Alain Morejón Calderón ஃCentro Nacional de Biopreparados | BioCen · Grupo de Ensayos Biológicos
Alain Morejón Calderón ஃ
Master en Patología Veterinaria
About
20
Publications
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Introduction
Alain Morejón Calderón ஃ currently works at the Grupo de Ensayos Biológicos, Centro Nacional de Biopreparados. Alain does research in Allergology, Pathology and Veterinary Medicine. Their current project is 'biomodelos murinos para alergia respiratoria y Alzheimer'.
Skills and Expertise
Additional affiliations
May 2015 - present
June 2017 - May 2020
April 2010 - May 2017
Education
March 2010 - June 2014
September 2001 - July 2006
Publications
Publications (20)
Introduction: The second generation anti allergic vaccine named PROLINEM DS is based on allergens from D. siboney house dust mite and a combination adjuvant containing PL and Alum. Allergen adsorption is relevant both safety and clinical efficacy in alum-adsorbed vaccines. Negative influence of phosphate ions on allergen adsorption was demonstrated...
Introducción:
La vacuna antialérgica de segunda generación PROLINEM-DS está compuesta por alérgenos del ácaro Dermatophagoides siboney y la combinación de adyuvantes: proteoliposoma de N. meningitidis B y gel de hidróxido de aluminio. La adsorción del alérgeno es relevante para la seguridad y eficacia clínica de las vacunas adsorbidas en gel de hid...
Introducción:
El ácaro del polvo doméstico Blomia tropicalis (Bt) es un agente etiológico importante del asma alérgica en zonas tropicales, que se distingue sustancialmente del género Dermatophagoides, más común globalmente. El objetivo de este trabajo fue evaluar las propiedades inmunobiológicas de los alergenos de Bt.
Métodos:
Se emplearon alérg...
Airway obstruction with increased airway resistance in asthma, commonly caused by smooth muscle constriction, mucosal edema and fluid secretion into the airway lumen, may partly be due to a poor function of pulmonary surfactant. Surfacen®, a clinical pulmonary surfactant, has anti-inflammatory action, but its effect on asthma has not been studied....
http://www.immunovaccipharmacuba.com
RESUMEN Durante los últimos 20 años BioCen ha desarrollado una línea de antianémicos y suplementos nutricionales que contienen hierro (Fe) en forma hemínica, los cuales han demostrado una elevada eficacia en la prevención y el tratamiento de la anemia, sin que se reporten las reacciones adversas comúnmente observadas en los preparados que contienen...
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive multifactorial disease with limited treatment options.
RESUMEN El objetivo de este trabajo fue analizar la respuesta celular pulmonar de los grupos de ratones inmunizados con diferentes formulaciones de una vacuna antialérgica respecto a los controles. En este modelo se utilizó en total 240 ratones BALB/c/cenp, distribuidos en seis grupos (placebo, control de la respuesta alérgica, vacuna antialérgica...
Introduction: the physiological process leading to nutritional iron deficiency anemia involves the depletion of mineral deposits, a decrease in the supply of iron for erythrocyte synthesis, and finally a reduction in the concentration of blood hemoglobin. Some studies have shown increased tissue susceptibility to oxidative damage in iron deficiency...
Allergen adsorption onto alum is relevant for safety and immunogenicity of alum- adjuvanted allergen vaccines, used for subcutaneous immunotherapy. Adsorption of the Group 1 Mite allergens can be impaired by phosphate buffers. On the other hand, diminishing or abolishing buffer salts can affect long term stability. Alum content can also influence i...
The anti allergic vaccine PROLINEM-DS is based on purified allergens from Dermatophagoides siboney and the combination adjuvant AFPL1®
containing a TLR-4 ligand and alum. This new product is intended to provide a treatment or preventative intervention of allergic disease using
fewer injections than with conventional allergen vaccines. In previous s...
La extensa actividad científica centrada en el asma es un indicador obvio de la importancia del problema. Este estudio se realiza con el objetivo de comprobar la funcionalidad de un modelo de murino de alergia respiratoria, desarrollado en BioCen, que emplea ratones BALB/c/cenp. Este modelo se destina al estudio de la inmunogenicidad de vacunas ant...
Allergy 2013 68(s97):498
Background: Although specific immunotherapy (SIT) is actually the only etiological treatment for allergic disorders, the underlying mechanism is still not fully understood. SIT induces changes in lymphocyte Th subsets from Th2 to Th1-Treg profile. This study aim to analyse the changes occurred in the main T cell subsets dur...
Influence of phosphate salts and alum content on to the immunogenicity of a Dermatophagoides siboney AFPL1-adjuvanted vaccine
Roxana Samalea (1), Wendy Ramírez (1), Beatriz Tamargo (2), Dámaris Torralba (1), Alain Morejón (1), Deibbys Martínez (1), Arelis Más (1), Yunia Oliva (1), Juan Francisco Infante (3), Alexis Labrada (1).
National Center of...
A MURINE MODEL OF ALLERGIC RESPIRATORY INFLAMMATION PROVOKED BY Dermatophagoides siboney ALLERGENS AS A TOOL FOR PRECLINICAL EVALUATION OF THERAPEUTIC ANTIALLERGIC VACCINES
Virgilio Bourg, Carlos Alemán, Bárbara González, Laudelina Lazo, Leonela Huergo, Alain Morejón, Wendy Ramírez and Alexis Labrada.
Nacional Center of Bioproducts, Havana 10600,...
