Alby Richard

Alby Richard

PhD MD FRCP(C)

About

22
Publications
4,261
Reads
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529
Citations
Education
July 2018 - June 2019
Harvard Medical School
Field of study
  • Movement Disorders
July 2013 - June 2018
McGill University
Field of study
  • Neurology
July 2010 - June 2013
University of Calgary
Field of study
  • Medicine

Publications

Publications (22)
Article
Full-text available
Although the induction of behavioural unconsciousness during sleep and general anaesthesia has been shown to involve overlapping brain mechanisms, sleep involves cyclic fluctuations between different brain states known as active (paradoxical or rapid eye movement: REM) and quiet (slow-wave or non-REM: nREM) stages whereas commonly used general anae...
Article
Full-text available
Our ability to explore our surroundings requires a combination of high-resolution vision and frequent rotations of the visual axis toward objects of interest. Such gaze shifts are themselves a source of powerful retinal stimulation, and so the visual system appears to have evolved mechanisms to maintain perceptual stability during movements of the...
Article
Full-text available
Corollary discharge signals are found in the nervous systems of many animals, where they serve a large variety of functions related to the integration of sensory and motor signals. In humans, an important corollary discharge signal is generated by oculomotor structures and communicated to sensory systems in concert with the execution of each saccad...
Article
Full-text available
The past three decades have seen multiple reports of patients with neurodegenerative disorders, or other forms of putative changes in their brains, who also show changes in how they approach and produce visual art. Authors argue that these cases may provide a unique body of evidence, so-called ‘artistic signatures’ of neurodegenerative diseases tha...
Article
Full-text available
Art making is a promising prism through which to appreciate the nuanced relationship between cognition, goal-directed behavior and the changing brain in the context of neurodegenerative diseases. As an area for future exploration, the value of art therapy as a potent behavioral and ultimately neurochemical, intervention has exciting potential.
Article
Full-text available
Chorea-acanthocytosis (ChAc) is a rare autosomal recessive neurodegenerative disease due to mutation of the VPS13A gene encoding the protein chorein. ChAc is a slowly progressive disorder that typically presents in early adulthood, and whose clinical features include chorea and dystonia with involuntary lip, cheek, and tongue biting. Some patients...
Article
Full-text available
Deutetrabenazine (DTBZ) is a US FDA-approved treatment for chorea in Huntington's disease. The substitution of deuterium for hydrogen at specific positions imparts a longer half-life on DTBZ, allowing for less-frequent daily dosing. As a reversible vesicular monoamine transporter Type 2 inhibitor, DTBZ depletes monoamines at presynaptic nerve termi...
Article
Full-text available
Background: In the Canadian context, health literacy has been shown to depend on place of birth, education level, socioeconomic status, language spoken and geographic location. This study seeks to determine whether currently available advance directive documentation in Canada is written in accordance with the average reading level of the populatio...
Article
Full-text available
Background: Visuomotor learning can be elicited experimentally by displacing the target of a saccade during the ongoing eye movement. In healthy subjects, the resulting mismatch between expected and experienced visual error after saccade completion elicits a gradual adaptation of saccade amplitude. The goal of this project was to explore the role o...
Article
Full-text available
In primates, inspection of a visual scene is typically interrupted by frequent gaze shifts, occurring at an average rate of three to five times per second. Perceptually, these gaze shifts are accompanied by a compression of visual space toward the saccade target, which may be attributed to an oculomotor signal that transiently influences visual pro...
Article
Amblyopia is characterised by visual deficits in both spatial vision and motion perception. While the spatial deficits are thought to result from deficient processing at both low and higher level stages of visual processing, the deficits in motion perception appear to result primarily from deficits involving higher level processing. Specifically, i...
Article
Changes in visual perception are known to accompany both the preparation and execution of saccadic eye movements. Specifically, saccades are associated with a decrease in visual sensitivity, as well as errors in visual spatial localization (Burr et al, 2002). Here we describe an enhancement of motion sensitivity that occurs in a period before the o...
Article
Recent psychophysical work has shown that performance on a direction discrimination task decreases with increasing stimulus size, provided the stimulus is high in contrast. This psychophysical surround suppression has been linked to the inhibitory spatial surrounds that have been observed throughout the primate visual system. In this work we have e...

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