Albert Stezin Sunny

Albert Stezin Sunny
National Institute of Mental Health and Neuro Sciences | NIMHANS · Department of Clinical Neuroscience and Neurology

MBBS, DGM, PhD (Neurology)

About

46
Publications
3,738
Reads
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179
Citations
Additional affiliations
July 2014 - June 2020
National Institute of Mental Health and Neuro Sciences
Position
  • Medical Doctor
December 2013 - May 2014
Malabar Medical College and Research Centre, Modakallur
Position
  • Clinical Tutor
Education
January 2015 - June 2016
MS Ramaiah Medical College- Indira Gandhi National Open University (IGNOU)
Field of study
  • Geriatrics
June 2014 - June 2020
August 2006 - December 2011
Christian Medical College Ludhiana
Field of study
  • Medicine, Surgery, Paediatrics

Publications

Publications (46)
Article
Full-text available
Introduction: Spinocerebellar ataxia type-12 (SCA12) is a rare form of SCA, most commonly reported from the Indian Agarwal and related families. In this study we describe the clinical, genetic, and radiological characteristics of a sizeable cohort of genetically proven SCA12. Methods: A retrospective chart-review of the genetically confirmed SCA...
Article
Objective: With the use of next-generation sequencing in clinical practice, several genetic etiologies of dystonia have been identified. This study aimed to ascertain the utility of clinical exome sequencing (CES) in dystonia and factors suggestive of a genetic etiology. Methods: This study was a retrospective chart review of patients with dysto...
Article
Background: Rapid eye movement sleep behaviour disorder (RBD) is considered to be one of the most frequent and important prodromal symptoms of Parkinson’s disease (PD). We aimed to study the neurophysiological abnormalities in patients of PD-RBD and PD without RBD (PD-nRBD) using transcranial magnetic stimulation (TMS). Methods: Twenty patients ea...
Preprint
Cognitive impairment is a debilitating non-motor symptom of Parkinson’s disease (PD). The diagnosis of PD with cognitive impairment (PDCI) is essentially through clinical and neuropsychological examinations. There is an emerging need to identify biomarker(s) to foresee cognitive decline in PD patients, at an early stage. We performed label-free unb...
Article
Introduction Cognitive impairment is reported but is poorly explored in spinocerebellar ataxia 2 (SCA2). This study was undertaken to evaluate and classify cognitive impairment (CI) in patients with SCA2 and to identify their grey matter (GM) correlates. Methods We evaluated the neurocognitive profile of 35 SCA2 and 30 age-, gender- and education-...
Article
Full-text available
Abstract: BACKGROUND AND PURPOSE: The corpus callosum (CC) consists of topographically arranged white matter (WM) fibers. Previous studies have indicated the CC to be discretely involved in WD. In this study, we strived to characterize the macrostructural properties of the CC using midsagittal cross-sectional area and thickness profile measureme...
Article
Objective: White matter (WM) integrity of Spinocerebellar ataxia 2 (SCA2) is poorly understood, more so in the early stages of SCA2. In this study, we evaluated the microstructural integrity of the WM tracts with an emphasis on the nature of in‐vivo pathological involvement in early SCA2. Materials and methods: We evaluated the MRI images of 26 ge...
Article
Sleep disturbance is one of the commonly reported non-motor symptoms in patients with Parkinson's disease (PD) as well as in Parkinson plus disorders such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS). Although there is a wealth of literature on sleep disturb...
Article
Full-text available
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Article
Full-text available
Objective: Non-motor symptoms (NMSs) significantly contribute to increased morbidity and poor quality of life in patients with parkinsonian disorders. This study aims to explore the profile of NMSs in patients with progressive supranuclear palsy (PSP) using the validated Non-Motor Symptom Scale (NMSS). Methods: Seventy-six patients with PSP were...
Conference Paper
Objective: i. To identify CSF protein biomarker/s in Parkinson’s disease (PD) with cognitive impairment using LC-MS/MS proteomics. ii. To estimate the level of known AD biomarkers in CSF of PD with cognitive impairment using Enzyme Linked Immunosorbent Assay (ELISA) Background: Cognitive impairment is a major non-motor symptom of PD. The cognitive...
Article
It is commonly thought that visuomotor adaptation is mediated by the cerebellum while reinforcement learning is mediated by the basal ganglia. In contrast to this strict dichotomy, we demonstrate a role for the basal ganglia in visuomotor adaptation (error‐based motor learning) in patients with Parkinson's disease (PD) by comparing the degree of mo...
Article
Background: With India enacting the Mental Health Care Act (MHCA; No. 10 of 2017a), Psychiatric Advance Directives (PADs) have been legalised and have become binding orders for psychiatrists treating patients. There is a paucity of research into acceptability of PADs in Indian mental health care, likely due to a lack of awareness. There are no edu...
Preprint
Full-text available
It is commonly thought that visuomotor adaptation is mediated by the cerebellum while reinforcement learning is mediated by the basal ganglia. In contrast to this strict dichotomy, we demonstrate a role for the basal ganglia in visuomotor adaptation (error-based motor learning) in patients with Parkinsons disease (PD) by comparing the degree of mot...
Article
This study describes the longitudinal changes of resting motor threshold (RMT) and central motor conduction time (CMCT) in 18 patients with Wilson’s disease (WD). The RMT, CMCT, and Global Assessment Scale for Wilson Disease (GAS-WD) were measured at baseline and at follow-up after 12.94 ± 7.23 months. There was a significant decrease in the RMT (7...
Article
Background: Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD); the pathogenesis and natural course of which has not been fully understood. Objectives: This study was performed to evaluate patients with FOG in PD and ascertain factors contributing to an early onset of FOG in patients with PD. Methodology: A char...
Article
Background Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD); the pathogenesis and natural course of which has not been fully understood. Objectives This study was performed to evaluate patients with FOG in PD and ascertain factors contributing to an early onset of FOG in patients with PD. Methodology A chart...
