Albert F. Wright

Albert F. Wright
Institut Laue-Langevin · Retired, Research Group Coordinator, Head of Communications

ARIC, PhD
Developing sulforaphane-rich solutions to slow progression of Parkinson's disease . www.patientresearcher.com

About

63
Publications
13,650
Reads
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1,462
Citations
Introduction
Exploring activation of transcription factor Nrf2 to combat oxidative stress, mitochondrial dysfunction and inflammation in Parkinson's disease. 30 months of self-experimentation using sulforaphane-rich solutions.
Additional affiliations
April 1976 - July 2005
Institut Laue-Langevin
Position
  • Research Group Co-ordinator, Head of Communications (retired)
April 1976 - July 2005
Institut Laue-Langevin
Position
  • Retired
April 1973 - April 1975
University of Oxford
Position
  • PostDoc Position
Education
September 1966 - June 1967
Northumbria University
Field of study
  • Chemistry

Publications

Publications (63)
Preprint
Full-text available
Activating the transcription factor Nrf2 has been proposed as an effective method for combatting oxidative stress and inflammation in neurodegenerative diseases for 2 decades. We review the known mechanisms and evidence in favour of activating Nrf2 to stimulate the production of cytoprotective antioxidant enzymes and anti-inflammatory cytokines dir...
Preprint
Full-text available
Levodopa is administered orally in Parkinson’s disease therapy and is converted to dopamine in the brain to make up for reduced intrinsic production from lost dopaminergic cells. Given alone it is estimated that only 1% reaches the target destination. The rest is metabolized by a large number of different enzymes, especially in the intestines and t...
Article
Analysis of single-crystal data on the α to β transformation in quartz, which takes place at 573°C, showed that the model which, till now, has best agreed with available X-ray data, does not hold for the neutron data. In an earlier model both oxygen and silicon atoms move to special positions (6j and 3c in the space group P6222). The new data for β...
Article
Full-text available
The crystal structures of the ‘cristobalite’ phases of SiO4 and AlPO4 have been determined from X-ray data collected at high temperatures. A model is suggested which gives a much better fit to the data than previously published structures. In this model, the 16 oxygen atoms of the unit cell are statistically distributed over the 96 positions (h) of...
Article
Full-text available
Small angle neutron scattering has been applied to a study of the crystallization of a cordierite glass ceramic incorporating TiO//2 as nucleating agent. The technique can be used to discriminate between nucleation and growth processes when used in conjunction with two stage and in-beam heat treatments. The small angle scattering curves show strong...
Presentation
Full-text available
The story of the first 4 years of a scientist’s journey with Parkinson’s disease. It begins with the diagnosis and the neurologist’s affirmation: “The cause of Parkinson’s Disease is unknown," an affirmation shown to be untrue. Other themes: a model for the progressive loss of dopamine neurons, plant-based molecules - a dilemma , “STOP” - Scientist...
Preprint
Full-text available
Over the last two decades, cutting-edge research has demonstrated how the transcription factor Nrf2 can be activated to attenuate oxidative stress and inflammation in neurons but this hypothesis has not been officially tested on Parkinson’s disease patients. Here we report on a series of eight independent (n-of-1) experiments carried out at their o...
Preprint
Full-text available
Levodopa is administered orally in Parkinson’s disease therapy to generate dopamine in the brain to compensate for reduced production from lost dopaminergic cells. It is metabolized by several enzymes, in the intestines and the liver, some of which are inhibited by prescription drugs. Even so its half-life remains short (about 90 minutes), which le...
Preprint
Full-text available
Introduction The gold standard for symptom relief of patients suffering from Parkinson's Disease (PD) is a combination of synthetic L-Dopa and a decarboxylase enzyme inhibitor. Carbidopa inhibits the peripheral decarboxylation of L-Dopa to dopamine by the Amino Acid Decarboxylase enzyme (AADC), also called Dopa Decarboxylase (DDC) and enables more...
Research
