Albert Cerussi

Albert Cerussi
University of California, Irvine | UCI

About

131
Publications
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5,957
Citations
Citations since 2017
3 Research Items
1712 Citations
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20172018201920202021202220230100200300
20172018201920202021202220230100200300

Publications

Publications (131)
Article
Background Currently, there are no reliable, accurate, non-invasive methods of assessing hemodynamic parameters, tissue hemoglobin, and 0, content for physiologic monitoring. Recent advances in the field of optical diagnostics have lead to new imaging modalities capable of evaluating regional in-vivo tissue composition using its optical properties....
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Ideally, neoadjuvant chemotherapy (NAC) assessment should predict pathologic complete response (pCR), a surrogate clinical endpoint for 5-year survival, as early as possible during typical 3- to 6-month breast cancer treatments. We introduce and demonstrate an approach for predicting pCR within 10 days of initiating NAC. The method uses a bedside d...
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We present a framework for characterizing the performance of an experimental imaging technology, diffuse optical spectroscopic imaging (DOSI), in a 2-year multicenter American College of Radiology Imaging Network (ACRIN) breast cancer study (ACRIN-6691). DOSI instruments combine broadband frequency-domain photon migration with time-independent near...
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Near-infrared spectroscopy (NIRS) has long been used to measure tissue-specific O2 dynamics in exercise, but most published data have used continuous wave devices incapable of quantifying absolute Hemoglobin (Hb) concentrations. We used time-resolved NIRS (TR-NIRS) to study exercising muscle (Vastus Lateralis, VL) and prefrontal cortex (PFC) Hb oxy...
Conference Paper
Full-text available
Colorectal cancer (CRC) is the second most common cause of cancer death in the western world, with a high lifetime incidence of 6%. The optimization of surgical techniques, introduction of neoadjuvant therapies and recent developments in diagnostic imaging modalities, contributed to the significant decrease of the mortality by 20% in the last years...
Article
Purpose: Time-resolved near-infrared spectroscopy was used to quantify tissue oxy- and deoxyhemoglobin concentrations ([HbO2] and [HbR]) and O2 saturation (stO2) in the oblique fibers of the vastus medialis muscle and brain prefrontal cortex during knee extension with and without blood flow restriction (BFR). Methods: Six young healthy males per...
Conference Paper
In patients with locally-advanced breast cancer, neoadjuvant chemotherapy can produce a complete pathological response, which is an important endpoint that correlates with survival. Because many patients do not respond to neoadjuvant chemotherapy, and conventional clinical assessments do not adequately predict pathological response, there is intere...
Article
Background: In addition to being a strong risk factor for breast cancer, data from recent studies suggests that breast density changes correlate with response to preventative or adjuvant tamoxifen treatment for breast cancer. Breast density may be a surrogate biomarker for survival and indication of the need for additional treatments such as radiot...
Conference Paper
Full-text available
Diffuse optical spectroscopy imaging (DOSI) has shown great potential for the early detection of non-responding tumors during neoadjuvant chemotherapy in breast cancer, already one day after therapy starts. Patients with rectal cancer receive similar chemotherapy treatment. The rectum geometry and tissue properties of healthy and tumor tissue in th...
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Radiographic density adversely affects the performance of x-ray mammography and can be particularly problematic in younger and high-risk women. Because of this limitation, there is signficant ongoing effort to develop alternative cancer screening and detection strategies for this population. This pilot study evaluates the potential of Diffuse Optic...
Conference Paper
Organ protection and physiology optimization are important goals when taking care of anesthetized patients undergoing surgery. Postoperative cognitive dysfunction and perioperative stroke are unwarranted potential outcomes. Neurovascular coupling, the match between cerebral metabolic demand and substrate supply, should be regarded as the essential...
Article
The use of near-infrared time-resolved spectroscopy (TRS-20, Hamamatsu Corporation) in two resistance type exercise applications in human subjects is described. First, using isometric flexion of the biceps, we compared the magnitude and relevance of tissue hemoglobin concentration and oxygen saturation (stO2) changes when assuming constant scatteri...
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Introduction: In addition to being a risk factor for breast cancer, breast density has been hypothesized to be a surrogate biomarker for predicting response to endocrine-based chemotherapies. The purpose of this study was to evaluate whether a noninvasive bedside scanner based on diffuse optical spectroscopic imaging (DOSI) provides quantitative m...
Article
While the decrease in blood carbon dioxide (CO2) secondary to hyperventilation is generally accepted to play a major role in the decrease of cerebral tissue oxygen saturation (SctO2), it remains unclear if the associated systemic hemodynamic changes are also accountable. Twenty-six patients (American Society of Anesthesiologists I–II) undergoing no...
