Akaninyene Asuquo Otu

Akaninyene Asuquo Otu
University of Calabar | unical · Department of Internal Medicine

MBBCh, DTM&H, DipRCPath. MPH, MRCP(London) MRCP(UK), FWACP, FFPH

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129
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1,685
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Citations since 2017
101 Research Items
1596 Citations
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Publications

Publications (129)
Article
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Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In this review, we present the clinical spectrum and pathogenesis of syndromes caused by Aspergillus in COPD namely invasive aspergillosis (IA), community-acquired Aspergillus pneumonia, chronic pulmonary Aspergillosis and Aspergillus sensitisation. Some of...
Poster
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On July 2022, NHS England launched a novel delinked “subscription-type” payment model for ceftazidime/avibactam and cefiderocol. This funding model is intended to allow affordable use of these antimicrobials for patients with drug-resistant infections in individual NHS Trusts. It also aims to align industry financial incentives with good stewardshi...
Article
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The COVID-19 pandemic has ushered in high-throughput sequencing technology as an essential public health tool. Scaling up and operationalizing genomics in Africa is crucial as enhanced capacity for genome sequencing could address key health problems relevant to African populations. High-quality genomics research can be leveraged to improve diagnosi...
Article
Invasive fungal infections are a serious concern globally, especially in African settings which are typified by poorly funded and fragile healthcare systems. Low performance diagnostics, limited therapeutics and poor societal awareness of invasive fungal infections are some of the perennial challenges which have contributed to the unacceptably high...
Chapter
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Probiotic-based multi-component preparations refer to a mixture of bioactive agents, containing probiotics or postbiotics as main functional ingredients, and prebiotics, protectants, stabilizers, encapsulating agents, and other compounds as additional constituents.
Article
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Following the confirmation on July 21, 2022, of a case of poliomyelitis related to circulating vaccine-derived poliovirus (cVDPV) type 2 in an unvaccinated adult from Rockland County, NY, USA,1 there has been a renewed global drive to strengthen surveillance for the detection of cases and increase vaccination coverage against polio. This is the fir...
Article
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Background: Sickle cell anaemia (SCA) is associated with significant morbidity and mortality linked to multi-systemic complications. With recent improvements in healthcare globally, it is expected that SCA patients in Nigeria will live longer. The cardiovascular complications may thus become prevalent. Subjects and methods: Fifty-two patients wi...
Article
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Objective To pilot the use of a scalable innovative mobile health (mHealth) non-communicable diseases (NCDs) training application for nurses at the primary care level. Design Mixed methods pilot of mHealth training on NCD care for nurses at primary healthcare (PHC) facilities. We provide a descriptive analysis of mHealth training test scores, with...
Article
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Probiotics and related preparations, including synbiotics and postbiotics, are living and non-living microbial-based multi-components, which are now among the most popular bioactive agents. Such interests mainly arise from the wide range and numerous beneficial effects of their use for various hosts. The current minireview article attempts to provi...
Preprint
Full-text available
Following the confirmation on July 21, 2022, of a case of poliomyelitis related to circulating vaccine-derived poliovirus (cVDPV) type 2 in an unvaccinated adult from Rockland County, NY, USA,1 there has been a renewed global drive to strengthen surveillance for the detection of cases and increase vaccination coverage against polio. This is the fir...
Article
Full-text available
It is unclear how statin-use influences the adoption of healthy lifestyle choices. It is important to understand the nature of this relationship as this could facilitate targeted public health interventions which could help promote a healthy lifestyle, curb the rise of non-communicable diseases, and facilitate overall health. This study aimed to ex...
Preprint
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Introduction Sepsis is a leading cause of morbidity and mortality worldwide. In low- to middle-income countries (LMICs) such as Nigeria, the disproportionately high mortality rate is linked to lack of awareness, poor recognition, and late implementation of sepsis care bundles among health workers. Training of health workers using digital platforms...
Article
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Following confirmation of the first case of monkeypox in the UK by the UK Health Security Agency (UKHSA) on May 7, 2022, events have evolved with dizzying rapidity—as of May 21, 2022, 92 laboratory confirmed cases and 28 suspected cases of monkeypox have been reported in 12 non-endemic countries across three WHO regions.1 Monkeypox is a rare viral...
Preprint
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As of 21 May, 92 laboratory confirmed cases, and 28 suspected cases of monkeypox have been reported in 12 non-endemic countries across three WHO regions (See Table 1).1 There are concerns that this outbreak of monkeypox may become the next global pandemic. Complicating the situation is the fact that most of the cases have occurred in gay, bisexual...