An Attempt to Evaluate the Efficacy of Hafnium Oxide Nanoparticles NBTXR3 as a Radiotherapy-enhancer for the treatment of Soft Tissue Sarcoma In this article I have reviewed existing data from various clinical trials and protocols in order to evaluate the progress that could be expected from using NBTRX3 in this pathology. The critical parameters...
Article
Phase separation of quenched supersaturated Ni-(9.5-12.0)at.% Ti single crystals was followed by small-angle neutron scattering during in-beam aging at 773, 813 and 853 K. With the incident beam along <110>, scattering maxima in <100> directions were observed from the earliest stages of decomposition. While the results obtained at 773 K may be comp...
Article
Gels have been prepared in the H2O, HOiPr, (BuO)2Al-O-Si(OEt)3 ternary phase diagram in a large range of oxide concentrations. The gelation time is governed by the initial water concentration, showing that the hydrolysis of Si-OR groups is the rate-determining process for the gelation. The structure of clusters and the kinetics of aggregation have...
Article
Full-text available
A powder neutron diffraction study of alpha -AgI has been carried out at several temperatures between 180 degrees C and 450 degrees C. The results do not support the widely quoted model for the distribution of silver ions originally proposed by Strock (1934-36) but instead indicate the silver ions are confined to the twelve tetrahedral sites of the...
Article
Over the last few years, several sectors of industry have used the facilities of the Institut Laue-Langevin (ILL) to make neutron scattering measurements related to their product research, control, and development. ILL seeks to increase its involvement in industry. A one-day workshop was held on June 29,2000 dedicated to the “Characterization of In...
Article
Full-text available
We present results concerning the structure of clusters and the kinetics of aggregation obtained by SANS for different compositions in the H2O, HOiPr, (BuO)2AlOSi(OEt)3 system.Information about the growth kinetics has been obtained from the time dependence of the Guinier radius, of the maximum intensity on the scattering curve and of the integral...
Article
An investigation of the change in certain physical properties such as density, refractive index, and thermal coefficient of expansion in silica-titania glasses as a function of titania content disclosed a discontinuity at around 12 percent TiO//2; this discontinuity has been attributed to the precipitation of a second phase rich in titania in the g...
Article
Devitrification of vitreous BeF2 at 355°C yields beta-quartz BeF2 which on cooling to ambient temperature undergoes a displacive transition to give the alpha-quartz form. Both alpha- and beta-quartz BeF2 have tetrahedral (BeF4) structures which are very closely related to the corresponding SiO2 polymorphs. At ambient temperature the Be-F bond lengt...
Article
The authors earlier investigation of nucleation and crystallisation in tholeitic basalt glass by small angle neutron scattering has been extended. We report here small angle x-ray scattering, wide angle x-ray diffraction, and electron paramagnetic resonance measurements on glasses of the same origin but prepared under various redox conditions. Thes...
Article
The nucleation and crystallization behaviour of basalt glass has been studied dynamically by small angle neutron scattering (SANS). The interparticle interference effect shows a pronounced maximum in the SANS spectra at the growth temperature of 710C for different nucleated samples. The number density of particles decreases with the time of growth...
Article
The decomposition of Ni ∼ 11.5 at.% Ti single crystals was studied for an ageing temperature of 540°C. In this alloy, coherent ordered zones of γ′-Ni3Ti (Cu3Au structure) are formed prior to the stable n precipitates. The early stages of zone formation were investigated by in-beam SANS and transmission electron microscopy (TEM). Electron diffractio...
Article
Full-text available
Les spectres Raman des verres de cordierite soumis à différents traitements thermiques de nucléation montrent l'existence d'une bande à fréquence beaucoup plus basse que la "bande des bosons" observée habituellement dans les verres. Elle est attribuée aux germes présents dans le verre. On montre expérimentalement que sa position dépend de la taille...
Article
Full-text available
Sophisticated new methods of preparation developed over the last decade have considerably extended the range and nature of amorphous materials, many of which have a microstructure on a scale of 10–1000 Å. Whilst in some cases this is due to the composition, in others it is a direct result of the preparation technique. This paper reviews the present...
