Akiva Trattner

Akiva Trattner
Rabin Medical Center · dermatology

MD

About

112
Publications
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Introduction
Skills and Expertise

Publications

Publications (112)
Article
Background: The clinical diagnosis of papular eruptions is common but poorly characterized in the literature and the etiology is often unknown. Objective: To characterize the entity of idiopathic papular dermatitis in the spectrum of chronic papular eruptions. Methods: The cohort consisted of patients who presented at a tertiary medical center...
Chapter
Contact dermatitis is common in military personnel with an incidence of 9.6–32%. Occupational contact dermatitis may be due to oils, fuels, and solvents, explosives; munitions and fuses; combat gases; weapons and arms; and paints and detergents. Environmental contact dermatitis may be due to plants or insect bites. Other causes for allergic contact...
Article
Full-text available
Background/objectives: Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review p...
Article
Full-text available
Background: Allergic contact dermatitis (ACD) is associated with increased production of cytokines. The patch test is the "gold-standard" diagnostic method, but it poses a risk of false results. Objective: To evaluate a novel laboratory technique, the Luminex LiquiChip, which simultaneously measures blood levels of multiple cytokines, as a diagn...
Article
We present the case of a male born prematurely at 32 weeks gestation by cesarean section following overt symptoms of maternal preeclampsia. He developed severe penoscrotal edema anew one month from birth. No remarkable exposure or trauma was identified. This unexplained swelling remained uniform till 4 months of age, while the penile edema resolved...
Chapter
Contact dermatitis is common in military personnel with an incidence of 9.6-32%. Occupational contact dermatitis may be due to oils, fuels and solvents, to explosives, munitions and fuses, to combat gases, to weapons and arms, paints and detergents. Environmental contact dermatitis may be due to plants or insect bites. Other causes for allergic con...
Article
The prevalence of cosmetics-related contact dermatitis is rising, owing mainly to the wider use of cosmetics by the public and the routine diagnostic use of patch tests. To determine the prevalence of cosmetics allergy in Israel. A questionnaire was distributed to a random sample of 360 female customers of pharmacies and beauty salons in two areas...
Article
Allergic contact cheilitis may appear after exposure to different substances, including dental materials, toothpastes, cosmetics, foods and medications. To compare the rate of toothpaste allergy between patients with and without cheilitis and to examine the yield of our proposed toothpaste patch test kit for use in patients with cheilitis. A patch...
Article
There appear to be no published studies on the rates of positive allergic reactions to oil and cooling fluids. To determine the yield of the oil and cooling fluid series from Chemotechnique Diagnostics in patients in Israel who are suspected to have occupational allergic contact dermatitis. The authors reviewed the findings in 175 patients with sus...
Article
Allergic contact dermatitis induced by the occupational use of products containing essential oils has not been studied comprehensively. The aim of the present report was to describe the characteristics, diagnosis, and outcome of 5 patients with occupational contact dermatitis because of essential oils attending our outpatient dermatology clinics ov...
Article
The reproducibility of the patch test is of great importance to its diagnostic utility. The objective of this study was to quantitatively and qualitatively compare the reproducibility of patch test reactions between the manufacturer-loaded TRUE Test (TT) panel and the investigator-loaded IQ Chamber (IQC) system using the European Standard Series (E...
Article
Previous studies have shown that the prevalence of specific allergens varies by geographic area, population, age and sex. The objective of the present study was to determine the relative frequency of positive reactions to different sensitizers in Israeli patients with clinically suspected contact dermatitis (CD) and to identify possible sex and age...
Article
Full-text available
Exogenous factors implicated in or suspected of precipitating connective tissue diseases are reviewed. These include environmental agents, such as ultraviolet light, drugs, chemicals, pesticides, heavy metals, infectious viruses, and bacteria. The possible roles of occupational exposures and the environmental factors early in life are discussed as...
Article
Pemphigus vulgaris is an autoimmune disease with a well-established immunological basis. Treatment is based on high dose and maintenance systemic corticosteroids. We report on a patient with a recurrence of full-blown pemphigus vulgaris after a trial of alternative hypnosis therapy to replace the corticosteroids.
Article
Tefillin (phylacteries) are a religious article worn by observant Jewish men. Only two cases of allergic contact dermatitis from tefillin have been reported previously. We describe 7 new cases of tefillin contact dermatitis and review the literature on contact allergy caused by religious objects and practices. All our patients had contact allergy t...
Article
Exogenous factors implicated in or suspected of precipitating cutaneous lupus erythematosus are reviewed. Environmental risk factors (including infectious disease, dietary data, ultraviolet light, medications, pesticides and heavy metals) that are potentially related to the development of lupus erythematosus are discussed.
Article
