Alberto Foletti

Italian National Research Council | CNR · Institute of Translational Pharmacology IFT

Only recently has the critical importance of electromagnetic (EM) field interactions in biology and medicine been recognized. We review the phenomenon of resonance signaling, discussing how specific frequencies modulate cellular function to restore or maintain health. The application of EM-tuned signals represents more than merely a new tool in inf...

This paper explores physical signalling in biological communications, the so-called biophysical pathways, and especially the role of electromagnetic signalling in cell-cell interactions. The experiments were designed to evaluate whether different cell populations physically interfere when incubated in separate Petri dishes placed in close proximity...

According to Quantum Electro-Dynamical Theory by G. Preparata, liquid water can be viewed as an equilibrium between of two components: coherent and incoherent ones. The coherent component is contained within spherical so called "coherence domains" (CDs) where all molecules synchronously oscillate with the same phase. CDs are surrounded by the incoh...

In this paper we discuss living systems as a non-linear self-interacting phenomenon, stabilized by the non-linear interaction between matter and self-created electromagnetic field. Such electromagnetic field can arise, in particular, as the radiation from electrosolitons which mediate the charge transport along macromolecules in metabolic redox pro...

Background and Aims Atherosclerosis is the leading cause of infarction. Atherosclerotic lesions are considered to be advanced when the accumulation of lipid is associated with the disorganization and deformity of the arterial wall. In this study, we investigated focused ultrasound effectiveness on destruction of neovessles in advanced atherosclerot...

Background and Aims Mechanical changes include thickening of arterial wall, alteration of arterial elasticity, contraction of smooth muscle, increase in sensitivity to pharmacological stimulation and increase in arterial viscoelasticity, i.e., arteriosclerosis. There is therefore interest in the application of non-invasive clinical tools to assess...

Background and Aims The aim of this study was to generate an experimental rabbit carotid artery model of intermediate stage atherosclerosis with morphological similarities to the human disease and subsequent, investigating the effect of Extremely Low Frequency (ELF) magnetic field exposure on plaque structure in this model.

Background and Aims The rupture of vulnerable atherosclerotic plaques and the subsequent formation of thrombi are the main factors responsible for myocardial infarctions. Macrophages are responsible for the prevalence of inflammation in atherosclerotic lesions. In the present study, we developed a shock wave sonoporation therapy system and investig...

Back pain is still a leading cause of disability, ranking steadily at the first place of the global burden of disease, and very common to face in the primary care setting. Any innovative treatment, effective and efficient, for its management has to be carefully investigated in order to lower its considerable personal and socioeconomic burden. For i...

According to the biophysical paradigm, it is possible to merge biochemical knowledge on the dynamics of health and disease with new insights and new clinical applications physical based. The working hypothesis is that every living activity, at every molecular, cellular, tissue and systemic level relate to the incessant emission of electromagnetic s...

Chronic Kidney Disease (CKD) is an emerging issue, due to an increasingly aging population. Previous evidence indicates that a biophysical integrated approach can significantly improve renal function. CKD contributes to a general functional decline and thereby to an increase in cumulative biological risk, ultimately affecting both morbidity and mo...

We estimate the contagions of Sars-Covid-19 in Italy until June 2020 and we compare the results with our previous estimations. We obtain that the fractal model we use, estimates the behavior of the experimental data and prediction with an r2 value of 0.95. We have that the time of peak is 37.80 days for the prediction 1 and 37.33 days for predictio...

We compute the factor R 0 (t) by using the SIR model in Italy and its some regioneal countries. We find that it is descending to a minimum value of 1.11 in Italy and respectively of 1.89, 1.86 and 3.13 for each region respectively..

We demonstrate that the SARS-CoV-2 is a multifractal and we study the implications of this discovery at the basic level as well as when this structure is intended for its function and when it could be used for test in the clinical applications depending the area of the singularity spectrum of the inspected virus and the other its characterizing par...

