Ahmed Awad Zaki

Ahmed Awad Zaki
Mansoura University · Department of Pharmacognosy

PhD
Associate Professor of Pharmacognosy

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58
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Publications

Publications (58)
Article
Full-text available
Cancer is the world’s second-largest cause of death. Although there are numerous cancer treatment options, they are typically uncomfortable owing to side effects and ineffectual due to increased resistance to traditional anti-cancer medications or radiation therapy. A key method in cancer treatment is to target delayed/inhibited inflammation and ap...
Article
Full-text available
In this study, the crude extract and its isolated compounds from the stem bark of Annickiachlorantha were tested for their larvicidal, developmental, and repellent activity against the mosquito vector, Culex pipiens, besides their toxicity to the non-target aquatic organism, the zebrafish (Danio rerio). The acute larvicidal activity of isolated com...
Article
Two new tetralin compounds were isolated from the aerial parts of Panicum turgidum Forssk. Their structures were elucidated by comprehensive 1 D and 2 D NMR experiments as well as high resolution ESI mass spectrometry. In addition, these two compounds have been tested for in vitro cytotoxicity against SKOV3 (Ovarian Carcinoma) and BT-549 (Breast Ca...
Article
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The study evaluated prebiotic potential and the enzyme inhibition of extracts and isolated compounds of Rumex vesicarius (ruby dock), family Polygonaceae. Eight known compounds were identified in the roots of R. vesicarius. Extracts and compounds (1 - 8) increased the growth rate of Escherichia coli Nissle 1917 differentially compared to controls....
Article
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Changes in the activities of antimicrobial, antitumor, and antioxidant properties of postbiotics (YCG) are related to changes in the composition of phenolic compounds. Antimicrobial activity was found to be highest in postbiotic (YCG-7) against P. aeruginosa, S. aureus, and E. faecalis with an MIC of 3.1 µg/mL. YCG-7 revealed the most cytotoxicity...
Article
A germacranolide (1) together with four guaianolide sesquiterpenes (2 - 5) were isolated from Reichardia tingitana, with the first report on the separation of compounds 1 - 4 from this plant. Their structures were identified as, 3β-hydroxybalchanolide (1), 15-desacetylmatricarin-8-O-β-d-glucopyranoside (2), 11β, 13-dihydro-lactucin (3), cichoriosid...
Article
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A new phytoconstituent; (6Z,9Z)-heptadeca-6,9-diene-5,11-dione (1) was isolated from Calendula officinalis methanol extract. The structure of 1 was determined based on the analysis of NMR spectra and HRESIMS. It was tested for antimicrobial and antiprotozoal activities. Compound 1 showed leishmanicidal activity against L. donovani amastigote with a...
Article
Full-text available
Bioassay-guided investigation of Panicum turgidum extract resulted in the identification of seven steroidal saponins (Turgidosterones 1–7).
Article
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Chromatographic fractionation of the methanolic extract of Asteriscus hierochunticus whole plant led to the identification of a new humulene glucoside (1). The chemical structure of the isolated compound was elucidated by IR, 1D, 2D NMR, and HRESIMS data analysis to be (-)-(2Z,6E,9E)8a-hydroxy-2,6,9-humulatrien-1(12)-olide. In this study, we report...
Article
Full-text available
Two humulene derivatives (asteriscunolides A (1) and C (2)) were isolated from the methanolic extract of the whole plant of Asteriscus hierochunticus. Their structures were characterized by IR, 1D, and 2D NMR and HRESIMS data analysis, in addition to comparison with literature. Compounds 1 and 2 exhibited excellent in vitro antileishmanial activiti...
Article
Full-text available
Abstract Background and Aim: The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, natural products can provide therapeutic alternatives that could be employed as an effective safe treatment for COVID-19. Experimental procedure: Twelv...
Article
Full-text available
Prebiotics are non-digestible food ingredients that are selectively fermented by probiotics. The aim of this study was to investigate the chemical properties of a polysaccharide extracted fromCassia fistulamature fruit pulp and to evaluate its effects on probiotic strains:L. casei,L. rhamnosus,E. coliNissle 1917 (EcN), andE. faecalis. These strains...
Article
Full-text available
Eight methanolic extracts were tested for their cytotoxic activity against HepG2, PC3, and MCF-7 cell lines using MTT assay. The rhizomes of Cyperus rotundus extract showed the highest activity, divided into five fractions (petroleum ether, methylene chloride, ethyl acetate, butanol, and aqueous) and re-evaluated for cyto-toxicity. The petroleum et...
