Alan Dogan

Alan Dogan
Case Western Reserve University | CWRU · Department of Biomedical Engineering

Master of Science

About

7
Publications
796
Reads
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71
Citations

Publications

Publications (7)
Article
Full-text available
While peptide and protein therapeutics have made tremendous advances in clinical treatments over the past few decades, they have been largely hindered by their ability to be effectively delivered to patients. While bolus parenteral injections have become standard clinical practice, they are insufficient to treat diseases that require sustained, loc...
Article
Full-text available
As the prevalence of age-related fibrotic diseases continues to increase, novel antifibrotic therapies are emerging to address clinical needs. However, many novel therapeutics for managing chronic fibrosis are small-molecule drugs that require frequent dosing to attain effective concentrations. Although bolus parenteral administrations have become...
Article
Machine learning have been widely adopted in a variety of fields including engineering, science, and medicine revolutionizing how data is collected, used, and stored. Their implementation has led to a drastic increase in the number of computational models for the prediction of various numerical, categorical, or association events given input variab...
Preprint
Full-text available
Face masks have been proven to be medicine’s best public health tool for preventing transmission of airborne pathogens. However, in situations with continuous exposure, lower quality and “do-it-yourself” face masks cannot provide adequate protection against pathogens, especially when mishandled. In addition, the use of multiple face masks each day...
Article
Small-molecule drugs are utilized in a wide variety of clinical applications, however, many of these drugs suffer from one or more suboptimal property that can hinder its delivery or cellular action in vivo, or even shelf an otherwise biologically tolerable drug. While high-throughput screening provides a method to discover drugs with altered chemi...
Article
Polymers that are refillable and sustain local release will have a great impact in both preventing and treating local cancer recurrence as well as addressing non-resectable disease. Polymerized cyclodextrin (pCD) disks, which reload drug into molecular "pockets" in vivo using affinity interactions, have previously shown to localize doxorubicin (Dox...
Article
Full-text available
Large doses of chemical pesticides are required to achieve effective concentrations in the rhizosphere, which results in the accumulation of harmful residues. Precision farming is needed to improve the efficacy of pesticides, but also to avoid environmental pollution, and slow-release formulations based on nanoparticles offer one solution. Here, we...

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