Albert-Laszlo Barabasi

Albert-Laszlo Barabasi
Northeastern University | NEU · Department of Physics

About

550
Publications
333,232
Reads
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200,360
Citations
Citations since 2016
138 Research Items
85582 Citations
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201620172018201920202021202202,0004,0006,0008,00010,00012,000
201620172018201920202021202202,0004,0006,0008,00010,00012,000

Publications

Publications (550)
Article
Full-text available
Background: In recent years, the possibility to noninvasively interact with the human brain has led to unprecedented diagnostic and therapeutic opportunities. However, the vast majority of approved interventions and approaches still rely on anatomical landmarks and rarely on the individual structure of networks in the brain, drastically reducing t...
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Understanding the genetic relationships between human disorders could lead to better treatment and prevention strategies, especially for individuals with multiple comorbidities. A common resource for studying genetic-disease relationships is the GWAS Catalog, a large and well curated repository of SNP-trait associations from various studies and pop...
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Pharmacologically active compounds with known biological targets were evaluated for inhibition of SARS-CoV-2 infection in cell and tissue models to help identify potent classes of active small molecules and to better understand host-virus interactions. We evaluated 6710 clinical and preclinical compounds targeting 2183 host proteins by immunocytofl...
Preprint
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Traditional Chinese medicine (TCM) relies on natural medical products to treat symptoms and diseases. While clinical data have demonstrated the effectiveness of selected TCM-based treatments, the mechanistic root of how TCM herbs treat diseases remains largely unknown. More importantly, current approaches focus on single herbs or prescriptions, mis...
Preprint
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While philanthropic support plays an increasing role in supporting research, there is limited quantitative knowledge about the patterns that characterize the distribution of philanthropic support. Here, we map philanthropic funding to universities and research institutions based on IRS tax forms from 685,397 non-profit organizations. We identify ne...
Preprint
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The important role diet plays in health has prompted extensive national programs to measure and catalog the nutritional content of all food. These efforts document that nutrient concentrations span eight orders of magnitude, a range driven by the complexity of biochemical processes responsible for their production and modulation. Here we analyze th...
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Extensive programmes around the world endeavour to measure and catalogue the composition of food. Here we analyse the nutrient content of the full US food supply and show that the concentration of each nutrient follows a universal single-parameter scaling law that accurately captures the eight orders of magnitude in nutrient content variability. We...
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The offering of grocery stores is a strong driver of consumer decisions, shaping their diet and long-term health. While processed food has been increasingly associated with unhealthy diet, information on the degree of processing characterising an item in a store is virtually impossible to obtain, limiting the ability of individuals to make informed...
Preprint
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Identifying novel drug-target interactions (DTI) is a critical and rate limiting step in drug discovery. While deep learning models have been proposed to accelerate the identification process, we show that state-of-the-art models fail to generalize to novel (i.e., never-before-seen) structures. We first unveil the mechanisms responsible for this sh...
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Despite the accumulating evidence that increased consumption of ultra-processed food has adverse health implications, it remains difficult to decide what constitutes processed food. Indeed, the current processing-based classification of food has limited coverage and does not differentiate between degrees of processing, hindering consumer choices an...
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Significance The COVID-19 pandemic has highlighted the importance of prioritizing approved drugs to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Here, we deployed algorithms relying on artificial intelligence, network diffusion, and network proximity to rank 6,340 drugs for their expected efficacy against SARS-CoV-...
Preprint
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Identification of host factors contributing to replication of viruses and resulting disease progression remains a promising approach for development of new therapeutics. Here, we evaluated 6710 clinical and preclinical compounds targeting 2183 host proteins by immunocytofluorescence-based screening to identify SARS-CoV-2 infection inhibitors. Compu...
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A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22939-x
