Alaaeldin A. HamzaNational Organization for Drug Control & Research | NODCAR · Biology Department
Alaaeldin A. Hamza
Professor in Physiology
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About
127
Publications
39,158
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2,739
Citations
Citations since 2017
Introduction
AWARDS
I have been ranked among the top scientists in United Arab Emirates institutions according to GSC public profiles since 2017–2023, and
The Best Research Award, The 9th Annual Research Conference, U.A.E. University, Al-Ain. April 21–23, 2008.
Recognized as one of the best reviewers in Elsevier (2011).
I am a member of the Medical Research Council, specialized scientific councils, and the National Committee for Biochemistry and Molecular Biology of the Egyptian Academy of Scientific Resear
Additional affiliations
January 2019 - March 2020
January 2018 - February 2019
January 2011 - present
Position
- The isolation and identification of the chemical components of some UAE plants and their use as potential anti cancer agents
Description
- The purpose of this project is concentrated at the chemical investigation of major components and the anti-cancer of some UAE plants and its sub-fractions against cultured human breast and colon cancer cells.
Education
June 2000 - June 2003
Cairo University, Cairo, Egypt
Field of study
- Animal Physiology, Zoology Department, Faculty of Science
May 2000 - May 2003
Independent Researcher
Field of study
Publications
Publications (127)
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies, with continuously increasing cases and fatalities. Diagnosis often occurs in the advanced stages, confining patients to systemic therapies such as sorafenib. Sorafenib (SB), a multi-kinase inhibitor, has not yet demonstrated sufficient efficacy against advanced HCC. There is...
Cisplatin (CIS) is a broad-spectrum anti-carcinogen that causes cytotoxic effects both in normal and cancer cells. The purpose of this study was to test whether Hibiscus sabdariffa (HS) extract can reduce CIS-induced hepatotoxicity in rodents and to assess its anticancer activity in vitro. Treatment with HS extract at daily doses of 500 mg/kg befor...
Background
Ketoconazole (KET) is a broad-spectrum antifungal drug that has been reported to induce hepatotoxicity in humans and animals.
Methods
The safe guarding response of Gentiana extract (GEN) against KET-induced hepatotoxicity was investigated in this study using male Wistar rats. GEN ethanol extract was orally administered to rats (1 g/kg b...
Introduction: Metal nanoparticle synthesis using plant has emerged as an eco-friendly, clean, and viable strategy alternative to
chemical and physical approaches.
Methods: The fruit extract of Salvadora persica (SP) was utilized as a reducing and stabilizing agent in the synthesis of gold (AuNPs)
and copper (CuNPs) nanoparticles.
Results: UV–Vis sp...
I have been ranked among the top 2% of researchers in the world by Stanford University, within the top 2% of scientists of their main subfield 2022. My Ranking in toxicology was 424, in pharmacology was 376 and in Physiology (Clinical medicine) was 36807.
I have been ranked among the top 2% of researchers in the world by Stanford University, within the top 2% of scientists of their main subfield 2022. My Ranking in toxicology was 424, in pharmacology was 376 and in Physiology (Clinical medicine) was 36807.
Member in National Committee for Biochemistry and Molecular Biology, Egyptian Academy of Scientific Research and Technology. 1-6-2022-until now.
• Academic Editor for Asian Journal of Case Reports in Endocrinology 15-2-2018-14-2-2022
Reviewer for Journal of Biochemical and Molecular Toxicology
Naturally occurring phytochemicals especially polyphenolic compounds have received increasing attention as chemopreventive agents. The chemopreventive potential of the ethanolic extract of Salvadora persica L. fruits SP, (the arak tree or miswak) on 7,12-dimethylbenz (a) anthracene (DMBA)-induced mammary carcinogenesis in female albino rats was inv...
Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural products and their derived biomolecules are potential resources to mine for novel anti-cancer drugs. Chemopreventive effects of safranal, a major bioactive ingredient of the golden spice "saffron", were evaluated in this study against diethylnitrosamine (...
Background
The therapeutic value of doxorubicin as an effective anti-neoplastic agent is limited by its cardiotoxic side effects. We investigated the effects of ethanolic leaf extracts of olive leaf OL on cardiotoxicity as well as oxidative stress which was induced by doxorubicin (DOX) in Wistar rats. The cardiotoxicity was induced by intraperitone...
I was classified in 2021 according to AD Scientific Index ranking of the top scientists (78) in United Arab Emirates University.
I was accepted as a member of the Medical Research Council, which is one of the Council, Specialized scientific councils, at Egyptian Academy of Scientific Research and Technology.
I was classified in 2021 among the top 2% of scientists in the world according to the Stanford. My classification order was 524 in toxicology and 454 in pharmacology and in physiological (medical Science) No 53247
Editorial Board member for Journal of Exploratory Research in Pharmacology 2021
The "Lifetime Achievement Award" in the International Scientist Awards on Engineering, Science, and Medicine 2021. From VDGOOD PROFESSIONAL ASSOCIATION, India.