Article
We have reported that a transient increase of oxyhemoglobin level measured 24 hours after the start of neoadjuvant chemotherapy using noninvasive Diffuse Optical Spectroscopic Imaging (DOSI) may be useful in discriminating nonresponding from reponding breast cancer patients (PNAS. 2011 Aug 30;108(35):14626–31). To elucidate the underlying biologica...
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Full-text available
Tissue hemoglobin oxygen saturation (i.e., oxygenation) is a functional imaging endpoint that can reveal variations in tissue hypoxia, which may be predictive of pathologic response in subjects undergoing neoadjuvant chemotherapy. In this study, we used diffuse optical spectroscopic imaging (DOSI) to measure concentrations of oxyhemoglobin (ctO(2)H...
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Tissue water content and molecular microenvironment can provide important intrinsic contrast for cancer imaging. In this work, we examine the relationship between water optical spectroscopic features related to binding state and magnetic resonance imaging (MRI)-measured water diffusion dynamics. Broadband diffuse optical spectroscopic imaging (DOSI...
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The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near infrared light propagation in thick tissues. We present theory and methods of DOI focusing on model-based techniques for quantitative, in vivo measurements of endogenous tissue absorption and sc...
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Tissue simulating phantoms are an important part of instrumentation validation, standardization/training and clinical translation. Properly used, phantoms form the backbone of sound quality control procedures. We describe the development and testing of a series of optically turbid phantoms used in a multi-center American College of Radiology Imagin...
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Multiple studies have shown that cerebral tissue oxygen saturation (Sct(O(2))) is decreased after phenylephrine treatment. We hypothesized that the negative impact of phenylephrine administration on Sct(O(2)) is affected by arterial blood carbon dioxide partial pressure (Pa(CO(2))) because CO(2) is a powerful modulator of cerebrovascular tone. In 1...
Article
Background Imaging technologies monitoring and predicting breast cancer response to neoadjuvant chemotherapy (NAC) are of increasing interest. The utility of conventional imaging approaches varies and identifies the need for alternate functional imaging strategies. The use of model-based photon migration methods to quantitatively separate light abs...
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During anesthesia, maneuvers which cause the least disturbance of cerebral oxygenation with the greatest decrease in intracranial pressure would be most beneficial to patients with intracranial hypertension. Both head-up tilt (HUT) and hyperventilation are used to decrease brain bulk, and both may be associated with decreases in cerebral oxygenatio...
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Diffuse optical spectroscopic imaging (DOSI) non-invasively and quantitatively measures tissue haemoglobin, water and lipid. Pilot studies in small groups of patients demonstrate that DOSI may be useful for longitudinal monitoring and predicting breast cancer neoadjuvant chemotherapy pathological response. This study evaluates the performance of a...
Article
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We previously developed a self-referencing differential spectroscopic (SRDS) method to detect lesions by identifying a spectroscopic biomarker of breast cancer, i.e., the specific tumor component (STC). The SRDS method is based on the assumption of the exclusive presence of this spectroscopic biomaker in malignant disease. Although clinical results...
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We describe an algorithm to calculate an index that characterizes spatial differences in broadband near-infrared [(NIR), 650-1000 nm] absorption spectra of tumor-containing breast tissue. Patient-specific tumor spatial heterogeneities are visualized through a heterogeneity spectrum function (HS). HS is a biomarker that can be attributed to differen...
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Approximately 8-20% of breast cancer patients receiving neoadjuvant chemotherapy fail to achieve a measurable response and endure toxic side effects without benefit. Most clinical and imaging measures of response are obtained several weeks after the start of therapy. Here, we report that functional hemodynamic and metabolic information acquired usi...
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How phenylephrine and ephedrine treatments affect global and regional haemodynamics is of major clinical relevance. Cerebral tissue oxygen saturation (Sct(O2) )-guided management may improve postoperative outcome. The physiological variables responsible for Sct(O2) changes induced by phenylephrine and ephedrine bolus treatment in anaesthetized pati...
Article
s: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX Background: Breast cancer patients who do not respond to neoadjuvant chemotherapy undergo months of unwarranted side effects. Early, non-invasive markers of response would provide physicians a valuable tool to make evidence-based changes to treat...
Article
(Background) Diffuse Optic Spectroscopy Imaging (DOSI) is non-invasive imaging technology that employs near-infrared (NIR) light to quantitatively characterize the hemodynamic and metabolic properties of breast cancer tumors. (Methods) We utilized DOSI to measure baseline tumor concentrations of oxy-hemoglobin (ctO2Hb), deoxy-hemoglobin (ctHHb), to...
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A need exists for a breast cancer risk identification paradigm that utilizes relevant demographic, clinical, and other readily obtainable patient-specific data in order to provide individualized cancer risk assessment, direct screening efforts, and detect breast cancer at an early disease stage in historically underserved populations, such as young...