Chapter
The aqueous electrolytes LiClnD2O can be prepared in the glassy state over a very large range of concentration. The devitrification processes have been studied by using Differential Scanning Calorimetry (D.S.C.) and neutron scattering (Diffraction and Small Angle Scattering (S.A.N.S.)). We identify different behaviour for the two concentration rang...
Chapter
The classical heat treatment schedule for glass ceramics includes a holding temperature, usually slightly above Tg, for between several minutes and a few hours to promote nucleation of the crystallites (1). This is followed by a temperature ramp through crystallisation and sometimes phase transformation zones (2) to the final ceramming temperature....
Book
Glass ••• Current Issues is the proceedings of a NATO Advanced Study Institute held in Puerto de la Cruz, Tenerife between the 2nd and 13th April 1984. The objectives of the School were twofold. Firstly to inform participants of actual and developing technolog­ ical applications of glassy materials in which fundamental science makes a strong contri...
Article
The nucleation and growth of crystal nuclei in magnesium aluminosilicate glasses is of considerable importance given the wide ranging application of the corresponding glass ceramics. In this paper we look at the nucleation of glasses containing Cr//2O//3, which is recognized as a powerful nucleating agent but for which little published information...
Article
Phase transformations of AlPO4 with structures similar to SiO2 were investigated. The high temperature phase on AlPO4-quartz (Berlinite) was studied with a view to a twinning of the deep phase. The phonons were measured at room temperature. The phase transformation of AlPO4-quartz at 846K is deduced from the lattice dynamics. The structures of SiO2...
Article
Full-text available
The neutron diffraction camera method is used for studying the crystallographic and magnetic phase transitions. Since this method shows a two-dimensional view of the reciprocal space at the same time, it is very useful for observing the pattern of satellite reflections or diffuse scatterings related to any kind of structural phase transitions. And...
Article
Full-text available
The nucleation and crystallization behaviour of a basalt glass-ceramic was studied by small-angle neutron scattering (SANS). The interparticle interference effects in the SANS spectra of the different nucleated samples indicate that the number density of crystallites, measured at the longest crystallization time at 710 C, saturates with the nucleat...
Article
The evaluation of the magnitude of fluctuations of alkali oxide concentrations in a binary silicate glass has been made from electrical measurements. The dc conductivity is highly dependent on the alkali oxide concentration, and analysis of the complex impedance plot has been used with conductivity data to yield directly the concentration fluctuati...
Article
The possibility that the high-T beta phase is disordered has recently been supported by a neutron diffraction structural study. The Landau theories of first-order phase transitions give a good description of the behaviour of the alpha phase right up to the alpha -beta transition, but many anomalous features of the beta phase cannot be explained wit...
Article
Controlled conditions for the nucleation of ice from concentrated electrolyte solutions can be achieved by choosing concentrations such that the homogeneous nucleation temperature TH lies very close to the glass transition temperature Tg. We may obtain TH from experiments using emulsions of the electrolyte solutions, but Tg is almost constant at 14...
Article
RESUME. Un modSle est proposd pour l'interprdtation des arcs de cercle observds en diagrame drimp6dance complexe pour des verres conducteurs ioniques. Ce modsle conduit B la ddtermination de l'amplitude des fluctuations de concentration dans ces verres et est comfort6 par des donn6es thermodynamiques et des rssultats obte- nus par diffusion neutron...
Article
Small angle X-ray and neutron scattering studies have recently added considerably to the understanding of the formation and growth of heterogeneities in glass. These extend from fluctuations through glass-in-glass phase separation to crystallization. By way of introduction, the parameters controlling their formation and growth are discussed in term...
Article
Full-text available
