Albert Y Jin

Albert Y Jin
Queen's University | QueensU · Centre for Neuroscience Studies

About

56
Publications
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1,576
Citations

Publications

Publications (56)
Article
Background and Objectives: CT findings of acute and chronic ischemia are associated with stroke risk. We sought to validate these associations in a large prospective cohort of patients with TIA or minor stroke. Methods: We included prospectively enrolled emergency department patients from 13 centers with a final ED diagnosis of TIA or non-disabling...
Article
Background Transient ischemic attack (TIA) and non-disabling stroke are common emergency department (ED) presentations. Currently, there are no prospective multicenter studies determining predictors of neurologists confirming a diagnosis of cerebral ischemia in patients discharged with a diagnosis of TIA or stroke. The objectives were to (1) calcul...
Article
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Objective To validate the previously derived Canadian TIA Score to stratify subsequent stroke risk in a new cohort of emergency department patients with transient ischaemic attack. Design Prospective cohort study. Setting 13 Canadian emergency departments over five years. Participants 7607 consecutively enrolled adult patients attending the emer...
Article
Background and purpose: There is interest in what happens over time to the thrombus after intravenous alteplase. We study the effect of alteplase on thrombus structure and its impact on clinical outcome in patients with acute stroke. Methods: Intravenous alteplase treated stroke patients with intracranial internal carotid artery or middle cerebral...
Article
Background: Optimal stroke care requires access to resources such as neuroimaging, acute revascularization, rehabilitation, and stroke prevention services, which may not be available in rural areas. We aimed to determine geographic access to stroke care for residents of rural communities in the province of Ontario, Canada. Methods: We used the O...
Article
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Background and purpose: Intracranial hemorrhage is a known complication following endovascular thrombectomy. The radiologic characteristics of a CT scan may assist with hemorrhage risk stratification. We assessed the radiologic predictors of intracranial hemorrhage following endovascular therapy using data from the INTERRSeCT (Identifying New Appr...
Article
Whereas many studies have examined the properties of the compromised neocortex in the first several days following ischemia, there is less information regarding the initial 12 h poststroke. In this study we examined live mouse neocortical slices harvested immediately and 12 h after a 30-min middle cerebral artery occlusion (MCAo). We compared nonis...
Article
Background Rural residence is associated with stroke incidence and mortality, but little is known about potential rural/urban differences in ambulatory stroke care. Methods and Results We used the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) cohort, created from linked administrative databases from the province of Ontario, Can...
Article
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Pregnancy evokes many challenges on the maternal cardiovascular system that may unmask predispositions for future disease. This is particularly evident for women who develop pregnancy-related disorders, for example, pre-eclampsia and gestational diabetes or hypertension. Such pregnancy-related syndromes increase the risk for cardiovascular disease...
Article
Introduction: Residents of rural areas may have limited access to certain health care services. However, little is known about rural-urban differences in stroke secondary prevention care, or in the risk of recurrent stroke and death. We used linked population-based administrative databases from the province of Ontario, Canada, to assess the associa...
Conference Paper
Background and Aims: To compare different methods of intracranial thrombus perviousness measurements on NCCT and CTA with respect to their ability to predict early recanalization. Method: Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus perviousness was measured using the following methods: Method 1¼Mea...
Article
View-Dependent Prosopometamorphopsia after Stroke - Yue Jiang, Sanskriti Sasikumar, Albert Y. Jin
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Background and purpose: The Ontario Acute Stroke Medical Redirect Paramedic Protocol (ASMRPP) was revised to allow paramedics to bypass to designated stroke centers if total transport time would be <2 hours and total time from symptom onset <3.5 hours. We sought to evaluate the impact and safety of implementing the Revised ASMRPP. Methods: We co...
Article
Introduction: Little is known about stroke incidence, mortality and risk factor prevalence in rural versus urban regions. We used linked population-based administrative databases to compare cardiovascular risk factors, stroke incidence and stroke-related death in residents of rural and urban Ontario, Canada. Methods: We used a sub-population of the...
Article
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Study hypothesis: Placental growth factor (PGF) is expressed in the developing mouse brain and contributes to vascularization and vessel patterning. Study finding: PGF is dynamically expressed in fetal mouse brain, particularly forebrain, and is essential for normal cerebrovascular development. What is known already: PGF rises in maternal plas...
Article
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Pregnancy induces cardiovascular adaptations in response to increased volume overload. Aside from the hemodynamic changes that occur during pregnancy, the maternal heart also undergoes structural changes. However, cardiac modulation in pregnancies complicated by gestational hypertension is incompletely understood. The objectives of the current inve...
Article
A majority of acute cerebrovascular syndromes are transient ischemic attacks (TIA) or minor ischemic strokes. They are often thought of and managed as though benign, but are in fact a warning of impending disabling stroke. The risk of stroke progression or recurrence is highest in the first hours to days from initial symptom onset, with a 6.7% risk...
Article
Full-text available
The maternal system is challenged with many physiological changes throughout pregnancy to prepare the body to meet the metabolic needs of the fetus and for delivery. Many pregnancies, however, are faced with pathological stressors or complications that significantly impact maternal health. A shift in this paradigm is now beginning to investigate th...
Poster
Patients from the ongoing prospective multicenter INTERRSECT recanalization study with an M2 occlusion identified by baseline CTA were analyzed. M2 diameter was measured on baseline CTA at the most distal point of normal vessel upstream to the clot by consensus. Recanalization (modified AOL score 2-3) was assessed on 4 hour follow-up CTA. Infarct v...
Article