Article
The essential oil of Egyptian Cyperus rotundus rhizomes was obtained by hydrodistillation and analyzed by GC/MS. The oil is composed mainly of oxygenated sesquiterpenes. Thirty-seven compounds were identified including, humulene epoxide (38.43 %) and caryophyllene oxide (21.03 %) as major components. Correlations between different C. rotundus essen...
Article
Full-text available
The essential oil of Egyptian Cyperus rotundus rhizomes was obtained by hydrodistillation and analyzed by GC/MS. The oil is composed mainly of oxygenated sesquiterpenes. Thirty-seven compounds were identified including, humulene epoxide (38.43 %) and caryophyllene oxide (21.03 %) as major components. Correlations between different C. rotundus essen...
Article
Full-text available
Nine flavonoids and one saponin were isolated from the aerial parts of Cleome amblyocarpa. Molecular Docking of isolated compounds on COVID-19 virus main protease showed variable binding affinities with scores ranging from (-8.63 to -6.08) compared to N3 inhibitor (-10.10) and binding modes better than N3 inhibitor in some of the isolated compounds...
Article
Continued chromatographic investigation of Calendula officinalis flowers led to the isolation of two sesquiterpenes, including one new, viridiflorol-10-O-β-quinovopyranoside-2`-O-(3``-methyl-2``-pentenoate) (1), along with a previously reported compound viridiflorol-10-O-β-fucopyranoside-2`-O-(3``-methyl-2``-pentenoate) (2). The new compound 1 was...
Article
Full-text available
The chromatographic reinvestigation the methanol extract of Tetraena aegyptia led to the separation of a new flavonoid glycoside, isorhamnetin-3-O-[2```,3```-O-isopropylidene-α-L-rhamnopyranosyl]-(1```→6``)-O-β-D-glucopyranoside (1), together with two known flavonoids, isorhamnetin (2) and isorhamnetin-3-O-glucoside (3), isolated for the first time...
Article
The rhizomes of Bulbine natalensis furnished six previously unreported anthraquinone derivatives (1-6), together with eight known specialized metabolites. Their structures were determined by interpretation of 1D and 2D NMR and HRESIMS data. The absolute configurations of compounds 1-6 were determined by specific rotation and circular dichroism expe...
Article
Machaerinic acid 3-O-β-D-glucuronopyranoside (1), along with ten known compounds (2-11) were isolated from the methanol extract of Calendula officinalis L. aerial parts. Their structures were confirmed by 1D and 2D NMR analysis and HRESIMS. Compound 1 was evaluated for the anti-proliferative activity against 95D and HT29 cancer cell lines and showe...
Article
Anabasis articulata, traditionally used to treat diabetes, is rich in saponin content. This study was performed to investigate the agonistic effect of its saponins on peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ in human hepatoma (HepG2) cells to explore the possibility of the involvement of these nu...
Article
Full-text available
The chromatographic investigation of Cyperus conglomeratus Rottb. aerial parts resulted in the isolation of three new flavan derivatives, 7,3′-dihydroxy-8,4′-dimethoxyflavan (1), 7,4′-dihydroxy-5,3′-dimethoxy-8-methylflavan (2) and 7,4′-dihydroxy-5,3′-dimethoxy-8-prenylflavan (3), and two new stilbene derivatives, 4-hydroxy-5′-methoxy-6′′,6′′dimeth...
Article
Full-text available
Eight compounds were isolated for the first time from the methanolic extract of Malva rotundifolia L. Based on spectroscopic data and mass techniques, the structures of these compounds were identified as palmitic acid (1), β-sitosterol (2), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (3), di-(2-ethylhexyl)phthalate (4), β-sitosterol 3-O-β-D-glucoside (5)...
Conference Paper
Full-text available
Panicum turgidum (Poaceae) is a perennial desert grass, occurs in Egypt for many centuries. It is one of the wild plants which used as a supplementary food resource for desert inhabitants in the Middle East. The phytochemical investigation of methanolic extracts of P. turgidum resulted in the isolation of phenyl alkanoid glycosides and steroidal sa...
Poster
Phytochemistry of the medicinal plant Sutherlandia frutesence
Article
In our continuing work on Vitex genus, the phytochemical investigation of leaves of Vitex grandifolia led to the isolation of two iridoids known in the literature as agnuside and bartsioside. The chemical structures were characterized by combined spectroscopic analysis. These compounds were isolated from this specie for the first time, this study g...
Conference Paper
Phytochemical investigation of the methanolic extract of Sutherlandia frutescens using different chromatographic techniques resulted in the isolation of five new 9,10-seco-9,19-cyclolanostane glycosides, sutherlandiosides J - N, together with sutherlandiosides A - I, p-coumaric acid, quercetin 3-O-sambubioside, kaempferol 3-O-sambubioside, kaempfer...