A study of the controlled homogeneous nucleation of ice has been performed by neutron scattering at temperatures between the glass transition Tg = 141 K and the homogeneous nucleation TH in 10.5 moles % amorphous LiCl.D2O, as a complement to a neutron small angle scattering investigation. The diffraction pattern observed is that of D2O cubic ice (I...
Article
LiUO2AsO4.4D2O has a 7.0969(1), c 9.1903(2) A, space group P4/n; Z = 2. The Li+ ion is tetrahedrally coordinated to four water molecules unlike the K+ and 036NH4+ ions in KUO2AsO4.3H2O (abernathyite) and NH4UO2AsO4.3H2O (M.A. 17-260) which replace H3O+ ions. -J.E.C.
Article
The process by which ice forms during the cooling of water and aqueous solutions has been studied intensively mostly in conditions where the nucleation occurs heterogeneously—on some particulate impurity surface. When the more fundamental homogeneous process has been deliberately investigated1–3 it has nearly always been in conditions in which the...
Article
Diffusion and conductivity mechanisms for DUO2AsO4·4D2O (DUAs) are considered in the light of neutron diffraction evidence for partial ordering and the presence of D5O+2 and D4O2 units in the structure.
Article
Full-text available
The density and small angle neutron scattering of a variety of silicon hydride films have been measured as function of heat treatment. Anode deposited samples have previously been shown to have a columnar morphology with a dominant column diameter of ∼60 Å. This is confirmed and the new studies establish that the matrix separating the columns is of...
Article
Full-text available
The construction and performance of a neutron Weissenberg camera for temperatures down to 4 K is described. Exposure times are similar to the X-ray case. The background from the cryostat walls can be eliminated. Examples of applications in the fields of magnetic structures which are incommensurate with their chemical unit cells, crystallographic ph...
Article
Full-text available
The construction and performance of an area collimator for use with film or multidetectors is described. A cylindrical assembly of high divergence slits, resembling a venetian blind, at a short distance from the sample permits the detector to observe only scattering from the sample or very close to it. Parasitic scattering from cryostats or furnace...
Article
Full-text available
A power neutron diffraction study of the good proton conductor DUO2AsO4·4D2O at 305 K shows the presence of [D2O5]+ ions and indicates hydrogen ordering effects in the plane of water molecules.
Article
Small-angle scattering measurements using both neutrons and X-rays have been made on a series of plasma-deposited a-Si : H films. One class of sample exhibits strong anisotropic scattering indicating rod-like microstructure normal to the film surface with a dominant rod diameter of ~ 60 Å. Other samples show isotropic scattering with a similar dime...
Article
Full-text available
THE nucleation of phase separation in bulk solids remains one of the more elusive phenomena in both experimental and theoretical terms1. Experimentally, the difficulties centre on the problem of gaining detailed structural information about the small composition fluctuations from which the precipitate develops. Theoretically, progress has been made...
Article
Full-text available
Verfeinerung der . Neutronenbeugungsdaten durch Profilanalyse auf der Grundlage der Raumgruppe Fdd2 mit Z=8 f?hrt zu oktaedrischer Koordination des Pd, wobei nicht alle F-Atome ?quivalent sind.
Article
The effects of pile irradiation on various modifications of silica have been extensively studied in the past. Structural investigations are reported here of the effects of such irradiation on the cristobalite form of silica and on a variety of materials related to silica structurally or chemically. These are GeO//2, BeF//2, SnO//2, TiO//2, AlPO//4,...
Article
Full-text available
The α—β transition in the cristobalite phases of SiO2 and AlPO4 has been studied using X-ray powder diffraction. The transitions show marked hysteresis but also occur over a range of about 20°C in which the α and β phases coexist. The lattice parameters show a smooth and slow variation with temperature for each phase and a discrete difference betwe...
Article
Full-text available
THREE structures have been proposed for high cristobalite, which exists for T273° C in pure, well-ordered material. These have been described by Wyckoff1 and by Sosman2 who suggests that all three might be correct for different specimens. The first investigation, by Wyckoff3,4 himself, from powder photographs taken at 290 and 430° C on a specimen...