By using the methods of the non parametric time series prediction we obtain that in the next ten days we will reach the size of 8000-9000 contagions in Italy.

References Conte E..Norman R.,Mordeniz C.,Conte S.,Marvulli R., Ianieri G., Megna M.(2016), A Multifractal Analysis of Neuron Locations and Calcium Activity in C-Elegans, Chaos and Complexity Letters,Vol. 10, 1, 1-23. Escós, J. M., Alados, C. L., Emlen, J. M., and Escos, J. M. (1995). Fractal Structures and Fractal Functions as Disease Indicators...

Progressively, the biophysical approach has shed new light over the understanding of health and disease dynamics. Accordingly, it has been possible to develop new biophysical insights into the pathogenesis of disease as well as into their possible integrative clinical management. We can consider therefore, in this framework, that any living activit...

The biophysical paradigm is rapidly evolving encompassing new perspectives in understanding health and disease dynamics. According to the biophysical paradigm, it is possible to combine biochemical knowledge on the dynamics of health and disease with new insights and new clinical applications. If we consider, as a working hypothesis, that every liv...

By using the methods of the non parametric time series prediction we obtain that in the next ten days we will reach the size of 8000-9000 contagions in Italy.

Anxiety and depression impact dramatically on public health, underlying the importance of alternative cost-effective treatments. Previous studies have shown that biophysical treatment can significantly reduce anxiety symptoms and recently, salivary alpha-amylase (SAA) has been identified as an objective correlate of the sympathetic-parasympathetic...

Digital transformation has impacted almost all areas of modern lifestyle. Digital implications and applications are not negligible anymore even in the area of health and wellbeing [1] and therefore in the area of medical education. Moreover, the concept of health and disease themselves need to be redefined in order to update efficaciously and effi...

From the past, we know how much “serendipity” has played a pivotal role in scientific discoveries. The definition of serendipity implies the finding of one thing while looking for something else. The most known example of this is the discovery of penicillin. Fleming was studying “Staphylococcus influenzae” when one of his culture plates became cont...

Certificate of Science at a Glance E-Poster Presentation- This is to certify that Farhad Masoumi Presented the abstract: RADIOFREQUENCY THERMAL BALLOON ANGIOPLASTY ACCOMPANIED BY 5- AMINOLEVULINIC ACID - LOADED PESDA MICROBUBBLES- MEDIATED BLUE LASER PHOTODYNAMIC THERAPY REDUCE NEOINTIMAL HYPERPLASIA at the 87th EAS Congress, held in Maastr...

Background Chronic Kidney Disease (CKD) and its clinical evolution are an emerging issue, due to an increasingly aging population. Consequently, the evaluation of integrative strategies to manage the decline in renal function is warranted. The previous evidence indicates that a biophysical integrated approach can significantly improve renal functio...

The Electro Magnetic Information Transfer Through Aqueous System (EMITTAS) reported a number of interesting and positive experimental effect on cells, receptors, bacteria, fungi, and seeds [1-5]. So far, no evidences were available about the possibility to employ the same procedure aimed to transfer endogenously generated pattern of electromagnetic...

Introduction: Neointimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of arterial walls and decreased arterial lumen space. Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as stenting or angiopl...

Introduction: Atherosclerotic lesions are considered intermediate by histological criteria when accumulations of lipid, cells, and matrix components, including minerals, are associated with macrophages foam cells-rich soft plaque formation, structural disorganization, repair, and thickening of the intima, as well as deformity of the arterial wall....

So far, electromagnetic signals have been widely considered as an epiphenomenon or a by-product of the biochemical activity of the living organisms. In spite of this fact that a number of biophysical analysis has become part of biomedical investigations such as, for instance, electrocardiograms, electroencephalograms, evoked potentials, electromyog...

