Aida A Mahmoud

• MD
• Professor at Sohag University

Background: A definite anemia [hemoglobin (HB) 10-12 g/dl] or the need for significantly higher Erythropoietin (EPO) dosages of epoetin alfa are symptoms of EPO resistance, respectively. The recommended restorative goal is to maintain HB levels between 11 and 12 g/dl. Fe deficiency, concurrent inflammation, inadequate dialysis, hyperparathyroidism,...

Background: Tobacco use is responsible for millions of preventable deaths due to cancer. Nicotine, an alkaloid chemical found in tobacco was proved to cause chronic inflammation and oxidative stress. The transcription factor STAT1 induces the expression of many proinflammatory genes and has been suggested to be a target for anti-inflammatory thera...

This study aimed to evaluate the therapeutic role of erythropoietin (EPO) or myoinositol versus metformin (MET) in improving the reproductive functions and glucose tolerance in a rat model of polycystic ovary (PCOS). Oral letrozole (LTZ) was used for induction of PCOS in wester rats for 21 days, after that, MET, EPO and myoinositol were administere...

Background: Introduction: Oxytocin (OT) has been proposed to assist in the regulation of bone remodeling and to exert an antiosteoporotic effect. We evaluated the possible protective effect of OT against bone degeneration in ovariectomized (OVX) rats. Methods: The study was performed on three groups of adult female rats; group I was subjected to...

Background and aim DNA repair represents a protective mechanism against cell injury and cancer. 8-hydroxy-deoxyguanosine (8-OHdG) is the main ROS-induced DNA mutation. The current study aimed to evaluate urinary 8-OHdG levels in patients with chronic hepatitis C virus (HCV) and its related hepatocellular (HCC) and correlate its level to XRCC1 rs254...

Background In this study, we aimed to examine the association of adiponectin (ADIPOQ) rs2241766 (+45T/G) and rs266729 (−11377C/G) gene polymorphisms with serum ADIPOQ in non-alcoholic fatty liver disease (NAFLD). Methods ADIPOQ rs2241766 and rs266729gene polymorphisms were genotyped by using TaqMan 5′-nuclease assay and serum ADIPOQ level was meas...

Curcumin has been proved to have antioxidant and antiinflammatory actions. We investigated the prophylactic effect of curcumin against the development of non-alcoholic fatty liver (NAFLD) disease in high fat diet (HFD)-fed rats. The study included three groups of rats, group I were fed low-fat diet, group II were fed HFD and group III were fed HFD...

Background Osteopontin (OPN) is an extracellular matrix protein of the integrin family that is involved in several biological pathways. Genetic polymorphisms in OPN gene has been found associated with many types of cancer. Aims In this investigation, we aimed to study the possible role of OPN and its rs11730582 C/T single nucleotide polymorphism (...

The aim of the study was to evaluate the association between the gene polymorphisms in interleukin-10 (IL-10) and interferon gamma (IFN-γ) genes with susceptibility and severity of hepatitis C virus (HCV) infection among Egyptian patients. Interleukin-10 -592 A/C, -1082 G/A and IFN-γ +874 T/A genotypes were determined in 100 chronic HCV patients an...

Tuberculosis is a major health problem worldwide. Genetic factors are considered important determinants of the host susceptibility to Mycobacterium tuberculosis. The aim of the current study was to evaluate the association between pentraxin 3 genetic variants and the susceptibility and severity of active pulmonary tuberculosis. The study included 1...

Lung cancer is the malignant tumor of highest mortality rate in men worldwide, and its rate is increasing in women. Ornithine decarboxylase (ODC) is the first enzyme in the pathway of polyamines synthesis and its expression was found increased in many types of tumor tissues. This investigation aimed at measuring ODC activity and gene expression in...

Sirtuin 1 (SIR1) is a NAD +-dependent nuclear deacetylase that is involved in various metabolic pathways affecting energy homeostasis. In this investigation, we aimed to study the association of three SIRT1 gene single nucleotide polymorphisms (SNPs); rs7895833 A/G, rs7069102 C/G and rs2273773 C/T, located on the promotor, intron and exon regions r...