Article
Introduction: To evaluate the non-ataxic clinical manifestations in genetically proven Spinocerebellar ataxia 2 (SCA2) and identify their determinants and predictors. Methods: Seventy-three subjects with genetically proven SCA2 were evaluated clinically for the common non-ataxic manifestations. Based on the presence or absence of non-ataxic mani...
Article
Objective: Multiple system atrophy (MSA) is a neurodegenerative disorder with progressive motor and autonomic dysfunction. There is a paucity of information on the early neurostructural changes in MSA, especially its subtypes, MSA-P (patients with predominant parkinsonism) and MSA-C (patients with predominant cerebellar signs). This study investig...
Article
Improvement in motor symptoms with levodopa is one of the hallmark features of Parkinson’s disease (PD). The response to levodopa may reduce during the course of the illness. Few studies have also reported reduced response to levodopa in patients with PD several years after deep brain stimulation (DBS) of the subthalamic nucleus (STN) on both the s...
Article
Background: To investigate the diagnostic utility of signal intensity measurement of the substantia nigra pars compacta (SNc) using three dimensional (3D) neuromelanin-sensitive 31MRI, for discrimination of patients with PD from healthy controls. Methods: T1-weighted neuromelanin sensitive images of 16 patients with PD and 15 controls were quant...
Article
Background: The occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) is frequently attributed to dopamine replacement therapy. However, not all patients who receive medication develop ICDs. Recent imaging studies have suggested specific neuroanatomical abnormalities in patients with PD and ICD. Objectives: This study aims t...
Article
Background: The spectrum of symptoms exhibited by patients with essential tremor (ET) extends far beyond the classical tremor. This study aims to explore and establish the presence of subtle balance abnormalities in ET using dynamic posturography (DP). Methods: DP was performed on 18 patients with ET and 26 controls. Diagnosis of ET was based on...
Article
INTRODUCTION: Dystonia is one of the most prevalent forms of movement disorders and is characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Dystonia causes significant morbidity with an adverse impact on the quality of life. When dystonia is medically refractory, causing se...
Article
Introduction Patients with Parkinson’s disease (PD) may develop several non-motor symptoms (NMS). Psychosis is one of the debilitating NMS of PD. The neurobiology of psychosis is not fully understood. This study aims to compare the frontal lobe functions of PD patients with and without psychosis using the Frontal Assessment Battery (FAB). Methodol...
Article
Full-text available
Background: Involvement of the central nervous system in patients with syphilis (neurosyphilis) may result in several neuropsychiatric symptoms. Rarely, patients with neurosyphillis may develop movement disorders with different phenomenology. Subtle orofacial dyskinesias have been reported in patients with neurosyphilis, known as the candy sign. Ca...
Article
Full-text available
Objective: To determine the diagnostic characteristics of poor visualisation of nigrosome-1 as a neuroimaging biomarker in Parkinson's disease (PD) and to explore the relationship of poor visualisation of nigrosome-1 and clinical asymmetry. Methods: High-resolution gradient-echo sequences of 67 patients with PD and 63 healthy controls were revie...
Article
Progressive supranuclear palsy (PSP) is a progressive neurological disorder characterized by presence of supranuclear gaze palsy, early postural instability, parkinsonism and cognitive impairment. Advanced structural neuroimaging studies have demonstrated variable areas of grey and white matter involvement in PSP. Grey matter (GM) involvement is pr...
Article
Full-text available
Introduction To explore the neuroanatomical correlates of primary writing tremor (PWT) and the role of cerebellum, using advanced structural neuroimaging. Till date, there are no studies exploring the gray and white matter changes using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) in PWT. Methods Ten male patients with PWT were...
Article
Objectives: To determine cortical grey matter (GM) changes and their clinical and biochemical correlates in patients with Wilson's disease using voxel based morphometry (VBM). Methods: Clinical and imaging data of 10 patients (all male, mean age 16.0 ± 6.3years) with Wilson's Disease were analyzed. T1W volumetric MRI data of patients without obv...
Conference Paper
Full-text available
Introduction: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism resulting in neurodegeneration. The most important neurological manifestation is extrapyramidal (EP) and is mainly tremor, dystonia, parkinsonism, or a combination. It is unknown what determines the initial EP symptoms. In this study, we aimed to compare pat...

Questions

Questions (3)
Question
I performed a neuro-psychological battery consisting of 6 tests that measures different aspects of executive function. Each test has between 3 to 15 subscores. There is no consensus on whether one test or subscore is better than the other. There are a total of 64 subscores which are all non-normally distributed.
In this condition, is it appropriate to compare patients and controls using 64 univariate comparison using Mann whitney U and then perform Bonferroni correction or is there a more appropriate statistical model that I can use?
Question
After doing TBSS analysis, is there a method of extracting out the tracts, their coordinates, tscores and no of voxels ?
Question
I use TMS to evaluate the cortical excitability of subjects with different movement disorders. Recently, I have started acquiring recordings from patients who have rest tremor or dystonia of hand (from FDI muscle). In many cases, the surface EMG recordings are not silent. Should I classify these recording as RMT or AMT? Is there any technique to ensure RMT is measured despite muscle activity?
Thanks in advance!!

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Projects

Projects (3)
Project
Characterizing the clinical, neurophysiological and neuroimaging correlates of genetic and non-genetic neurodegenerative ataxic disorders