Akhil Sivan

• Doctor of Philosophy
• Professor (Assistant) at Amrita Vishwa Vidyapeetham, Kollam, Kerala, India

The keyword “Fluorene” search in SciFinder found more than 57,000 results, including high-impact journal articles, review articles, patents, books, proceedings, etc. Against this background, a detailed enquiry has been made by our group on various classes of fluorenes and their relevancy. For the past several decades, fluorene and its related compo...

We present here a series of 4,6-diarylpyrimidin-2-amine derivatives (5a-j) with tunable optical properties both in the solid and solution states. Our plug-and-play fluorophore design demonstrates that the aryl groups at the 4th and 6th positions of the 2-aminopyrimidine core enable distinct optical characteristics for each derivative. The fluoropho...

Diabetes mellitus is a rapidly evolving planetary challenge with substantial societal, salubrity, and financial connotations. Derivatives of isatin with hydrazides, coumarin and aldehydes have proven to possess anti-diabetic activities. Hence, as a novel perspective, isatin was merged with a polycyclic aromatic compound, 2-amino fluorene to build a...

Polycyclic heterocycles are the most common and critical structural motifs found in a variety of natural products, medicines, fertilizers, and advanced materials. Because of their widespread use in biologically active compounds and material chemistry, functionalised dibenzo heterocyclic compounds, especially dibenzofuran, dibenzothiophene, and carb...

Water pollution has grown to be a severe concern due to unethical human deeds and improper management of water resources. The malignancy of organic wastes and contaminants in aquatic systems can adversely affect the flora and fauna. Traditional and modern water treatment techniques that require liquid separation have been widely used to address thi...

Isatin, also known as indoline‐2,3‐dione, is a fused, N‐heterocyclic aromatic compound first isolated and purified in 1841. Since then, isatin and its derivatives emerged as a hot research topic for the scientific community. The number of research publications on isatin justifies their popularity. Researchers explored isatins and their derivatives...

The synthesis of a novel pyrazole-cored push-pull system (Donor-Acceptor-Donor/D-A-D) in which thiophene serves as the donor and N-substituted pyrazole ring serves as the acceptor moieties is reported. The photophysical and electrochemical properties of the synthesised compounds were investigated using UV–Visible spectroscopy, photoluminescence spe...

Fluorene is a well conjugated, planar, polycyclic aromatic organic compound that was first noticed, isolated, and purified by a French chemist, Marcellin Berthelot, in 1867. Since then, plenty of scientific investigators has spent years and decades understanding more about fluorene and its derivatives because of its high scope of applications in po...

Simple heterocyclic moieties are quite famous in synthetic organic chemistry due to their bioavailability, ease of laboratory synthesis, and variety of applications in multidisciplinary fields. Benzimidazole is an N-containing benzofused chemical compound with the formula C7H6N2 and belongs to the family of heterocyclic aromatic organic compounds....

An easy and simple access to 2,3-dihydrofuran derivatives from 1,3-dicarbonyl compounds and methyl cinnamate is reported here. The reaction was facilitated by the CAN mediated oxidative free radical cyclisation reaction. Moderate to good yields of products were obtained and preliminary studies of these showed potential medicinal activities. These c...

Benzimidazole, one of the finest classes of heterocyclic aromatic compounds have the characteristic structure of benzene fused with a five-membered imidazole ring. Despite being made their first appearance in the late 1870s, they are considered as a ‘privileged molecule’. The applications of this wonder molecule range from medicinal chemistry to ma...

A mild and effective protocol for benzimidazolesynthesis from o-phenylenediamine and aromatic aldehydes catalysed by DBU is described. The synthesized compounds find application in the pharmaceutical, dye and material science fields. Mild reaction conditions, low amount of chemicals and use of metal-free catalysts are the highlights of the reaction...

Silver nanoparticles are well known for their medicinal properties from time immemorial. Improving their potential applications demands a greener approach to synthesise them. Embelin, a bioactive molecule belonging to the Myrsinaceae family has gained considerable research interest over the past few years due to its diverse properties as anti-infla...

A mild and efficient protocol for the synthesis of vicinal tricarbonyl compounds from β-dicarbonyls in a single step using cerium(IV) ammonium nitrate as a catalytic oxidant is described. Ease of execution, wide substrate scope and the suitability for the synthesis of commercially important compounds like ninhydrin, alloxan and oxoline make this re...

A mild and efficient protocol for the synthesis of vicinal tricarbonyl compounds from b-dicarbonyls in a single step using cerium(IV) ammonium nitrate as a catalytic oxidant is described. Ease of execution, wide substrate scope and the suitability for the synthesis of commercially important compounds like nin-hydrin, alloxan and oxoline make this r...

The reaction results in a simple synthesis of multisubstituted furan derivatives.

Cerium(IV) ammonium nitrate mediated oxidative addition of 1,3-dicarbonyl compounds to terminal acetylenes to yield multisubstituted furan derivatives is reported here. The simplicity of the reaction and the ease of execution are particularly noteworthy.