Alan Roger Santos-Silva

State University of Campinas (UNICAMP) | UNICAMP · Departamento de Diagnóstico Oral

Introduction Certain aspects of indigenous communities, such as cultural practices and access to care, have been discussed as potential determinants of oral health. However, research on this topic remains limited. Understanding the factors influencing oral health and their perceptions is crucial for developing culturally appropriate interventions....

Purpose Oral mucositis (OM) reflects a complex interplay of several risk factors. Machine learning (ML) is a promising frontier in science, capable of processing dense information. This study aims to assess the performance of ML in predicting OM risk in patients undergoing head and neck radiotherapy. Methods Clinical data were collected from 157 p...

The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years...

Objective Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites. Materials and Methods A retrospective cohort study (2011–2021) at Instituto do Câncer do Estado de São Paulo , involving 3052 HNSCC...

Background Despite recent advancements, women still encounter significant challenges in various fields, including dentistry. However, the increasing interest in female participation in science acknowledges its fundamental role in the advancement of knowledge. This study aims to assess indicators of women's involvement in Brazilian research in the a...

Purpose This study aimed to conduct a systematic review summarizing the clinicopathological, prognostic, and molecular features of salivary gland intraductal carcinoma (SGIC). Methods This study followed the PRISMA 2020 guidelines and was registered in the PROSPERO database. It included case reports, case series studies, and cohort studies of SGIC...

Head and neck squamous cell carcinoma (SCC) predisposing factors include smoking and alcohol consumption. However, other agents have been investigated, including viruses. We aimed to investigate the presence of DNA of four different types of human polyomavirus (HPyV) in the oral cavity and oropharyngeal SCC samples from an oncology center in Brazil...

Aim: This study aims to evaluate the accuracy and readability of responses generated by two large language models (LLMs) (ChatGPT-4 and Gemini) to frequently asked questions by lay persons (the general public) about signs and symptoms, risk factors, screening, diagnosis, treatment, prevention, and survival in relation to oral cancer. Methods: The...

The present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J, and PBM 1 J. Applications for PBM occurred three...

Oral epithelial dysplasia (OED) is a potentially malignant histopathological diagnosis given to lesions of the oral cavity that are at risk of progression to malignancy. Manual grading of OED is subject to substantial variability and does not reliably predict prognosis, potentially resulting in sub-optimal treatment decisions. We developed a Transf...

Objective This study aimed to implement and evaluate a Deep Convolutional Neural Network for classifying myofibroblastic lesions into benign and malignant categories based on patch-based images. Methods A Residual Neural Network (ResNet50) model, pre-trained with weights from ImageNet, was fine-tuned to classify a cohort of 20 patients (11 benign...

Aims To develop a model capable of distinguishing carcinoma ex‐pleomorphic adenoma from pleomorphic adenoma using a convolutional neural network architecture. Methods and Results A cohort of 83 Brazilian patients, divided into carcinoma ex‐pleomorphic adenoma ( n = 42) and pleomorphic adenoma ( n = 41), was used for training a convolutional neural...

Teledentistry has emerged as a promising tool in bridging the gap in healthcare accessibility, particularly in regions like Latin America region, where resources for oral healthcare are often limited. Drawing upon a comprehensive review of literature, this overview assessed the applications and clinical outcomes of teledentistry in diagnosing oral...

Objective: This study aimed to review the current body of literature on underexplored areas of photobiomodulation (PBM) for preventing and/or treating oral adverse events. Background: Recent studies suggest that PBM may offer potential benefits in managing cancer-related toxicities other than oral mucositis. Nevertheless, further research to establ...

Introduction: Recent studies have highlighted a significant global increase in e-cigarette use, particularly among young adults. This narrative review targets the important topics related to e-cigarettes that should be introduced to dental professionals. Objective: To review current knowledge of e-cigarettes, the impact on human health and the envi...

Central odontogenic fibroma (COF) is a rare benign tumor from odontogenic mesenchyme, accounting for less than 5% of odontogenic tumors. Central giant cell granuloma (CGCG) is also benign but locally aggressive, featuring multinucleated giant cells in a fibrovascular stroma. Hybrid lesions with features of both COF and CGCG are extremely rare, with...

Head and neck cancers are a growing global health concern, with oral squamous cell carcinoma (OSCC) accounting for 90-95% of all cases within this region. OSCC near dental implants can resemble benign inflammatory lesions, posing diagnosis challenging. A 74-year-old man presented with an ulcerated, asymptomatic lesion in the upper right alveolar mu...

Objective To analyze the characteristics of a series of oral reactions to injectable soft tissue fillers. Materials and Methods Cases diagnosed as oral reactions to injectable soft tissue fillers were selected from eight Pathology laboratories. Information was retrieved from the laboratory charts and from the review of the hematoxylin and eosin‐st...

Background: The study of notable people as advocates for raising cancer awareness began in the latter decades of the 20th century. This research aimed to identify Pan-American notable people with head and neck cancer (HNC) and to explore senior health professionals’ perspectives on communicating stories of notable patients with HNC to promote preve...

