Aldo R. Boccaccini

Aldo R. Boccaccini
Friedrich-Alexander-University of Erlangen-Nürnberg | FAU · Department of Materials Science and Engineering

Prof. Dr.-Ing. habil.

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1,530
Publications
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Publications

Publications (1,530)
Article
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Out of the wide range of calcium phosphate (CaP) biomaterials, calcium phosphate bone cements (CPCs) have attracted increased attention since their discovery in the 1980s due to their valuable properties such as bioactivity, osteoconductivity, injectability, hardening ability through a low-temperature setting reaction and moldability. Thereafter nu...
Article
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Electrospun fibers based on biodegradable polyanionic or polycationic biopolymers are highly beneficial for biomedical applications. In this work, electrospun nanofibers made from poly(epsilon caprolactone) (PCL), chitosan (CS) and κ-carrageenan (κ-C) were successfully fabricated using several mixtures of benign solvents containing formic acid (FA)...
Article
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Due to the pivotal role of angiogenesis in bone regeneration, the angiogenic properties of biomaterials are of high importance since they directly correlate with the biomaterials’ osteogenic potential via ‘angiogenic-osteogenic coupling’ mechanisms. The impact of bioactive glasses (BGs) on vascularization can be tailored by incorporation of biologi...
Article
Electrospun fibers of poly (lactic acid) (PLA) containing 10 and 20 wt% of bioactive glass (n-BG) and magnesium oxide (n-MgO) nanoparticles of ca. 27 and 23 nm respectively, were prepared toward to application in bone tissue engineering. The addition of both nanoparticles into the PLA will produce a synergic effect increasing its bioactivity and an...
Article
Bioactive glass (BG) is a frequently used biomaterial applicable in bone tissue engineering and known to be particularly effective when applied in nanoscopic dimensions. In this work, we employed the scalable reactive laser fragmentation in liquids method to produce nanosized 45S5 BG in the presence of light‐absorbing Fe and Cu ions. Here, the func...
Article
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A novel approach, in the context of bioprinting, is the targeted printing of a defined number of cells at desired positions in predefined locations, which thereby opens up new perspectives for life science engineering. One major challenge in this application is to realize the targeted printing of cells onto a gel substrate with high cell survival r...
Article
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In this research work, the fabrication of biphasic composite implants has been investigated. Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glas...
Article
Objective: Bioactive glasses (BAGs) have been researched extensively for dentistry due to their favourable biocompatibility and hard tissue bonding ability. However, the specific application of BAGs produced through sol-gel synthesis in restorative dentistry has not been reviewed previously. This review provides a comprehensive account of the princ...
Article
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The effect of the chemical composition on the morphology and microstructure of poly(ether ether ketone) (PEEK)/reduced graphene oxide (RGO) nanocomposite coatings is analyzed. RGO induced three main morphological features in the nanocomposites: (i) a large-scale co-continuous morphology related to nanosheets whose basal planes were mainly aligned w...
Article
The development of hydrogels suitable for biofabrication is essential to enable advanced approaches for tissue engineering and regenerative medicine. Applications in both hard and soft tissues require tailor-made bioinks to guide cellular behavior in a 3D matrix. In this study we aimed to enhance the stability and adjust the degradation behavior of...
Article
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Due to the limited regenerative capacity of natural human myocardium, 3D printing of the cyclic polyester poly (glycerol sebacate) (PGS) offers a promising alternative to produce scaffolds (cardiac patches) for cardiac tissue engineering. Since the 3D printability and subsequent thermal crosslinking of pure PGS without any modification or additives...
Article
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Giant cell tumors of bone (GCTB) are associated with massive bone destructions and high recurrence rates. In a previous study, we observed cytotoxic effects of three different compositions of bioactive glasses (BGs) towards GCTSC but not bone marrow derived stromal cells (BMSC) indicating that BGs represent promising candidates for the development...
Article
Multidrug-resistant bacterial strains represent an emerging global health threat and a great obstacle for bone tissue engineering. One of the major components of the extracellular matrix of the bone is a collagen protein, while selenium is an element that has antimicrobial potential, and is also important for bone metabolism and bone health. Here w...
Article
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Borate 1393-B3 bioactive glasses doped with ZnO or Ga2O3 (1, 3, and 6% mol) were produced by conventional melt quenching. All doped glasses showed in-vitro bioactivity in simulated body fluid (SBF). For the first time, the dissolution behavior of the glasses both in phosphate buffer saline (PBS) and cell culture medium was investigated. The ion rel...
