Albert T Lebedev

Albert T Lebedev
Lomonosov Moscow State University | MSU · Department of Organic Chemistry

D.Sc. in 1992, Ph.D. in 1982

About

257
Publications
44,205
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Introduction
Albert T Lebedev currently works as a full Professor at the Department of Organic Chemistry , Lomonosov Moscow State University. Albert does research in Analytical Chemistry, Organic chemistry, Proteomics, Chemical Biology and Environmental Chemistry. Several current projects deal with aquatic chlorination of organic compounds including UV-filters, targeted and non targeted analysis of organic compounds in water, snow, clouds, soil, etc., de novo sequencing of natural peptides, study of mechanisms of the gas phase reactions, the search for the new lipids - biomarkers of the cardio-vascular diseases.
Additional affiliations
January 1982 - September 2018
Lomonosov Moscow State University
Position
  • Professor (Full)
Education
October 1979 - December 1982
Lomonosov Moscow State University
Field of study
  • Organic chemistry
September 1974 - June 1979
Lomonosov Moscow State University
Field of study
  • Chemistry

Publications

Publications (257)
Article
Aim To prospectively investigate the associations of urinary phthalate metabolite concentrations measured at four time points spanning pubertal development with semen parameters in Russian men. Design 516 boys were enrolled at ages 8–9 years (2003–2005) and followed annually. Methods Urine samples were collected annually and pooled into four expo...
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Limonene (1-methyl-4-(1-methylethenyl)-cyclohexene) is one of the most widespread monocyclic terpenes, being both a natural and industrial compound. It is widely present in the environment, including in water supplies. Therefore, it may be subjected to aqueous chlorination at water treatment stations during drinking water preparation. Besides, bein...
Article
Background Although phthalate exposures have been associated with adverse effects on male reproductive health, few studies have explored longitudinal associations with male pubertal development. Objectives We examined the association of prepubertal urinary concentrations of phthalate metabolites with age at pubertal onset in a prospective cohort o...
Article
Cardiolipidology – a new direction in cardiology – is developing intensively owing to the method of mass spectrometry. This method has acquired particular importance for the determination of molecular types of sphingolipids, the metabolism of which is closely related to the metabolism of cholesterol. Changes in the level of a number of sphingolipid...
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The present review covers available results on the application of FT‐MS for the de novo sequencing of natural peptides of various animals: cones, bees, snakes, amphibians, scorpions, and so forth. As these peptides are usually bioactive, the animals efficiently use them as a weapon against microorganisms or higher animals including predators. These...
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The number of known priority pollutants and emerging contaminants of environmental concern currently exceeds several thousand (US EPA Part 423, US EPA Part 401) [...]
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Although being successfully applied all over the world for more than 100 years water disinfection by means of chlorination possesses certain drawbacks, first of all formation of hazardous disinfection by-products (DBP). Aromatic halogenated DBPs significantly contribute to the total organic halogen and developmental toxicity of chlorinated water. T...
Article
Metal oxides can effectively activate peroxymonosulfate (PMS) to degrade organic contaminants but are usually synthesized via chemical/physical processes involving extreme conditions and hazardous materials. In this study, an innovative bio-synthesis method with a strain of manganese oxidizing bacteria Pseudomonas sp. was developed to prepare multi...
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Соли бензалкония широко используются в составе антимикробных препаратов в промышленности и быту, а также альгицидов для обработки воды бассейнов. В процессе дезинфекции водопроводной или сточной воды активным хлором в присутствии природных или антропогенных бромид-анионов, а также при использовании брома в качестве дезинфектанта воды бассейнов, кат...
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Parkinson’s disease (PD) is a neurodegenerative disease incurable due to late diagnosis and treatment. Therefore, one of the priorities of neurology is to study the mechanisms of PD pathogenesis at the preclinical and early clinical stages. Given the important role of sphingolipids in the pathogenesis of neurodegenerative diseases, we aimed to anal...
Article
An indole derivative umifenovir (Arbidol) is one of the most widely used antiviral drugs for the prevention and treatment of COVID-19 and some other viral infections. The purpose of the present study was to shed light on the transformation processes of umifenovir in municipal wastewater, including disinfection with active chlorine, as well as to as...
Article
Existing and newly developed technologies for clean-up of wastewaters and soils contaminated with rocket fuel unsymmetrical dimethylhydrazine (UDMH) are based on the oxidative treatment, as well as gasification in supercritical water. Being easily transformed by a radical mechanism, UDMH is capable of producing an extremely wide range of potentiall...
