Akolade Oladipupo

Akolade Oladipupo
University of Lagos | Unilag · Department of Pharmaceutical Chemistry

About

19
Publications
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24
Citations
Introduction
At the Department of Pharmaceutical Chemistry, University of Lagos. Current project: Bioprospecting and development of novel anticancer agents.

Publications

Publications (19)
Article
Full-text available
Background: Malaria remains a devastating disease, particularly in the tropics, where it is the highest killer of pregnant women and children under the age of 5 years. Significant efforts and resources have been vested in malaria control and eradication programmes, but the unavailability of malaria vaccine and the emergence of resistance of malaria...
Article
Full-text available
The search for novel, safe and effective anticancer agents has been a continuous and recurring objective in cancer research. Olax subscorpioidea is a medicinal plant used for ethnomedicinal treatment of cancer in Nigeria. In this study, we investigated the cytotoxic, anti-mitotic and cytogenetic effects of methanol extracts of the leaves and stems...
Article
Phaulopsis falcisepala is a herb found in the forest zone of West Africa. It is applied ethnomedicinally for treating wounds and cancer. This study investigated the chemical constituents, cytotoxicity, and antimitotic activity of P. falcisepala leaves and stems. Chemical constituents were evaluated using phytochemical methods. Cytotoxicity was...
Article
Full-text available
Every segment of society uses minerals and mineral resources each day for various purposes, including in diet and medications. One of such minerals is kaun, a crude mixture of various salts. Kaun, which is mainly a hydrated sodium carbonate but erroneously locally called "potash", is the second most popularly used salt to sodium chloride in Nigeria...
Article
Full-text available
The discovery and development of the statins provides an insight into the many facets of the drug discovery process and also shows the time and resources that must be devoted to developing a clinically useful drug from an initial concept. It began from the conceptual search for metabolites that could inhibit an important enzyme in cholesterol biosy...
Article
In this study, phenolic and flavonoid contents of various extracts of Acalypha fimbriata Schum. & Thonn. leaf and stem were determined. The metabolic profile of one extract was studied using GC-MS analysis. The antioxidant activities of the extracts were evaluated using in vitro and in silico studies. Four extracts each of leaf and stem of A. fimbr...
Article
Full-text available
Fruits are important worldwide due to their nutritional, commercial, and nutraceutical values. Doubtless, the increased demand for fruits is instrumental in the use of various artificial ripening methods in their production. The most frequently applied chemical for this purpose is calcium carbide (CaC2). However, due to its toxicity, the use of cal...
Article
Full-text available
Oxidative stress has been implicated in thepathogenesis of many diseases, while multiple drug resistance constitutes a major problem in management of infectious diseases. These stressrequires continuous investigations for development of novel antioxidant and antimicrobial agents. Here, phytochemical constituents, antioxidant, and antimicrobialactiv...
Article
Ethnopharmacological relevance: Malaria remains one of the most prevalent infectious diseases in tropical regions of the world, particularly in sub-Saharan Africa, where it remains epidemiologically holoendemic. The absence of effective vaccines and Plasmodium resistance to antimalarial drugs have been the major challenges to malaria control measu...
Article
Scientific evidence suggests that antioxidants could reduce the risk of chronic diseases, including cancer and cardiovascular diseases, and play an important role in general wellbeing. Sickle cell disease (SCD) is a debilitating monogenic disorder considered as a public health problem in many countries, but with a major burden in Sub-Saharan Africa...
Article
Full-text available
The use of antioxidants has emerged as a promising therapeutic strategy for the management of mitochondrial dysfunction and other oxidative stress-related degenerative pathologies. Tetrapleura tetraptera is a well-known tree and its fruit is applied traditionally as spice and in the preparation of remedies for different ailments. In this study, t...
Article
Full-text available
The advent of the angiotensin-converting enzyme (ACE) inhibitors is a landmark in drug discovery and a breakthrough in the management of hypertension. Their clinical introduction has led to appreciable increase in the lifespan of hypertensive patients. And their development initiated a new era of structure-based or rational drug design that has sub...
Article
Full-text available
Herbs constitute a common medicinal alternative for disease treatment in many cultures around the world. In Nigeria, these medicinal herbs are widely used in the treatment and prevention of various ailments including malaria, a global disease endemic to the tropics. In spite of their cultural trust and claimed medicinal properties, lack of standard...
Preprint
Every segment of society uses minerals and mineral resources each day for various purposes, including in diet and medications. One of such minerals is kaun, a crude mixture of various salts. Kaun, which is mainly a hydrated sodium carbonate but erroneously locally called "potash", is the second most popularly used salt to sodium chloride in Nigeria...
Article
Full-text available
Phytochemical constituents of plants extracts have been well investigated as leads for drug discovery and development. However, aside their immense medicinal properties, their safety is also of paramount importance, therefore evaluating the toxicity of plants extracts and their phytochemicals is an important aspect of quality measures to meet the r...
Article
Propolis has been used as medicinal agent for centuries. Among the many compounds identified in propolis, flavonoids are considered to be responsible for its main biological activities. Therefore, determination of flavonoids in propolis is a key parameter for evaluation of propolis quality. To continue our research on chemical composition of propol...

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