Article
Hydrogels are ideal materials for mimicking and engineering soft tissue. Hyaluronic acid (HA) is a linear polysaccharide native to the human extracellular matrix (ECM). In this study, we firstly develop and characterize two hydrogel compositions built from oxidized hyaluronic acid (OHA) and gelatin with and without alginate-di-aldehyde (ADA) crossl...
Article
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Mesenchymal stem cells (MSCs) are primary candidates in tissue engineering and stem cell therapies due to their intriguing regenerative and immunomodulatory potential. Their ability to self-assemble into three-dimensional (3D) aggregates further improves some of their therapeutic properties, e.g., differentiation potential, secretion of cytokines,...
Article
Bioprinting has seen significant progress in recent years for the fabrication of bionic tissues with high complexity. However, it remains challenging to develop cell-laden bioinks exhibiting superior physiochemical properties and bio-functionality. In this study, a multifunctional nanocomposite bioink is developed based on amine-functionalized copp...
Article
A systematic microstructural, thermo-mechanical and electrical characterization of simultaneous Fe–Cu doped Mn–Co spinel coatings processed by electrophoretic co-deposition on Crofer 22 APU is here reported and discussed. An innovative approach for the simultaneous electrophoretic deposition of three spinel precursors is designed, conceived and opt...
Article
Stem cell bioengineering and therapy require different model systems and materials in different stages of development. If a chemically defined biomatrix system can fulfill most tasks, it can minimize the discrepancy among various setups. By screening biomaterials synthesized through a coacervation‐mediated self‐assembling mechanism, a biomatrix sys...
Article
In this work, we analyzed the reliability of alginate-gelatin microcapsules as artificial tumor model. These tumor-like scaffolds are characterized by their composition and stiffness (∼25 kPa), and their capability to restrict -but not hinder- cell migration, proliferation and release from confinement. Hydrogel-based microcapsules were initially ut...
Article
The combination of electrospinning and sol-gel methods is attracting the interest of the scientific community for developing three-dimensional bioactive glass (BG)-based fibers. This paper reports the fabrication of cotton-like copper-doped BG fibers by combining electrospinning and sol-gel techniques. Acellular bioactivity in simulated body fluid,...
Article
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Editorial on the Research Topic Multifunctional Bioactive Nanomaterials for Tissue Regeneration, Volume 2
Article
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As a low cost, biocompatible, and bioresorbable synthetic polymer, poly (ɛ-caprolactone) (PCL) is widely used for different biomedical applications including drug delivery, wound dressing, and tissue engineering. An extensive range of in vitro and in vivo tests has proven the favourable applicability of PCL in biomedicine, bringing about the FDA ap...
Article
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The lymphatic system is crucial for the regeneration of many tissues due to its fundamental role in immune cell trafficking, protein transport, and tissue homeostasis maintenance. Strategies stimulating lymphangiogenesis can provide new therapeutic approaches for tissue repair and regeneration (e.g., chronic wound healing). Here, we explored the ef...
Article
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Cancer is one of the top life-threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (M...
Article
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Tendon injuries are at the frontier of innovative approaches to public health concerns and sectoral policy objectives. Indeed, these injuries remain difficult to manage due to tendon’s poor healing ability ascribable to a hypo-cellularity and low vascularity, leading to the formation of a fibrotic tissue affecting its functionality. Tissue engineerin...
Article
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The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis, to influence blood clotting, and to induce anti-cancer and anti-bacterial activity. Gallium-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses, calcium phosphate bioceramics, metals and coatings....
Article
Sepsis is a dysregulated host response of severe bloodstream infections, and given its frequency of occurrence and high mortality rate, therapeutic improvements are imperative. A reliable biomimetic strategy for the targeting and separation of bacterial pathogens in bloodstream infections involves the use of the broad-spectrum binding motif of huma...
Chapter
This chapter provides a review of the main types of bioactive ceramics and glasses used or under development for tissue engineering applications. Bioactive ceramics and glasses have been researched and developed mainly for the repair and regeneration of bone. However, increasing studies have shown the capacity of bioactive glasses to heal soft tiss...
Chapter
Cardiovascular diseases (CVDs) are still a major health problem, being one of the main causes of mortality and morbidity worldwide. A common manifestation of CVDs is myocardial infarction, which can cause significant structural and biochemical changes in the heart and can lead to reduced contractility of the cardiac muscle and thereby to chronic or...