Article
Diffuse Optical Spectroscopic Imaging (DOSI) provides non-invasive functional biomarkers that correlate with final pathological response to pre-surgical (neoadjuvant) chemotherapy in breast cancer patients that are measured at various timepoints throughout the therapy
Article
Imaging tumor response to neoadjuvant chemotherapy in vivo offers unique opportunities for patient care and clinical decision-making. Detailed imaging studies may allow oncologists to optimize therapeutic drug type and dose based on individual patient response. Most radiologic methods are used sparingly because of cost; thus, important functional i...
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We describe the development of a non-invasive method for quantitative tissue temperature measurements using Broadband diffuse optical spectroscopy (DOS). Our approach is based on well-characterized opposing shifts in near-infrared (NIR) water absorption spectra that appear with temperature and macromolecular binding state. Unlike conventional refle...
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Diffuse optical imaging (DOI) is a model-based technique used for noninvasive characterization of subsurface tissue function and structure. Compared to more common transmission geometries, reflectance DOI has the advantage of being portable and easily implemented in a clinical setting. However, reflectance measurements are generally not compatible...
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Diffuse optical spectroscopy (DOS), which is used to image tumor metabolic response to neoadjuvant chemotherapy (NAC), shows large changes in tumor functional parameters with significant reductions in oxy- and deoxyhemoglobin for responders versus nonresponders. Although investigational, DOS may provide a cost-effective, risk-free method for optimi...
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Diagnosing sinusitis remains a challenge for primary care physicians. There is a need for a simple, office-based technique to aid in the diagnosis of sinusitis without the cost and radiation risk of conventional radiologic imaging. We designed a low-cost near-infrared (NIR) device to transilluminate the maxillary sinuses. The use of NIR light allow...
Conference Paper
Using broadband Diffuse Optical Spectroscopy, deep tissue temperature was measured non-invasively by correcting bound water effect. Results from phantoms correlated with invasive thermal probe (R2=0.93, ?=1.1±0.91°C, 28-48°C) and temperature in in-vivo human forearms was measured.
Article
Background: In our previous work, we have shown that biochemical tissue water state correlates with histopathological scores of breast cancer (R=-0.96). Based on the result, we extended our research to test whether the tissue water measurement can differentiate heterogeneous pathological structures of cancer tissues of different grades. Diffuse Opt...
Article
Ongoing multi-center clinical trials are crucial for Biophotonics to gain acceptance in medical imaging. In these trials, quality control (QC) and assurance (QA) are key to success and provide "data insurance". Quality control and assurance deal with standardization, validation, and compliance of procedures, materials and instrumentation. Specifica...
Article
A self-referencing differential spectroscopy analysis approach has been developed for broadband near-infrared (NIR 650-1000 nm) absorption spectra to reveal intrinsic optical breast cancer biomarkers. Through the application of this method that accounts for inter-patient variability using the normal tissue as an internal control, we have characteri...
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To develop a near-infrared spectroscopic method to identify breast cancer biomarkers and to retrospectively determine if benign and malignant breast lesions could be distinguished by using this method. The study was HIPAA compliant and was approved by the university institutional review board. Written informed consent was obtained. By using self-re...
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We investigated the effects of operator-applied force on diffuse optical spectroscopy (DOS) by integrating a force transducer into the handheld probe. Over the typical range of contact forces measured in the breasts of eight patients, absorption and reduced scattering coefficients (650 to 1000 nm) variance was 3.1 +/- 1.0% and 1.0 +/- 0.4%. For tra...
Article
Optical imaging biomarkers measured by Diffuse Optical SpectroscopicImaging(DOSI) provide unique physiological profiles of tissue biochemistry that may be useful in breast cancer for detecting/characterizing lesions and evaluating tumor response to therapy. Imaging technologies have long played an important role in oncology, covering early detectio...
Article
#6056 Background: Diffuse Optical Spectroscopic Imaging (DOSI) is a non-invasive, bedside functional imaging technique that quantifies the concentrations and molecular states of tissue hemoglobin, water, and lipids. Pilot studies have shown that DOSI may be a useful tool for quantifying neoadjuvant chemotherapy response, typically by comparing the...
Article
#5065 Background: Response to cancer treatments such as radiotherapy, chemotherapy, and photodynamic therapy are less effective when tumors are hypoxic. Hyperoxic gas intervention has been shown to improve tumor oxygenation. Here we report how hemodynamic changes due to oxygen intervention are related to the tumor response during cisplatin treatmen...
Article
Full-text available
Current imaging modalities allow precise visualization of tumors but do not enable quantitative characterization of the tumor metabolic state. Such quantitative information would enhance our understanding of tumor progression and response to treatment, and to our overall understanding of tumor biology. To address this problem, we have developed a w...
