Alakbar Huseynzada

Alakbar Huseynzada
Baku State University | BSU · Department of Chemistry

Master of Science

About

32
Publications
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123
Citations

Publications

Publications (32)
Article
The lack of information about the chemical composition and structure of asphaltenes in crude oil, which has a sufficient share in the economy of Azerbaijan, complicates its processing and use. As a first attempt, this research is devoted to the detailed analysis of the average molecular structure and properties of asphaltenes isolated from crude oi...
Article
Full-text available
We herein report the determination of the cytotoxic activity and expression profiles of some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The studied novel compounds were synthesized by a condensation reaction and received compounds were characterized by 1 H and 13 C NMR spectroscopy methods. Furthermore,...
Article
This study is devoted to the synthesis of various ensembles on the basis of graphene oxide nanolayers and dihydropyrimidines and the investigation of their antimicrobial activity. The “building blocks” of ensembles, viz dihydropyrimidines were synthesized by the Biginelli reaction in the presence of low-toxic copper triflate under microwave conditi...
Article
This study is devoted to the synthesis of a 40-membered macroheterocycle with its further nanostructuring by magnetite nanoparticles. The mentioned macroheterocycle was synthesized by the [2+2] cyclocondensation of the oxygen-containing...
Article
We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy-two-membered macroheterocyclic compounds and the investigation of their activity against the neuroblastoma cell line. The synthesis of targeted compounds was done by condensation of dialdehydes with polyamines and their structures were investigated by...
Article
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Herein, we report the preparation of methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylate 2, obtained by the regioselective oxidative dehydrogenation of the dihydropyrimidine derivative 1 in the presence of cerium ammonium nitrate. The structure of compound 2 was investigated by single-crystal X-ray diffraction (SC-XRD), whic...
Article
Full-text available
Objective: Cancer arises as a result of the failure of the mechanisms controlling normal division in a group of cells. It is known that some new synthesis compounds intended for use in cancer treatment have anti-fungal, anti-bacterial, anti-carcinogenic effects. In this study, it was aimed to apply the newly synthesized B-108 compound to the A-549...
Article
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Objective: Lung cancer is one of the most common cancers in the world. It is known that angiogenesis plays a role in the development and metastasis of lung cancer. The anticancer properties of azomethine derivatives known as Schiff bases have been demonstrated. In this study, we aimed to determine the anticancer activity of the newly synthesized az...
Article
The main aims of anticancer drug development studies is to reduce the toxicity of the developed compound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, scientists have accelerated their research on new molecules with anticancer activity. In recent years, new drugs containing the azomet...
Article
We herein reported the synthesis of dihydropyrimidines 1 and 2 on the basis of nitro and brominated salicylaldehyde derivatives by Biginelli reaction in microwave conditions in the presence of cheap low toxic copper triflate. The structures of both compounds were investigated by the X-ray single-crystal diffraction method. The presence of non-coval...
Article
We report herein the synthesis of a new biologically active 3,4-dihydropyrimidin-2(1H)-thione derivative (4) from 9-phenanthrenecarboxaldehyde, thiourea, and methyl acetoacetate by the Biginelli reaction. The structure of the synthesized compound was investigated by NMR spectroscopy, mass spectrometry, and elemental analysis. Moreover, to gain insi...
Article
We report herein the synthesis of new derivatives of dihydropyrimidine on the basis of 2,4,6-trimetoxybenzaldehyde, which was further regioselectively oxidized in the presence of cerium ammonium nitrate (CAN) with the formation of 5-acetyl-6-methyl-4-(2,4,6-trimethoxyphenyl)pyrimidin-2(1H)-one. The structures of both novel compounds were investigat...
Article
Full-text available
Correction for ‘Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products’ by Alakbar E. Huseynzada et al. , RSC Adv. , 2021, 11 , 6312–6329, DOI: 10.1039/D0RA10255E.
Article
Full-text available
The syntheses and investigations of new biologically active derivatives of dihydropyrimidines by Biginelli reaction in the presence of copper triflate are reported. Due to the fact that salicylaldehyde and its derivatives under Biginelli reaction conditions can lead to the formation of 2 types of dihydropyrimidines, the influence of copper triflate...
Article
Full-text available
The nanostructuring of hydroxyl-substituted diazacrown-ether (DC) by silver nanoparticles was obtained by green synthesis method in order to increase the antibacterial activity of silver nanoparticles. The synthesized DC, nanoparticles, and nanosupramolecular complex (Ag@DC) were studied by TEM, powder-XRD, and NMR, IR, and UV spectroscopy methods....
Article
Full-text available
1942 Азасахара или иминосахара, как класс орга-нических соединений с атомом азота в цикле, являются предметом пристального интереса в настоящее время [1-3]. Причина этого заключается в том, что исследования позволили обнаружить ин-тересную структурную особенность данного класса соединений. Было установлено, что незначите-льное перемещение азота в п...
Article
Full-text available
New (S)‐(1,2,3,6‐tetrahydropyridazin‐3‐yl)methanol was synthesized by Lewis acid catalyzed and self‐assembled Diels‐Alder (LACASA‐DA) cycloaddition reaction using (S)‐BINOL as a chiral inductor. The N‐2 pyridazine position was protected, the hydroxyl group was carbonylated to form the new bicyclic structure. The protective group was removed and the...
Article
Full-text available
(S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol was synthesized in two steps by the Diels-Alder reaction of penta-2,4-dien-1-ol with diethyl azodicarboxylate in the presence of (S)-BINOL as chiral catalyst. The subsequent Boc-protection of the 2-position of the pyridazine ring, ring-closing carbonylation of the hydroxy group, and deprotection afford...
Conference Paper
Full-text available
İminoşekerlerin yeni bisiklik iminoşeker türevleri optikçe saf (S)-(1,2,3,6-tetrahidropiridazin-3il)metanol molekülü baz alınarak yüksek verimlerde sentezlenmiştir. Sentezlenen bileşenlerin S.aureus, E.coli ve Ps.aeruginosa’ ya karşı aktiviteleri incelenmiştir.
Article
Full-text available
C 21 H 25 NO 8 , P 2 1 / n , (no. 14), a = 12.905(3) Å, b = 13.370(3) Å, c = 13.090(3) Å, β = 118.19(3)°, V = 1990.5(8) Å ³ , Z = 4, Rgt ( F ) = 0.0629, wRref ( F² ) = 0.1966, T = 100(2) K.
Article
Full-text available
In this paper is reported the synthesis of new derivative of pyrrolo-pyridine condensed heterocycle that might reveal biological activity, similar to nootropic effects. The 4,6-dimethyl-2-(2-oxyethyl)-1,2-dihydro-3H-pyrrolo[3,4-C]pyridine-3-one was synthesized by reaction of ethyl 2,6-dimethyl-4-(chloromethyl)pyridine-3-carboxylic acid with ethanol...

Questions

Questions (2)
Question
I have performed the nitration of 2-hydroxy-5-nitrobenzaldehyde in various conditions (for example, in the presence of sulphuric acid or acetic acid). However, in all cases, the precipitate that I received at the end of the reaction was an initial compound (2-hydroxy-5-nitrobenzaldehyde). Which methodology should I use?
Question
Hi. I am looking for someone who can give tuition in Hirshfeld surface analysis and crystal structure determination by single-crystal XRD. Is there anyone who can help me?

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