Aileen Hill

Aileen Hill
University Hospital RWTH Aachen · Departments of Anesthesiology and Intensive Care

Dr. med.
Clinician Scientist, Intensivist&Nutritionist - improving patient´s perioperative outcomes through nutrition&exercise

About

42
Publications
6,153
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269
Citations
Introduction
Dr. med. Aileen Hill is resident in the Departments of Anesthesiology and Intensive Care Medicine at the University Hospital RWTH Aachen. Her research focuses on nutrition in critically ill patients. Her special emphasis lies on improving the physical outcome of critically ill patients through nutrition, re- and prehabilitation, as well as on the modulation of systemic inflammation and prevention of organ dysfunction through micronutrients.
Additional affiliations
October 2018 - present
Medical Faculty RWTH Aachen
Position
  • Teacher for Physical Outcome Assessment
January 2018 - present
University Hospital RWTH Aachen
Position
  • Medical Doctor
March 2017 - present
Medical Faculty RWTH Aachen
Position
  • Medical Professional
Education
July 2007 - June 2015
Medical Faculty RWTH Aachen
Field of study
  • Medicine

Publications

Publications (42)
Article
Full-text available
Background: Uncertainty remains about the best route and timing of medical nutrition therapy in the acute phase of critical illness. Early combined enteral (EN) and parenteral nutrition (PN) may represent an attractive option to achieve recommended energy and protein goals in select patient groups. This meta-analysis aims to update and summarize th...
Article
Introduction There is a need to improve the efficiency of clinical trials in burn care. The objective of this study was to validate “Persistent Organ Dysfunction” (POD) plus death as endpoint in burn patients and to demonstrate its statistical efficiency. Methods This secondary outcome analysis of a dataset from a prospective international multice...
Article
While medical nutrition therapy is an essential part of the care for critically ill patients, uncertainty exists about the right form, dosage, timing and route in relation to the phases of critical illness. As enteral nutrition (EN) is often withheld or interrupted during the ICU stay, combined EN and parenteral nutrition (PN) may represent an effe...
Article
Full-text available
Background: Cardiac surgery is associated with oxidative stress and systemic inflammation, which both contribute to postoperative organ dysfunction. Vitamin C is a pleiotropic, antioxidant, and potentially organ-protective micronutrient. Past clinical trials and meta-analyses have focused predominantly on occurrence of postoperative atrial fibrill...
Article
We thank Vargas et al (1) for their interest in our recently published study in Critical Care Medicine (2). By analyzing the fragility index (FI) of all randomized controlled trials (RCTs) included in our systematic review and performing a trial sequential analysis (TSA) of our meta-analysis of overall mortality, they agreed with our position that...
Preprint
Background: Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and ass...
Article
Full-text available
Zusammenfassung Die Erhebung des Ernährungsstatus zum Zeitpunkt der Aufnahme im Intensiv- oder Intermediate Care Bereich hat sowohl prognostische als auch therapeutische Relevanz im Hinblick auf die Planung einer individualisierten medizinischen Ernährungstherapie (engl. „medical nutrition therapy“, MNT). Diese Planung wird im Rahmen der Erstversor...
Article
Full-text available
Background: Parenteral lipid emulsions in critical care are traditionally based on soybean oil (SO) and rich in pro-inflammatory omega-6 fatty acids (FAs). Parenteral nutrition (PN) strategies with the aim of reducing omega-6 FAs may potentially decrease the morbidity and mortality in critically ill patients. Methods: A systematic search of MEDLI...
Article
Background: Systemic inflammation and oxidative stress remain the main cause of complications in heart failure patients receiving a left ventricular assist device (LVAD). Selenoproteins are a cornerstone of antioxidant defense mechanisms for improving inflammatory conditions. Methods: We conducted a monocentric double-blinded, randomized pilot t...
Article
Objectives: To conduct a systematic review and meta-analysis to evaluate the impact of IV vitamin C on outcomes in critically ill patients. Data Sources: Systematic search of MEDLINE, EMBASE, CINAHL, and the Cochrane Register of Controlled Trials. Study Selection: Randomized controlled trials testing IV vitamin C in critically ill patients....
Article
Full-text available
Background: While consent exists, that nutritional status has prognostic impact in the critically ill, the optimal feeding strategy has been a matter of debate. Methods: Narrative review of the recent evidence and international guideline recommendations focusing on basic principles of nutrition in the ICU and the treatment of specific patient gr...
Article
Background: Uncertainty remains about the best route and timing of medical nutrition therapy in the acute phase of critical illness. Early combined enteral (EN) and parenteral nutrition (PN) may represent an attractive option to achieve recommended energy and protein goals in select patient groups. This meta-analysis aims to update and summarize t...
Article
Full-text available
Cardiac surgery (CSX) can be lifesaving in elderly patients (age ≥ 80 years) but may still be associated with complications and functional decline. Frailty represents a determinant to outcomes in critically ill patients, but little is known about its influence on elderly CSX-patients. This is a secondary exploratory analysis of a multi-center, pros...
Article
Full-text available
The authors thank the readers for pointing out the issues [1] in their publication [2], and wish to make a correction in the published version of their paper as the response of the readers' Comment. p-values have been corrected in the following parts of the paper.
Article
This review provides an overview for health care teams involved in the perioperative care of cardiac surgery patients. The intention is to summarize key determinants of delirium, its impact on short- and long-term outcomes as well as to discuss effective management strategies. The first component of this review examines the prevalence and the facto...
