Ajaz Ahmad Malik

Ajaz Ahmad Malik
Sher-i-Kashmir Institute of Medical Sciences | SKIMS · Department of Gen.and Minimal Access Surgery.

MBBS;MS;FAIS;FICS;FMAS;MAMS;FIAGES;FACS;

About

132
Publications
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Introduction
Head & Chair General,Gastrointestinal and Laparoscopic Surgery Division Head Endocrine & Breast Surgery Postgraduate Guide/Co-investigator/Examiner in MS & DNB General Surgery & Surgical Gastroenterology . Member Academy of Medical Sciences India Member Academic Council SKIMS Deemed University SKIMS Head National Medical Commission (NMC Section)SKIMS. Executive editor JMS journal. Actively involved in advanced surgical practice and research ,minimal access and cancer surgery.

Publications

Publications (132)
Article
Presence of free gastric cancer cells in the peritoneal cavity of patients who undergo surgical treatment for gastric cancer is considered as a negative prognostic factor. It manifests as peritoneal metastasis and causes rapid recurrence of diseases. The aim of this study was to analyse factors associated with positive peritoneal cytology and ident...
Article
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A prospective evaluation of haemmorrhoidectomy surgery comparing two energy devices.
Article
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Background: Since with widespread availability of ERCP and liberal use of endoscopic sphincterotomy, more and more surgeons feel comfortable in performing primary closure which significantly reduces the hospital stay. There is however still the apprehension of a greater incidence of bile leak and post-operative cholangiogram is not possible. Theref...
Preprint
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Helicobacter pylori infection has been associated with the onset of gastric mucosal inflammation and is known to perturb the balance between T-regulatory (Treg) and T-helper 17 (Th17) cells which causes a spurt of interleukin 17 (IL17) and transforming growth factor-b (TGF-b) from Th17 and Treg cells within the gastric milieu. IL17 instigates a sur...
Article
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PurposeThe true association between primary hyperparathyroidism (PHPT) and pancreatitis continues to be controversial. In this study, we present clinical data, investigative profile, management and follow-up of PHPT patients with pancreatitis and compare this group with PHPT patients without pancreatitis.Methods Records of 242 patients with PHPT ma...
Article
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Predictive factors for successful Non operative management of splenic trauma in Adults.
Article
A 29-year-old female presented to the out-patient Department of Surgery with history of recurrent kidney stones. Patient was on medical management for recurrent kidney stones for the last 5 years and even had undergone uretroscopic lithotripsy (URSL) for impacted left ureteric stone. Patient was evaluated in the past but no primary diagnosis was ma...
Chapter
Advances in surgery have led to many technological improvements in surgical procedures. Surgical stapling devices have been used with an attempt to achieve better patient outcome. However, various pitfalls and several risks are associated with the use of staplers. There is a continuous evolution and improvement in these devices. Surgical stapler is...
Article
The techniques of single-incision laparoscopic surgery (SILS) is developed and based on that of conventional laparo-endoscopic surgery. At first, surgeons wanted to devise a method for visceral surgery with no incision on body’s surface, which is called natural orifice transluminal endoscopic surgery (NOTES). As early as the 1970s, Dr. Raimund Witt...
Article
Hydatid diseases is caused by echinococcus (granulosus and multilocularis). Humans are accidental intermediate hosts where as other animals can be either intermediate or definitive hosts. Liver is involved in 50-70% of cases. Once in the liver the hydatid cyst grows upto 1 cm in first six months and 2-3 cm annually thereafter. We received a 36-year...
Article
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Background: Although, traditional laparoscopic cholecystectomy is performed using four-port technique, various modifications were made to further enhance the advantages of laparoscopic cholecystectomy. Aim of the study is to compare the results of three-port and four-port laparoscopic cholecystectomy at single center in terms of technical feasibili...
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This aim was to study the clinic pathological features, diagnosis, management and outcome of colorectal cancer in young adults under the age of 40.
Article
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Background: Despite the tremendous progressive evolution in the field of medicine, wherein, most of the diseases can be diagnosed based on history, clinical examination and investigations, there are quite a number of diseases which remain undiagnosed. It is here, where the role of diagnostic laparoscopy becomes important to reach to a conclusion fo...