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Polyphenols, natural products present in plant-based foods, play a protective role against several complex diseases through their antioxidant activity and by diverse molecular mechanisms. Here we develop a network medicine framework to uncover mechanisms for the effects of polyphenols on health by considering the molecular interactions between poly...
Article
A new analysis traces the story of the draft genome’s impact on genomics since 2001, linking its effects on publications, drug approvals and understanding of disease. A new analysis traces the story of the draft genome’s impact on genomics since 2001, linking its effects on publications, drug approvals and understanding of disease.
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While the structural characteristics of a network are uniquely determined by its adjacency matrix1–3, in physical networks, such as the brain or the vascular system, the network’s three-dimensional layout also affects the system’s structure and function. We lack, however, the tools to distinguish physical networks with identical wiring but differen...
Article
Significance A fundamental question of neuroscience is how the brain wires itself. Here, we propose a modeling framework that explains how cellular connectivity emerges from neuronal identity, allowing us to offer experimentally falsifiable predictions on the genetic encoding of the connectome. The rapid advances in brain science require quantitati...
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Environmental factors, and in particular diet, are known to play a key role in the development of Coronary Heart Disease. Many of these factors were unveiled by detailed nutritional epidemiology studies, focusing on the role of a single nutrient or food at a time. Here, we apply an Environment-Wide Association Study approach to Nurses' Health Study...
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Thanks to the many chemical and nutritional components it carries, diet critically affects human health. However, the currently available comprehensive databases on food composition cover only a tiny fraction of the total number of chemicals present in our food, focusing on the nutritional components essential for our health. indeed, thousands of o...
Preprint
Full-text available
Environmental factors, and in particular diet, are known to play a key role in the development of Coronary Heart Disease. Many of these factors were unveiled by detailed nutritional epidemiology studies, focusing on the role of a single nutrient or food at a time. Here, we apply an Environment-Wide Association Study approach to Nurses' Health Study...
Preprint
Full-text available
Polyphenols, natural products present in most plant-based foods, play a protective role against several complex diseases through their antioxidant activity and by diverse molecular mechanisms. Here we developed a network medicine framework to uncover the mechanistic roles of polyphenols on health by considering the molecular interactions between po...
Preprint
Full-text available
The current pandemic has highlighted the need for methodologies that can quickly and reliably prioritize clinically approved compounds for their potential effectiveness for SARS-CoV-2 infections. In the past decade, network medicine has developed and validated multiple predictive algorithms for drug repurposing, exploiting the sub-cellular network-...
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Network Medicine is now an established scientific discipline, having generated key insights on integrated mechanisms underlying complex human diseases. The next discovery phase will emphasize innovating analytics that optimize networks for advancing precision medicine. Accomplishing this goal will require organizing a scientifically diverse team st...
Preprint
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Despite rapid advances in connectome mapping and neuronal genetics, we lack theoretical and computational tools to unveil, in an experimentally testable fashion, the genetic mechanisms that govern neuronal wiring. Here we introduce a computational framework to link the adjacency matrix of a connectome to the expression patterns of its neurons, help...
Preprint
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The COVID-19 pandemic demands the rapid identification of drug-repurpusing candidates. In the past decade, network medicine had developed a framework consisting of a series of quantitative approaches and predictive tools to study host-pathogen interactions, unveil the molecular mechanisms of the infection, identify comorbidities as well as rapidly...
Article
The COVID-19 pandemic demands the rapid identification of drug-repurpusing candidates. In the past decade, network medicine had developed a framework consisting of a series of quantitative approaches and predictive tools to study host-pathogen interactions, unveil the molecular mechanisms of the infection, identify comorbidities as well as rapidly...
Article
Full-text available
Nutritional decisions may be important for health, and yet identifying trustworthy sources of advice can be difficult to achieve. Many people turn to books for nutritional advice, making the contents of these books and the expertise of their authors relevant to public health. Here, the top 100 best-selling books were identified and assessed for bot...
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Significance Empirical evidence suggests significant gender differences in the total productivity and impact of academic careers across science, technology, engineering, and mathematics (STEM) fields. Paradoxically, the increase in the number of women academics over the past 60 years has increased these gender differences. Yet, we find that men and...
