and two asthma definitions: dichotomic and asthma score. Methods: We included 2547 adults aged 43.6 (37.2-49.5) years from 15 cities with never asthma at ECRHS I nor ECRHSII. NO2...
Article
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Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very limited. We investigated multi-generation causal associations to estimate the causal effects of tobacco smoking on lung function within...
Article
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Raising tobacco prices effectively reduces smoking, the main risk factor for chronic obstructive pulmonary disease (COPD). Using the Health Impact Assessment tool “DYNAMO-HIA”, this study quantified the reduction in COPD burden that would occur in Italy, England and Sweden over 40 years if tobacco prices were increased by 5%, 10% and 20% over curre...
Article
Full-text available
Although there are many health benefits from being active, there was no benefit observed in this study from vigorous physical activity in reducing the risk of asthma onset in middle-aged adults https://bit.ly/3bEtHDn.
Article
Full-text available
Objectives: To investigate if air pollution and greenness exposure from birth till adulthood affects adult asthma, rhinitis and lung function. Methods: We analysed data from 3428 participants (mean age 28) in the RHINESSA study in Norway and Sweden. Individual mean annual residential exposures to nitrogen dioxide (NO2), particulate matter (PM10...
Article
Full-text available
We investigated if greenness and air pollution exposure in parents’ childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Sp...
Article
Full-text available
Background Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogen...
Preprint
Chipboard production is a source of ambient air pollution. We assessed the spatial variability of outdoor pollutants and residential exposure of the paediatric population living in Viadana, in proximity to the largest industry for chipboard production in Italy. We used data on NO2, formaldehyde, and BTEX collected by the regional environmental agen...
Article
Full-text available
Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassifi...
Article
Full-text available
Background Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS)....
Article
Full-text available
Background: Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. Objective: We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis. Methods: Participants with rhinitis from 2 multicenter European cohor...
Article
Rationale: Interactions between early life and adult insults on lung function decline are not well understood, with most studies investigating pre-bronchodilator (BD) FEV1 decline. Objective: To investigate relationships between adult risk factors and pre- and post-BD lung function decline and their potential effect modification by early life an...
Article
Full-text available
Background and objectives Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population. Methods We used data collected in the Gene...
Article
Background: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. Objective: To assess whether allergic sensitization can modify the associat...
Article
Full-text available
Introduction: Recent research focused on the interaction between land cover and the development of allergic and respiratory disease has provided conflicting results and the underlying mechanisms are not fully understood. In particular, green space, which confers an overall positive impact on general health, may be significantly contributing to adv...
Article
BACKGROUND: Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population. METH...
Article
Full-text available
Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution exposure and respiratory function. This study assesses the role of SES either as confounder or effect modifier of the associa...
Article
Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants o...
Article
Full-text available
Background and objective Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA)...
Article
Full-text available
Background: Smoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 an...
Article
Full-text available
Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly se...
Conference Paper
DHEA-S is the most abundant circulating steroid hormone in humans. Low concentrations of DHEA-S have been linked to several chronic diseases, but it is unclear if DHEA-S affects respiratory health. As part of the ALEC project [EU H2020 grant #633212], the associations of DHEA-S concentrations with lung function levels and decline were evaluated in...
Conference Paper
We investigated the 10 year variation of asthma cost by the change of disease severity/control in adults from 11 European countries taking part in a cohort study (the European Community Respiratory Health Survey – ECRHS).We identified 562 adults (aged 29–56) with physician-diagnosed current asthma at the ECRHS II (1999–2003, baseline) and ECRHS III...
Article
Full-text available
Background Tobacco consumption is the largest avoidable health risk. Understanding changes of smoking over time and across populations is crucial to implementing health policies. We evaluated trends in smoking initiation between 1970 and 2009 in random samples of European populations. Methods We pooled data from six multicentre studies involved in...
Data
Minimal data set to replicate the analyses. (CSV)
Data
Distribution of the subjects by centre and study. a ECRHS, European Community Respiratory Health Survey; RHINE, Respiratory Health in Northern Europe study; GA2LEN, Global Allergy and Asthma Network of Excellence study; ISAYA, Italian Study on Asthma in Young Adults; GEIRD, Gene Environment Interactions in Respiratory Diseases study. (DOCX)
Data
Number of samples, participation rates, and characteristics of participants by study. a original study samples, which correspond to centres (or centres crossed by age group in GEIRD); see S1 Table. b participation rates at the first wave (baseline) for studies with follow up data. In the case of ECRHS clinical, ECRHS Italy and RHINE, which were fol...
Data
Cohort effects in males (blue dots) and females (red dots). a a APC modelling. The dots represent deviance residuals from Age-Period models according to Cohort (birth year). The fitting lines were obtained by local polynomial smoothing for a visual purpose. P-values are from Wald tests: the null hypothesis is that the regression coefficients for bi...
Data
Comparison of age at smoking initiation reported at different study waves in ECRHS and ISAYA. (DOCX)