Article
Skin secretion represents the only means of defense for the majority of frog species. That phenomenon is based on the fact that the main components of the secretion are peptides demonstrating greatly varying types of bioactivity. They fulfill regulatory functions, fight microorganisms and may be even helpful against predators. These peptides are co...
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Environmental issues in the Arctic region are of primary importance due to the fragility of the Arctic ecosystem. Mainly persistent organic compounds are monitored in the region by nine stationary laboratories. Information on the volatile (VOC) and semi volatile (SVOC) organic priority pollutants is very limited, especially for the Russian Arctic....
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Lipid-lowering drugs affect standard lipoproteins. However, we have no knowledge of changes in other plasma lipids upon treatment. The study was aimed to assess the dynamic changes in cholesterol, high- and low-density lipoproteins (HDL and LDL), triglycerides, and sphingolipids against the background of lipidlowering therapy in patients with prema...
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The endemic brown macroalga Fucus virsoides J. Agardh from the Adriatic Sea was in the focus of the present research. The volatiles of fresh (FrFv) and air-dried (DrFv) samples of F. virsoides obtained by headspace solid-phase microextraction (HS-SPME) and hydrodistillation (HD) were analyzed by gas chromatography equipped with flame ionization det...
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The main drawback of drinking water chlorination involves the formation of quite hazardous disinfection by-products (DBPs), represented mainly by halogenated species. Based on the authors’ monitoring data since 2002, the prevalence of chlorine over bromine in the composition of volatile DBPs was shown for the drinking water in Ufa (Russia). However...
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Rationale: Host defense peptides accumulated in the skin glands of the animals constitute the basis of the adaptive and immune system of amphibians. The peptidome of the Cuban frog Osteopilus septentrionalis was established using tandem mass spectrometry as the best analytical tool to elucidate the sequence of these peptides. Methods: Manual int...
Article
RATIONALE Mummification is one of the defining customs of Ancient Egypt. The nuances of the embalming procedure and the composition of the embalming mixtures have attracted the attention of scientists and laypeople for a long time. Modern analytical tools make mummy studies more efficient. METHODS Comprehensive two‐dimensional gas chromatography ‐...
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Environmental exposure assessment is an important step in establishing a list of local priority pollutants and finding the sources of the threats for proposing appropriate protection measures. Exposome targeted and non-targeted analysis as well as suspect screening may be applied to reveal these pollutants. The non-targeted screening is a challengi...
Article
The present paper deals with the study of condensation reaction of aniline with acetone under electrospray ionization (ESI) conditions . An experimental setup is described for conducting reactions under ESI conditions with a possibility of the accumulation of reaction products. The aniline and acetone condensation products were analyzed by gas chro...
Article
Trans-resveratrol becomes more and more popular all over the world as a powerful antioxidant. Since its positive properties, including antioxidant, anti-inflammatory, anti-tumor are indisputable, nowadays trans-resveratrol is used as a component of various products from nutriceutics to body care formulations, where it is supposed to behave as natur...
Article
Studies of the chemical composition of atmospheric aerosols, rain water and snow in various regions of the globe quite often show the presence of pyridine and a number of its low mass derivatives. Nevertheless, the sources of those compounds in the environment have not yet been established and definitely require elucidation, supported by reliable e...
Article
The number of priority and emerging contaminants nowadays exceeds several thousands. As a consequence, it is a daunting task to monitor thousands of compounds using classical gas chromatography–mass spectrometry (GC–MS). Preliminary non-targeted screening is thus usually performed to identify the most relevant contaminants. Here we analyzed complex...
Article
Doxazosin (DOX), a selective alpha blocker, is widely used in medical therapy as an effective antihypertensive agent. It is a frequently prescribed drug and for this reason, environmental and ecotoxicological research is of great importance in terms of exposure and risk for both aquatic species and humans. In this study we focused on photolytic and...
Article
Anthropogenic pollution of the Arctic atmosphere is of great interest due to the vulnerability of the Arctic ecosystems, as well as the processes of global transport and accumulation of atmospheric aerosols at high latitudes under conditions of cold climate. The present work throws light upon chemical composition of Arctic snow as a natural deposit...
Article
N‐(2‐Methoxybenzyl)‐2,5‐dimethoxyphenethylamines (NBOMes) are synthetic phenethylamine derivatives emerging on the drugs of abuse market and reported to be associated with untoward effects in people using drugs. The mechanism of action involves agonism at serotonin 5‐HT2A receptors affecting cognitive and behavioral processes. At the same time, cer...
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The increased use of sunscreens and other cosmetics containing UV filters causes human and environmental burden. Avobenzone is a widely used UV filter. In its pure form it is known to undergo several transformations including photo-isomerisation, photodegradation, and halogenation. Over 60 disinfection by-products were identified as transformation...