Article
Full-text available
Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair...
Article
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The replication method is a widely used technique to produce bioactive glass (BG) scaffolds mimicking trabecular bone. However, these scaffolds usually exhibit poor mechanical reliability and fast degradation, which can be improved by coating them with a polymer. In this work, we proposed the use of custom-made poly(urethane)s (PURs) as coating mat...
Article
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Editorial on the Research Topic Combating Bacterial Infections Through Biomimetic or Bioinspired Materials Design and Enabling Technologies
Article
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During the healing and repair of bone defects, uncontrolled inflammatory responses can compromise bone regeneration. Biomaterials with anti-inflammatory activity are favorable for bone tissue regeneration processes. In this work, multifunctional Zn-containing mesoporous bioactive glass nanoparticles (Zn-MBGs) exhibiting favorable osteogenic and ant...
Article
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Iron and magnesium are being considered as promising candidates for biodegradable materials in medical applications, both materials having their specific advantages and challenges. A hybrid of metallic iron and magnesium in a layered composite is studied in the present work, to combine the merits of both metals. A single-step dip-coating method was...
Article
The viscoelastic behavior of hydrogel matrices sensitively influences the cell behavior in 3-D culture and biofabricated tissue model systems. Previous reports have demonstrated that cells tend to adhere, spread, migrate and proliferate better in hydrogels with pronounced stress relaxation. However, it is currently unknown if cells respond more sen...
Article
In this work, a new combination of ceramic materials is proposed for bone tissue engineering applications. Multilayer scaffolds consisting of a core composed mainly of calcium pyrophosphate and external coatings of silica and calcium doped with Fe³⁺, Sr²⁺ and Mg²⁺ were prepared. To study the influence of the arrangement of dopant ions in the extern...
Article
Bacterial infections are one of the leading causes for long-term failure of medical implants, associated with hospitalization, costly revision surgeries, increased morbidity and even mortality. Electrophoretic deposition (EPD) appears as a suitable coating technology to confer antibacterial efficacy to implant surfaces without changing the properti...
Article
Full-text available
The present study analyzes the capacity of collagen (coll)/sulfated glycosaminoglycan (sGAG)-based surface coatings containing bioactive glass nanoparticles (BGN) in promoting the osteogenic differentiation of human mesenchymal stroma cells (hMSC). Physicochemical characteristics of these coatings and their effects on proliferation and osteogenic d...
Article
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Magnesium (Mg2+) is known to play a crucial role in mineral and matrix metabolism of bone tissue and is thus increasingly considered in the field of bone tissue engineering. Bioactive glasses (BGs) offer the promising possibility of the incorporation and local delivery of therapeutically active ions as Mg2+. In this study, two Mg2+-doped derivative...
Article
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In the quest to increase the quality of life and life expectancy, there is a great demand to develop advanced medical devices capable of facing current health challenges. Santa Barbara Amorphous (SBA-15) mesoporous silica has been demonstrated to be a remarkable option for a variety of biomedical applications, from tissue engineering to drug delive...
Article
Mg alloys are increasingly being investigated as a versatile and economical alternative for developing bone repair implants because of their high mechanical strength, wide availability, adjustable structure and properties. In this study, magnesium alloy WE43 is coated on both sides with gelatin nanosphere/chitosan (GNs/CTS), a coating enhanced by i...
Article
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Even though antibiotic treatment remains one of the most common tools to handle bacterial infections, the excessive antibiotic concentration at the target site may lead to undesired effects. Aiming at the fabrication of antibiotic-free biomaterials for antibacterial applications, in this work, we propose the synthesis of gallium (III)—chitosan (Ga...
Article
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Mesoporous bioactive glass nanoparticles (MBGNPs) are attracting significant attention as suitable materials for multifunctional biomedical applications. In this study, cerium was incorporated into MBGNPs using two different approaches. In the first approach, cerium was added to the glass system directly during the synthesis, while in the second ap...
Article
3D printing enables a better control over the microstructure of bone restoring constructs, addresses the challenges seen in the preparation of patient-specific bone scaffolds, and overcomes the bottlenecks that can appear in delivering drugs/growth factors promoting bone regeneration. Here, 3D printing is employed for the fabrication of an osteogen...
Article
Multicomponent sodium alginate-based coatings reinforced with hydroxyapatite (HA) nanoparticles and graphite oxide (GtO) nanosheets consisting of graphene oxide (GO) packages were electrophoretically deposited on CP-Ti and Ti-13Nb-13Zr alloy. The suspension properties, electrophoretic deposition (EPD) mechanisms and kinetics were studied to deposit...
