Ahmet Ali BerberÇanakkale Onsekiz Mart Üniversitesi | ÇOMÜ · Medical Services and Techniques
Ahmet Ali Berber
PhD
About
14
Publications
4,514
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65
Citations
Citations since 2017
Introduction
Ahmet Ali Berber currently works at Çanakkale Onsekiz Mart University. Ahmet does research in Cell Biology and Genetics.
Publications
Publications (14)
Abstract The genotoxic potential of rosuvastatin as one of the statin drugs was assessed by chromosomal aberrations (CAs), micronucleus (MN) and DNA damage by comet assay in the human peripheral blood lymphocytes. Rosuvastatin was used at concentrations of 0.0625, 0.125, 0.25, 0.5 and 1 µg/mL for these in vitro assays. In all assays, a negative and...
In this study, possible genotoxic effects of zinc oxide (ZnO) nanoparticles were investigated in cultured human peripheral lymphocytes by using chromosome aberrations and micronucleus assays (MN). For this purpose, the cells were treated with ZnO (1, 2, 5, 10, 15 and 20 μg/mL) for 24 and 48 h. In this research, four types of chromosome aberrations...
Saxagliptin (SAX) is an oral drug that is a hypoglycemic (between an
anti-diabetic agent) dipeptidyl peptidase-4 inhibitor. In this study,
cytotoxic, genotoxic effects and DNA damage of SAX on human
lymphocytes were investigated. For this purpose, Single Cell Gel
Electrophoresis (SCGE), Micronucleus (MN) and Mitotic Index (MI)
tests were used. Base...
Abstract The aim of present study, to evaluate the genotoxic potential of 1-(4-(3,3-dimethyl-1,6-dioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b] phthalazine-13yl)phenyl)-2-phenylazetidine-3-yl-acetate which was synthesised assuming that it may be a pharmaceutical raw material and found to inhibit human carbonic anhydrase I, II isozymes. To determin...
methanol extract (ST) of the endemic Sideritis trojana, which is consumed as tea among the public, against the clastogenic / anogenic effect induced by mitomycin (MMC) on human peripheral lymphocytes were evaluated in vitro with the Micronucleus (MN)
test system. For this purpose, the effect of 0.1, 1, 10, 100 and 500 μg / mL concentrations of ST w...
Micro and nano-sized plastic particles are found almost everywhere, especially the aquatic system and because of their size, they can be ingested as food by many organisms and these plastics which enter the food chain, raise a great concern. In this study, the effects of 50 nm diameter of polystyrene nanoplastics (PNPs) on Brachionus plicatilis and...
Pollution of the aquatic environment by microplastic could be having a massive impact on marine life. As far as the dimensions of the microplastics decrease, the negative effects are also increasing. In this study, the effects of 1 μm diameter polystyrene microplastics (PSMs) on Daphnia magna and Neocaridina davidi were investigated. The acute toxi...
Pollution of the aquatic environment by micro-plastic could be having a massive impact on marine life. As far as the dimensions of the microplastics decrease , the negative effects are also increasing. In this study, the effects of 10-22 µm diameter fluorescent polyethylene microplastics (PEMs) on Bra-chionus plicatilis and Daphnia magna were inves...
Sweet cherries (Prunus avium) are rich in flavonoids such as anthocyanins that are beneficial for the
immune system. The aim of the present study was to investigate in vitro antigenotoxicity and
anticytotoxicity of total antochyanins extracted from Prunus avium (TAP) using by chromosomal aberration
(CA), single cell gel electrophoresis (Comet) and...
In the present study, it was aimed to assess the genotoxic potentials of [4,4-Dimethyl-2,6-dioxocyclohexylidene) methylamino) benzene-sulfonamide] (2b) and [4-((1,3-Dimethyl-2,4,6-trioxo-tetrahydropyrimidin-5(6H)-ylidene) methyla mino) benzenesulfonamide] (2e) compounds which were synthesized considering that they may be used as drug raw materials...
In this study, a Cd(II) complex was synthesized using 8-hydroxyquinoline and thiocyanate as the ligands and structurally characterized with the combination of FTIR, (1)H-NMR, (13)C-NMR, UV-vis, and MS spectral data. Then, genotoxic effects of the prepared complex were investigated. Genotoxic properties of the dimeric 8-hydroxyquinolinthiocyanatoCd(...
The purpose of this study was to determine chromosome morphology and karyological features of 12 Centaurea L. species belonging to sections Cynaroides Boiss. ex Walp. and Phaeopappus (DC.) Boiss. from Anatolia, Turkey. The chromosome numbers were determined as 2n = 18 in all species. Karyotype analyses were made in detail for the first time for all...
Questions
Question (1)
Hi to all,
I have a rotifer culture and i want to gather the dormant eggs to use later. Because sometimes we encounter different problems such as contamination, elevation environmental conditions. To hinder this problem, keeping of the eggs best way to use them later without contaminations.
