Alessandra Pedrocchi

Alessandra Pedrocchi
Politecnico di Milano | Polimi

About

34
Publications
7,456
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
688
Citations
Citations since 2016
16 Research Items
651 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120

Publications

Publications (34)
Chapter
We tested the ability of a synergy-based myocontrol scheme to achieve simultaneous, continuous control of two degrees of freedom (DOFs) of a robotic arm that reproduces the child’s movement (or intention of movement), using muscle synergies extracted from muscles recorded during both isometric contractions and unconstrained flexion-extension moveme...
Article
The cerebellum plays a crucial role in sensorimotor control and cerebellar disorders compromise adaptation and learning of motor responses. However, the link between alterations at network level and cerebellar dysfunction is still unclear. In principle, this understanding would benefit of the development of an artificial system embedding the salien...
Article
The aim of this study was to develop a methodology based on muscle synergies to investigate whether rectilinear and curvilinear walking shared the same neuro-motor organization, and how this organization was fine-tuned by the walking condition. Thirteen healthy subjects walked on rectilinear and curvilinear paths. Electromyographic data from thirte...
Article
It has been largely suggested in neuroscience literature that to generate a vast variety of movements, the Central Nervous System (CNS) recruits a reduced set of coordinated patterns of muscle activities, defined as muscle synergies. Recent neurophysiological studies have recommended the analysis of muscle synergies to finely assess the patient's i...
Article
Full-text available
Recent studies advocated the use of active cycling coupled with functional electrical stimulation to induce neuroplasticity and enhance functional improvements in stroke adult patients. The aim of this work was to evaluate whether the benefits induced by such a treatment are superior to standard physiotherapy. A single-blinded randomized controlled...
Article
Full-text available
Cycling training is strongly applied in post-stroke rehabilitation, but how its modular control is altered soon after stroke has been not analyzed yet. EMG signals from 9 leg muscles and pedal forces were measured bilaterally during recumbent pedaling in 16 post-acute stroke patients and 12 age-matched healthy controls. Patients were asked to walk...
Article
Objective: To evaluate the effect of a group-based multidisciplinary rehabilitation programme on disability, pain and quality of life in subjects with chronic neck pain. Design: Randomized controlled trial. Setting: Specialized rehabilitation centre. Subjects: A total of 170 patients (mean age of 53 years (13); 121 females). Interventions:...
Chapter
This paper presents a control scheme for a 5 DOFs upper limb powered exoskeleton. A joystick-based interface was chosen in order to receive the desired cartesian position and relative orientation of the end effector from the user. The control scheme verifies the belonging of the commanded position to the exoskeleton workspace before proceeding with...
Conference Paper
Transcranial Magnetic Stimulation (TMS) is a widespread technique to study corticospinal excitability. Its use in longitudinal studies is crucial to analyze the plasticity induced by rehabilitation treatments on neuromotor-impaired subjects. As TMS-related measures fluctuate with time and attention, it is crucial to collect them rapidly. Recently,...
Chapter
Full-text available
The objective of the present study was to design and experiment a hand rehabilitation device for domestic intensive and repetitive training for subjects affected by hemiparesis, assuring their active participation during the exercise. The designed system is composed by the Gloreha hand rehabilitation glove along with its controller PC, and a device...
Chapter
The objective of the present study was to develop a myoelectric controller able to classify specific hand movements from few milliseconds window of the EMG signals, detected by a patient’s forearm muscles. Five hand functional tasks have been selected: i) pitching; ii) grasp an object; iii) grasping; iv) lateral grasp; v) wave. The EMG task-selecti...
Article
Full-text available
Anterior cruciate ligament (ACL) reconstruction restores knee stability but does not reduce the incidence of posttraumatic osteoarthritis induced by inflammatory cytokines. The aim of this research was to longitudinally measure IL-1 β , IL-6, IL-8, IL-10, and TNF- α levels in patients subjected to ACL reconstruction using bone-patellar tendon-bone...
Data
Full-text available
The supplementary material includes the description of the Matlab toolbox for neuronal spike sorting presented and validated in the work (see Results 1.1). In particular, guidelines on how to use the ‘test data' GUI as well as the ‘real data' off-line and on-line GUIs are here provided together with graphical examples.
Conference Paper
This research tunes and validates advanced robot-based technologies to facilitate recovery of arm and hand function in stroke survivors. RETRAINER system is robotic hybrid assistance allowing the end-users to use their own arm and hand as much and as soon as possible after the stroke, to achieve the best outcomes in rehabilitation. Residual functio...
Article
Full-text available
Neurorehabilitation effective delivery for stroke is likely to be improved by establishing a mechanistic understanding of how to enhance adaptive plasticity. Functional electrical stimulation is effective at reducing poststroke foot drop; in some patients, the effect persists after therapy has finished with an unknown mechanism. We used fMRI to exa...
Article
Full-text available
Two binding requirements for in vitro studies on long-term neuronal networks dynamics are (i) finely controlled environmental conditions to keep neuronal cultures viable and provide reliable data for more than a few hours and (ii) parallel operation on multiple neuronal cultures to shorten experimental time scales and enhance data reproducibility....