This is to certify that the following e-Poster was presented at the 11th World Stroke Congress in Montreal, Canada | 17-20 October 2018 EFFECT OF INTRAVENOUS HIGH- DOSE ATORVASTATIN- LOADED MICROBUBBLES ADMINISTRATION ON ULTRASOUND- GUIDED HIGH INTENSITY FOCUSED ULTRASOUND- MEDIATED HISTOTRIPSY OF CAROTID ARTERY ADVANCED ATHEROSCLEROTIC PLAQUE

Fröhlich proposed that the functionality and sensitivity in living systems results from ordered states within the apparently chaotic motions and arrangements of biological molecules in order to build and maintain its coherence regardless the ceaseless response to external stimuli due to adaptive dynamics. A consequence of this perspective is that m...

Background: Atherosclerosis is the leading cause of cerebrovascular disease. Aims: In this study, we developed an experimental pulsed- high intensity focused ultrasound (1MHz, 120 W/Cm2, 50 Hz), and investigated its effectiveness on advanced atherosclerotic plaque regression, wherein diagnostic B- mode ultrasound is combined with high intensity foc...

Aim: In- stent restenosis is related to neointimal hyperplasia. Sever coronary restenosis after stenting is a risk factor for ischemia and its related deaths. We developed a new sono- photodynamic combination therapy procedure, and investigated its effectiveness on intimal hyperplasia reduction. Methods: Briefly, rats underwent perivascular severe...

Aim: Intermediate stage atherosclerosis is highlighted by infiltration of oxidized low-density lipoprotein and foam cell formation, resulting in the thickening of arterial walls and decreased arterial lumen space. In this study, we developed an experimental shock wave therapy system, and investigated its effectiveness on intermediate stage atherosc...

Aim: As is well recognized, the majority of atherosclerosis start with an inflammatory process, resulting in endothelial dysfunction. We developed an experimental extracorporeal photobiomodulation therapy procedure, and investigated its effectiveness on endothelial function in the rat injured abdominal aorta. Methods: Briefly, rats underwent periva...

Objective: Macrophage foam cells play a critical role in the occurrence and development of atherosclerosis. It is well recognized that the local inflammation and associated macrophage activity can lead to foam cellrich plaque formation, which results to plaque rupture and thrombosis, making inflammation an important therapeutic target in stroke and...

Objective: Neointimal hyperplasia is an important clinical entity in vascular surgery because it limits the long-term effectiveness of surgical and endovascular interventions. Neointimal hyperplasia is usually defined in an artery as thickening of the intimal layer after an injury such as angioplasty, stenting or surgical repair. Neointimal hyperpl...

Background and Aims: Intimal hyperplasia is the major cause of restenosis after percutaneous coronary and carotid interventions such as stenting or angioplasty. Intimal hyperplasia refers to proliferation and migration of vascular smooth muscle cells. In this study, we developed an experimental shock wave- photodynamic combination therapy protocol,...

Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. Low- level focused- electrohydraulic shock wave therapy is one of the non- invasive methods to treat...

Articular pain is one of the most frequent complaints practitioners face in their daily work. With an aging population, many patients have multiple comorbidities that are associated with the presence of chronic diseases, while others experience allergies, side effects or do not respond to standard medications or procedures. Therefore, there is an u...

Knee osteoarthritis is a common disease leading to pain and disability in an increasing number of people. Since osteoarthritis is a progressive and degenerative skeletal disease, any therapy aimed to deal with it has to face from one side with the management of pain and recovery from disability; and from the other side with the slowing of osteoarth...

Biological organisms are complex open dissipative systems whose dynamical stability is sustained due to the exchange of matter, energy and information. Dynamical stability occurs through a number of mechanisms that sustain efficient adaptive dynamics. Such properties of living matter can be the consequence of a self-consistent state of matter and e...

The Electro Magnetic Information Transfer Through Aqueous System (EMITTAS) reported a number of interesting and positive experimental effect on cells, receptors, bacteria, fungi, and seeds. So far, no evidences were available about the possibility to employ the same procedure aimed to transfer endogenously generated pattern of electromagnetic signa...

