Alessandra Gorini

Alessandra Gorini
University of Milan | UNIMI · Department of Oncology and Hematoncology - DIPO

Phd

About

125
Publications
52,274
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,027
Citations
Additional affiliations
October 2015 - present
University of Milan
Position
  • Researcher
January 2013 - October 2015
University of Milan
Position
  • Researcher
January 2009 - June 2011
I.R.C.C.S. Istituto Auxologico Italiano
Position
  • PostDoc Position

Publications

Publications (125)
Article
Objective: This study aimed to explore risk estimations (perceived risk, dispositional optimism) related to COVID-19 perception and distress in oncologic outpatients undergoing active hospital treatments compared to the general population. Design and main outcome measures: Data were collected during the Italian lockdown on 150 oncologic outpatie...
Article
Full-text available
Rapid advances in genomic knowledge and widespread access to the web contributed to the development of genetic services by private companies or medical laboratories. In the European landscape, though, there is not a single coherent regulatory approach to genetic testing (GT). The study aimed to investigate differences and similarities between two p...
Article
Background and Aims Cardiometabolic risk is increased among disadvantaged people and ethnic minorities. Paradoxically, their uptake of primary cardiovascular prevention is relatively low. New strategies are needed to tackle this public health problem. Aims of this study were to assess the uptake (as well as its determinants) and effectiveness of a...
Article
Full-text available
Background In this paper we propose a novel framework for the definition of Personas for healthcare workers based on an online survey, with the aim of highlighting different levels of risk of developing mental disorders induced by COVID-19 and tailor psychological support interventions. Methods Data were gathered from Italian healthcare workers be...
Article
Full-text available
During an acute cardiac event, Takotsubo Syndrome (TTS) and Acute Coronary Syndrome (ACS) apparently share very similar clinical characteristics. Since only a few inconsistent studies have evaluated the psychological features that characterize these different patients, the aim of the present explorative research was to investigate if post-recovery...
Article
Full-text available
Purpose We present the preliminary results of the STRA-MI-VT Study (NCT04066517), a spontaneous, phase Ib/II study, designed to prospectively test the safety and efficacy of stereotactic body radiotherapy (SBRT) in patientswith advanced cardiac disease and intractable ventricular tachycardia (VT). Methods Cardiac computed tomography (CT) integrate...
Article
The existence of an important relationship between stress, the autonomic nervous system, and sudden cardiac death (SCD) has been long recognized. In the present essay we review the large number of conditions, acting at individual or at population level, that have been causally associated to SCD and discuss the mechanistic and translational value of...
Article
Full-text available
Background Ventricular tachycardia (VT) is a life-threatening condition, which usually implies the need of an implantable cardioverter defibrillator in combination with antiarrhythmic drugs and catheter ablation. Stereotactic body radiotherapy (SBRT) represents a common form of therapy in oncology, which has emerged as a well-tolerated and promisin...
Article
Full-text available
The coronavirus disease 2019 (COVID‐19) pandemic has burdened considerable psychological distress on health care workers, increasing the risk of burnout. This research aimed to investigate socio‐demographic, work‐related, COVID‐19 related and psychological factors associated with emotional exhaustion (the core component of burnout) among health car...
Article
Full-text available
Funding Acknowledgements Type of funding sources: None. Background Covid-19 pandemic has generated a huge amount of stress upon all healthcare workers, with an increased risk of developing burnout syndrome and Post Traumatic Stress Disorder (PTSD). Mobile health could provide tools for preventive interventions, whose efficacy could be improved by...
Article
Full-text available
Crucial to the success of the COVID-19 vaccination campaign is the rate of people who adhere to it. This study aimed to investigate the reasons underlying people’s willingness to get vaccinated in a sample of Italian adults, considering the effects of different individual characteristics and psychological variables upon positive vs. negative/hesita...
Article
Full-text available
Despite the widespread diffusion of direct-to-consumer genetic testing (GT), it is still unclear whether people who learn about their genetic susceptibility to a clinical condition change their behaviors, and the psychological factors involved. The aim of the present study is to investigate long-term changes in health-related choices, individual te...
Article
Full-text available
Background Takotsubo (TTS) syndrome is an acute cardiac condition characterized by transient and reversible left ventricle dysfunction that mainly affects postmenopausal women. Catecholamine burst is the most accredited mechanism underpinning TTS onset and leading to endothelial dysfunction and platelet activation. Even if the use of low dose acety...
Article
Background: Anxiety and depression are often associated with cardiovascular diseases. Nevertheless, few study authors have investigated psychological effects on immediate and long-term cardiac surgery-related outcomes, such as surgical complications, length of hospital stay (LOS), and long-term health-related quality of life (HRQoL). Objectives:...
Article
Full-text available
INTRODUCTION: Mixed reality (MR) allows surgeons to pre-operatively assess patients' anatomy (e.g., tissue to be removed). However, medical students have limited access to this technology, and express both the desire to try it and suspicious attitudes. OBJECTIVES: To assess students' experience with traditional vs. innovative technology for pre-ope...
Article