Article
Full-text available
The cerebellum is involved in learning and memory of sensory motor skills. However, the way this process takes place in local microcircuits is still unclear. The initial proposal, casted into the Motor Learning Theory, suggested that learning had to occur at the parallel fiber-Purkinje cell synapse under supervision of climbing fibers. However, the...
Conference Paper
Full-text available
Since the Marr-Albus model, computational neuroscientists have been developing a variety of models of the cerebellum, with different approaches and features. In this work, we developed and tested realistic artificial Spiking Neural Networks inspired to this brain region. We tested in computational simulations of the Vestibulo-Ocular Reflex protocol...
Conference Paper
This study presents an innovative multi-channel neuroprosthesis that induces a biomimetic activation of the main lower-limb muscles during treadmill gait training to be used in the rehabilitation of stroke patients. The electrostimulation strategy replicates the physiological muscle synergies used by healthy subjects to walk on a treadmill at their...
Article
Full-text available
The collection of good quality extracellular neuronal spikes from neuronal cultures coupled to Microelectrode Arrays (MEAs) is a binding requirement to gather reliable data. Due to physical constraints, low power requirement, or the need of customizability, commercial recording platforms are not fully adequate for the development of experimental se...
Article
Full-text available
Motor speed and accuracy are both affected in childhood dystonia. Thus, deriving a speed-accuracy function is an important metric for assessing motor impairments in dystonia. Previous work in dystonia studied the speed-accuracy trade-off during point-to-point tasks. To achieve a more relevant measurement of functional abilities in dystonia, the pre...
Article
Full-text available
The foreseen outcome of a rehabilitation treatment is a stable improvement on the functional outcomes, which can be longitudinally assessed through multiple measures to help clinicians in functional evaluation. In this study, we propose an automatic comprehensive method of combining multiple measures in order to assess a functional improvement. As...
Conference Paper
Full-text available
Eye blinking classical conditioning is one of the most extensively studied paradigms related to the cerebellum. In this work we have defined a realistic cerebellar model through the use of artificial spiking neural networks, testing it in computational simulations reproducing the eye blinking classical conditioning in multiple sessions of acquisiti...
Article
Full-text available
The cerebellum plays a crucial role in motor learning and it acts as a predictive controller. Modeling it and embedding it into sensorimotor tasks allows us to create functional links between plasticity mechanisms, neural circuits and behavioral learning. Moreover, if applied to real-time control of a neurorobot, the cerebellar model has to deal wi...
Article
Full-text available
An assistive device for upper limb support was developed and evaluated in terms of usability, user satisfaction and motor performance on six end-users affected by neuro-motor disorders (three spinal cord injury; one multiple sclerosis; two Friedreich's ataxia). The system consisted of a lightweight 3-degrees-of-freedom robotic exoskeleton arm for w...
Article
Purpose To evaluate the reliability and minimum detectable change (MDC) of spatial-temporal gait parameters in subjects with multiple sclerosis (MS) during dual tasking. Method This cross-sectional study involved 25 healthy subjects (mean age 49.9 ± 15.8 years) and 25 people with MS (mean age 49.2 ± 11.5 years). Gait under motor-cognitive and moto...
Article
Full-text available
Cycling induced by Functional Electrical Stimulation (FES) training currently requires a manual setting of different parameters, which is a time-consuming and scarcely repeatable procedure. We proposed an automatic procedure for setting session-specific parameters optimized for hemiparetic patients. This procedure consisted of the identification of...
Article
Full-text available
Within the European project MUNDUS, an assistive framework was developed for the support of arm and hand functions during daily life activities in severely impaired people. This contribution aims at designing a feedback control system for Neuro-Muscular Electrical Stimulation (NMES) to enable reaching functions in people with no residual voluntary...
Conference Paper
Full-text available
The cerebellum plays a crucial role in motor learning and it acts as a predictive controller. A biological inspired cerebellar model with distributed plasticity has been embedded into a real-time controller of a neurorobot. A cerebellum-driven task has been designed: the Vestibulo- Ocular Reflex (VOR), which produces eye movements stabilizing image...
Article
Full-text available
The aim of this work was to assess the feasibility of a treatment based on volitional cycling augmented by Functional Electrical Stimulation (FES) on hemiparetic adolescents. Six chronic hemiparetic adolescents were included in a case series study. Patients underwent FES-cycling training combined with voluntary pedaling. The intervention consisted...
Conference Paper
Full-text available
Background / Purpose: Functional Electrical Stimulation (FES) is a known rehabilitation treatment in clinic, but little is know about its mechanism of action that allows some patients to gain a functional effect that outlasts the period of stimulation (carry-over effect). Main conclusion: The cortical correlates of FES in the context of active...
Conference Paper
A time-domain NIRS multichannel system was used to monitor hemodynamic changes in the muscle of 6 healthy volunteers and 4 hemiplegic patients during knee flex-extension induced by functional electrical stimulation for rehabilitation purposes.

Network

Cited By

Projects

Projects (3)
Archived project
- experimental device for prolonged recordings from neuronal cultures coupled to Microelectrode Arrays - on-line multichannel signal processing