Article
Cardiac surgery is performed more often in a population with an increasing number of comorbidities. Although these surgeries can be lifesaving, they disturb homeostasis and may induce a temporary overall loss of physiologic function. The required postoperative intensive care unit and hospital stay often lead to a mid- to long-term decline of nutrit...
Article
Although nutritional support belongs to the key components of intensive care treatment, it still remains largely inadequate in the postoperative treatment of cardiac surgery patients. Ong et al demonstrated in their observational study that patients with complicated postoperative courses had an increased need for an intense postoperative nutrition...
Article
Medical nutrition therapy in daily intensive care often is challenging for the clinician. The severity of disease with possible compromises of conscience, hemodynamics, respiration, renal and gastrointestinal systems requires an individual adaptation of the nutrient-supply adjusted to the disease phase and secondary metabolic tolerance. For these a...
Article
Full-text available
Background The ethical framework for fluid management in the palliative care setting can vary. Objectives What are the relevant ethical implications related to dehydration during end-of-life care and what are the special requirements we need to consider as far as “terminal dehydration” is concerned? Materials and methods A comprehensive literatur...
Article
Full-text available
Background: The legal framework for fluid management in the palliative care setting varies between continents and even between countries. Objectives: What legal implications must be taken into account in Germany in dealing with "terminal" dehydration? Materials and methods: Relevant publications in English and German have been identified. Nota...
Article
Full-text available
Background: Oxidative stress contributes to organ dysfunction after cardiac surgery and still represents a major problem. Antioxidants, such as vitamins C and E might be organ protective. Methods: The primary objective of this prospective observational study was the description to evaluate the perioperative vitamin C and E levels in 56 patients...
Conference Paper
Rationale: A combination of enteral nutrition (EN) and parenteral nutrition (PN) may avoid large nutrition debts in critically ill patients. One strategy is the combined use of EN and PN (EN+PN) starting early after admission to the intensive care unit. Another possibility is the early initiation of EN with delayed start of supplemental PN if the n...
Article
Full-text available
Systemic and localized ischemia and reperfusion injury remain clinically relevant issues after organ transplantation and contribute to organ dysfunctions, among which acute kidney injury is one of the most common. An in vitro test-circuit for normothermic perfusion of porcine kidneys after warm ischemia was used to investigate the antioxidant prope...
Article
Full-text available
Background Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit fro...
Article
Full-text available
Background & aims: Recent studies indicate that vitamin D deficiency is associated with increased morbidity and mortality in critically ill patients. Knowledge about the functional role and clinical relevance of vitamin D for patients undergoing cardiac surgery is sparse. Therefore, we investigated the clinical significance of vitamin D levels on...
Article
Vitamin C, an enzyme cofactor and antioxidant, could hasten the resolution of inflammation, oxidative stress, and microvascular dysfunction. While observational studies have demonstrated that critical illness is associated with low levels of vitamin C, randomized controlled trials (RCTs) of vitamin C, alone or in combination with other antioxidants...
Article
Full-text available
The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ...
Article
Objectives: The first aim was the development of a human blood miniature mock-loop system consisting of 2 identical extracorporeal circuits, which enable systematic head-to-head comparisons of test substances. In a second step, we evaluated the suitability of the mock-loop system, by comparing 2 different brands of heparin (ROTEXMEDICA vs B.BRAUN)...
Preprint
The pleiotropic biochemical and antioxidant functions of Vitamin C (Vit C) have recently sparked interest in its application in intensive care. Vit C protects important organ systems such as the cardiovascular, neurologic and renal system during inflammation and oxidative stress. Vit C also influences the systems of coagulation and inflammation and...
Article
Zusammenfassung Der präoperative Ernährungsstatus und die perioperative Ernährungsstrategie spielen eine wichtige Rolle für das Outcome herzchirurgischer Patienten – dennoch gibt es nur wenige Studien zu Ernährungskonzepten für diese Patientengruppe. In diesem Beitrag werden die Ursachen der Mangelernährung, der Einfluss der Ernährungstherapie auf...
Article
Full-text available
Nutrition support is increasingly recognized as a clinically relevant aspect of the intensive care treatment of cardiac surgery patients. However, evidence from adequate large-scale studies evaluating its clinical significance for patients' mid-to long-term outcome remains sparse. Considering nutrition support as a key component in the perioperativ...
Preprint
Nutrition support is increasingly recognized as a clinically relevant aspect of the intensive care treatment of cardiac surgery patients. However, evidence from adequate large-scale studies evaluating its clinical significance for patients’ mid- to long-term outcome remains sparse. Considering nutrition support as a key component in the perioperati...
Article
The artificial placenta as a fascinating treatment alternative for neonatal lung failure has been the subject of clinical research for over 50 years. Pumpless systems have been in use since 1986. However, inappropriate dimensioning of commercially available oxygenators has wasted some of the theoretical advantages of this concept. Disproportional s...