Dispositional optimism (DO) and optimistic bias (OB) in risk perception are two distinct phenomena and previous studies about their reciprocal relationship report contrasting results. In the present study, we focused on the relationship between DO and OB when reporting the personal and the other persons' risk about COVID-19. We hypothesized that, w...
Preprint
Full-text available
This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract Background: Rapid advances in genomic knowledge and...
Chapter
In the first section of this chapter, we discuss the concepts that are at the basis of adequate comprehension of genetic risk information, such as health/genetic literacy and numeracy, aspects that the general public would need to acquire to make informed decisions. Then we will focus on the psychological implication related to genetic risk communi...
Article
Full-text available
Aim of the study: Genetic testing is becoming increasingly common in clinical practice and health management; nonetheless, little is known about how the population approaches genetic services through private companies. Our study aims to describe socio-demographic aspects, health-related habits, and overall beliefs and knowledge about genetic risk a...
Article
Objective: Despite the frequent association between anxiety, depression and cardiovascular diseases (CVD), cardiovascular inpatients are not usually screened for these psychopathological conditions. To fill this gap, especially in hospital environments, there is the need of brief screening instruments that provide reliable information in a very sh...
Article
A multicentre cross-sectional study was conducted to assess perceived risk and fear of contagion, as well as mental health outcomes among 650 Italian healthcare workers during the COVID-19 outbreak. A relevant proportion of the sample reported symptoms of anxiety, depression, and distress. Female sex, nursing profession, fear of being infected, as...
Article
Full-text available
Disease prevention is a multifaceted construct that has been widely studied. Nevertheless, in spite of its importance, it is still not sufficiently considered by the general population. Since the reasons for this lack of consideration are not yet fully understood, we created an Online Prevention Survey (OPS) to investigate the role of both sociodem...
Article
Full-text available
Despite the fact that American Heart Association (AHA) recommended a systematic screening for depression in cardiovascular inpatients, poor attention has been given to this issue. Furthermore, no specific guidelines exist for anxiety screening in cardiovascular inpatients. Thus, the aims of this study were to verify the feasibility of a depressive...
Article
Full-text available
Background: Over the last decade, genetic testing (GT) had markedly spread in European countries and struggled the debate concerning the psychological effects on the population. The aim of this study was to investigate the individual tendencies of GT consumers in a sample of Italian citizens. Methods: A total of 152 Italian clients from GenomaLab,...
Chapter
Full-text available
The P5 approach to medicine emphasizes the importance of psychological and cognitive factors in the healthcare process, namely, the enhancement of patients’ responsibility to participate in the medical decision making, patient education, as well as the measurement and support to quality of life. In the context of eHealth development and evaluation,...
Chapter
Full-text available
Avatars are an important feature of digital environments. Existing both in social networks and webchats (usually as static images) and in single-player and online video games (as dynamic characters, often humanoid), avatars are meant to represent users' action and communication within digital environments. Research has shown that, when they are cus...
Article
Avatars, or users' renditions within digital environments, may change depending on modifications of users' self-conception. According to literature, chronic health conditions influence patients and survivors' identity, because living with a disease requires people to reconfigure their self-representation and their own daily life and future plans. T...
Article
Full-text available
The lowering costs of DNA sequencing and the diffusion of numerous Direct to Consumer Genetic Testing (DTC-GT) services have made genetic testing easily available to the general public who can buy them without any medical prescription or consultation. Nevertheless, the knowledge required to understand the provided results and their implications is...
Article
Full-text available
In recent years, technology has been developed as an important resource for healthcare management, especially in regard to chronic conditions. In the broad field of eHealth, mobile technology (mHealth) is increasingly used to empower patients not only in disease management but also in the achievement of positive experiences and experiential growth....
Article
Objectives: to explore which factors have a personal significance of barrier or facilitator for physical activity (PA) in sedentary subjects living in a peripheral, multiethnic, and economically disadvantaged Italian neighbourhood. Design: qualitative, descriptive phenomenological study. Setting and participants: the study was carried out in P...
Preprint
BACKGROUND Genetic testing and genetic risk information are gaining importance in personalized medicine and disease prevention. However, progress in these fields does not reflect increased knowledge and awareness of genetic risk in the general public. OBJECTIVE Our aim is to develop and test the efficacy of a suite of serious games, developed for...
Article
Full-text available
La depressione e le malattie cardiovascolari sono oggi due delle patologie più diffuse nei Paesi industrializzati. Oltre ad avere basi patofisiologiche comuni, 1,2 esse si manifesta-no spesso in comorbidità, a dimostrazione del fatto che il legame cuore-cervello non può più essere considerato una mera speculazione teorica. Numerosi dati empirici e...
Article
Full-text available
