Ai-Zheng Chen

Ai-Zheng Chen
National Huaqiao University · Institute of Biomaterials and Tissue Engineering

Doctor of Philosophy

About

177
Publications
19,843
Reads
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3,752
Citations
Citations since 2016
100 Research Items
3223 Citations
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
Introduction
Postdoc positions are available (~300K RMB/year). Please contact Dr. Chen via azchen@hqu.edu.cn for more info. Dr. Chen received his Ph.D. in Biomedical Engineering from Sichuan University in 2007. After postdoctoral research in The Hong Kong Polytechnic University for two years, he joined Huaqiao University, where he is now Professor and Director of Institute of Biomaterials and Tissue Engineering, and Vice Dean of College of Chemical Engineering. He was a visiting professor for a year at Prof. Ali Khademhosseini‘s Lab in Harvard Medical School. He has been granted 6 National projects, and has published more than 100 peer-reviewed publications; His research interests are supercritical fluid technology, drug delivery system, tissue engineering and regenerative medicine.

Publications

Publications (177)
Article
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Although nano-immunotherapy has advanced dramatically in recent times, there remain two significant hurdles related to immune systems in cancer treatment, such as (namely) inevitable immune elimination of nanoplatforms and severely immunosuppressive microenvironment with low immunogenicity, hampering the performance of nanomedicines. To address the...
Article
The two-dimensional (2D) transition metal dichalcogenides (TMDCs)-based nanomaterials have acquired enormous interest due to their advantageous morphological properties and physicochemical characteristics, such as rich elemental composition, exceptional optical and electrical characteristics, as well as thermal stability, among others. In addition,...
Article
Indocyanine green (ICG), a water-soluble near-infrared (NIR) photosensitizer, has been enormously regarded in tumor diagnosis and phototherapy. Although tremendous progress in establishing the nanocarrier-based delivery systems has been explored, several limitations of low ICG encapsulation and sophisticated fabrication process remain significant c...
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Compared to traditional 3D models lacking the native cellular microenvironment, cartilage decellularized extracellular matrix (dECM) has shown great advantages in understanding complex mechanisms of cartilage inflammatory diseases and drug treatment by providing an extracellular matrix and mesenchymal-like microenvironment. Herein, dECM replicates...
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Lanthanide-doped upconversion nanoparticles (UCNPs) and cesium lead halide perovskite quantum dots (PeQDs) are highly compatible with each other: UCNPs produce anti-Stokes upconversion luminescence (UCL) under near-infrared (NIR) excitation and the emissive profiles of PeQDs can be conveniently tuned by varying the halide composition ratio. Therefo...
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Aripiprazole (ARI), a second-generation atypical antipsychotic drug approved for schizophrenia treatment, shows good efficacy against depression. However, the poorly aqueous solubility of ARI leads to low bioavailability and increased dose-related side effects, seriously limiting its application in pharmaceutics. Herein, we demonstrated the fabrica...
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Despite the success, it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic therapy. Herein, we report a near-infrared (NIR)/acid-induced nanoplatform based on chitosan (CS)-coated indocyanine green (ICG, photosensitizer)/luteolin (LUT, a natural quorum sensing inhibitor) nanocom...
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Despite the advantages and success in many fields, most elastomers currently fail to meet specific application requirements owing to their poor mechanical properties and limitations in the manufacturing of complex structures. 3D printing has emerged as an attractive manufacturing process for building a variety of complex structures for custom-confi...
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Liquid crystal display (LCD)-based 3D printing, a facile and cost-effective manufacturing technique, is often applied when fabricating objects with porcelain structures using photosensitive resins (PSRs). Currently, 3D printed constructions are typically used as models for demonstration purposes rather than industrial applications because of their...
Article
The tumor tissue delivery of nanomaterials and the components’ intracellular location are particularly critical for the effect of tumor treatment. However, the abominable conditions in the tumor microenvironment hinder nanomaterials’ penetration, inducing the therapeutic action only on the surface of tumor tissue. And it is low-efficiency for thera...
Article
Recently, layered double hydroxides (LDHs) have gathered vast interest due to overall positive charge, unique crystallinity, and biocompatibility for diverse applications. Despite the advantageous attributes, these hydrotalcites often result in several limitations concerning the application requirements, such as aggregation, as well as poor chemica...
