About
52
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Introduction
Akwasi Acheampong currently works at the Department of Chemistry, Kwame Nkrumah University Of Science and Technology. Akwasi does research in Analytical,
Pharmaceutical, Medicinal and Organic Chemistry. Projects-'1. Development of HPLC methods for simultaneous estimation of APIs in multi-component drugs.' 2. Determination of antimicrobial, antioxidant, anti-inflamatory properties of plant extracts and isolates, purification and elucidation of the chemical structures of the active ingredients.
Additional affiliations
June 2006 - present
Position
- Professor (Associate)
Description
- Lectures in Organic and Analytical Chemistry. Researches in Analytical, Organic, and Pharmaceutical Chemistry
February 2006 - September 2008
Position
- Lecturer
Description
- Taught Organic Chemistry and drug analysis practicals
Position
- Teacher
Education
September 2008 - November 2011
September 2008 - July 2011
September 2001 - June 2004
Publications
Publications (52)
Acetylsalicylic acid and paracetamol are often formulated together in combination with caffeine, an adjuvant, for the relief of pain, fever and inflammations. A new RP-HPLC method with PDA detection has been developed and validated for the simultaneous estimation of acetylsalicylic acid, paracetamol and caffeine in fixed dose combination tablets. A...
Tubers play a significant role in human diet. Samples of tubers were obtained from five different markets from Kumasi. Pulvurised samples were digested with concentrated nitric acid. Heavy metals Zn, Fe, Cu and Cd were analysed using Atomic Absorption Spectroscopy in four tubers which include yam, cassava, cocoyam and sweet potatoes. The metals wer...
A new simple strategy to identify triacylglycerols (TAGs) in oils and fats was performed using on line coupling of non aqueous reversed phase chromatography-electrospray ionization-mass spectrometry (NARP-LC-ESI-MS(2)) with silver nitrate (AgNO(3)) as post-column additive, and chromatographic data (partition number information and both the graphs o...
The kinetic method was applied to differentiate and quantify mixtures of regioisomeric triacylglycerols (TAGs) by generating and mass selecting alkali ion bound metal dimeric clusters with a TAG chosen as reference (ref) and examining their competitive dissociations in a quadrupole ion trap mass spectrometer. This methodology readily distinguished...
Chlorpheniramine maleate-paracetamol-caffeine tablet formulation is one of the common over-the-counter drugs used for the treatment of cold and cough. A reversed-phase high-performance liquid-chromatography method has been successfully developed for the simultaneous determination of chlorpheniramine maleate, paracetamol and caffeine in a drug formu...
In indigenous knowledge are practices that have been repeated over time and have become products and processes with a sound underlying set of scientific principles. Using the qualitative research method, the study explored indigenous materials, processes and scientific concepts employed in the production of two local alcoholic beverages akpeteshie...
Consuming plant products containing potentially toxic elements can have adverse health effects. This study aimed to assess the carcinogenic risks of lead, arsenic, and cadmium, as well as the non-carcinogenic risks associated with lead, arsenic, copper, cadmium, and mercury, by analyzing metal concentrations in medicinal plants collected from Ghana...
The leaves of Aspilia silphioides are effective for wound healing, stomach aches, headaches, worm infestations, and birth control. The purpose of this study was to determine the phytochemical components of the bulked fractions of A. silphioides and evaluate the antimicrobial, anti-helminthic, and antioxidant activities of various solvent fractions....
Background: Malaria continues to cause havoc on various populations because of the high mortality and economic burden associated with the disease. Progress made in the therapeutics of
the disease is threatened by the emerging parasite resistance to currently used first line treatment drugs. This has prompted the search for new, effective, and safe...
Background: Malaria continues to cause havoc on various populations because of the high mortality and economic burden associated with the disease. Progress made in the therapeutics of the disease is threatened by the emerging parasite resistance to currently used first line treatment drugs. This has prompted the search for new, effective, and safe...
Mareya micrantha, a medicinal plant, is used to treat pains, wounds, worm infestations and gastrointestinal disorders. The aim of this research was to investigate the anthelmintic and anti-inflammatory properties of the methanol and acetone extracts of Mareya micrantha leaves. Phytochemical screening was performed using standard methods with GC-MS...
African malaria mosquitoes (Anopheles gambiae sensu stricto) transmit a malaria parasite (Plasmodium falciparum) to humans. Te current control strategies for the vector have mainly focussed on synthetic products, which negatively impact the environment and human health. Given the potential use of environmentally friendly plant-derived volatiles as...
