Aine M Seavers

Aine M Seavers

MVB MRCVS

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99
Publications
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137
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Publications

Publications (99)
Article
Full-text available
To determine the thyroid status of Basenji dogs in Australia. Jugular or cephalic venipuncture blood samples were taken from 113 Basenji, comprising 47 males, 5 castrates, 48 entire and 13 spayed bitches, and sent on ice in plain and EDTA tubes to a single laboratory to determine haematocrit and serum concentrations of total thyroid hormone (thyrox...
Article
Full-text available
Unlabelled: SURVEY AIMS: A questionnaire was sent to veterinarians in Australia to determine the approximate number of cats presenting for permethrin spot-on (PSO) intoxication over a 2-year period. Findings: Of the 269 questionnaires returned, 255 were eligible for analysis. A total of 207 respondents (81%) reported cases of PSO intoxication in...
Article
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An entire female Staffordshire Bull Terrier presented with an exfoliative dermatopathy and with systemic clinical signs more classically associated with hypothyroidism, e.g. lethargy, apparent weight gain in the absence of polyphagia, bilaterally symmetrical dermatological lesions, rat's tail alopecia and irregular oestrus cycles. The presumed caus...
Article
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Case report: A 2-year-old male Airedale Terrier was presented with an acute and painful, predominantly ventral, vesicular skin eruption following putative dermal contact with Plumbago auriculata (Sky Flower, Leadwort). Prompt dermal decontamination and supportive therapy brought about a rapid recovery in the patient. Conclusion: Contact with bot...
Article
Full-text available
A nine-year-old female desexed Great Dane presented with a painful, proliferative, soft red putative neoplastic vascular mass on the nictitating membrane. Three, seven-day cycles of the topical cytotoxic drug mitomycin C 0.04%, applied four times daily to the lesion using a low dose alternate-week pulse therapy, brought about rapid remission of the...
Article
Rat Bait Poisoning.Emesis or Antidote Therapy Discussion
Article
Background and purpose: The P2X4 receptor is an emerging therapeutic target for the treatment of chronic pain and cardiovascular disease. Dogs are well-recognised natural models of human disease but information regarding P2X4 in dogs is absent. To aid the development and validation of P2X4-targeting therapeutics, this study aimed to characterise a...
Article
Missense variants are associated with various phenotypic traits and disorders in dogs. The canine P2RX7 gene, coding the ATP‐gated P2X7 receptor ion channel, contains four known missense variants. The current study aimed to examine the presence of these variants in a random sample of pedigree and mixed‐pedigree dogs. Exons 3, 8, 11 and 13 of the P2...
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Full-text available
Caudal duplication (dipygus) is an uncommon pathologic of conjoined twinning. The conjoined malformation is classified according to the nature and site of the union. We report the presence of this malformation in a female crossbreed puppy. The puppy was delivered by caesarean section following a prolonged period of dystocia. External findings showe...
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Feline perineal itch caused by Fannia spp environmental infestation
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Age and breed may account for dose related adverse responses in Basenji dosed with thyroxine at standard recommended doses. It is advisable, when conducting therapeutic thyroid supplementation trials in members of this breed, to administer the drug in gradually increasing doses to avoid inducing dose related side effects. In a breed with a lower th...
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Full-text available
The relative function of the P2X7 receptor, an ATP-gated ion channel, varies between humans due to polymorphisms in the P2RX7 gene. This study aimed to assess the functional impact of P2X7 variation in a random sample of the canine population. Blood and genomic DNA were obtained from 69 dogs selected as representatives of a cross-section of differe...
Article
Epithelial cells are important in inflammation and immunity. In this study, we examined if Madin-Darby canine kidney (MDCK) epithelial cells express functional P2X7 receptors, which bind the damage-associated molecular pattern extracellular adenosine 5'-triphosphate (ATP). Reverse transcription (RT)-PCR and immunoblotting revealed the expression of...
Article
P2X7, a damage-associated molecular pattern receptor and adenosine 5'-triphosphate (ATP)-gated cation channel, plays an important role in the activation of the NALP3 inflammasome and subsequent release of interleukin (IL)-1β from human monocytes; however its role in monocytes from other species including the dog remains poorly defined. This study i...
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Complete caudal duplication is an extremely rare type of conjoined twinning. This communication reports the birth and gross features of a live conjoined British Blue kitten born naturally to a healthy queen. The monocephalic dipygus kitten exhibited a normal skull and upper body, two separate pelves, four hind limbs and two tails. A cleft palate an...
Article
Full-text available
A 9-year old German Shepherd bitch was presented with a recent onset of seborrhoea oleosa, hyperpigmentation, erythema, pruritus and alopecia along the neck, thorax, ventrum and the dorsal area of the carpus. The skin changes were believed to be caused by Dirofilaria immitis infection. A combination of topical and parenteral anti-heartworm therapy...

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