Aim: In atherosclerosis, local inflammation and associated macrophage activity can lead to foam cell- rich plaque formation, which results to plaque rupture and thrombosis, making inflammation an important therapeutic target in cardiovascular disease. In this study,we developed an experimental electrohydraulic shock wave generator system (0- 20 Kv,...

Aim: Atherosclerosis is the leading cause of cardiovascular disease. The management of atherosclerosis reduces the risk of myocardial infarction and its related deaths. In this study, we developed an experimental confocal dual-pulse (20 Kv, 0.1 Hz and 8 Kv, 5 Hz) electrohydraulic shock wave generator, and investigated its effectiveness on advanced...

Several beneficial effects of the electromagnetic information transfer through aqueous system (EMITTAS) procedure have previously been reported in vitro. The clinical potential of this procedure has also started to be evaluated. Information flow in biological systems can be investigated through chemical and molecular approaches or by a biophysical...

Background and Aims: Atherosclerosis is the leading cause of stroke and cardiovascular disease. As is well recognized, the majority of atherosclerosis start with an inflammatory process, resulting in endothelial dysfunction. We developed an experimental focused electrohydraulic shock wave generator and investigated its effectiveness on inflammation...

Neck pain is a leading cause of disability, ranking steadily among the first places of the global burden of disease and consequently very common to face in the primary care setting. Therefore, any additional treatment suitable to its effective and quick management has to be carefully taken into consideration. It has been previously shown that the i...

Biophysical Therapies employing an Electromagnetic Information Transfer Through Aqueous System (EMITTAS) procedure has been shown to be effective in transferring on neuroblastoma cell line the activity of retinoic acid, and similarly it has been mimicked the effect of tiroxine, phorbol-myristate acetate, and other molecules. Nevertheless, no data w...

Aim: Atherosclerosis is the leading cause of cardiovascular disease. Atherosclerosis is a general process that affects the entire arterial system. The management of atherosclerosis reduces the risk of myocardial infarction and its related deaths. Long- term efficacy of surgical treatment for coronary atherosclerosis disease, including angioplasty,...

INTRODUCTION Are we on the right path in actual tissue engineering? Are we missing some dimension in the understanding of tissue dynamics as for their growth, renewal, and regeneration? Are there some additional features that could improve and foster the clinical implementation of the tissue engineering techniques at the bedside? We need to enlarge...

Low back pain is a very common complaint in general population. It is the most spread among spine's diseases and a leading cause of disability. The need for new strategies for its management is therefore continuously increasing. Biophysical therapies have been reported to be effective in the treatment of pain in comparison to the common anti inflam...

Biophysical Therapy has been shown to reduce pain in a general practice setting, to improve low back pain and disability, to treat refractory gynaecological infections, to increase the estimate filtration rate in chronic kidney disease,and to reduce fluctuating asymmetry as clinical correlate of allostatic load. No data are available, so far, conce...

Experimental evidence has accumulated to suggest that biologically efficacious informational effects can be derived mimicking active compounds solely through electromagnetic distribution upon aqueous systems affecting biological systems. Empirically rigorous demonstrations of anti-microbial agent associated electromagnetic informational inhibition...

Heretofore only observed in living systems, we report that weak-field ion cyclotron resonance (ICR) also occurs in inanimate matter. Weak magnetic field (50 nT) hydronium ICR at the field combination (7.84 Hz, 7.5 µT) markedly changes water structure, as evidenced by finding an altered index of refraction exactly at this combined field. This observ...

Chronic kidney disease (CKD) and its clinical progression are a critical issue in an aging population. Therefore, strategies aimed at preventing and managing the decline of renal function are warranted. Recent evidence has provided encouraging results for the improvement of renal function achieved through an integrated biophysical approach, but pro...

Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruva...

The ElectroMagnetic Information Transfer Through Aqueous Systems (EMITTAS) procedure has been supported by a number of experimental evidences on cells, receptors, bacteria, fungi, and seeds[1-4]. As his natural development this procedure has been recently translated into clinical applications in order to asses some medical applications [5]. Informa...