High frequencies of contact allergy to fragrance ingredients have been reported in recent years. Only approximately 70-80% are detected by fragrance allergens in the standard patch test series. This investigation compares the patch test reactions to fine fragrances with reactions to fragrance mix (FM), balsam of Peru (BP) (Myroxylon pereirae resin)...
Article
The use of in vitro release of interferon-gamma (IFN-gamma) in the diagnosis of contact allergy to potassium dichromate was studied in 20 patients who had positive patch tests to chromate and in 30 control subjects (10 patients with contact dermatitis, allergic to other allergens, 10 patients with other dermatologic diseases and 10 healthy subjects...
Article
Patch testing with the shoe series may be useful for the diagnosis of shoe contact dermatitis. The aim of the study was to verify the usefulness of the shoe series and the association of fungal infection with positive results in the shoe series. A total of 140 patients with suspected shoe contact dermatitis underwent patch testing with the standard...
Article
Allergy to chromium is relatively common, often in association with exposure to cement or in leather manufacture. However, in certain locations, there appears to be a relatively large cohort of chromium-sensitive individuals whose allergy cannot be explained by these common sources. In particular, this group include Israeli housewives with persiste...
Article
Many aspects of cutaneous surgical interventions have been perfected, employed, and then scientifically examined. Conversely, ubiquitous, indiscriminate demand for sterile conditions while performing an invasive procedure remains a field devoid of satisfactory critical appraisal. Ritual neonatal circumcision served as a prototype to assess scientif...
Article
The diagnosis of contact dermatitis caused by clothing may be difficult because of its clinical polymorphism. Data in the literature suggest that textile dermatitis is more common than previously thought. Our purpose was to study our patients suspected of having textile contact dermatitis from 1991 to 1997. The records of the patients with positive...
Article
Background: As part of our clinical experience we encountered a group of patients from a specific population with a similar peculiar pigmentation over the lower dorsal spine. Objective: We investigated these patients to see whether we could determine a common origin. Methods: Patients meeting the inclusion criteria underwent detailed history a...
Article
The cause of autoimmune progesterone dermatitis (AIPD) is unknown. It has been postulated that it may present a unique type of corticosteroid hypersensitivity. We report the case of a 68-year-old woman who had suffered for years from AIPD and corticosteroid sensitivity. For late menopausal syndrome she took an eostrogenprogesterone preparation (Pre...
Article
Pigmented contact dermatitis has been found to be caused by fragrances, cosmetics, washing powders, azo dyes in textiles, and rubber products in selected groups of patients. The aim of this study was to run screening patch tests in an unselected group of patients with pigmented contact dermatitis (n=29) encountered in our center over a 2-year perio...
Article
Skin disorders at ostomy sites are common and include irritant contact dermatitis from the draining fluid and/or the ostomy devices, intertrigo, and bacterial and mycotic infection (1). Allergic contact dermatitis has also been described, from a karaya seal ring (2), stoma adhesive paste (3), and rubber (4). The allergens causing contact dermatitis...
Article
Background: Kaposi's sarcoma (KS) accounts for more than 5% of malignancies in immunosuppressed organ transplant patients (OKS). A new herpesvirus (HHV-8) was identified with high prevalence in biopsy specimens of AIDS-KS, endemic KS, and classic KS and in OKS. KS has also been associated with other underlying diseases in patients treated with cor...
Article
Exposure to formaldehyde is common from both consumer products and industry. The reliability of the patch test is essential for the diagnosis of formaldehyde allergy as it is difficult to suspect from the patient's history. The recommended formaldehyde patch test concentration has been reduced over the last decades from 4-5% to 2% and is currently...
Article
There has been a controversy as to the origin of lupus miliaris disseminatus faciei (LMDF). It was originally thought to be associated with tuberculosis, due to its histopathological similarity. Recently, this association has been doubted, although there remain reported cases of LMDF associated with Mycobacterium tuberculosis. Three patients with t...
Article
We report a case of the association of blue rubber bleb nevus syndrome with diffuse angiokeratoma, without any evidence of enzyme deficiencies. The lesions of both disorders had a late-onset appearance.
Article
Eccrine poroma is a benign, slow growing, solitary adnexal tumor. Malignant degeneration may take place in longstanding solitary lesions; in such cases cutaneous and fatal visceral metastases have occurred. Our goal was to determine whether flow cytometry yields useful diagnostic and prognostic information on benign and malignant eccrine poroma. Fl...
Article
An elderly woman is presented who developed a rapidly fatal angiosarcoma of the upper extremity and ipsilateral breast in the setting of longstanding arm lymphedema following a childhood accident.
Article
Pentoxifylline (Trental®) is a hemorrheologic agent that enhances tissue perfusion and oxygénation through its effects on erythrocyte flexibility and blood viscosity in microcirculation. It has been shown to be effective in the treatment of patients with intermittent claudication due to chronic occlusive arterial disease of the limbs. Our purpose w...