Article
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We read with keen interest the BMJ report of seven cases of monkeypox that were confirmed in the UK by the 16 May 2022. Since then, 13 more cases of monkeypox have been identified by The UK Health security Agency (UKHSA) bringing the total number of monkeypox cases confirmed in the UK to 20 as of 20 May 2022. Why are these cases generating so much...
Article
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Background: Hepatitis D virus (HDV) can cause a chronic infection in the presence of hepatitis B surface antigen and contribute to the burden of chronic liver disease especially in regions where chronic hepatitis B virus (HBV) infection is endemic. Aim: To determine the prevalence and risk factors of HDV among asymptomatic carriers of HBsAg in C...
Article
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Dear Editor, We read with keen interest the recent article in The BMJ about cases of idiopathic hepatitis in children around the world. We are concerned that the gains of multi-sectoral mitigation responses to COVID-19 is under threat by this evolving situation. Cases of idiopathic acute hepatitis were first identified in Scotland among 11 childre...
Article
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Background The burden of hepatitis B and hepatitis C virus (HBV, HCV) infection is exceptionally high in sub-Saharan Africa (SSA). Many countries in the SSA region are classified as hyperendemic for HBV by the World Health Organization (WHO), with West Africa being most affected. Data from the WHO suggest that Africans infected with hepatitis virus...
Article
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Sickle cell disorder (SCD) is a multisystem disease with heterogeneous phenotypes. Although all patients have the mutated hemoglobin (Hb) in the SS phenotype, the severity and frequency of complications are variable. When exposed to low oxygen tension, the Hb molecule becomes dense and forms tactoids, which lead to the peculiar sickled shapes of th...
Article
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The increasing global human population is projected to reach 9.7 billion people by 2050. This population growth is currently linked to the trends of worldwide urbanization, growth of megacities and shifting dietary patterns. While humankind faces the daunting challenge of feeding and providing healthy lives for its teeming populations, urban agricu...
Preprint
Feasibility of personalized medical care for patients with sickle cell anaemia using a lab-on-chip microfluidic platform to mimic and unravel components of vaso-occlusive crisis. Abstract: Sickle cell disorder (SCD) is a multisystem disease with heterogeneous phenotypes. Although all patients have the mutated haemoglobin (Hb) in the SS phenotype, t...
Preprint
Full-text available
The increasing global human population is projected to reach 9.7 billion people by 2050. This population growth is currently linked to the trends of worldwide urbanization, growth of megacities, and shifting dietary patterns. While humankind faces the daunting challenge of feeding and providing healthy lives for its teeming populations, urban agric...
Article
Full-text available
The African Union Bureau of Heads of State and Government endorsed the COVID-19 Vaccine Development and Access Strategy to vaccinate at least 60% of each country’s population with a safe and efficacious vaccine by 2022, to achieve the population-level immunity needed to bring the pandemic under control. Using publicly available, country-level popul...
Article
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STIs are infections that result from the transmission of a pathogenic organism by sexual contact. Globally, STIs constitute a major burden and a significant public health challenge, driven by health systems challenges related to inadequately resourced, poor quality services on the one hand and social stigma and discrimination surrounding STIs on th...
Article
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Background and objectives Commercial Aspergillus IgG antibody assays have become pivotal in the current diagnosis of chronic pulmonary aspergillosis (CPA). However, diagnostic cutoffs have been found to vary from manufactures’ recommendations in different settings. This study aimed to establish the Aspergillus IgG reference range among Nigerians an...
Article
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Aspergillus fumigatus is a species of fungus that is commonly found in the environment, household dust, soil, and decaying plant matter. The fungus produces spores which are inhaled by humans daily, although the host defence mechanisms of most people limit inflammatory responses and promote fungal clearance. Inhalation of the spores of A fumigatus...
Article
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Background: Health worker training is an essential component of epidemic control; rapid delivery of such training is possible in low-middle income countries with digital platforms. Methods: Based on prior experience with the Ebola outbreak, we developed and deployed a bespoke InStrat COVID-19 tutorial app, to deliver accurate and regularly updated...
Article
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Background and Aims: Patients with chronic pulmonary aspergillosis (CPA) who discontinue antifungal therapy commonly exhibit disease recurrence. We aimed to evaluate the utility of the St. George’s respiratory questionnaire (SGRQ) in predicting the likelihood of clinical recurrence of CPA in patients who come off antifungal therapy. Methods: This a...
