Ainhoa Arana Echarri

Ainhoa Arana Echarri
University of Bath | UB · Department for Health

PhD Researcher at the University of Bath

About

5
Publications
721
Reads
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28
Citations
Introduction
I am a PhD Researcher at the University of Bath, in the Department for Health, currently in my 3rd year. I am part of the GW4 BioMed MRC DTP program, and my research is focused on the potential role of immune function, liquid biopsies and lifestyle variables as predictors of breast cancer treatment outcomes. I am also involved in studies looking at factors that contribute towards cancer risk, as well as other studies looking at other types of cancer, such as lung cancer.
Additional affiliations
January 2017 - August 2017
University of Sussex
Position
  • Master's Student
Description
  • Under the supervision of Prof. Sarah Newbury, I carried out a project entitled XRN1 as a treatment of Mesenchymal Stem Cell lineage Cancers. It aimed to build up the knowledge on this exoribonuclease and its role in cancer development
September 2015 - June 2016
Universidad Autónoma de Madrid
Position
  • Extracurricular placement (after finishing my B.Sc)
Description
  • Supervised by Prof. C. Gutiérrez, I carried out a cloning strategy to get a triple system of cell cycle markers in cells of Arabidopsis thaliana, to study the dynamics of the cell cycle and monitor its progression without the need of crosses
February 2015 - May 2015
Université Catholique de Louvain - UCLouvain
Position
  • Laboratory placement during my B.Sc (Erasmus internship program)
Description
  • Supervised by Prof.F. Bontemps, I analysed the DNA repair pathways activated in response to treatment with purine analogs. My results were included in a publication of my research group (Starczewska et al, Oncotarget 7, 38367-379, 2016. PMID: 27223263).
Education
September 2016 - September 2017
University of Sussex
Field of study
  • Cancer Cell Biology
September 2011 - August 2015
University of Alcalá
Field of study
  • Health Biology (Biologia Sanitaria)

Publications

Publications (5)
Article
Full-text available
Purine analogs are among the most effective chemotherapeutic drugs for the treatment of chronic lymphocytic leukemia (CLL). However, chemoresistance and toxicity limit their clinical use. Here, we report that the DNA polymerase inhibitor aphidicolin, which displayed negligible cytotoxicity as a single agent in primary CLL cells, markedly synergizes...
Article
Full-text available
Assessing cell proliferation dynamics is crucial to understand the spatiotemporal control of organogenesis. Here we have generated a versatile fluorescent sensor, PlaCCI (plant cell cycle indicator) on the basis of the expression of CDT1a-CFP, H3.1-mCherry and CYCB1;1-YFP, that identifies cell cycle phases in Arabidopsis thaliana. This tool works i...
Article
Full-text available
Breast cancer is the most common malignancy among women worldwide. Over the last four decades, diagnostic and therapeutic procedures have improved substantially, giving patients with localized disease a better chance of cure, and those with more advanced cancer, longer periods of disease control and survival. However, understanding and managing het...
Article
Introduction: T cells are important for tumour control and surveillance, but it is not well known how breast cancer treatment impacts their characteristics in blood. Methods: Healthy women (n=38, age 45 ± 11 y), breast cancer survivors (n=27, age 56 ± 6 y) and breast cancer patients (n=5, age 44 ± 9 y) took part. Survivors comprised women who had r...

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