Article
Rationale α‐Substituted cyclic amino nitriles show different reactivity and stability in solution depending on their ring size. Mass‐spectrometric modeling of the reactions, which normally take place in the solution, may shed light on the nature of the studied compounds and explain some observations. Methods Stability of the nitriles in an acidic...
Article
Disinfection is an essential technological stage in water treatment. It is used not only for potable water but also for, e. g., swimming pool water. Water chlorination is the most common method for eliminating microorganisms today. However, active chlorine reacting with natural and anthropogenic compounds dissolved in water gives rise to the format...
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The aim of this study was to evaluate changes in the content of sphingoid bases - sphingosine (SPH), sphinga-nine, and sphingosine-1-phosphate (SPH-1-P) - and in expression of genes encoding enzymes involved in their metabolism in the brain structures (hippocampus, cortex, and cerebellum) and spinal cord of transgenic FUS(1-359) mice. FUS(1-359) mi...
Article
The reactions of thioamides with azides in water were studied. It was reliably shown that the reaction of 2-cyanothioacetamides 1 with various types of azides 2 in water in the presence of alkali presents an efficient, general, one-step, atom economic, eco-friendly method for the synthesis of 1,2,3-thiadiazol-4-carbimidamides 5 and 1,2,3-triazole-4...
Article
The maintenance of public swimming pools requires numerous technological steps. One of the most important issues involves microbiological safety. Benzalkonium chloride (BAC) encompasses homologous alkylbenzyldimethylammonium chlorides with various alkyl chains, in particular C12 and C14, and is known as a popular algaecide for keeping water clean....
Article
Existing methods for cleanup of wastewaters and soils polluted with the extremely toxic rocket fuel unsymmetrical dimethylhydrazine (UDMH) are mainly based on the treatment with various oxidative reagents. Until now, the assessment of their effectiveness was based on the residual content of UDMH and did not take into account the possibility of the...
Article
Olive mill wastewater (OMW) as a by-product of olive oil extraction process has significant polluting properties mainly related to high organic load, increased COD/BOD ratio, high phenolic content and relatively acidic pH. Raw OMW from Slovenian Istria olive oil mill and its polar fraction were investigated in this study. Chemical characterization...
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Disinfection of drinking water with chlorine-containing reagents leads to the formation of a large number of disinfection by-products, resulting from the chlorination of natural dissolved organic matter. High-performance liquid chromatography/high-resolution mass spectrometry with solid-phase preconcentration on a polymeric sorbent was used to stud...
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Phenol is toxic and can be found in many environments, in particular in the atmosphere due to its high volatility. It can be emitted directly from manufacturing processes or natural sources, and it can also result from benzene oxidation. Although phenol biodegradation by microorganisms has been studied in many environments, the cloud medium has not...
Article
Gas chromatography-mass spectrometry (GC–MS) is one of the most accurate, well developed, and reliable analytical tools for the analysis of volatile and semivolatile compounds. The GC–MS data have been extensively improved by enhancing the separation capacity via comprehensive two-dimensional gas chromatography (GC × GC). The reliability of the ide...
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Full-text available
Phenol is particularly toxic and can be found in many environments, in particular in the atmosphere due to its high volatility. It can be emitted directly from manufacturing processes or natural sources, and it can also result from benzene oxidation. Although phenol biodegradation by microorganisms has been studied in many environments, the cloud m...
Article
Although organic species are transported and efficiently transformed in clouds, more than 60% of this organic matter remains unspeciated. Using GCxGC-HRMS technique we were able to detect and identify over 100 semi-volatile compounds in 3 cloud samples collected at the PUY station (puy de Dôme mountain, France) while they were present at low concen...
Article
Environmental contamination of the Arctic has widely been used as a worldwide pollution marker. Various classes of organic pollutants such as pesticides, personal care products, PAHs, flame retardants, biomass burning markers, and many others emerging contaminants have been regularly detected in Arctic samples. Although numerous papers have been pu...
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This review is devoted to the scientific achievements of the departments of organic chemistry in higher schools of Russia within the past decade.
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Disinfection of drinking water with chlorine-containing reagents leads to the formation of a large number of disinfection by-products resulting from the chlorination of natural dissolved organic matter. High-performance liquid chromatography/high-resolution mass spectrometry with preliminary solid-phase concentration on a polymeric sorbent was used...