Article
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Paul Adepoju provides a report on how Africa lags behind in the global race to roll out COVID-19 mass vaccination. This race is unprecedented and characterized by high-income countries adopting strategies such as pre-ordering millions of doses before the COVID-19 vaccines completed clinical trials. Africa has now embarked on the biggest immunisatio...
Article
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Urbanization, armed confict, and deforestation in African countries have increased the risk of zoonotic infections, which requires a One Health approach focused on the environment, animal health and human health. This approach facilitates the assessment of risks from the human-animal-environment interface. Only by fully implementing One Health appr...
Article
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Mobile health (mhealth) tools delivered through wireless technology are emerging as effective strategies for delivering quality training, ensuring rapid clinical decision making, and monitoring implementation of simple and effective interventions in under-resourced settings. We share our early experience of developing and deploying the InStrat COVI...
Article
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Across Africa, there is some evidence of COVID-19 private sector activities to tackle COVID-19 which include the development of rapid diagnostic kits, deployment of e-health platforms for bespoke health workforce training, disease surveillance, reporting, auto-screening and advisories. Inequities in living and access to care by disadvantaged popula...
Preprint
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Background As part of the Global Action Plan against antimicrobial resistance (AMR), countries are required to generate local evidence to inform context-specific implementation of national action plans against AMR (NAPAR). We aimed to evaluate the knowledge, attitude, and practice (KAP) regarding antibiotic prescriptions (APR) and AMR among physici...
Article
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On 3 March 2020, the first case of coronavirus was confirmed in the country, approximately five months after 18 October 2019, one of Chile’s biggest episodes of civil unrest since its return to democracy in the 90s [1]. This social unrest was triggered by deep social inequalities and resulted in massive protests throughout the country. The citizens...
Article
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A significant proportion of the world’s population does not have access to essential health services, incurs catastrophic health expenditure, and suffers impoverishment owing to out-of-pocket (OOP) expense. The World Health Organization (WHO) has identified “achieving Universal Health Coverage (UHC), with one billion more people benefitting from th...
Article
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Madam, Bloodstream infections (BSI) constitute a significant disease burden and are estimated to affect more than 30 million people worldwide every year resulting in over 6 million deaths [1]. Prompt identification of microorganisms grown in blood cultures facilitates earlier targeted clinical intervention for patients with sepsis. Therefore, reduc...
Article
Isavuconazole is the newest triazole antifungal, and it displays a favorable pharmacokinetic and safety profile. Less is known about its long-term use in immunocompetent hosts. We performed a retrospective service evaluation of isavu-conazole therapeutic drug monitoring in patients with chronic pulmonary aspergillo-sis. Adverse events (AEs) and dos...
Article
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There has been mounting evidence of the disproportionate involvement of black, Asian and minority ethnic (BAME) communities by the Covid-19 pandemic. In the UK, this racial disparity was brought to the fore by the fact that the first 11 doctors to die in the UK from Covid-19 were of BAME background. The mortality rate from Covid-19 among people of...
Article
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Introduction: it has been estimated that about 11.8% of the Nigerians suffer serious fungal infections annually. A high index of suspicion with early diagnosis and institution of appropriate therapy significantly impacts on the morbidity and mortality of invasive fungal infections (IFIs). Methods: we conducted a cross-sectional multicentre surve...
Preprint
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The coronavirus disease 2019 (COVID-19) is now a pandemic with devastating social and economic consequences. The extent of the spread of COVID-19 within populations is uncertain since diagnostic tests have not been carried out on all eligible persons and doing such diagnostic tests on everyone is much less feasible in developing countries such as N...
Chapter
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Histoplasmosis, caused by the thermally dimorphic fungus Histoplasma capsulatum, is an uncommon multisystem disease with a global distribution. The spectrum of clinical manifestations ranges from an asymptomatic or minimally symptomatic acute pulmonary disease following inhalation of a large inoculum of Histoplasma microconidia to chronic pulmonary...
Article
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The COVID-19 pandemic has ushered in a new climate of uncertainty which is fuelling protectionism and playing into nationalist narratives. Globalisation is under significant threat as governments scramble to reduce their vulnerability to the virus by limiting global trade and flows of people. With the imposition of border closures and strict migrat...
Article
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With one of the highest testing rates of COVID-19 in Latin America, Chile continues to record low mortality rates from the disease. Several measures such as curfews, cancellation of large gatherings, and closure of schools and businesses have been implemented. Against the backdrop of high levels of alcohol/substance abuse, mental health disorders,...
Article
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COVID-19 has further exposed the strong association between race, ethnicity, culture, socioeconomic status and health outcomes and illuminated monumental ethnoracialised differences reflecting the ‘colour of disease’. Racism, segregation and inequality have been invisibly and pervasively embedded in dominant cultures and social institutions for de...
