Aleksander Sieron

Aleksander Sieron
Medical University of Silesia in Katowice | SUM · Department and Clinic of INternal Diseases, Angiology and Physical Medicine

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375
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Introduction
Skills and Expertise

Publications

Publications (375)
Article
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Cancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the oth...
Article
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Objective: The aim of the study was to assess the influence of electromagnetic fields with divergent physical properties on the prooxidative and antioxidative balances in homogenates of the tongue, salivary glands, esophagus, stomach, and small and large intestines of rats. Material and Methods: Forty rats were randomly divided into four equal grou...
Article
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Introduction Chronic venous diseases (CVD), because of its chronic and progressive nature, impairs patients' quality of life (Qol). Aim: To compare the QoL in patients with primary superficial venous insufficiency at different stages before and after compression therapy (CT). Material and methods We compared the change in the QoL parameters from b...
Article
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Introduction: Treatment of decubitus ulcers is a grave medical problem. In many cases, it is difficult to cure a pressure ulcer, especially when it is deep and extensive, and prognosis is usually unfavourable. Treatment of decubitus ulcers requires new specialist dressings, which play an important role in the healing process. Aim: To evaluate th...
Article
One of the most important features of optical biopsy methods is its non-invasive nature, high sensitivity and resolution in comparison to traditional diagnostic methods. Optical diagnostic methods, contrary to histopathological tests and biochemical analysis, do not require the collection of tissue samples for analysis, and the amount of analyzed m...
Article
This article presents the current state of knowledge and a review of the literature in terms of the prevalence, etiopathogenesis, differential diagnosis, management, prognosis, and treatment of malignant tumors of the duodenum. The role of autofluorescence and photodynamic diagnosis as an emerging treatment method for rarely occurring duodenal mali...
Article
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This paper contains structured information on photodynamic diagnostics. Photodynamic diagnostics is a young diagnostic modality used in the detection of pre-neoplastic and very early neoplastic lesions. A characteristic feature of the presented method is its completely non-invasive nature and thus the possibility of multiple repetitions at the same...
Article
Background Many aspects are currently being investigated, with the aim of improving the application of PDT in the clinic by rendering it more effective. One of the current trends focuses on the use of nanocarriers. We were encouraged to undertake this task by the results of previous studies, in which we obtained a synergy effect in photodynamic the...
Article
Background One of the most frequent type of malignant skin lesion (almost 95 percent of all skin tumours) is basal cell carcinoma (BCC). It is often treated by radiotherapy using ionizing radiation as well by photodynamic therapy (PDT) which is a selective method directed only on cancer cells and well tolerated by patients. Materials and methods E...
Article
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The purpose of this review is to present an overview of the development of photodiagnostic and photodynamic therapy (PDD and PDT) techniques in Poland. The paper discusses the principles of PDD, including fluorescent techniques in determining precancerous conditions and cancers of the skin, digestive tract, bladder, and respiratory tract. Methods o...
Article
Background The most common non-melanoma skin carcinomas (NMSC) are basal cell carcinomas (BCC). The autofluorescence study allows to perform non-invasive distinction of neoplastic lesions from benign lesions, whereas fluorescence spectroscopy enables qualification of the patient for possible photodynamic or surgical treatment. The aim of the study...
Article
Development of biochemistry and engineering allows not only for better reuse of biological material obtained from the patient but also allows for the development of new materials for bone replacement. The specific factors contributing to the growing trend of the reconstructive medicine market are: the growing geriatric population, the increasing nu...
Article
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This review study describes the problem of duodenal tumours, which are rare but important in gastrological practice. The most common location of small intestinal tumours is the duodenum, and this observation is probably partly due to the greater diagnostic availability for most proximal segments of the small intestine. Among tumours the following s...
Conference Paper
The purpose of this research project was to demonstrate the the efficacy of photodynamic therapy (PDT) as an alternative to antibiotic therapy for the treatment of infected chronic LUs. PDT using irradiation at fluency 80 J / cm2 and 20% 5-aminolevulinic acid topically applied for 4 hrs, was performed during 10 days of hospitalization in 10 patient...
Article
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Compression therapy (CT) is an established treatment method in chronic venous disease. Despite years of clinical experience, choosing the optimum compression therapy, including grade and pressure distribution, which determine the efficacy of treatment poses a challenge. The paper discusses CT physical assumptions (stiffness, elasticity, static and...
Article
Full-text available
Compression therapy (CT) is an established treatment method in chronic venous disease (CVD). The paper presents information on different CT forms with indications and contraindications based on expert consensuses from recent years. A high prevalence of CVD implies continuous development of compression materials, systems and techniques as well as me...
Article
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Objective: The main aim of the study was an assessment of the influence of rapid weight loss on oxidative stress parameters in judokas differing in weight reduction value. Materials and methods: The study included 30 judokas with an age range of 18-30 years (mean age: 22.4 ± 3.40 years). Enzymatic and nonenzymatic antioxidative markers, lipid pe...