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Our scientific interests involve de novo sequencing of non-tryptic natural amphibian skin peptides including those with intramolecular S–S bond by means of exclusively mass spectrometry. Reliable discrimination of the isomeric leucine/isoleucine residues during peptide sequencing by means of mass spectrometry represents a bottleneck in the workflow...
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Flubendiamide is a ryanodine insecticide that shows a strong insecticidal activity and is relatively safe for non-target organisms. Actually only flubendiamide and its product desiodo-flubendiamide have been studied during catalytic degradation using TiO2 and ZnO. Therefore, here we tested the photocatalytic removal of flubendiamide in the presence...
Article
Electron-transfer dissociation (ETD) and electron-transfer and higher-energy collision dissociation (EThcD) spectra of short tryptic peptides with leucine/isoleucine residues in neighboring positions demonstrate intensive w-ions. On the contrary, u-ions possess very low intensities (if present at all). Therefore radical site migration is negligible...
Article
Full-text available
Disinfection is an important step in the purification of drinking and swimming pool water. The most common procedure includes chlorination, which efficiently eliminates microorganisms. However, the reaction of active chlorine with dissolved organic matter produces numerous organochlorine compounds posing a hazard to the environment and human health...
Article
An array of similar halogenated nitrogen-containing compounds with elemental composition CnH2nNO2X, CnH2n–2NO2X and CnH2n-1NOX2 (X = Cl, Br; n = 16, 18, 22) was detected in drinking water with high pressure liquid chromatography – high resolution mass spectrometry (HPLC-HRMS) method. Compounds of this type were never mentioned among disinfection by...
Article
1,2,3-Triazoles and 1,2,3-thiadiazoles have been receiving permanent interest due to their exciting chemical reactivity and interesting biological properties including antibacterial, anticancer and antiviral activities. There are four compounds bearing 1H-1,2,3-triazole core in clinical studies which may appear in the market of drugs in nearest fut...
Article
Stability studies of two avobenzone transformation products: chloro-avobenzone [2-chloro-1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione] and dichloro-avobenzone [2,2-dichloro-1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione (dichloro-avobenzone)] have been performed at different pHs values as well as under UV A light and com...
Article
An EThcD-based approach for the reliable discrimination of isomeric leucine and isoleucine residues in peptide de novo sequencing procedure has been proposed. A multistage fragmentation of peptide ions was performed with Orbitrap Elite mass spectrometer in electrospray ionization mode. At the first stage, z-ions were produced by ETD or ETcaD fragme...
Article
Synthesis of drugs, biologically active compounds or their derivatives always requires precise and reliable method of their identification, including differentiation of the possible isomers. Pseudodistamines and their precursors became a matter of elevated attention due to their different enzymatic inhibition. This paper deals with one of the group...
Article
Solvent-base-controlled, transition metal-free and high yield synthesis of 4,5-functionalized 1,2,3-thiadiazoles and 1,2,3-triazoles from 2-cyanothioacetamides and sulfonyl azides is described. Under diazo transfer conditions in the presence of a base in an aprotic solvent 2-cyanothioacetamides operating as C-C-S building blocks produce 5-amino-4-c...
Article
LC-MS/MS was applied to establish the composition of the skin peptidome of a Slovenian green frog belonging to the Pelophylax esculentus complex. As this was similar to the peptidome of the Moscow population of Pelophylax ridibundus, it allowed us to identify the Slovenian frog from the Pelophylax esculentus complex as Pelophylax ridibundus. The se...
Article
The most common mass spectrometry approach analyzing contamination of the environment deals with targeted analysis, i.e. detection and quantification of the selected (priority) pollutants. However non-targeted analysis is becoming more often the method of choice for environmental chemists. It involves implementation of modern analytical instrumenta...
Article
We studied the reactions of 4-tert-butyl-4'-methoxydibenzoylmethane (avobenzone), the most common UV filter in formulations of sunscreens, under the conditions of disinfection. Three chlorinated compounds were identified as the main products. Their structures were confirmed by high-performance liquid chromatography-tandem mass spectrometry (HPLC–MS...
Article
Rationale: Mass spectrometry is known as an excellent method to predict the behavior of organic compounds in solution. The behavior of organic compounds in the gas-phase inside an ion source of a mass spectrometer allows their intrinsic properties to be defined, avoiding the influence of intermolecular interactions, counter ions and solvent effect...
Article
Emergence of new psychoactive substances (NPS), hallucinogenic phenethylamines in particular, in illicit market is a serious threat to human health in global scale. We have detected and identified N-(2-methoxybenzyl)-2-(2,4,6-trimethoxyphenyl)ethanamine (2,4,6-TMPEA-NBOMe), a new compound in NBOMe series. Identification was achieved by means of gas...