The uniqueness of a patient as determined by the integration of clinical data and psychological aspects should be the aspired aim of a personalized medicine approach. Nevertheless, given the time constraints usually imposed by the clinical setting, it is not easy for physicians to collect information about the patient’s unique mental dimensions and...
Conference Paper
Full-text available
Personalized medicine should target not only the genetic and clinical aspects of the individual patients but also the different cognitive, psychological, family and social factors involved in various clinical choices. To this direction, in this paper, we present instruments to assess the psycho-emotional status of cancer patients and to evaluate th...
Article
Full-text available
This article provides an analysis of cancer decision aids (DAs), instruments developed to support oncologic patients facing tough screening or treatment decisions, with a particular attention to their level of personalisation. As discussed in our previous works, we argue that the personalisation of medicine should regard not only the genetic and cl...
Article
Full-text available
Participation in phase I trials gives patients the chance to obtain control over their disease by trying an experimental therapy. The patients' vulnerability, the informed consent process aiming at understanding the purpose and potential benefits of the phase I trial, and the complexity of the studies may impact the patient's final decision. Emotio...
Article
Personalized medicine should target not only the genetic and clinical aspects of the individual patients but also the different cognitive, psychological, family and social factors involved in various clinical choices. To this direction, in this paper, we present instruments to assess the psycho-emotional status of cancer patients and to evaluate th...
Article
Full-text available
Cancer clinical trials and, in general, cancer clinical research by definition need a multi-modality approach. It is not enough to discover and register new drugs. To get cancer under control requires us to perform complex clinical studies that integrate drugs, companion diagnostics, new or improved surgical procedures and new radiotherapy approach...
Article
Full-text available
Due to the lack of other treatment options, patient candidates for participation in phase I clinical trials are considered the most vulnerable, and many ethical concerns have emerged regarding the informed consent process used in the experimental design of such trials. Starting with these considerations, this nonsystematic review is aimed at analyz...
Article
Full-text available
The concept of “passive risk taking”, which refers to the risk brought on or magnified by inaction, has recently appeared in the literature on risk taking. Keinan and Bereby-Meyer (2012) have developed a scale to measure the personal tendency for passive risk taking (PRT); the scale has criterion validity and high test-retest reliability; it correl...
Article
Full-text available
The European Journal of Human Genetics is the official Journal of the European Society of Human Genetics, publishing high-quality, original research papers, short reports, News and Commentary articles and reviews in the rapidly expanding field of human genetics and genomics.
Article
Full-text available
Chess is thought to be a game demanding high cognitive abilities to be played well. Although many studies proved the link between mastery in chess and high degree of intelligence, just few studies proved that chess practice can enhance cognitive abilities. Starting from these considerations, the main purpose of the present research was to investiga...
Article
Full-text available
The advent of "personalized medicine" has been driven by technological advances in genomics. Concentration at the subcellular level of a patient's cancer cells has meant inevitably that the "person" has been overlooked. For this reason, we think there is an urgent need to develop a truly personalized approach focusing on each patient as an individu...
Conference Paper
Patient empowerment is necessary to increase patients’ participation and shared decisions in clinical settings. In order to promote and increase patient empowerment, clinical settings should be organized around the patient’s demands, needs and values. At the same time, patients should be provided with clear and understandable information that make...
Article
Full-text available
Thoracic surgery appears to be the treatment of choice for many lung cancers. Nevertheless, depending on the type of surgery, the chest area may be painful for several weeks to months after surgery. This painful state has multiple physical and psychological implications, including respiratory failure, inability to clear secretions by coughing, and...
Article
Full-text available
In this study, we used a transcranial direct-current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) of two samples of subjects (18 dependent cocaine users and 18 control subjects) to investigate the effects of left and right cortical excitability on two risk tasks: the Balloon Analog Risk Task (BART) and the Game of Dice Task (...
Article
Full-text available
In an epoch where shared decision making is gaining importance, a patient's commitment to and knowledge about his/her health condition is becoming more and more relevant. Health literacy is one of the most important factors in enhancing the involvement of patients in their care. Nevertheless, other factors can impair patient processing and understa...
Conference Paper
Full-text available
Direct to the consumer genetic test (DTC GT) service is an indisputable and increasing phenomenon which portray internet society. It lets hypothesize that common people search for more health information and more sense of responsibility on their health behaviors. Indeed, proponents of DTC GT argue that making consumers able to calculate the relativ...
Article
Full-text available
Prophylactic mastectomy to reduce the risk of developing breast cancer in the presence of a BRCA mutation has been available for many years. Yet, immediately after Angelina Jolie’s announcement of her decision to undergo a bilateral prophylactic mastectomy, the level of women’s interest in genetic testing and/or preventive surgical intervention soa...