Article
The palliative care patient is definitely a unique type of patient. Due to the complexity of the symptoms requires a holistic therapeutic approach. Modern methods of treatment in palliative and hospice care underline an important role of physio, kinesiotherapy and pharmacological treatment coexistence. The rehabilitation reduces clinical symptoms,...
Article
Full-text available
Compression therapy (CT) is an established treatment method in chronic venous disease. Despite years of clinical experience, choosing the optimum compression therapy, including grade and pressure distribution, which determine the efficacy of treatment poses a challenge. The paper discusses CT physical assumptions (stiffness, elasticity, static and...
Article
In the literature, the relationship between musculoskeletal diseases and the age of patients is more and more often mentioned. One of the diseases that arouses great interest of clinicians due to its prevalence is the degenerative disease of the lumbar spine. Increasingly younger patients reporting spinal pain, together with low availability of lit...
Article
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In a modern approach to palliative and hospice care, apart from pharmacological treatment, physio- and kinesiotherapy also play an important role. It affects the reduction of clinical symptoms, accompanying the basic disease and also significantly increase of the quality of life for palliative patients and their families. It becomes an inseparable...
Article
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Background: We examined the effectiveness of the systemic cryotherapy in terms of the temperature and duration of the therapeutic series measured by oxidative stress markers in the rat animal model. Methods: Antioxidants in serum, plasma, liver, and erythrocytes were evaluated in two study groups following 1 min exposure to - 60°C and - 90°C, fo...
Article
Background: This study assessed the efficacy of autofluorescence endoscopy (AFE) using the Onco-LIFE system and numerical color value (NCV) estimation in comparison to white light endoscopy (WLE) in endoscopic surveillance for identification of early dysplasia in Barrett's esophagus (BE) to aid in real-time image elucidation and minimize the overr...
Article
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Objective: The aim of the study was to evaluate the effects of a 28-day exposure to a 50 Hz electromagnetic field of 10 kV/m on the oxidative stress in selected rat central nervous system (CNS) structures. Material and methods: Twenty male Wistar rats served as experimental subjects. Ten rats were exposed to an electromagnetic field with a frequ...
Conference Paper
Full-text available
Diabetic foot ulcers are main reason for hospitalization in diabetic patients. In 85% of cases diabetic foot ulcers antecede lower limb amputatuions which have high post amputation five-year mortality. Diabetes mellitus has been proved to alter rheological properties of blood however there are little reports about hemorheology in people with diabet...
Article
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Introduction. Phlegmon is a disease which causes purulent inflammation of the subcutaneous tissue, being of unlimited character. This disease does not only affect the external coverings of the body; it may also be transmitted to the internal organs, and lead to their insufficiency. Case report. The study presents the results of the physical therapy...
Article
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The most frequent causes of leg ulcers are chronic venous disease (CVD) related mainly to venous hypertension and peripheral arterial disease (PAD) related to disseminated atheromatous lesions in lower limb arteries. In 15%–21% of patients, ulcers of mixed venous-arterial etiology occur, which are usually more resistant for conservative therapy (co...
Article
The health benefits in Primary Health Care (PHC) are given to patients who have made a declaration to the unit having signed a contract with the National Health Fund. Benefits hall be provided in an outpatient clinic, and in cases of medically justified also in the patient's home. The accuracy and rapidity of a diagnosis in the doctor's office ofte...
Article
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Background White light endoscopy (WLE) is the gold standard for detection of colorectal cancer. Autofluorescence endoscopy (AFE) is among the novel methods expected to increase the sensitivity and specificity of endoscopic diagnosis. The main objective of the study was to determine the diagnostic efficacy of AFE for the detection of preneoplastic...
Article
Aktualne możliwości terapeutyczne chorób naczyniowych W analizie schorzeń układu krążenia obwodowego należy uwzględnić schorzenia układu tętniczego, mikrokrążenia, układu żylnego oraz układu limfatycznego. Postępy w leczeniu umożliwiają zmniejszenie liczby patologii naczyniowych i ich skutków. OPM,6/2018, 44-49
Chapter
In this chapter many factors have been described that are associated with the pathophysiology of venous leg ulcerations.
Article
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The aim of the study was to compare three types of meat snacks made from ostrich, beef, and chicken meat in relation to their nutrients content including fat, fatty acids, heme iron, and peptides, like anserine and carnosine, from which human health may potentially benefit. Dry meat samples were produced, from one type of muscle, obtained from ostr...
Article
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Objective The aim of the study was to estimate the impact of whole body cryotherapy (WBC) on oxidative stress when performed in a closed cryochamber on patients with ankylosing spondylitis (AS). Material and methods The effect of ten WBC procedures lasting 3 minutes a day with a subsequent 60-minute session kinesiotherapy on oxidative stress in ma...