Article
Despite significant advances in drug formulation, the clinical application of most active ingredients from traditional Chinese herbs remained a significant challenge owing to their poor solubility. To address this crucial issue, astragaloside-IV (AS-IV) was selected as a model drug to prepare nanoparticles with a large specific surface area via a c...
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Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D printing to create cell-laden structures. Recently, d...
Article
In recent years, antibody-based cancer therapy has emerged as one of the efficient therapeutic strategies, such as immune checkpoint inhibitors (ICIs), angiogenesis inhibitors, antibody-drug conjugates (ADCs), multi-specific antibodies, and chimeric antigen receptor T (CAR-T) cells, among others. To date, various drug delivery platforms have been d...
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The transition elements (groups IIIB to IIB)-based materials present advantageous morphological and physicochemical attributes due to the exceptionally variable valence states and highly stable metal ions. Among the first-row transition elements-based materials, manganese dioxide (MnO2) has garnered enormous interest from researchers due to the eas...
Article
The anti‐Stokes upconversion luminescence (UCL) generated from lanthanide‐doped upconversion nanoparticles (UCNPs) has been highly favorable. Nevertheless, the future success of UCNPs is critically reliant on efficient tailoring of UCL, which has always been intensively focused and comprehensively studied. Notably, in recent years, several reports...
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Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs often suffer from various limitations in biomedicine, such as reduced drug encapsulation efficacy, deprived compatibility, and poor degradability, resulting in poor the...
Article
Malignant osteosarcoma is one of the serious health concerns attributed to inferior prognosis and uncontrolled metastasis in clinics. Indeed, multifunctional therapeutics with precise tumor killing and subsequent regeneration of damaged tissue are of immense requirement in treating osteosarcoma. Herein, this study demonstrates the fabrication of ve...
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Indeed, the body articulation units, commonly referred to as body joints, play significant roles in the musculoskeletal system, enabling body flexibility. Nevertheless, these articulation units suffer from several pathological conditions, such as osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, gout, and psoriatic arthritis....
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TCPP molecules and ytterbium ions are grown into nanoscale (∼200 nm) Yb-TCPP MOFs, which can generate ¹ O 2 under 655 nm illumination. In vitro PDT efficacy is studied, revealing the potential of Yb-TCPP MOFs as the future anticancer agent.
Article
We describe the synthesis of MnO2-coated porous Pt@CeO2 core-shell nanostructures (Pt@CeO2@MnO2) as a new theranostic nano-platform. The porous Pt cores endow the core-shell nanostructures with high photothermal conversion efficiency (80%) in the near-infrared region, allowing for photothermal therapy (PTT) and photoacoustic imaging (PA) of tumors....
Article
Various conventional treatment strategies for volumetric muscle loss (VML) are often hampered by the extreme donor site morbidity, the limited availability of quality muscle flaps, and complicated, as well as invasive surgical procedures. The conventional biomaterial-based scaffolding systems carrying myoblasts have been extensively investigated to...
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The construction of biomimetic vasculatures within the artificial tissue models or organs is highly required for conveying nutrients, oxygen, and waste products, for improving the survival of engineered tissues in vitro. In recent times, the remarkable progress in utilizing hydrogels and understanding vascular biology have enabled the creation of t...
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In recent times, the supercritical carbon dioxide (scCO2) process has attracted increasing attention in fabricating diverse materials due to the attractive features of environmentally benign nature and economically promising character. Owing to these unique characteristics and high-penetrability, as well as diffusivity conditions of scCO2, this hig...
Article
Despite the success in developing various pharmaceutical formulations, most of the active pharmaceutical ingredients (APIs)/drugs, according to the Biopharmaceutics Classification System (BCS), often suffer from various intrinsic limitations of solubility and permeability, substantially hindering their bioavailability in vivo. Regardless of the fac...
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Recently, hydrogels have gained enormous interest in three-dimensional (3D) bioprinting towards developing functional substitutes for tissue remolding. However, it is highly challenging to transmit electrical signals to cells due to the limited electrical conductivity of the bioprinted hydrogels. Herein, we demonstrate the 3D bioprinting-assisted f...