Article
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Aims: Death-associated protein kinase-1 (DAPK1) is a pro-apoptotic Ser/Thr kinase that participates in cell apoptosis and tumor suppression. DAPK1 is frequently lost in many different tumor types including breast cancer. The aim of this study was to evaluate the promoter methylation status of DAPK1 and a possible correlation with the expression of...
Article
Background; A Spigelian hernia is a very rare hernia which develops through the aponeurotic layer between the rectus abdominal muscles medially, and the semilunar line laterally. Aim: The aim of this study is to understand the clinical presentation and management of this rare hernia. Material and methods: This study was conducted over a period of f...
Article
Gallstone ileus is an uncommon and often life-threatening complication of cholelithiasis. In this case report, we discuss a difficult diagnostic case of gallstone ileus presenting as small gut obstruction with ischemia. A 56-year-old female presented with abdominal pain and vomiting. A CT scan was performed and showed an evolving bowel obstruction...
Book
The book explores various aspects of hydatid disease, including the background, parasitology, epidemiology, etiology, pathogenesis and presentation in humans. It features dedicated chapters on hydatidosis of liver, spleen, peritoneum, kidney, pelvis, and disseminated hydatid disease, and also provides detailed information on the latest surgical and...
Chapter
Hydatid disease of kidney is extremely rare and constitutes only 2–3% of all cases and usually associated with hydatid disease of liver or lungs (Diamond et al. 1976). Primary hydatid disease of kidney without the involvement of the liver and lungs is even rarer (Gogus et al. 2003). The age of the patients is 30 and 50 years (Aragona et al. 1984)....
Chapter
Primary splenic hydatidosis is defined as the presence of isolated splenic hydatid cysts in absence of such cysts in any other part of the body. It is an uncommon condition accounting for about 2% of the overall hydatid disease burden. Spleen is the third most common organ to be affected by the disease after liver and the lungs.
Chapter
Hydatid disease is a worldwide parasitic disease that is endemic in certain parts of the world, such as Australia, New Zealand, Mediterranean countries, Turkey, North Africa, South America, the Philippines, Northern China, and the Indian subcontinent (Buttenschoen and Carli Buttenschoen 2003).
Chapter
The clinical presentation of hydatid disease of the liver depends on several factors which include location and the size of cyst, the stage of development and whether the cyst is alive or dead. The majority of patients with hydatid liver disease have indolent presentation in an otherwise healthy individual. Almost 75% of patients are asymptomatic,...
Chapter
Medical management of hydatidosis has been tried with many drugs including antimony, arsenic, iodides and mercury (Arif et al. 2008). However there was no evidence of any success. Lately the benzimidazole carbamate group of drugs was introduced and was found effective against larval stage of both E. granulosus and E. multilocularis. This benzimidaz...
Chapter
Hydatid disease in humans also known as echinococcosis is caused by four known species of Echinococcus, namely, Echinococcus granulosus, E. multilocularis, E. vogeli and E. oligarthus. Only the former three are of medical importance. E. granulosus causes cystic hydatid disease, whereas E. multilocularis causes alveolar hydatid disease. E. multilocu...
Chapter
The mainstay of treatment of hepatic hydatid disease is surgery and is presently the only viable treatment for alveolar hydatid disease (Arif et al. 2008). Even today, controversy exists as to the extent of operation performed. Advances in management have been made with the use of newer anthelminthic and application of percutaneous aspiration in se...
Chapter
Infection caused by larval stage of E. multilocularis in humans is less common as compared to E. granulosus and is known as alveolar hydatid disease. It is very rare in our part of the world and is mostly seen in Eastern France, Switzerland, Austria, Bulgaria, Turkey, Iran Japan, Afghanistan and Russia (Rausch et al. 1991). It is one of the most li...
Chapter
Hydatid disease, also known as echinococcosis, is a parasitic infestation that has a worldwide distribution. The term “hydatid” is from the Greek word meaning a drop of water or “watery vesicle”. The word “echinococcus” means “hedgehog berry”. Hydatid disease was alluded to by Hippocrates around 400 BC. Its parasitic nature was hypothesized by Pall...