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Projects

Projects (7)
Project
Once again, we’ve systematically reviewed 53 topics on critical care nutrition have posted our updated summaries on our website. We have included all RCTs of nutritional interventions involving critically ill patients examining clinically important outcomes published since 1980. Visit the Critical Care Nutrition website (https://www.criticalcarenutrition.com/systematic-reviews) to access these Systematic Reviews. The included studies have undergone a formal review by our review committee and data have been extracted in duplicate. The updated Systematic reviews are being made available starting in February 2021 and all will hopefully be updated by the end of March 2021. Refer to the topics below for a full list of the topics and for links to the available systematic reviews. We are hoping you find these summaries of evidence updates helpful in your day to day practice. Also, we wanted to offer a thank you to our collaborators who worked on this update. This would not possible without a full team effort. Review Committee: Dr. Daren Heyland, MD Dr Jayshil Patel, MD Dr Aileen Hill, MD Zheng Yii Lee, MSc Cindy Yap, BSc Luis Alfonso Ortiz Reyes, MSc John Clarke, MSc, RKin Rupinder Dhaliwal, RD
Project
To determine the influence of macronutrient supply on outcome of the critically ill patient with special emphasis on functional outcomes, such as muscle strength and physical function. To determine the influence of certain micronutrients on inflammation oxidative stress and organ dysfunction.
Project
Investigate the influence of nutrition strategies on clinical outcome in ICU patients