Article
Poor solubility limits anticancer efficiency of Artemisinin (ART). Here, two types of micronized ART products were produced in one system, using supercritical CO2. ART microfibers (0.590 μm ± 0.160 μm) were obtained at a pressure of 25 MPa, temperature of 55 °C, and concentration of 4 mg/mL. ART microparticles (0.890 μm ± 0.610 μm) were obtained at...
Article
A biomolecule-guided self-assembly is a powerful approach to systematically organize diverse inorganic nanoparticles into predefined nanostructures in multiple dimensions. A class of supramolecular proteins is one kind of such biomolecules natively possessing exquisite structures and modifiable ligands, providing a desired candidate for templating...
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Despite the enormous applicability, the traditional, oversimplified in vitro two-dimensional (2D) monolayer cell culture models for preclinical drug screening towards evaluating pharmacological as well as toxicological properties fail to recapitulate structural, biological, and functional attributes of their in vivo counterparts. In this regard, bi...
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Despite the accessibility to porous architectures through various biofabrication approaches for tissue engineering, incorporating various active growth regulators within their matrices that act as biochemical cues is also an essential attribute for effective tissue growth. To address these facts, icariin (ICA)-encapsulated polymeric scaffolds are f...
Article
In the past few decades, although tremendous advancements have been witnessed by the progress in the fabrication of various kinds of nanomaterials, only those types of nanomaterials with unique features in terms of advantageous morphological attributes and physicochemical properties have become the area of focus towards their applicability in diver...
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Indocyanine green (ICG), a near-infrared (NIR) agent with an excellent imaging performance, has captivated enormous interest from researchers owing to its excellent therapeutic and imaging abilities. Although various nanoplatforms-based drug delivery systems (DDS) with the ability to overcome the clinical limitations of ICG has been reported, ICG-m...
Article
In recent times, numerous efforts have been put forward to fabricating the self-propelling micro-/nano-motors (MNMs) for various applications, such as drug delivery, environmental remediation, biosensing, and precision surgery at the micro-/nanoscale, among others. Owing to their potential advantages, the application of such innovative architecture...
Article
Herein, an efficient strategy to fabricate well-organized one-dimensional (1D) inorganic nanostructures is demonstrated by utilizing the hollow tobacco mosaic virus coat protein (TMVCP) as a restrictive template. Considering the advantages of the unique hollow structure and the dynamic self-assembly attribute of TMVCP, foreign nano-objects are succ...
Article
Hydrogen sulfide (H2S) has recently emerged as a novel gaseous mediator with protective actions in the treatment of pulmonary arterial hypertension (PAH). However, the therapeutic potential of H2S in PAH has been substantially hampered due to the lack of appropriate donors that could mimic the slow and continuous generation of H2S in vivo. Large po...
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Abstract Compared to various traditional 2D approaches, the scaffold‐based 3D tumor models have emerged as an effective strategy to investigate the complex mechanisms behind cancer progression and responses to drug treatments, by providing biomimetic extracellular matrix and stromal‐like microenvironments including the vascular elements. Herein, th...
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Owing to their attractive physicochemical and morphological attributes, mesoporous silica nanoparticles (MSNs) have attracted increasing attention over the past two decades for their utilization in diversified fields. Despite the success, these highly stable siliceous frameworks often suffer from several shortcomings of compatibility issues, uncont...
Article
In recent times, the combination therapy has garnered enormous interest owing to its great potential in clinical research. It has been reported that disulfiram (DSF), a clinical anti-alcoholism drug, could be degraded to diethyldithiocarbamate (DDTC) in vivo and subsequently resulting in the copper-DDTC complex (Cu(DDTC)2) towards ablating cancer c...
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In recent years, the stimuli-responsive delivery of drugs based on diselenide-bridged polymeric nanocomposites have gathered significant attention from researchers towards augmented anticancer therapy, owing to the unique dual reactive oxygen species (ROS) as well as glutathione (GSH) redox-responsive diselenide bonds. Despite their success in deli...
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The over-developed lysosomes in cancer cells are gaining increasing attention towards more precise and effective organelle-targeted cancer therapy. It is suggested that rods/plates-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in nanomaterials transme...