Chronic Kidney Disease (CKD) and its subsequent complications and consequences are an increasing concern in general population. A biophysical integrated approach in early stages of CKD was investigated in 30 patients with a 12-month follow-up. A clinical approach based on the use of an electro medical device (Medselect 729) was employed following p...

Refractory gynecological infections are often very difficult to treat. The need for new strategies in their management is therefore continuously increasing. Some researchers have recently pointed up that microorganisms could emit specific electromagnetic signals. Moreover electromagnetic signals could be able to yield response from immune system. T...

Human and animal diseases are brought about by pathological alterations of production, composition, and conformation of macromolecules and structures in cells. Additional contributing factors include changes in physiological states caused by disturbances of energy supply, energy transduction, energy dissipation in moving or oscillating parts, and p...

Since biophysical treatment has been reported to be effective in the general management of pain, we decided to assess the specific effect and treatment duration of this therapeutic strategy in low back pain. We were interested in verifying the possibility that a single clinical procedure could reduce pain and improve patients' quality of life withi...

Several years ago just before Christmas, in a small meeting room at the Institute of Pharmacology at the University of Rome, we had the opportunity to attend a meeting on "The role of QED in medicine" by Emilio Del Giudice and Giuliano Preparata. Before that meeting, we were more oriented towards a mechanistic view of Biochemistry and Medicine, bel...

Anxiety and Depressive Disorders are two emerging concerns in world’s population being ranked respectively at the sixth and second position of the global burden of disease impacting public health. Therefore new effective strategies to cope with them are advisable bridging evidence based and personalized medicine. By bridging physics and biology liv...

This chapter emphasizes some basic aspects of entropy, enthalpy, free energy and how these interact under various conditions. We first present the classical physico-chemical point of view to promote a proper understanding of how biotic structures are seen from this perspective, which helps to comprehend the complexity of biotic response patterns. T...

Abstract: Some experimental evidences of the procedure defined as electro-magnetic information delivery, mediated through aqueous system, have accumulated in the last two decades. The present work is based on the hypotheses that an aqueous system like those enfolded in livings, could play an additional synergic role in modulating biological functio...

"In vivo" control of osteoblast differentiation is an important process needed to maintain the continuous supply of mature osteoblast cells for growth, repair and remodelling of bones. The regulation of this process has also an important and significant impact on clinical strategies and future applications of cell therapy. In this paper we studied...

Pain management is a daily part of current medical practice. The aim of this pilot study was to assess the efficacy of a biophysical procedure (Med Select 729) compared to a usual pain killer drug (Ibuprofen), and to placebo in order to disclose some effective procedures to be employed especially in elderly people with multiple comorbidities, in pa...

Biomacromolecules in solution modify the structure and the dynamics of the bulk water at the solute-solvent interface. The ordering effects of biomolecules, in particular proteins, are extended for several angstroms. The role of the hydration shells around a protein has yet to be completely understood. Hydrated proteins maintain more dynamic flexib...

Aqueous systems not only provide the basis for the origin of life but also play a dynamic active role in the maintenance of allostasis, namely the ceaseless process aimed to keep stability through dynamic changes, in any cell and organism. Interestingly aqueous systems possess not only the longtime acknowledged biochemical properties but also some...

The Director of the retirement home 'Casa Anziani Malcantonese' (CAM) -promoted at the beginning of 2012 a research project on pain reduction using chromopuncture by Peter Mandel. The CAM already offers to its guests a wide variety of therapeutic options, i.e. physiotherapy, 100% ; music therapy, 20%; and currently chromopuncture, 30%. The CAM is l...

Autoimmune nephrotic syndrome is often characterized by frequent recurrence. It is commonly associated with reduced response to steroid therapy and its clinical management may be challenging. We report a case in which the combination of standard therapy with a biophysical treatment resulted in both clinical improvement and disappearance of autoimmu...