The efficacies of ethanol and hexane crude extracts of shea nut cakes were assessed on Sitophilus zeamais Motsch and Prostephanus truncatus Horn. Phytochemical screening was performed using standard methods. The insecticidal activity of the extracts was assessed using contact toxicity, impregnated filter paper toxicity, and repellency tests. The ph...
Lead, cadmium, arsenic, and copper are potentially toxic elements that are of concern to man because of their negative effects on human health. The Atomic Absorption Spectrometer was used to evaluate the quantities of these heavy metals, and a value of heavy metal consumption in human meals was derived to determine the danger to human health. The m...
The efficacies of ethanol and hexane crude extracts of shea nut cakes were assessed on Sitophilus zeamais Motsch and Prostephanus truncatus Horn. Phytochemical screening was performed using standard methods. The insecticidal activity of the extracts was assessed using contact toxicity, impregnated filter paper toxicity, and repellency tests. The ph...
The emission of potentially toxic metals from both anthropogenic and natural sources into the ecosystem has resulted in the contamination of soils. This study evaluated the levels of potentially toxic metals accumulation and enrichment in soils supporting medicinal plants in the Ashanti Region of Ghana. Soil physical characteristics (pH), cation ex...
Vernonia camporum is used ethnomedicinally to treat diseases such as malaria, fever, hypertension, mouth sores, pains, inflammation, and skin rashes in Africa. This study aims at investigating the biological activities (anthelminthic, anti-inflammatory, antioxidant, and antimicrobial) and separating some of the biologically active components in the...
Basil (Ocimum basilicum Linn.) is a plant that has found use in traditional medicine and household remedy against human ailments. The present study aimed at investigating hexane and ethanol fruit extracts of Ocimum basilicum Linn. for their phytoconstituents and anti-inflammatory, antioxidant, and anthelmintic activities. Phytochemical screenings w...
Ficus sur (Moraceae), is a plant that has found use in traditional African medicine in the treatment of sickle cell disease, epilepsy, pain and inflammations. The present study was aimed at investigating hexane and methanol stem-bark extracts of Ficus sur for their phytoconstituents, anti-inflammatory, antimicrobial and antioxidant activities. Phyt...
Sclerocarya birrea, has been used as a medicinal plant in folkloric medicine for managing inflammation, stomach disorders, infections and metabolic disorders in Africa. The present study aimed to investigate the in vitro anthelmintic, anti-inflammatory and antioxidant activities of ethanol and aqueous root extracts (ERE and ARE) of S. birrea. Phyto...
Griffonia simplicifolia has ethnomedicinal use in the treatment of depression, fibromyalgia, bladder and kidney problems, insomnia, malaria, obesity, migraine, as an aphrodisiac and a remedy for cough. The aim of this present study is to investigate the biological activities (antimicrobial and antioxidant) and isolate some of the components in the...
Griffonia simplicifolia has ethnomedicinal use in the treatment of depression, fibromyalgia, bladder and kidney problems, insomnia, malaria, obesity, migraine, as an aphrodisiac and a remedy for cough. The aim of this present study is to investigate the biological activities (antimicrobial and antioxidant) and isolate some of the components in the...
The stem-bark of Psydrax peruviana is used in folkloric medicine in the treatment of gonorrhoea and syphilis. In this study, methanol and hexane extracts of P. peruviana were evaluated for antimicrobial and antioxidant properties. Phytochemical screening, antimicrobial (agar and broth dilution method) and antioxidant (total antioxidant capacity (TA...
Background. Anthropogenic activities such as artisanal mining pose a major environmental health concern due to the potential for discharge of toxic metals into the environment.
Objectives. To determine the distribution and pollution patterns of arsenic (As), iron (Fe), nickel (Ni), cobalt (Co), chromium (Cr), manganese (Mn), copper (Cu) and zinc (Z...
Alchornea cordifolia has ethnomedicinal use in the treatment of wounds, gonorrhea, conjunctivitis, diarrhea, urinary disorder and gastrointestinal disorder. The main focus of this study was to verify the biological activities (anthelmintic, antimicrobial and antioxidant) and isolate some of the components in the chloroform, methanol, and petroleum...
The stem-bark of Psydrax peruviana is used in folkloric medicine in the treatment of gonorrhoea and syphilis. In this study, methanol and hexane extracts of P. peruviana were evaluated for antimicrobial and antioxidant properties. Phytochemical screening, antimicrobial (agar and broth dilution method) and antioxidant (total antioxidant capacity (TA...
Exposure to endocrine disruptors such as bisphenols (BPs), for example, bisphenol A, bisphenol S and bisphenol F in early life may contribute to obesity. BPs are man-made chemicals found in lots of household products including food packaging, drink containers, lotions, toys, plastic PVC flooring and water pipes. Human exposure to these chemicals ha...