Chapter
The diagnosis of uncomplicated hydatid cyst or any of its complication rests on a strong clinical suspicion. History and clinical examination remain the mainstay of diagnosis of hepatic hydatid disease. The history of having resided or travelled in an endemic area is always a strong diagnostic lead. Despite the extent of lesion, the patient is gene...
Article
Diagnostic laparoscopy is the basic procedure in laparoscopic surgery that has wide utility in practice, thus avoiding morbidity associated with open surgery. Laparoscopy is a minimally invasive technique wherein a fibre optic instrument is inserted through the abdominal wall to view the organs in abdomen/pelvis and permit the diagnosis and necessa...
Article
Cardiovascular disease are among the principal causes of disability and death in older persons and therefore preventive interventions for such diseases are a high priority.Secondary prevention trials have established the efficacy of low dose aspirin for the prevention of cardiovascular disease (fatal , non-fatal myocardial infarction fatal or non-f...
Article
Introduction: Worldwide antibiotic prescription in surgical practices are inappropriate quite often, reasons being inappropriate indication, inappropriate antibiotic prophylaxis, continuation of empiric therapy despite negative cultures in a stable patient, and a lack of awareness of susceptibility patterns of common pathogens. Extended-spectrum b-...
Article
75 years was referred from SMHS hospital as a case of left-sided irreducible inguinal hernia. The patient was a known case of rheumatic heart disease on multiple drugs. The patient was having a history of constipation for 4 days and mild pain lower abdomen. All investigations were within normal limit and patient was afebrile. The abdomen was soft,...
Article
Background: Surgical wound infection is a common postoperative complication and causes significant postoperative morbidity and mortality, prolongs hospital stay, and adds to hospital costs. Aims and objectives: This study was designed and carried out in the Department of General surgery SKIMS Srinagar in order to find infection rate after clean and...
Article
Hydatid disease or Echinococcosis is a zoonotic disease (Krabbe and Finsen 1862) caused by the larva of Echinococcus species and is one of the oldest known parasitic diseases to man. The disease has a worldwide distribution and is also well recognised and documented in the Indian subcontinent. The disease is caused by the larval stage of Echinococc...
Article
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Rearranged during transfection (RET) is a proto oncogene implicated in thyroid carcinogenesis of papillary type (PTC). The RET proto-oncogene in PTC is constitutively activated by fusion of its tyrosine kinase domain with the 5 ´region of another gene thereby generating chimeric products collectively named RET/PTCs. RET/PTC1 and RET/PTC3 are best c...
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Gastrointestinal stromal tumors (GISTs) are rare tumors of gastrointestinal tract arising from interstitial cells of Cajal. They present with varied clinical features most of which are non-specific. This study was done to identify the clinical features of GISTS and immunohistochemistry. It was a retrospective and prospective study. The total number...
Article
Editor's Note The 22nd Postgraduate Research Presentation Program (PGRPP) is being held at Sher-i-Kashmir Institute of Medical Sciences Srinagar (SKIMS) from 27th to 28th April. The program, started by SKIMS in the year 1998, serves as an important platform to all post-graduate doctors to present their research work, besides to learn the art of pre...
Article
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Background:The development of Colorectal Cancer (CRC) is a complex multistep process involving an accumulation of multiple genetic and epigenetic alterations. Epigenetic modifications, particularly DNA methylation in selected gene are recognized as common molecular alterations in human tumors. Netrin-1 receptors are aberrantly methylated in primary...
Article
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Background Parathyroidectomy has been traditionally performed through bilateral neck exploration (BNE). However, with the use of intraoperative parathyroid hormone (IOPTH) assay along with preoperative localization studies, focused parathyroidectomy can be performed with good surgical success rate, multiglandular disease can be predicted, and hence...
Article
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Musculoskeletal hydatidosis though rare, should not overlooked while coming across a cystic lesion in musculoskeletal system. Failure of correct diagnosis at the outset may result in sub-optimal treatment and possibly recurrence later on.