Projects
Projects (4)
Saksagliptin, hipoglisemik (bir anti-diyabetik madde arasında) dipeptidil peptidaz-4 (DPP-4) inhibitörü olan ve ülkemizde de kullanılan oral bir ilaçtır. Bu çalışmada Saksagliptin’in insan lenfositleri üzerinde meydana getirdiği DNA hasarı ve sitotoksik etkisi incelenmiştir. Bu amaçla, günlük kullanım dozları (2,5 ve 5 mg) baz alınarak 0,017, 0,035, 0,07, 0,14 µg/mL’lik konsantrasyonlarda ökaryotik hücrelerdeki DNA hasarını hücre bazında saptayabilen duyarlı test metodu olan Komet Assay (KA); yine genotoksik ve anojenik etkinin değerlendirilmesi için Mikronükleus Testi (MN); sitotoksisitenin belirlenmesi için de hem 24 hem de 48 saatlik uygulamayla Mitotik İndeks (MI) testi yapılmıştır. Çalışmalarda kontrol grubu olarak pozitif ve negatif kontroller de dahil edilmiştir.
24 saatlik Saxagliptin maruziyeti ile mitotik indeks saatlik uygulamada sadece en yüksek konsantasyonlarda kontrole göre anlamlı farklılık göstermiştir. MN testi ile elde edilen sonuçlara göre MN frekansı sadece 0,14 µg/mL’lik konsantrasyonda kontrole göre istatistiksel olarak anlamlı fark oluşturduğu tespit edilmiştir. KA testinde ise kuyruk uzunluğunun istatistiksel değerlendirilmesi yapıldığında 0,035 ve 0,14 µg/mL’lik konsantrasyonlar kontrole göre istatistiksel olarak anlamlı bulunmuştur. Saxagliptin maruziyeti ile Komet kuyruk momenti ve kuyruk yoğunluğu sadece en yüksek konsantrasyon olan 0,14 µg/mL’de anlamlı bir şekilde artmıştır.
Sonuç olarak, çalışmada Saxagliptin Komet ve Mikronükleus testlerinde sadece piyasada kullanımı olmayan en yüksek konsantrasyonlarda istatistiksel olarak kontrole göre farklılıklar oluşturmuştur (kuyruk uzunluğu, 0,035 µg/mL hariç). Mitotik indeks testinde de benzer şekilde sadece yüksek dozlarda sitotoksik etki gösterdiği tespit edilmiştir.
Environmental Toxicology and Ecology (ETOXEC) dergisi yılda 2 defa yayımlanacak olan hakemli akademik bir dergidir. Dergimizin Mart (2021) 1. sayısı için makale çağrısına çıkmış bulunmaktayız.
“ ETOXEC, toksikoloji (biyolojik, endüstriyel, klinik, ve teknolojik toksinlerin çevreye etkisini), ekoloji, çevre alanında yapılan bilimsel çalışmalarınızı yayımlamakta olup, makale göndermek ve yazım kurallarına ulaşmak için etoxec.com adresini ziyaret ediniz.
İlgi ve desteğinizi umuyor, çalışmalarınızda kolaylık diliyoruz.
Saygılarımızla.
ETOXEC Dergi Editörlüğü
Environmental Toxicology and Ecology (ETOXEC) is a peer-reviewed academic journal that will be published twice a year. We are calling for articles for the 1st issue of our journal in March (2021).
“ETOXEC publishes your scientific studies in the field of toxicology (the effect of biological, industrial, clinical and technological toxins on the environment), ecology, environment, and visit etoxec.com to submit articles and access writing rules.
We hope for your interest and support and wish you convenience in your work.
Regards.
Editorship of ETOXEC Journal
Değerli Bilim İnsanları,
Environmental Toxicology and Ecology (ETOXEC) dergisi yılda 2 defa yayımlanacak olan hakemli akademik bir dergidir. Dergimizin Mart (2021) 1. sayısı için makale çağrısına çıkmış bulunmaktayız.
“ ETOXEC, toksikoloji (biyolojik, endüstriyel, klinik, ve teknolojik toksinlerin çevreye etkisini), ekoloji, çevre alanında yapılan bilimsel çalışmalarınızı yayımlamakta olup, makale göndermek ve yazım kurallarına ulaşmak için etoxec.com adresini ziyaret ediniz.
İlgi ve desteğinizi umuyor, çalışmalarınızda kolaylık diliyoruz.
Saygılarımızla.
ETOXEC Dergi Editörlüğü
Dear Scientists,
Environmental Toxicology and Ecology (ETOXEC) is a peer-reviewed academic journal that will be published twice a year. We are calling for articles for the 1st issue of our journal in March (2021).
“ETOXEC publishes your scientific studies in the field of toxicology (the effect of biological, industrial, clinical and technological toxins on the environment), ecology, environment, and visit etoxec.com to submit articles and access writing rules.
We hope for your interest and support and wish you convenience in your work.
Regards.
Editorship of ETOXEC