Questions

Questions (6)
Question
A small group of People with Parkinson's disease, of which I am one, are doing some research to try to standardize a preparation method to make precise quantities of the isothiocyanate sulforaphane from glucoraphanin, a glucosinolate found in Broccoli seeds. The glucoraphanin is hydrolysed by the enzyme myrosinase to form an unstable intermediate which then undergoes a Lossen-type rearrangement to form sulforaphane or alternatively sulforaphane nitrile. We need to measure the sulforaphane concentration as a function of temperature and time during the reaction in order to choose the best temperature and processing time to get the most constant yield.
You can find research program of this group here... https://patientresearcher.com/
and my research on the application to Parkinson's disease here :
The Lossen rearrangement equation can be found on page 11 of this document, "Reflections of a Scientist with Parkinson's disease", which you can download from here
We already know a lot about this process but we have reason to believe that it is more complicated than that, possibly due to simultaneous decomposition of sulforaphane. We would appreciate any help from scientists interested in this subject especially those with access to laboratories equipped to help resolve these issues.
We intend to use this method to analyse for isothiocyanates,
Finally, if anyone has a working UV-Vis spectrometer that they don't need and could donate it to the Group, we would be very grateful. I am based in Grenoble France.
Albert Wright
Question
I'm a retired research chemist/physicist with Parkinson's disease and I've been working on upregulating Nrf2 with sulforaphane to fight oxidative stress.
The results I achieved on my PD and with a group of 8 people with PD have shown that sulforaphane strongly attenuated non-motor symptoms especially fatigue and lack of motivation, suggesting that the first target for Nrf2 seems to be mitochondria. I am not an expert in this subject and I would like to reach out to research groups and Parkinson's disease specialists to discuss how to take this idea further.
You can find the background here :
And a preprint I have written on RG here:
Question
I'm looking for a lab set up to analyse sulforaphane in an aqueous solution
Question
The gold standard for symptom relief of patients suffering from Parkinson's Disease (PD) is a combination of synthetic L-Dopa and a decarboxylase enzyme inhibitor. Even so the half life of this drug remains short (60-90 minutes). This creates the well-known on/off states for patients on this treatment that ruins their quality of life as the drug wears off. There is now sufficient evidence to support the hypothesis that metabolism by the Cytochrome P450 enzyme, CYP3A4 is the cause of this problem. Inhibition of CYP3A4 could literally change the lives of PD sufferers.
There is currently no direct experimenal work published on this subject. The field is scientifically very interesting, but remains totally open. It also has a strong human and economic impact. It could easily provide the material for at least one PhD thesis in pharmacology or pharmacokinetics.
Drug companies have no interest in pursuing this research for two reasons ; 1) Inhibition of CYP3A4 would lead to much lower consumption of PD drugs. 2) Inhibition of CYP3A4 could expose patients and drug companies to the impact of drug-drug interactions (DDIs) involving other drugs with a narrow therapeutic window and high sensitivity to CYP3A4.
Parkinson's disease patients are however immensely interested in exploring this research. The article posted below received more than 600 reads in 4 days, mostly from PD patients. It could open the way to therapy that could change the lives of millions of people through intelligent personalised medecine that could vastly reduce the risk of DDIs.
Improving the knowledge about the relation between CYP3A4 and levodopa would greatly benefit PD patients Although I have done a much of the groundwork, I can't make a significant impact in this field alone. I believe that by working together, we can make significant progress quite quickly. I look forward to your suggestions.
Albert F Wright
Question
The high temperature structures of quartz and cristobalite have a structure in which the oxygen atoms are statistically disordered with 1/6 occupation of O sites in what is probably a micro-twinned structure which preserves the observed high-symmetry crystal structure whilst enabling a lower-symmetry local structure consistent with accepted bonding relations. This has been demonstrated in high quartz (Wright & Lehmann 1981) and in the high cristobalite phases of Silica and AlPO4 (Wright & Leadbetter 1975, Leadbetter, Smith & Wright 1973). Although this work is not recent, (mostly from my theses work) it still attracts interest and citations today. There is still work to be done on quartz at the low-high transition and on the high quartz phase of AlPO4 and analogues. I'm open to any proposals, esp. from crystallographers.
Best regards,
Albert Wright
Question
Where can I find an introduction to Kinases with free access :
How and by what are they produced (expressed) ?
How do they go wrong (mutations, overexpression) ?
What are kinase inhibitors and how do they work ?
many thanks for your help.

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Projects

Projects (5)
Project
Exploring the activation of transcription factor Nrf2 to combat oxidative stress, inflammation and slow progression in Parkinson's disease. New results (n=8) released Jan, 2021, show that activating Nrf2 strongly attenuates non-motor symptoms of PD. See update file below.
Archived project
Historical work on X-ray and neutron diffraction revisited