Article
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Diffuse optical spectroscopy (DOS) has been used to monitor and predict the effects of neoadjuvant (i.e., presurgical) chemotherapy in breast cancer patients in several pilot studies. Because patients with suspected breast cancers undergo biopsy prior to treatment, it is important to understand how biopsy trauma influences DOS measurements in the b...
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Structural changes in water molecules are related to physiological, anatomical and pathological properties of tissues. Near infrared (NIR) optical absorption methods are sensitive to water; however, detailed characterization of water in thick tissues is difficult to achieve because subtle spectral shifts can be obscured by multiple light scattering...
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A board-level broadband frequency domain photon migration (mini-FDPM) instrument has been constructed to replace a conventional network-analyzer-based FDPM instrument. The mini-FDPM instrument with four wavelengths (681, 783, 823, and 850 nm), matches conventional FDPM instrument in performance (-88 dBm noise level, 100 dB dynamic range) and bandwi...
Article
Diffuse optical imaging (DOI) is a noninvasive optical technique that employs near-infrared (NIR) light to quantitatively characterize the optical properties of thick tissues. Although NIR methods were first applied to breast transillumination (also called diaphanography) nearly 80 years ago, quantitative DOI methods employing time- or frequency-do...
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#806 Background: Near infrared (NIR) light is sensitive to several important tissue components and has been used to detect, characterize, and monitor breast tumor functions. However, little is known about the relationship between anatomic and functional contrast derived from intrinsic optical signals. Diffuse Optical Spectroscopic Imaging (DOSI) is...
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We have discovered quantitative optical biomarkers unique to cancer by developing a double-differential spectroscopic analysis method for near-infrared (NIR, 650-1000 nm) spectra acquired non-invasively from breast tumors. These biomarkers are characterized by specific NIR absorption bands. The double-differential method removes patient specific va...
Article
A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of ab...
Conference Paper
We present a novel 3-D visualization and guidance system for handheld optical imaging devices. The system enables more accurate longitudinal studies, 3-D reconstruction of optical handheld measurements and joint analysis with other imaging modalities. Article not available.
Article
Full-text available
We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal...
Article
Full-text available
HBS is a handheld system for noninvasive breast cancer detection based on frequency domain photon migration. It performs broadband modulation on near-infrared laser intensity and derives the scattering and absorption coefficients from phase and amplitude measurements. Recovered optical properties of phantom and tissue by HBS clearly show the differ...
Article
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We report the recovery of broadband (650-1000 nm) diffuse optical absorption and reduced scattering spectra stratified by layer in a two-layer phantom. The broadband optical properties of the phantom featured top and bottom layers designed to simulate adipose and muscle, respectively. The absolute value and dynamic variation of chromophore concentr...
Article
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Diffuse optical spectroscopy (DOS) and imaging are emerging diagnostic techniques that quantitatively measure the concentration of deoxy-hemoglobin (ctHHb), oxy-hemoglobin (ctO2Hb), water (ctH2O), and lipid in cm-thick tissues. In early-stage clinical studies, diffuse optical imaging and DOS have been used to characterize breast tumor biochemical c...
Article
Differences in tissue water state have been measured in normal and malignant breast tissues. Broadband Diffuse Optical Spectroscopy (DOS) has been used to acquire 650-1000 nm absorption spectra of normal and tumor breast tissues from 7 patients in vivo. The absolute values of spectral differences between normalized tissue water spectra and pure wat...
Article
We have developed a novel D visualization and guidance system for handheld optical imaging devices. In this paper, the system is applied to measurements of breast/cancerous tissue optical properties using a handheld diffuse optical spectroscopy (DOS) instrument. The combined guidance system/DOS instrument becomes particularly useful for monitoring...
Article
Full-text available
We develop a double-differential spectroscopic analysis method for broadband near-infrared (NIR, 650 to 1000 nm) absorption spectra. Application of this method to spectra of tumor-containing breast tissue reveals specific cancer biomarkers. In this method, patient-specific variations in molecular composition are removed by using the normal tissue a...
Article
The purpose of this study is to demonstrate the feasibility of broadband diffuse optical spectroscopy (DOS) for noninvasive optical monitoring of differentiating patterns of total tissue hemoglobin (THC), oxy- (OxyHb), and deoxyhemoglobin (DeOxyHb) concentrations during hypovolemic shock and subsequent fluid replacement with saline and whole blood....
Conference Paper
Full-text available
HBS, for Handheld Breast Scanner, is a miniature medical instrument for non-invasive breast cancer detection based on the principle of frequency domain photon migration spectroscopy. It performs content-based analysis by deriving scattering and absorption coefficients from amplitude and phase differences in backscattered, broadband-modulated (10 MH...