Alan B Copperman

• Reproductive Medicine Associates of New York

Purpose: This longitudinal study compared the presence of information about gender-affirming care (GAC) on U.S. pediatric hospital websites in March 2022, when bans on the provision of pediatric GAC had been passed in two states, versus in October 2023, when bans had been passed in 22 states and implemented in 15 states without court blockage. Meth...

Purpose: In 2021, New York State passed legislation that eliminated the requirement that same-sex female couples needed up to 12 months of intrauterine insemination with donor sperm to meet the medical definition of infertility and qualify for insurance coverage. This study compared the duration of time from consultation to utilization of in vitro...

Objective: Utilization of fertility preservation treatments has increased since the American Society for Reproductive Medicine lifted the "experimental" label for oocyte cryopreservation in 2012. This study characterizes changes in insurance coverage, clinical outcomes, and live birth probabilities over a span of a decade (2012-2022) in patients wh...

Purpose This study is to evaluate duration of oocyte cryostorage and association with thaw survival, fertilization, blastulation, ploidy rates, and pregnancy outcomes in patients seeking fertility preservation. Methods Retrospective cohort study to evaluate clinical outcomes in patients who underwent fertility preservation from 2011 to 2023 via oo...

Purpose: The objective was to evaluate whether the mid-luteal progesterone (MLP) assessment in same-sex female couples benefits clinical outcomes in natural cycles using donor sperm intrauterine insemination (IUI). Methods: This retrospective cohort study included same-sex female couples undergoing donor sperm IUI from January 2004 to April 2022. C...

Purpose To evaluate the association between spironolactone use and controlled ovarian hyperstimulation (COH) outcomes. Methods Retrospective study, including patients who underwent COH. Oocyte yield and maturation rates were compared by categories of spironolactone use at the start of their cycle. Results 402 patients were included. 83 patients c...

Purpose Determine if the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes are bidirectionally influenced by co-culture during in vitro maturation (IVM). Methods Fertility patients aged 25 to 45 years old undergoing conventional ovarian stimulation donated denuded immature oocytes for research. Oocytes were randomly...

Introduction. Fertility-related concerns cause significant anxiety among patients with Hereditary Breast and Ovarian Cancer Syndrome (HBOC). The Society of Gynecologic Oncology and the American Society for Reproductive Medicine recommend patients diagnosed with HBOC receive early referral to a reproductive endocrinologist. However, evidence about f...

Objective: To assess whether the change in embryo morphology from precryopreservation to postthaw is associated with the embryo transfer success rates in single euploid embryo transfer cycles. Design: Retrospective cohort study. Setting: Academic affiliated fertility clinic. Patient(s): Patients who underwent a single euploid embryo transfer cycle...

To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds. This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with pre...

Objective To evaluate fertility treatment outcomes among transgender (TG) men with a history of gender-affirming hormone therapy with exogenous testosterone. Design Descriptive, retrospective cohort study. Patients Transgender men with a history of gender-affirming hormone therapy with exogenous testosterone underwent fertility treatments, includ...

OBJECTIVE: The prevalence of embryo mosaicism does not seem to be determined by the same rules that govern embryo aneuploidy, as it is neither associated with meiotic errors nor maternal age. Recent publications found higher mosaicism rates in patients with severe male factor infertility, although the underlying biological mechanism remains unknown...

Purpose What is the rate of euploidy and clinical viability of embryos resulting from micro 3 pronuclei zygotes? Methods Retrospective cohort analysis in a single, academic in vitro fertilization (IVF) center from March 2018 to June 2021. Cohorts were separated by fertilization as either a 2 pronuclear zygote (2PN) or micro 3 pronuclear zygote (mi...

Study question: Do infertile couples who recently utilized clomiphene citrate (CC) for ovulation induction or ovarian stimulation (<90 days previously) followed by a single euploid embryo transfer (SEET) have lower implantation potential compared with patients who were not exposed to CC within 90 days before embryo transfer (ET)? Summary answer:...

Preeclampsia is a heterogeneous and complex disease associated with rising morbidity and mortality in pregnant women and newborns in the US. Early recognition of patients at risk is a pressing clinical need to reduce the risk of adverse outcomes. We assessed whether information routinely collected in electronic medical records (EMR) could enhance t...

Objective: To assess whether open and minimally invasive myomectomy are associated with changes in postoperative ovarian reserve as measured by serum anti-müllerian hormone (AMH) level. Methods: This prospective cohort study included patients who were undergoing open abdominal myomectomy that used a tourniquet or minimally invasive (robot-assist...

We characterize the clinical utility and economic benefits of a comprehensive pan-ethnic carrier screening panel that spans 282 monogenic disease conditions in a large, diverse population of 397,540 reproductive health patients. For 142,049 of these patients, we were able to accurately estimate genetic ancestries across 7 major population groups. W...

Objective To explore cycle characteristics and outcomes of single and coupled intended fathers using assisted reproductive technology. Design Cross-sectional study. Setting Multi-center, fertility practices in the U.S. from 2016-2021. Patient(s) In this study, cycles among single and coupled intended fathers with access to fertility coverage fro...

Research Question Can we develop an interpretable machine learning model that optimizes starting gonadotropin dose selection in terms of mature oocytes (MIIs), fertilized oocytes (2PNs), and usable blastocysts? Design This is a retrospective study of patients undergoing autologous IVF cycles from 2014 - 2020 (n=18,591) in 3 assisted reproductive t...

Study question What is the expected benefit of using a machine learning model for predicting the optimal starting dose of gonadotropin during ovarian stimulation? Summary answer Patients who had an optimal starting gonadotropin dose had improved outcomes and used significantly less total FSH compared to propensity matched patients who did not. Wh...

Study question What is the combined expected benefit of using machine learning algorithms to optimize the starting gonadotropin dose and day of trigger during ovarian stimulation? Summary answer Patients who had an optimal starting dose and optimal day of trigger had significantly improved outcomes compared to propensity matched patients who did n...

Study question What is the expected benefit of using a machine learning model for predicting the optimal day of trigger during ovarian stimulation? Summary answer Patients who had an optimal day of trigger had improved outcomes compared to propensity matched patients who were triggered late or early. What is known already The timing of the final...

Objective To analyze the correlation between TE grading and initial β-hCG serum level after single euploid embryo transfer. Secondarily, to explore the association between TE grading with subsequent IVF outcomes. Design Retrospective cohort analysis. Setting Single, academic, private infertility and assisted reproductive care institute. Patients...