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In recent times, the copper chalcogenide (Cu2-xE, E=S, Se, Te)-based nanomaterials have emerged as potent photothermal agents for photothermal therapy (PTT) owing to their advantageous features, such as the low cost, reduced toxicity, biodegradability, and the strong absorption of near-infrared (NIR) light in a relatively wide range of wavelength....
Article
Despite the success in exploring and repurposing of its various biological efficacies such as antitumor and others, disulfiram (DSF), a copper-dependent antitumor drug, suffers from multiple shortcomings of poor aqueous solubility and instability in the physiological environment, which often hinder its clinical applicability. Moreover, the limited...
Article
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Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are of particular importance for use in diverse fields including, but not limited to, adsorption, catalysis, and medicine. Despite their intri...
Article
Exosomes could serve as delivery platforms, owing to their good biocompatibility, stability, and long blood circulation time. Tracking biological fate of exosomes in vivo is essential for evaluating their functions, delivery efficacy, biosafety, and is invaluable for guiding exosome-based therapy. Here, we merged a single-cell technology, mass cyto...
Article
The practical application of chrysin (CHS) is significantly hindered due to its poor aqueous solubility. To address this issue, a delivery platform based on CHS-polyvinylpyrrolidone (CHS-PVP) sub-microparticles was fabricated using the supercritical antisolvent (SAS) process. Initially, the effects of different operating parameters, including tempe...
Article
Owing to its poor solubility, the applicability of dihydromyricetin (DMY) is limited in various biomedical applications. To overcome this issue, nano-sized DMY particles (DMY NPs) were fabricated using the supercritical antisolvent (SAS) approach for improving the bioavailability of DMY. Initially, the experimental conditions were optimized such as...
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Due to its hydrophobicity, fisetin (FIS) often suffers from several limitations in terms of its applicability during the fabrication of pharmaceutical formulations. To overcome this intrinsic limitation of hydrophobicity, we demonstrate here the generation of poly (vinyl pyrrolidone) (PVP)-encapsulated FIS nanoparticles (FIS-PVP NPs) utilizing a su...
Article
In an attempt to attain synergistic therapeutic benefits and address various intrinsic limitations of the highly efficient black phosphorus quantum dots (BPQDs), we fabricated poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer (PLLA-PEG-PLLA)-based nanocomposites co-loaded with BPQDs and gambogic acid (GA) using the supercriti...
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With the advent of nanotechnology, various modes of traditional treatment strategies have been transformed extensively owing to the advantageous morphological, physiochemical, and functional attributes of nano-sized materials, which are of particular interest in diverse biomedical applications, such as diagnostics, sensing, imaging, and drug delive...
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Despite the significant advancements in the development of a wide-variety of nanocarriers-based delivery systems for cancer therapy, several predominant issues remain unaddressed such as active combat of cancer multidrug resistance (MDR) and the limited penetration efficacy of the delivery systems. To address these issues, herein, we demonstrate th...
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Recently, metal-organic frameworks (MOFs) have garnered enormous attention from researchers owing to their superior physicochemical properties, which are of particular interest in various fields such as catalysis and the diverse areas of biomedicine. Despite their position in the utilization for various applications compared to other innovative nan...
Article
Despite the significant advancements in fabricating various scaffolding systems over the past decades, generation of functional tissues towards vascularization remains challenging for the currently available biofabrication approaches. On the other hand, the applicability of traditional surgical transplantation of vascularized tissue constructs is l...
Article
Gelatin methacryloyl (GelMA) hydrogels have been commonly used in fabricating cannular tissue constructs due to their excellent cytocompatibility, as well as amenity to migration and proliferation of encapsulated cells. Here we present a simple yet efficient approach for fabricating hollow structures with gelatin-based hydrogels using a modified mi...
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Despite their inherent efficacy in significantly accelerating the rate of chemical reactions in biological processes, the applicability of natural enzymes is often hindered due to their intrinsic limitations such as high sensitivity, poor operational stability, and relatively high cost for purification as well as preparation. Thus, the fabrication...
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In article number 1901397, Yu Shrike Zhang, Ai‐Zheng Chen, and co‐workers fabricate highly open porous microspheres (HOPMs) using a microfluidic technique for harboring skeletal myoblasts towards cell delivery applications in situ. The structure of the HOPMs conveniently provides a favorable microenvironment for cell adhesion and proliferation, imp...