Ginger has been proposed as quite a promising candidate for cancer prevention. The purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this study investigated the possible mechanisms of a standardized extract drawn from the rhizomes of ginger against diethylnitrosamine (DEN)-induced liver cancer in Wistar rats....
Objective:
This study evaluated hepatoprotective effect of aescin (AES) and diosmin (DIO), individually or in low-dose combination in chemically induced liver injury in rats. Rats were divided into 6 groups; Group 1, control, Group 2, injected with a single dose of a mixture of corn oil and carbon tetrachloride (CCl4) to induce hepatic toxicity. B...
Hawthorn (HAW) is a herbal preparation extracted from Crataegus oxyacantha. HAW has cardioprotective, antioxidants, anti-inflammatory, and anti-hypotensive effects. HAW’s effect on hepatic fibrosis remains, however, unknown. This study evaluated the impact of HAW on carbon tetrachloride (CCl4)-induced hepatic fibrosis in rats and elucidated its mec...
I have been ranked among the top 2% of researchers in the world by Stanford University, within the top 2% of scientists of their main subfield 2020. My Ranking in toxicology was 907, in reproductive medicine was 762 and in Physiology (Clinical medicine) was 45124
Objectives
This study aimed to explore the pharmacological properties of pinoresinol‐4‐O‐β‐D‐glucopyranoside (PG), isolated from prunes.
Methods
In‐vitro antioxidant activity was assessed using ferric reducing antioxidant power (FRAP) and 2,2'‐azino‐bis [3‐ethylbenzothiazoline‐6‐sulfonic acid]‐diammonium salt (ABTS) assays. In‐vivo hepatoprotectiv...
Background
Liver fibrosis is the main contributor to the chronic liver-associated morbidity and mortality.
Purpose
The study was conducted to evaluate the effects of whole plant powder of dandelion ( Taraxacum officinale ) on liver fibrosis.
Methods
Liver fibrosis was induced by the oral administration of 20% carbon tetrachloride (CCL4), twice a...
Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Safranal(SAF), an essential oil derived from saffron, possesses a potent antioxidant, anti-apoptotic and anticancer properties. The current study aimed to investigate the protective effect and underlying mechanisms of SAF on the hepatotoxicity induced by VPA. SAF at the dose of...
Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Safranal(SAF), an essential oil derived from saffron, possesses a potent antioxidant, anti-apoptotic and anticancer properties. The current study aimed to investigate the protective effect and underlying mechanisms of SAF on the hepatotoxicity induced by VPA. SAF at the dose of...
Bioassays are methods employed to estimate the effect of a given substance in living matter, and therefore they are frequently used in the pharmaceutical industry. Bioassays are a vital part of the overall assessment of a product's efficacy, safety, lotto lot consistency and stability. These more complex entities can challenge the developer of the...
Member in National Committee for Biological Science. Egyptian Academy of Scientific Research and Technology.
This study was designed to assess whether the protective effects of bone marrow-derived mesenchymal stem cells (MSCs) against diabetes could be enhanced by pioglitazone (PIO), a PPARγ agonist. Combined MSCs and PIO treatments markedly improved fasting blood glucose, body weight, lipid profile levels, insulin level, insulin resistance, β cell functi...
Certificate of Joining as Academic Editor for Asian Journal of Endocrinology
The purpose of this study was to investigate the anti-cancer property of grape seed extract (GSE) during early stages of developing liver cancer using a two-stage carcinogenic model combining diethylnitrosamine (DEN) and acetylaminofluorene. Administration of GSE at doses 25, 50 and 100 mg/kg per day started at the beginning of promotion periods an...
The 6th International Conference of Pharmaceutical & Drug Industries Research Division Under the theme Research and Development in Drug Industry with The Sustainable Development Goals of Egypt Vision 2030 National Research Centre Cairo, Egypt October 23-24 2017
Cardiotoxicity is a limiting factor of doxorubicin (DOX)-based anticancer therapy. Due to its beneficial effects, we investigated whether standardized extract of Melissa officinalis (MO) can attenuate doxorubicin-induced cardiotoxicity and can potentiate the efficacy of DOX against human breast cancer cells. MO was administered orally to male albin...
Cardiotoxicity is a limiting factor of doxorubicin (DOX)-based anticancer therapy. Due to its beneficial effects, we investigated whether standardized extract of Melissa officinalis (MO) can attenuate doxorubicin-induced cardiotoxicity and can potentiate the efficacy of DOX against human breast cancer cells. MO was administered orally to male albin...
Cisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widely employed anticancer agents in treating various solid tumors including prostate cancer. Since heme-oxygenase-1 (HO-1) is a cytoprotective enzyme with anti-oxidative stress, anti-inflammatory...
The angiogenesis inhibitor, sorafenib, remains the only available therapy of the poorly diagnosed hepatocellular carcinoma (HCC). Only recently patents of VEGF receptors-3 inhibitors are developed.; hence,Thus, a novel approach against HCC is essential for a better therapeutic outcome. Saffron and its active constituents were reported to have anti-...