Every year, approximately 62 000 people with stroke and transient ischemic attack are treated in Canadian hospitals. The 2014 update of the Canadian Secondary Prevention of Stroke guideline is a comprehensive summary of current evidence-based recommendations for clinicians in a range of settings, who provide care to patients following stroke. Notab...
Article
Ischemia on computed tomography (CT) is associated with subsequent stroke after transient ischemic attack. This study assessed CT findings of acute ischemia, chronic ischemia, or microangiopathy for predicting subsequent stroke after transient ischemic attack. METHODS: This prospective cohort study enrolled patients with transient ischemic attack o...
Article
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Investigations regarding hypertension and dietary sodium, both factors that influence stroke risk, have previously been limited to using genetically disparate treatment and control groups, namely the stroke-prone, spontaneously hypertensive rat and Wistar-Kyoto rat. In this investigation, we have characterized and compared cerebral vasoactive syste...
Article
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Noreen Kamal, Oscar Benavente, Karl Boyle, Brian Buck, Ken Butcher, Leanne K. Casaubon,RobertCote,AndrewMDemchuk,YanDeschaintre,DarDowlatshahi,GordonJGubitz,GaryHunter,Tom Jeerakathil, Albert Jin, Eddy Lang, Sylvain Lanthier, Patrice Lindsay, Nancy Newcommon,Jennifer Mandzia, Colleen M. Norris, Wes Oczkowski, Celine Odier, Stephen Phillips,Alexandr...
Article
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Background: Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. However, paroxysmal atrial fibrillation is often asymptomatic and likely to go undetected and untreated in the routine care of patients with ischemic stroke or transient ischemic attack (TIA). Methods: We rando...
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Global ischemia caused by heart attack, pulmonary failure, near-drowning or traumatic brain injury often damages the higher brain but not the brainstem, leading to a ‘persistent vegetative state’ where the patient is awake but not aware. Approximately 30,000 U.S. patients are held captive in this condition but not a single research study has addres...
Article
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Background Isolated dysarthria is an uncommon presentation of transient ischemic attack (TIA)/minor stroke and has a broad differential diagnosis. There is little information in the literature about how often this presentation is confirmed to be a TIA/stroke, and therefore there is debate about the risk of subsequent vascular events. Given the unce...
Article
Introduction: Occlusions of the M2 branch show recanalization rates of 44% at 2 hours post treatment with IV-tPA when measured by TCD however no studies have looked at recanalization rates in early (<6h) time windows with angiography. Objectives: We aim to define recanalization rates for M2 occlusions with IV-tPA in an early time window (<6H) using...
Article
The occurrence of a transient ischemic attack (TIA) increases an individual's risk for subsequent stroke. The objectives of this study were to determine clinical features of patients with TIA associated with impending (≤7 days) stroke and to develop a clinical prediction score for impending stroke. We conducted a prospective cohort study at 8 Canad...
Article
Full-text available
The ABCD2 score (Age, Blood pressure, Clinical features, Duration of symptoms and Diabetes) is used to identify patients having a transient ischemic attack who are at high risk for imminent stroke. However, despite its widespread implementation, the ABCD2 score has not yet been prospectively validated. We assessed the accuracy of the ABCD2 score fo...
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A 74-year-old man presented with a four week history of behavioural disturbances, upper and lower extremity numbness and impaired balance. He had been treated with metronidazole for six months for osteomyelitis of the right hallux. Examination revealed encephalopathy, and glove-and-stocking sensory loss to pinprick with reduced vibration threshold...
Article
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A library of 35 benzylacetamide derivatives was evaluated for anticonvulsant activity as reflected in the ED50 (mg/kg) required to suppress seizure activity in the maximal electroshock seizure (MES) test. Using the method of partial least-squares regression in conjunction with cross-validation, the influence of 31 topological, electronic, physico c...
Article
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MM2 force field parameters for phospholipids were developed. These parameters — MM2(Lipid) — were employed in energy-minimization calculations (using crystal structures as starting conformations) on four phospholipids: dimyristoylphosphatidylglycerol, dilauroylphosphatidyl-N,N-dimethylamine, 1,2-dilauroyl-dl-phosphatidylethanolamine, and deoxylysop...
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The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of the early phase of leukocyte recruitment in acute ischemia is also a major contributor to early BBB dysfunction following stroke. This was investigated by examining the rel...
Article
An afebrile 88-year-old man with a right internal carotid artery stent inserted 2 years previously in October 2006 presented acutely with right side visual loss and neck mass. CT angiogram showed contrast extravasation surrounding the stent (figure) and a large infected hematoma encapsulating the right common and internal carotid artery. Streptococ...
Article
Single gate transcranial Doppler spectrogram (sgTCD) has a high variability in the detection of microembolic signals (MES), Adding Power M-mode Doppler (PMD) information may improve MES detection. Our study's aim is to derive combined PMD/sgTCD microemboli criteria to overcome this limitation. Patients with symptomatic carotid disease were prospect...
Article
We have developed a magnetic resonance molecular imaging method using a novel iron-oxide contrast agent targeted towards P-selectin - MNP-PBP (magnetic nanoparticle-P-selectin binding peptide) - to image endothelial activation following cerebral ischemia/reperfusion. MNP-PBP consists of approximately 1000 PBP ligands (primary sequence: GSIQPRPQIHND...
Article
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Article
An 18-year-old man with recurrent oral and genital ulcers presented with uveitis, encephalopathy, headache, spastic paraparesis, and urinary retention. MRI demonstrated periventricular and hypothalamic lesions, sinus thrombosis, and longitudinally extensive spinal cord lesions (figure). Treatment with high-dose steroid medication resulted in dramat...
Article
Thrombolytic treatment for acute stroke has focused attention on accurate identification of injured vs. salvageable brain tissue, particularly if reperfusion occurs. However, our knowledge of differences in acute magnetic resonance imaging changes between transient and permanent ischemia and how they reflect permanently damaged tissue remain incomp...
Article
We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structur...