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In article number 1800910 by Yu Shrike Zhang, Ai‐Zheng Chen, and co‐workers, insulin‐loaded poly‐l‐lactide porous microspheres (INS‐PLLA PMs) are fabricated by using supercritical fluid technology, serving as an inhalation delivery system potentially used towards diabetes therapy. The PLLA PMs show negligible toxicity to lung‐derived cells, and the...
Article
Despite the captivating interest for its potential anticancer efficacy against multiple types of cancer and ability to overcome multidrug resistance, the practical application of gambogic acid (GA)has been hampered by its poor water solubility. Herein, the fabrication of nanosized GA particles (251.2 nm ± 85.6 nm)using eco-friendly supercritical fl...
Article
Current preclinical drug evaluation strategies that are explored to predict the pharmacological parameters, as well as toxicological issues, utilize traditional oversimplified cell cultures and animal models. However, these traditional approaches are time-consuming, and cannot reproduce the functions of the complex biological tissue architectures....
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With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, i.e., drug efficacy and toxic...
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Herein, the assembly of 3D uniform gear‐like architectures is demonstrated with a tobacco mosaic virus (TMV) disk as a building block. In this context, the intrinsic behavior of the TMV disk that promotes its assembly into nanotubes is altered by a synergistic effect of dual functional modifications at the 53rd arginine mutation and the introductio...
Article
Spurred by the current advancements in engineering various intelligent nanoparticle‐based drug delivery systems, conjugation of drugs with the stimuli‐responsive molecular switches has become one of the most efficient approaches to deliver a drug cargo in spatiotemporal controlled fashions. In this study, we fabricated an innovative pH‐triggered Hy...
Article
Biodegradable drug‐eluting stents (DESs) are used today to treat atherosclerotic arteries and as vehicles to deliver inhibitors to suppress restenosis, with potential applications also in localized cancer therapy. Here the development of a series of drug‐eluting poly(glycerol sebacate) (PGS) coils that may find possible use as DESs is reported. PGS...
Article
The impact of nanotechnology and its advancements have allowed us to explore new therapeutic modalities. To this end, we designed nanoparticles-laden porous microparticles (NIPMs) co-loaded with small-interfering ribonucleic acid (siRNA) and glucagon-like peptide-1 (GLP-1) using the supercritical carbon dioxide (SC-CO2) technology as an inhalation...
Article
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Some basic requirements of bone tissue engineering include cells derived from bone tissues, three-dimensional (3D) scaffold materials, and osteogenic factors. In this framework, the critical architecture of the scaffolds plays a crucial role to support and assist the adhesion of the cells, and the subsequent tissue repairs. However, numerous tradit...
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Recently, the tremendous progress has been evidenced by the advancements in developing innovative three dimensional (3D) scaffolds using various techniques for addressing the autogenous grafting of bone. Herein, we demonstrated the fabrication of porous polycaprolactone (PCL) scaffolds for osteogenic differentiation based on supercritical fluid-ass...
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Pulmonary delivery of drugs has attracted increasing attention in healthcare as the lung is an easily accessible site for non-invasive systemic delivery of drugs. Although pulmonary inhalation of porous microparticles has been shown to sustain drug delivery, there are no reports on efficient delivery of insulin and inhalation therapy of diabetes ba...
Article
Despite the success and advantages over traditional chemotherapeutic strategies, photothermal therapy (PTT) suffers from certain limitations such as poor stability and low therapeutic efficacy of PTT agents in vivo, and their affinity loss during the multi-step synthesis process of delivery carriers, among others. To address these limitations, we d...
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Background: In recent times, the co-delivery therapeutics have garnered enormous interest from researchers in the treatment of cancers with multidrug resistance (MDR) due to their efficient delivery of multiple agents, which result in synergistic effects and capable of overcoming all the obstacles of MDR in cancer. However, an efficient delivery pl...
Data
Relative cell viability of L929 cells after treatment with naked NEPMs. Notes: Cells were seeded at a density of 5×104 cells per well of a 96-well plate and incubated overnight for proper attachment. The cultured media was then replaced with the media containing CS-PLLA PMs at different concentrations (250, 500, and 1,000 µg/mL) exposed for differe...