Article
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Results of research assessing the biological impact of static magnetic fields are controversial. So far, they have not provided a clear answer to their influence on cell functioning. Since the use of permanent magnets both in everyday life and in industry becomes more and more widespread, the investigations are continued in order to explain these c...
Article
Background: Photodynamic therapy has apart from a direct cytotoxic effect also immunomodulatory properties. The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. Methods: We used two human colo...
Article
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For many years the increasing number of patients who indulge different accidents and injuries during executing buildings works was observed. The medical help offered to those patients - the most often surgical or orthopedic - in form of surgical debridement of wound should enable its complete healing. However in many cases the healing process of wo...
Article
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Objective The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male...
Article
Full-text available
Background: Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults. Objectives: The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot. Material and methods: The study included...
Article
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Undoubtedly, the ever frequent use of physical medicine methods in many fields of medicine is a fact. A wide spectrum of procedures enables instituting suitable treatment, reducing treatment time, as well as social and economic costs of treatment. The above applies to pathological states and injuries of the locomotor system, soft tissues, as well a...
Article
Background: Photodynamic therapy (PDT), eliminates not only the tumor, but also modulates signaling factors release, e.g. vascular endothelial growth factor (VEGF), which plays a crucial role in cancer progression. Assessment of the VEGF-secreting activity of resistant colon cancer cells in different degree of malignancy: SW480 and SW620 under hyp...
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Since the number of patients awaiting dialysis and survival time for kidney dialysis patients are on the increase, the issue of pre-emptive vascular access creation, care and use for hemodialysis is gaining importance. This paper summarizes the principles, policies and procedures aimed to achieve the longest survival time and the best possible qual...
Article
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Objective The primary aim of the study was to assess levels of oxidative stress markers, soluble CD40 ligand (sCD40L), serum pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF) as well as carotid intima-media thickness (IMT) in patients with ankylosing spondylitis (AS) with active phase without concomitant classical c...
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Introduction: Introduction. The number of accidents in agriculture involving children as the victims continues to increase year-by-year. Parents often allow children to perform certain tasks, or even entrust them to perform such tasks as a duty. Case report: The paper presents results of treatment using a 3D magnetic field in a 31-year- old pati...
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Leczenie trudno gojących się ran stanowi nadal poważny, interdyscyplinarny problem medyczny. W ostatnich latach w leczeniu schorzeń i urazów narządu ruchu, tkanek miękkich, a także przewlekłych ran coraz częściej z powo-dzeniem wykorzystywane są nowoczesne metody medycyny fizykalnej. W artykule przedstawiono korzystny efekt leczenia rany pooperacyj...
Article
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The potential health consequences of common exposure of human organisms to high-voltage industrial frequency and radio-frequency electromagnetic fields have not yet been completely recognized. The aim of this study was to evaluate the impact of a 50 Hz electromagnetic field generated by high-voltage alternating electric current transmission lines,...
Article
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Introduction Chronic wounds are the ones that present no healing progress for more than three months. The most common reasons for the chronic wound development in the lower limbs include long-lasting diabetes mellitus, venous insufficiency and peripheral arterial disease. However, it is estimated that 15%–20% of the lower limb chronic wounds are of...
Data
Table. 3. Body weight of the studied groups, the activity of antioxidant enzymes: total superoxide dismutase (SOD) in serum and haemolisates (Hgb), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST) as well as glutathione reductase (GR) in liver and haemolisates (Hgb) of rats after WBC.
Article
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Barrett's esophagus is characterized by abnormal columnar epithelium in the lower esophagus. It binds with a significantly increased risk of developing esophagus adenocarcinoma. Until recently, the only treatment of patients with Barrett's esophagus and high-grade dysplasia was surgical operation. Currently, they are more widely used endoscopic tre...
Article
MATERIAL AND METHODS: It the examination groups were 42 patients (21 women and 21 men) in age from 45-65 years with low back pain about different etiology. All studied were thirty interventions of whole body cryotherapy and then practices kinesitherapy exercises by 30 minutes subjected on gymnastic room. To evaluation of stepping pain ailments was...
Article
The constipations belong to the most frequent intestinal dyspepsia ailments in the industrialized populations. Alimentary canal answers for the correct admission and digesting foods, their absorption and dismissing. In case of disorders relating dismissing the names a constipation, discomfort in everyday life constrain ill's to modification style o...
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Background. Whole-body cryostimulation (WBC) is the therapeutic exposure of the total human body (without underwear) to a very low temperature (below –100°C) for 120–180 s. Currently, WBC is used more frequently not only in the treatment of patients suffering from various diseases, but also by healthy people as a wellness method. Objectives. The ai...
Article
Full-text available
Introduction. Inflammatory lesions and erosions of the glans penis defined as balanitis or balanoposthitis constitute a disease in which the effectiveness of conservative treatment is not sufficient. Objective. To present the therapeutic efficacy of magneto-LED therapy in the treatment, and to present a patient with inflammatory lesions and erosio...