Oxidative stress is involved in the development and progression of diabetic complications. Salvia fruticosa was reported to have a protective action against oxidative stress. In the present study, diabetes was induced in male Wister rats using streptozotocin (60 mg/ kg body weight). Diabetic rats exhibit not only the symptoms of diabetes like the l...
Hepatic injury is a dose-limiting side effect of sodium valproate (VPA), a common used drug in the management of numerous nurological disorders, including epilepsy. The present study was designed to investigate the effect of Apium Grafionalies (AG) and Rosmarinus officinalis (RO) against VPA-induced liver injury. Hepatic toxicity was induced by the...
Background:
The angiogenesis inhibitor, sorafenib, remains the only available therapy of hepatocellular carcinoma (HCC). Only recently patents of VEGF receptors-3 inhibitors are developed. Thus, a novel approach against HCC is essential for a better therapeutic outcome.
Objective:
The aims of this study were to examine the chemopreventive action...
Aim
Besides a cholesterol-lowering effect, rosuvastatin (RUV) possesses antioxidant and anti-inflammatory properties. The present study investigates the possible protective effects of RUV in diabetes-induced reproductive damage in rats.
Main methods
Diabetes was induced in male Wistar rats by injecting a single dose of streptozotocin (65 mg/kg, i.p...
Cisplatin (CIS) provides oxidative stress and inflammations in testicular tissues. Fenugreek seed extract (FSE) is a widely used herbal medicine with potent antioxidant and anti-inflammation properties. The purpose of this study was to investigate the protective effects and the possible mechanisms of FSE against CIS-induced testicular damage in rat...
One therapeutic approach for decreasing postprandial hyperglycemia is to delay absorption of glucose by inhibition of α-glucosidase. Polyphenol-rich extracts from thirteen widely used traditionally anti-diabetic plants in Asia and Mediterranean regions were evaluated for their potential α-glucosidase inhibitory activity. Among the evaluated plants,...
Leptadenia pyrotechnica has been commonly used traditionally for the treatment of tumors in Gulf countries.
However, the molecular mechanism of the anti-cancer activity of Leptadenia pyrotechnica remains unclear. In the present study, 80% ethanolic extract of Leptadenia pyrotechnica and its fractions (n-hexane, EA, n-butanol and aqueous) were evalu...
Importance of Open Access for Pharmacological Researchers in
Developing Countries
Alaaeldin A. Hamza*
Faculty of Science, Department of Biology, UAE University, UAE
I am an Egyptian biologist and a researcher in a UAE University
and the online availability of the latest pharmacological and medical
literature through my university’s subscription ha...
Abstract Isotretinoin (Iso) is a widely used retinoid for the treatment of dermatologic conditions. Although it has broad side effects, there is no well-designed study about preventive effects against its hepatic toxicity. This study was undertaken to evaluate the protective effect of selenium (Se) against Iso -induced hepatotoxicity in Wistar rats...
Phytochemicals have been of great interest as a source of natural antioxidants used for health
promotion, food preservation, food flavoring and cosmetics. In this research, alcoholic extract
from Caralluma arabica and different solvent fractions were evaluated for their antioxidant, anti-
inflammatory and anti-cancer properties as well as their pol...
Workshop on ‘Proteomics: Drug Targets and Biomarkers Discovery” Biotechnology Center for Services and Research, Cairo University , 13-15 May 2014.
Ketoconazol (KET) is an antifungal drug with a broad spectrum of activity. KET was found to induce reproductive toxicity in human and animals. The protective effect of Gentiana extract (GEN) (Gentiana lutea) against KET–induced testicular damage was evaluated in male Wistar rats. GEN was administered orally (one gm/kg b.wt) for 26 days. Three weeks...
Effect of Solvents on the Antioxidant and Phytochemical Characteristics of Extracts from Salvia libanotica
ABSTRACT
Antioxidants are powerful in combating inflammation and lowering heart disease and cancer risk. They are promising therapeutic agents for treating wide spectrum of human diseases. In this study, the antioxidant activities of extract...
Background/Question/Methods
Traditional uses of native plant species have not been well documented, especially in desert areas. As conservation measures of such floral species will not only be important as an ecological resource but also as a medicinal heritage. Acridocarpus orientalis (locally known as Qafas) is a good example of such a traditio...
Acridocarpus orientalis (AO) is a traditional medicinal plant used for treatment of inflammatory diseases that may have potential in cancer treatment. In the present study, the aqueous ethanolic crude extract of Acridocarpus aerial parts obtained from Al Ain and Oman were evaluated for their antioxidant capability, polyphenolic content, anti-lipoxy...
Abstract: In this research, alcoholic extract from Calotropis procera (Ait) R. Br. and different solvent fractions were evaluated for their antioxidant, anti-inflammatory and anti-cancer properties as well as their polyphenolic compositions. The total antioxidant property was estimated by the ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2...