Purpose Oral alterations are frequently observed in patients undergoing palliative care and are linked to the direct or indirect effects of the primary medical condition, comorbidities and medical management, leading to oral pain, impacting oral intake, and affecting quality of life. This systematic review aims to assess the prevalence of oral dise...

Objective This systematic review and meta‐analysis aimed to compare the risk of recurrence and cancer progression after surgical treatment for oral potentially malignant disorders (OPMD) and precancerous lesions in different anatomical sites. Materials and Methods A comprehensive search was conducted in nine databases and grey literature. We inclu...

Background: Oral cancer (OC) and oral potentially malignant disorders (OPMD) pose significant challenges to public health in Brazil. This study aimed to estimate the prevalence of oral cancer (OC) and oral potentially malignant disorders (OPMD) among patients who would be treated by Brazilian dentists during their careers. Material and Methods: Dat...

Pierre Fauchard, considered the father of dentistry, contributed to the development of different fields of dentistry that we know today. However, the contribution of this important individual to the fields of oral medicine and oral and maxillofacial pathology is unknown. This study aimed to identify Pierre Fauchard’s contribution to these areas of...

The objective of the present study was to investigate the frequency of oral leukoplakia and oral erythroplakia among young patients from three Brazilian reference centers in Oral and Maxillofacial Pathology. A retrospective study was carried out from 2011 to 2021 on 861 patients diagnosed with oral leukoplakia and oral erythroplakia. Demographic an...

Background: This study aimed to explore the clinical, histopathologic, and immunohistochemical characteristics of myofibromas (MFs) affecting the head and neck region. Material and methods: Formalin-fixed paraffin-embedded tissue blocks of patients diagnosed with MFs in the head and neck were retrieved from the archives of three oral and maxillo...

Pierre Fauchard, considered the father of dentistry, contributed to the development of different fields of dentistry that we know today. However, the contribution of this important individual to the fields of oral medicine and oral and maxillofacial pathology is unknown. This study aimed to identify Pierre Fauchard's contribution to these areas of...

Purpose A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the management of salivary gland hypofunction and xerostomia in cancer patients. Methods This CPS was develope...

Cancer disclosure represents a complex healthcare dynamic. Physicians or caregivers may be prompted to withhold diagnosis information from patients. This study aims to comprehensively map and synthesize available evidence about diagnosis nondisclosure regarding head and neck cancer (HNC) patients. Following the Joanna Briggs Institute guidelines, a...

Purpose This study describes a large, well-documented case series of salivary gland polymorphous adenocarcinomas (PAC) from a single Brazilian center. Methods Demographic data, clinical presentation, histopathological and immunohistochemical features from 26 cases of PAC were analyzed and discussed in detail. Results Most patients were females (n...

Objective. To assess the clinical scenarios in which nerve blocks are employed in the context of burning mouth syndrome (BMS). Study Design. This scoping review followed the PRISMA-ScR. A protocol was generated on Open Science Framework. Electronic searches were performed in the following databases: PubMed, Scopus, EMBASE, Web of Science, LILACS,...

Objective Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, a...

Objective This study evaluated the influence of a single educational intervention on the perception and knowledge of strategies for communicating oral cancer diagnoses. Methods A educational intervention, 72 dentists and 41 dental undergraduates participated in the ‘Maio Vermelho Project’, a continuing education activity. Participants completed a...

Warthin Tumor, also known as papillary cystadenoma lymphomatosum, is the second most prevalent benign parotid gland tumor, accounting for approximately 2 to 15% of all cases. A 62-year-old male patient presented with a progressively painless swelling in the lower left face region that had been developing for 4 years. During the extraoral examinatio...

Sialoliths, or sialolithiasis, are benign lesions and represent the most common cause of obstruction and swelling in the major salivary glands. We report two cases of patients attended at different dental services. In Case 1, a 49-year-old man with no comorbidities presented to the dental office with complaints of pain, fever, and swelling on the l...

Background Salivary gland cystadenoma (SGCA) is a rare benign tumor that predominantly occurs in the parotid gland. SGCAs affecting the minor salivary glands are uncommon and often resemble, clinically and histopathologically, other salivary gland lesions. Methods This study aimed to describe a series of four cases of SGCA affecting intraoral site...

Background Neural tumors are difficult to distinguish based solely on cellularity and often require immunohistochemical staining to aid in identifying the cell lineage. This article investigates the potential of a Convolutional Neural Network for the histopathological classification of the three most prevalent benign neural tumor types: neurofibrom...

Background The purpose of this systematic review (SR) is to gather evidence on the use of machine learning (ML) models in the diagnosis of intraosseous lesions in gnathic bones and to analyze the reliability, impact, and usefulness of such models. This SR was performed in accordance with the PRISMA 2022 guidelines and was registered in the PROSPERO...

The dental treatment of patients with oral cavity and oropharyngeal squamous cell carcinoma (OOPSCC) may be challenging for dentists. This study aimed to characterize systemic changes in patients with OOPSCC undergoing dental treatment prior to cancer therapy, with a specific focus on laboratory assessments. The primary objectives included identify...