Purpose: To elucidate the role of heat shock protein-70 (HSP70) and hypoxia inducible factor-1α (HIF-1α) in diabetic retinopathy (DR) patients. Design and methods: A comparative study was done on the serum level of both HSP70 and HIF-1α in 50 patients with type 2 diabetes mellitus (T2DM) without DR, 50 patients with T2DM and DR and 70 healthy co...

Objectives: Several candidate genes are implicated in the pathogenesis of type 2 diabetes mellitus (T2DM), one of which is interleukin (IL-10). In this investigation, we aimed to study the association between IL-10 (-592A/C) gene polymorphism with its level in T2DM with and without nephropathy. Methods: IL-10 (-592A/C) gene polymorphism was genotyp...

Background: Sirtuin-1 (SIRT-1), a protein has been found to protect the cells against oxidative stress due to its deacetylase activity. In this investigation, we aimed to study SIRT-1 gene rs2273773 C > T single nucleotide polymorphism and markers of serum protein oxidation (protein carbonyl and sulfhydryl groups) in asthmatic patients. Subjects an...

Background Rheumatoid arthritis (RA) patients are at an increased risk of developing type-2 diabetes mellitus (T2DM) compared to the general population. Interferon-γ (IFN-γ) was found to have a role in both RA and T2DM. Aim of the work To investigate the role of IFN-γ and its +874T/A gene polymorphism in the development of T2DM in RA patients. Pati...

Background: Apolipoprotein E (apo E) gene polymorphism was found to be associated with coronary artery disease in several studies. In this investigation, we aimed to study the association between apo E gene polymorphism and acute coronary syndrome in Egyptian population. Subjects and methods: The study included 200 patients with acute coronary synd...

The aim of the present study was to evaluate the association between the polymorphisms in interleukin-10 and interferon- γ genes with susceptibility and severity of HCV infection in Sohag University Hospital, Sohag, Egypt. The study was carried out on 100 patients with chronic HCV who were allocated into 2 groups; chronic HCV patients without cirrh...

Background Vitamin D is a potent immunomodulator of innate immune responses, and its deficiency was implicated in the activation of tuberculosis (TB). The effects of vitamin D are exerted by the interaction with the vitamin D receptor (VDR) and may be influenced by polymorphisms in the VDR gene. Methods We conducted a case–control study to identif...

Hyperglycemia is one of the most important factors that are responsible for oxidative stress and production of reactive oxygen species (ROS) in diabetes. Proteins are likely to be major targets of ROS, as a result of their abundance in cells, plasma, and most tissues, and their rapid rates of reaction both with many radicals and with other oxidants...

Hyperglycemia is one of the most important factors that are responsible for oxidative stress and production of reactive oxygen species (ROS) in diabetes. Proteins are likely to be major targets of ROS, as a result of their abundance in cells, plasma, and most tissues, and their rapid rates of reaction both with many radicals and with other oxidants...

Leptin is a 16 KDa protein, consists of 167 amino acid residues. It has many functions including angiogenesis. Leptin either induces angiogenesis itself or influences the levels of other angiogenic factors. The aim of the present investigation was to study the effect of leptin on the levels of the angiogenic factors; vascular endothelial growth fac...

Objectives. The aim of the present investigation was to study the activity of glucose-6-phosphate dehydrogenase (G6PD) andcorrelate its activity to protein oxidation markers in type 2 diabetic patients under poor glycemic control. Methods. G6PD activity, protein carbonyl group concentration, and total thiol group content were measured in blood samp...

Background: Leptin, an adipocytokine was found to be associated with essential hypertension in several studies and butyrylcholinesterase enzyme (BChE) is an enzyme that hydrolyzes acetylcholine in plasma. Recent studies link between BChE and cardiovascular risk factors. Objectives: The aim of the present investigation was to study the relationship...

The occurrence of anemia, iron status and calcium-phosphorus levels were studied in 70 rheumatoid arthritis (RA) patients. Obtained results revealed that anemia was found in 52.8% of the patients, 43.24 % of the anemic patients had iron deficiency anemia (microcytic, hypochromic anemia , low serum iron, low serum ferritin and an increase in total i...

Serum protein carbonyl group, total thiol group and nitric oxide were studied in 30 patients with rheumatoid arthritis. Obtained results revealed that, Serum protein carbonyl content and nitric oxide (nitrite and nitrate) were significantly higher in rheumatoid arthritis patients than in the controls. However, total thiol group decreased significan...