Article
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Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone) (PCL-TES) loaded with bioactive glasses (BG) are here presented. Unloaded PCL-TES, as well as PCL/BG nanocomposite fibers, are also considered for comparison. It is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of...
Article
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Silicone resins, filled with phosphates and other oxide fillers, yield upon firing in air at 1100 °C, a product resembling Biosilicate® glass-ceramics, one of the most promising systems for tissue engineering applications. The process requires no preliminary synthesis of parent glass, and the polymer route enables the application of direct ink writ...
Article
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Magnetic 45S5 bioactive glass (BG) based scaffolds covered with iron- loaded hydroxyapatite nanoparticles (Fe-HA-BG) were obtained and its cytotoxicity investigated. Iron-loaded hydroxyapatite nanoparticles (Fe-HA) were synthesized by a wet chemical method involving the simultaneous addition of Fe2+/ Fe3+ ions. BG based scaffolds were prepared by t...
Article
Cardiac tissue engineering (CTE) is a rising field of research aiming to provide strategies to repair or regenerate damaged heart tissue after events like myocardial infarction. Here, poly(1,8-octanediol-co-citrate) (POC) has been blended with poly(ε-caprolactone) (PCL) and the blend polymer was electrospun using the benign solvents acetic acid and...
Article
In this study, novel bioactive glass flakes (BGFs) (45S5 composition), obtained by compression in the liquid phase in a stirred media mill, are combined with chitosan (CS) to develop composite membranes via solvent casting for guided bone regeneration (GBR). The incorporation of BGFs endows CS membranes with superior bioactivity as evidenced by rap...
Article
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Alginate hydrogels have been used as a biomaterial for 3D culturing for several years. Here, gene expression patterns in melanoma cells cultivated in 3D alginate are compared to 2D cultures. It is well-known that 2D cell culture is not resembling the complex in vivo situation well. However, the use of very intricate 3D models does not allow perform...
Article
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Editorial on the Research Topic Antimicrobial Nanostructured Polymeric Materials and Nanocomposites
Article
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The ability of the Nagelschmidtite (Nagel) phase to promote osteogenesis, cementogenesis, and angiogenesis increased the interest in using this calcium silicophosphate bioceramic for tissue regeneration and vascularization applications. Nagel phase is a solid solution with the general formula Ca7-xNax(PO4)2+x(SiO4)2-x, which allows several substitu...
Article
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The concept of adding inorganic fillers into hydrogels to form hydrogel nanocomposites often provides advantageous properties which can be exploited for successful 3D biofabrication. In this study, a new composite hydrogel combining oxidized alginate–gelatin (ADA‐GEL) hydrogel and laponite nanoclay as inorganic nanofiller was successfully developed...
Article
In vitro tests that verify the ability of a material to form bone-like apatite precipitated (HAp) use a solution that imitates the inorganic part of blood plasma, simulated body fluid (SBF). During such tests, it is necessary to maintain a neutral pH, for which purpose the International Standards Organization recommends the TRIS (tris(hydroxymethyl...
Article
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The regulatory functions of the immune response in tissue healing, repair, and regeneration have been evidenced in the last decade. Immune cells play central roles in immune responses toward inducing favorable tissue regenerative processes. Modulating and controlling the immune cell responses (particularly macrophages) is an emerging approach to en...
Article
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In this study, binary SiO2-CaO hollow mesoporous bioactive glass nanoparticles (HMBGNs) are prepared by combing selective etching and impregnation strategies. Spherical silica particles (SiO2 NPs) are used as hard cores to assemble cetyltrimethylammonium bromide (CTAB)/silica shells, which are later removed by selective etching to generate a hollow...
Article
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This paper seeks to examine how the Mn–Co spinel interconnect coating microstructure can influence Cr contamination in an oxygen electrode of intermediate temperature solid oxide cells, at an operating temperature of 750 °C. A Mn–Co spinel coating is processed on Crofer 22 APU substrates by electrophoretic deposition, and subsequently sintered, fol...
Preprint
Full-text available
The viscoelastic behavior of hydrogel matrices sensitively influences the cell behavior in 3D culture and biofabricated tissue model systems. Previous reports have demonstrated that cells tend to adhere, spread, migrate and proliferate better in hydrogels with pronounced stress relaxation. However, it is currently unknown if cells respond more sens...