Article
Low-dose heparin devoid of anticoagulant activity is capable of inhibiting T lymphocyte heparanase activity, crucial in T cell migration to target tissues. We studied the efficacy of a low dose of enoxaparin (Clexane), a low molecular weight heparin, as monotherapy in 6 females suffering from typical widespread histopathologically proven lichen pla...
Article
Flow cytometric DNA analysis of various tumours has indicated a correlation between the degree of malignancy and ploidy; results which could have clinical significance. We analysed the ploidy of Kaposi's sarcoma (KS) tumours, and classified the results according to clinical history and histological findings. We found that patients on steroid treatm...
Article
Low-dose low molecular heparin inhibits T lymphocyte-mediated autoimmune disease and allograft reactions in mice in vivo and in vitro. High doses of heparin are not effective. The purpose of this preliminary study was to analyze the effect of low-dose, low molecular weight heparin (Enoxaparin, Clexane) on the expression of patch testing in patients...
Article
Darier disease is an autosomal dominant abnormality of epidermal differentiation characterized clinically by the presence of hyperkeratotic papules on the skin and histologically by the loss of cell cohesion and by disorderly keratinization. Two groups recently found evidence that the gene whose mutations underlie this disease is located at chromos...
Article
Darier's disease is an acantholytic dyskeratotic genodermatosis with autosomal dominant inheritance. A predictive diagnostic marker for this disorder would be beneficial because of the relatively late onset and the large number of sporadic cases of the disease. The dermatoglyphic features of patients with Darier's disease were examined to determine...
Article
A 57-year-old woman who had undergone lumpectomy for infiltrating duct-cell carcinoma of the right breast was found to have morphea after receiving radiation therapy. Three years later she developed a vesicular eruption on the area of the morphea, which was diagnosed as bullous morphea. The histologic findings of the vesicular component were charac...
Article
Background. Darier's disease is an acantholytic dyskeratotic genodermatosis with autosomal dominant inheritance. A predictive diagnostic marker for this disorder would be beneficial because of the relatively late onset and the large number of sporadic cases of the disease. The dermatoglyphic features of patients with Darier's disease were examined...
Article
A patient noted the appearance of a few asymptomatic lesions on both areolae eighteen months after delivery of her last son. Histologic examination showed typical seborrheic keratosis. A brief review of the differential diagnosis of skin problems of the nipple and the areola is provided.
Article
Kaposi's sarcoma has been reported in patients receiving immunosuppressive therapy, most of whom are organ transplant recipients. The development of Kaposi's sarcoma after treatment with corticosteroids has been reported in only 38 patients who have not had acquired immunodeficiency syndrome or undergone organ transplantation. Cutaneous Kaposi's sa...
Article
Interferon alpha-2a, which has antineoplastic, antiviral, immunomodulatory, and antiangiogenic effects, was evaluated in a prospective study, treating 10 lesions of patients with classical Kaposi's sarcoma. Ten patients received injections of interferon alpha-2a intralesionally in a dose of 3 million units three times weekly for 4 weeks, and in a v...
Article
We review our experience with nine patients with partial unilateral lentiginosis (PUL), a rare pigmentary disorder. Our purpose was to define the characteristics of PUL and to discuss the differential diagnosis. The records of nine patients with PUL were reviewed. A literature review on diagnosis, association with other disorders, and differential...
Article
Four epidemiologic types of Kaposi sarcoma (KS) are known: classic KS, endemic African KS, epidemic or acquired immunodeficiency syndrome-related KS, and KS associated with immunosuppressive therapy. In most of the latter patients, KS was reported to have developed after organ transplantation, particularly renal transplantation. Thirty-nine patient...
Article
Background. Four epidemiologic types of Kaposi sarcoma (KS) are known: classic KS, endemic African KS, epidemic or acquired immunodeficiency syndrome–related KS, and KS associated with immunosuppressive therapy. In most of the latter patients, KS was reported to have developed after organ transplantation, particularly renal transplantation. Thirty-...
Article
von Willebrand factor (vWF) is synthesized almost exclusively by endothelial cells and is stored there as ultra-high-molecular-weight multimers. The vWF multimers that are detected in the plasma are smaller than those stored within the endothelium. In two previous studies, comprising small series of cases with classic Kaposi's sarcoma (KS), an endo...
Article
We present a case of black grain mycetoma caused by Madurella mycetomatis. The diagnosis was made on the basis of conventional light microscopy and mycological studies. After 12 months of oral therapy with ketoconazole, the patient showed partial response. This is the first native Israeli case of black grain mycetoma.
Article
To report smoking intolerance that occurred in two patients while they were treated with minoxidil. Minoxidil is a potent vasodilator useful in treating severe hypertension. Topical minoxidil was approved as a treatment for androgenital alopecia. Only few side effects have been reported during treatment with topical minoxidil, most of them localize...