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The molecular and clinical features of a complex disease can be influenced by other diseases affecting the same individual. Understanding disease-disease interactions is therefore crucial for revealing shared molecular mechanisms among diseases and designing effective treatments. Here we introduce Flow Centrality (FC), a network-based approach to i...
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is nee...
Preprint
Full-text available
Thanks to the many chemical and nutritional components it carries, diet critically affects human health. However, the currently available comprehensive databases on food composition cover only a tiny fraction of the total number of chemicals present in our food, focusing on the nutritional components essential for our health. Indeed, thousands of o...
Article
Full-text available
Our understanding of how diet affects health is limited to 150 key nutritional components that are tracked and catalogued by the United States Department of Agriculture and other national databases. Although this knowledge has been transformative for health sciences, helping unveil the role of calories, sugar, fat, vitamins and other nutritional fa...
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Abstract Reading remains a preferred leisure activity fueling an exceptionally competitive publishing market: among more than three million books published each year, only a tiny fraction are read widely. It is largely unpredictable, however, which book will that be, and how many copies it will sell. Here we aim to unveil the features that affect t...
Article
Synthetic lethality, the finding that the simultaneous knockout of two or more individually non-essential genes leads to cell or organism death, has offered a systematic framework to explore cellular function, and also offered therapeutic applications. Yet, the concept lacks its parallel in neuroscience – a systematic knowledge base on the role of...
Article
A scientific paper today is inspired by more disciplines than ever before, shows a new analysis marking the journal’s 150th anniversary. A scientific paper today is inspired by more disciplines than ever before, shows a new analysis marking the journal’s 150th anniversary.
Preprint
Synthetic lethality, the finding that the simultaneous knockout of two or more individually non-essential genes leads to cell or organism death, has offered a systematic framework to explore cellular function, and also offered therapeutic applications. Yet, the concept lacks its parallel in neuroscience - a systematic knowledge base on the role of...
Preprint
There is extensive, yet fragmented, evidence of gender differences in academia suggesting that women are under-represented in most scientific disciplines, publish fewer articles throughout a career, and their work acquires fewer citations. Here, we offer a comprehensive picture of longitudinal gender discrepancies in performance through a bibliomet...
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The original version of this Article contained an error in Acknowledgements, which incorrectly omitted the following: ‘This work was also supported by NHLBI grant P01HL132825 to A.-L.B.’ This has been corrected in both the PDF and HTML versions of the Article.
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In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combined perturbation, and therefore...
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Despite exceptional experimental efforts to map out the human interactome, the continued data incompleteness limits our ability to understand the molecular roots of human disease. Computational tools offer a promising alternative, helping identify biologically significant, yet unmapped protein-protein interactions (PPIs). While link prediction meth...
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Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating multiple complex diseases. Yet, our ability to identify and validate effective combinations is limited by a combinatorial explosion, driven by both the large number of drug pairs as well as dosage combinations. Here we propose a netwo...
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Over the past decades, the diversity of areas explored by physicists has exploded, encompassing new topics from biophysics and chemical physics to network science. However, it is unclear how these new subfields emerged from the traditional subject areas and how physicists explore them. To map out the evolution of physics subfields, here, we take an...
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Background: Chronic kidney disease (CKD) increases cardiovascular risk. Underlying mechanisms, however, remain obscure. The uremic toxin indoxyl sulfate is an independent cardiovascular risk factor in CKD. We explored the potential impact of indoxyl sulfate on proinflammatory activation of macrophages and its underlying mechanisms. Methods: We e...
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Collective memory and attention are sustained by two channels: oral communication (communicative memory) and the physical recording of information (cultural memory). Here, we use data on the citation of academic articles and patents, and on the online attention received by songs, movies and biographies, to describe the temporal decay of the attenti...