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Skin sparing mastectomy (SSM) refers to the maximum preservation of patients own skin with the removal of only nipple-areola complex and any breast skin involved with or close to the tumor. The aim of the study was to analyze the applicability of SSM with IBR, comparison of breast conserving surgery without reconstruction and SSM with IBR in terms...
Article
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Background: A significant proportion of individuals undergoing cholecystectomy for symptomatic cholelithiasis persist with symptoms even after surgery. Objectives: This study was aimed to test our hypothesis that age of presentation and duration of symptoms are the risk factors that predispose to negative symptomatic outcome after cholecystectomy....
Article
Sterilization is the absolute elimination or destruction of all forms of microbial life including spores. The aim of effective sterilization is to provide sterile product to the surgeon and to the patient. On the other hand disinfection is the relative removal of pathogenic organisms except spores. JMS 2015;18(2):123-127
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Hypermethylation of CpG islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. KLOTHO; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of...
Article
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Hydatid disease is a parasitic tapeworm infestation that usually involves liver and lungs. Primary retroperitoneal hydatid without liver and lung involvement is very rare. Surgery is the principle method of treatment for large retroperitoneal hydatid, whenever feasible. We report a case of primary retroperitoneal hydatid cyst in 29-year-old male pa...
Article
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Background: Echinococcosis is a human and animal health problem in many endemic areas worldwide. There are numerous reports and hospital-based studies from Kashmir, North India, yet there has been no epidemiological study conducted in Kashmir, the apparently endemic area for human hydatidosis. This study was designed to determine the seroprevalenc...
Article
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Fecaloma is a mass of hardened feces being impacted mostly in rectum and sigmoid. The most common sites of the fecaloma is the sigmoid colon and the rectum. There are several causes of fecaloma and have been described in association with Hirschsprung’s disease, psychiatric patients, Chagas disease, both inflammatory and neoplastic, and in patients...
Article
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Epigenetic mechanisms such as DNA methylation are being increasingly recognized to play an important role in cancer and may serve as a cancer biomarker. The aim of this study was to evaluate the promoter methylation status of MGMT (O6-methylguanine-DNA methyltransferase) and a possible correlation with the expression of MGMT and standard clinicopat...
Article
Ileocolic surgeries for various indications can be performed using staplers or sutures, and evidence based inference shows definite advantages with staplers over suturing in most of the studies. The present retrospective case control randomized study was undertaken to compare hand sewn and stapled techniques of ileocolic surgery in terms of outcome...
Article
Background: Chemical sphincterotomy is a novel way for treating patients of chronic anal fissure which avoids the risk of fecal incontinence associated with traditional surgical methods. Aims and objectives: The aim of this study was to compare the results of topical Diltiazem with topical Glyceril trinitrate in the management of chronic anal fissu...
Article
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Background: Aberrant promoter hypermethylation has been recognized in human breast carcinogenesis as a frequent molecular alteration associated with the loss of expression of a number of key regulatory genes and may serve as a biomarker. The E-cadherin gene (CDH1), mapping at chromosome 16q22, is an intercellular adhesion molecule in epithelial ce...
Article
ROLE OF PRE-OPREATIVE BILIARY DRAINAGE IN BENIGN SURGICAL OBSTRUCTIVE JAUNDICE
Article
Serological diagnosis of cystic echinococcosis (CE) is usually made by detecting specific antibodies in serum samples. However, collection of blood samples is difficult and may be hazardous and unsafe. Thus, it is important to assess alternative simple methods of sampling body fluids that give similar results. Saliva and urine have been suggested a...
Article
Pre-operative biliary drainage has been found to significantly improve overall mortality and morbidity in patients with surgical obstructive jaundice. Although there are some complications associated with preoperative biliary drainage, they can be avoided by proper rehydration, antibiotic cover and experience of the endoscopist. We conducted a stud...
Chapter
Acute appendicitis also called epityphlitis is the most common surgical emergency performed worldwide and must be distinguished from other causes of abdominal pain. Despite this, the methods for diagnosing acute appendicitis have significantly not changed over the past few decades. Accurate diagnosis cannot be made by any single test even in this m...