Article
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The novel SARS-CoV-2 coronavirus pandemic has emerged as a truly formidable threat to humankind’s existence. In the wake of the massively volatile global situation created by COVID-19, it is vital to recognize that the trauma it causes can affect people in different ways, at the individual and collective levels, resulting in mental health challenge...
Article
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Events have progressed with dizzying rapidity since the World Health Organization (WHO) was first alerted to cases of severe pneumonia in the Wuhan City of China on December 31st 2019. The novel SARS-CoV-2 coronavirus disease (COVID-19) was declared a pandemic on March 11th 2020. As of April 7th, a total of 1.38 million cases of COVID-19 had been d...
Data
Click on the following link for a blog post on the BMJ global health journal https://blogs.bmj.com/bmjgh/2020/03/29/covid-19-in-the-caribbean-region-early-indications-of-gendered-nature/?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork
Article
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National governments across the world are scrambling to contain the novel coronavirus disease 2019 (COVID-19). The Caribbean region has been affected later than other regions including Asia, Europe and Africa. As at 21st March 2020, twenty-four countries/territories in the Caribbean region have reported a total of 384 confirmed COVID-19 infections....
Article
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Objectives We aimed to identify the frequency and risk factors for disease relapse following cessation of antifungal therapy in CPA. Methods This retrospective audit at the National Aspergillosis Centre, Manchester, UK assessed outcomes for patients with CPA who had received antifungal treatment and for whom therapy was discontinued for at least o...
Article
Microbial contamination of heater cooler units used in extracorporeal membrane oxygenation is not aerosolized into the environment: A single-center experience - Stephanie Thomas, David Stevenson, Akaninyene A. Otu, Pascalis Vergidis, Julian Barker, Alan Ashworth, Paul Exton, Malcolm Richardson, Ryan George, Ginny Moore
Article
Antifungal treatment options for allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS) are largely limited to itraconazole based on the outcome of randomised controlled trials. It is unclear if nebulised amphotericin B deoxycholate (Fungizone® ) is a viable therapeutic option. We evaluated the safety and...
Preprint
Background The rise of cardiovascular diseases in sub-Saharan Africa strains fragile healthcare systems. Cardiovascular disease prevention involves the use of prophylactic medications like statins and the adoption of healthy lifestyle choices. However, the nature of the relationship between statin-use and the adoption of healthy lifestyle choices r...
Article
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We describe the frequency of Zika and malaria among patients presenting with fever to secondary health facilities in Cross River State, Nigeria. Using a cross-sectional, stratified survey design, we randomly selected nine facilities and consecutively recruited 100 participants (aged ≥ 1 year) who presented with fever. On testing blood samples using...
Article
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Background: In the last five decades, dengue has emerged as one of the most important infectious diseases, following a 30-fold increase in global incidence throughout tropical and sub-tropical regions of the world. The actual numbers of dengue cases are under-reported and many cases are misclassified. Objectives: This article describes the epidemio...
Article
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Trichosporon species are emerging opportunistic yeasts causing life-threatening disseminated disease in severely immunocompromised patients. Trichosporon japonicum is a very rare cause of invasive trichosporonosis. We describe a case of Trichosporon japonicum fungemia in an immunocompetent patient with a transcutaneous biventricular assist device.
Article
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Trichosporon species are emerging opportunistic yeasts causing life-threatening disseminated disease in severely immunocompromised patients. Trichosporon japonicum is a very rare cause of invasive trichosporonosis. We describe a case of Trichosporon japonicum fungemia in an immunocompetent patient with a transcutaneous biventricular assist device.
Article
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Background In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria. Methodology/Principal findings This cross-sectional...
Data
Checklist: STROBE Checklist. (DOC)
Article
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Triazole antifungals are useful in the treatment of Aspergillus disease and these drugs have side effects which clinicians should be aware of. Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts lanosterol to ergosterol, a vital component of the f...
Article
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BACKGROUND: Hepatitis B Virus (HBV) infection is a public health problem that is endemic in Nigeria. Cross River State, a tourist state, located in the coastal area of Nigeria has a relatively high prevalence rate. Insufficient knowledge and negative attitudes are barriers to effective control of infectious diseases. OBJECTIVES: To determine the Kn...
Article
The discipline of medical mycology has become increasingly relevant in the face of the rising incidence of invasive fungal infections (IFI), which pose diagnostic and therapeutic challenges for contemporary medical practice. While firmly established in developed countries, medical mycology remains obscure in many low and middle‐income countries (LM...