Concoctions of roots of Cnestis ferruginea and Citrus limon are used locally in the treatment of breast cancer, wounds, dysentery and tooth ache. In this study, methanol root extracts of Cnestis ferruginea and
ethanol root extracts of Citrus limon were evaluated for antimicrobial, and antioxidant capacities. Preliminary phytochemical screening of t...
Sulfadoxine and pyrimethamine are often formulated together and used in the treatment of malaria especially in pregnant women serving as a prophylaxis. A new simple, precise and accurate reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed for simultaneous identification and quantification
of sulfadoxine and pyri...
Microdesmis puberula is a plant that is used in traditional medicine for the treatment of diarrhea, stomach-ache, intestinal worms, menstrual complaints, sterility, miscarriage, loss of virility and venereal diseases, treat skin conditions, renal pain, severe headache, erectile dysfunction, and snake bite. In this work, methanol and petroleum ether...
The numerous reputed health benefits of the omega-3s (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]), particularly, their cardio-protective effects have led to the manufacture of omega-3 supplements by various pharmaceutical companies resulting in their flooding of the Ghanaian market. Coldwater fishes which are the primary sources of...
Many natural enemies of herbivorous insects are attracted to semiochemicals emitted by plants. Semiochemicals emitted by host plants can prime neigbouring plants to adjust their defensive mechanism against future attack. Crop protection, using plant signal is recently gaining momentum due to health and environmental concerns about the use of synthe...
Croton penduliflorus is used in folklore medicine for the treatment of dysmenorrhea, fever, wounds, gastro-intestinal and others. The study evaluated the anti-inflammatory, antimicrobial and antioxidant activities of a hydro-ethanolic extract of stem bark of Croton penduliflorus. Carrageenan-induced oedema model in chicks was used to evaluate the a...
Fruits and vegetables are known to have free radical scavenging abilities due to the antioxidants in them and this gives them the ability to prevent diseases and sicknesses. This study was carried out to investigate the total phenolic content and free radical scavenging abilities of some selected vegetables and to determine their minimum inhibitory...
The antimicrobial activity of hydrosols of the leaves and fruit peels of some plants have been assessed. The purpose of this study was to determine the antimicrobial potency of the hydrosols of leaves of Cymbopogon nardus, Chromolaena odorata, Ocimum gratissimum, Cymbopogon citratus, and fruit peels of Citrus sinensis and Citrus aurantifolia agains...
Soil variation and its effect on the physical and chemical properties of shea butter, a product from the nut of the shea tree, were investigated in four districts of the northern region of Ghana. Thirty-six samples of freshly extracted shea butter together with 36 soil samples were collected and stored at 25°C for analysis. Clinical analysis of soi...
Activity concentrations of radionuclides in water, soil and tuber crops of a major food-producing area in Ghana were investigated. The average gross alpha and beta activities were 0.021 and 0.094 Bq/L, respectively, and are below the guidelines for drinking water and therefore not expected to pose any significant health risk. The average annual eff...
Groundwater is a major source of water for commercial and drinking purposes for majority of the populace of developing nations. This study was carried out to assess the physicochemical and bacteriological quality of water from twenty five different hand-dug wells from five locations within the Ayeduase community. The study was carried out during th...
As a measure to prevent cardiovascular diseases and enhance in-utero development of the foetus, adequate omega-3 intake has been recommended. This has led to the manufacture of omega-3 supplements by various pharmaceutical companies and these products have flooded the market. Coldwater fishes are the primary sources of the omega-3 food supplements...
A reversed phase liquid chromatographic (rp-lc) method has been developed to determine simultaneously the amount of sulphamethoxazole and trimethoprim in co-trimoxazole tablets using salicylic acid as internal standard. The chromatographic resolution was achieved with 96% ethanol and 0.1M ammonium perchlorate buffer (95:5) on a reversed phase colum...
A reversed phase liquid chromatographic (rp-lc) method developed to assay sulphamethoxazole and trimethoprim in co-trimoxazole tablets has been modifid to determine the relative bioavailability of locally formulated tablets by monitoring unchanged sulphamethoxazole in the urine. It was however noted that the amount of trimethoprim in the urine was...
Questions
Question (1)
When a solvent has been used to obtain plant extract and the extract has been placed in a column and a solvent used to elute the components. Collection OF eluents was done and qualitative TLC was run on the collected eluents, followed by bulking. The bulked eluents were then run on preparative TLC to separate components. Each separated component was run on qualitative TLC and three spots were identified. Would we classify the separated components as fractions or isolates, knowing that each separated component produced 3 spots in TLC?