Article
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To compare the profile of postoperative outcome in secondary peritonitis with sepsis due to complicated appendicitis in two cohorts (drainage vs no-drainage) after appendicectomy in adults in the modern era of effective antibiotics. A retrospective review of all adult patients who were operated for secondary peritonitis with sepsis due to complicat...
Article
Carcinoma of gall bladder has early lymphatic and haematogenous spread. Most common extra abdominal site of metastasis is the lung. Metastasis to breast from carcinoma of breast is very rare. Our case describes an interesting case of carcinoma of gall bladder metastising to breast. A 50-year-old female presented to our outpatient department with a...
Article
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Gastric cancer remains a global disease worldwide. This is a partly preventable public health problem. Several factors are suspected to play a role in gastric carcinogenesis. High salt intake and gastric cancer are closely related. Dietary sodium chloride has been identified both epidemiologically and experimentally to be capable of increasing the...
Article
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Ulcerative colitis is a chronic disease that specifically affects the mucosa of the rectum and colon. Although the etiology of this recurring inflammatory disorder remains essentially unknown, there have been significant advances in identifying the likely genetic and environmental factors that contribute to its pathogenesis. The clinical course of...
Article
THIS ARTICLE HAS NO ABSTRACT (FIRST 100 WORDS OF THE ARTICLE ARE DISPLAYED): Staging of rectal cancer is necessary to provide the optimal treatment strategy although proctoscopy or sigmoidoscopy with biopsy are diagnostic. This is achieved by locoregional assessment of the disease by various available radiological investigations. Staging informatio...
Article
Pellet gunfire injuries inflicted while controlling agitated mobs has been studied. A total of 198 patients admitted to the Accident and Emergency Department with pellet gun injuries were studied in terms of anatomic site, severity and type of injury, treatment, and outcomes. 72.7% of patients were aged 16-25 years. The most common sites of injury...
Article
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Deep vein thrombosis (DVT) occurs at a lower rate in Asia than in the rest of the world. We wanted to study the significance and efficacy of low molecular weight heparin (LMWH) in prophylaxis of DVT in major general surgical patients in the Kashmir Valley (India, Asia) so as to make it a routine in our patients. This was a prospective study in whic...
Article
Full-text available
The hydatid disease most often involves the liver and the lungs. The disease can involve any part of the body except the hair, teeth and nails. Primary extrahepatico-pulmonary hydatid cysts are rare and only a few sporadic cases have been reported. Two hundred and forty-four patients with hydatid cysts managed surgically from January 2005 to Decemb...
Article
Interval appendectomy after acute appendicitis with lump formation (phlegmon) remains controversial. We conducted this study to determine the risk of recurrent appendicitis following initial non-operative treatment for appendicitis, and evaluate factors associated with recurrence. Secondarily, we evaluate the efficacy of interval appendectomy versu...
Article
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To determine the long-term results of choledochodudenostomy in patients with benign billiary obstruction. This prospective study was conducted at Sheri Kashmir Institute of Medical Sciences Srinagar Kashmir, India over a period of 10 years from January 1997 to December 2007. The total number of patients who underwent choledochoduodenostomy during t...
Article
Hydatid disease is a cyclo­zoonotic parasitic infection caused by Echinococcus granulosus. This disease is usually found in liver and lungs but no organ of body is immune. Location at unusual sites in the body can have atypical presentations and can pose a diagnostic challenge. A high index of suspicion, radiological investigations as well as histo...
Article
The association between gallstones and abnormal lipids and later increase in risk of coronary artery disease and stroke has been shown in many studies. The aim of study is to elucidate the association of dyslipidaemia with Cholilithiasis and effect of Cholecystectomy on the same. 73 patients with symptomatic gallstones were studied prospectively. P...
Article
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Breast gangrene is rare in surgical practice. Gangrene of breast can be idiopathic or secondary to some causative factor. Antibiotics and debridement are used for management. Acute inflammatory infiltrate, severe necrosis of breast tissue, necrotizing arteritis, and venous thrombosis is observed on histopathology. The aim of was to study patients w...