Article
Full-text available
Genus Salvia is one of important genera belonging to family lamiaceae. Most of reported biological activities of Salvia usually attributed to its volatile oil. The chemical composition of essential oil from Salvia lavandulifolia was analyzed by GC/MS. A total of sixty seven components were identified in the oil of S. lavandulifolia representing 95....
Article
Full-text available
The bio-guided fractionation and phytochemical investigation of Panicum turgidum extract resulted in the isolation of three steroidal saponins, identified as yamogenin-3β-O-α-L-rhamnopyranosyl-(12)-O-[α-L-rhamnopyranosyl-(14)]-β-D-glucopyranoside (1), yamogenin-3β-O-α-L-rhamnopyranosyl-(12)-O-[α-L-rhamnopyranosyl-(14)-rhamnopyranosyl-(14)]-β-D...
Article
Full-text available
A new neolignan, paniculignan (1), and a known lignan, tetracentronside B (2), were isolated from Panicum turgidum. The structure of 1 was elucidated by extensive spectroscopic methods including 1D and 2D NMR and HR-ESI-MS. The relative configuration of 1 was determined on the basis of circular dichroism spectroscopy, optical rotation, and NOESY co...
Poster
Vitex grandifolia G. (Verbenaceae) is widely distributed in West Africa mostly in Nigeria and Benin. The leaves of V. grandifolia are used in folk medicine for rheumatism, stomachic, diarrhea, bronchial complaints, rickets, sore, and fever. In this study, twelve compounds including four new ones belonging to iridiods, phenolics, flavoniods and lign...
Poster
Ecdysteroids and iridiods are two main classes of compounds in Vitex genus, which comprises approximately 750 species. Their constitutive presence has been reported in a number of genera in the family Verbenaceae. In addition to the utilization of morphological features of plants belonging to this family, ecdysteroids and Iridoids are useful chemot...
Poster
The genus Vitex belongs to the Verbenaceae family with approximately 750 species. Several Vitex species are used as medicinal plants in Africa, Asia and South America . Almost every part of the plant including the leaves, fruits, stembarks and roots have been used in traditional medicine for the management of an array of ailments while some species...
Poster
Trypanosomiasis and leishmaniasis are neglected tropical diseases caused by the parasites Trypanosoma and Leishmania, respectively. The emergence of drug-resistance, high toxicity which can result in unpleasant side effects and the need for cost-effective drugs in combating these diseases gives rise to this study [1 – 3]. The antitrypanosomal activ...
Article
Full-text available
Trypanosomiasis and leishmaniasis are neglected tropical diseases caused by the parasites Trypanosoma and Leishmania, respectively. The emergence of drug-resistance, high toxicity which can result in unpleasant side effects and the need for cost-effective drugs in combating these diseases gives rise to this study [1 – 3]. The antitrypanosomal activ...
Article
The genus Vitex belongs to the Verbenaceae family with approximately 750 species [1]. Several Vitex species are used as medicinal plants in Africa, Asia and South America [2]. Almost every part of the plant including the leaves, fruits, stembarks and roots have been used in traditional medicine for the management of an array of ailments while some...
Article
Vitex grandifolia G. (Verbenaceae) is widely distributed in West Africa mostly in Nigeria and Benin. The leaves of V. grandifolia are used in folk medicine for rheumatism, stomachic, diarrhea, bronchial complaints, rickets, sore, and fever [1]. In this study, twelve compounds including five new ones belonging to iridiods, phenolics, flavoniods and...
Article
The ethnomedicinal uses of Ceratotheca sesamoides include antidiarrheal, antimalarial, antidiabetic and anti-inflammatory [1]. The leaves of C. sesamoides are a delicious delicacy in Nigeria [2]. Ten compounds, including iridiods, phenolics and flavonoids were isolated so far in this study from this plant which includes two new ones. Structures of...
Article
Phytochemical examination of butanol fraction of Calendula officinalis seeds led to the isolation of two compounds identified as 28-O-β-D-glucopyranosyl-oleanolic acid 3-O-β-D-glucopyranosyl (1→3)-β-D-glucopyranosiduronic acid (CS1) and oleanolic acid 3-O-β-D-glucopyranosyl (1→3)-β-D-glucopyranosiduronic acid (CS2). Biological evaluation was carrie...
Article
Incensole is a macrocyclic diterpene with a wide spectrum of bioactivities. It was isolated from the oleogum resin of Boswellia carterii Birdwood. This study discusses for the first time the potential hypoglycemic and hypolipidemic effects of incensole on diabetic rats. Biochemical and histochemical studies completed and confirmed our findings. Dia...
Article
Full-text available
Zygophyllum aegytpium (Zygophyllaceae) is a perennial, woody undershrub with evergreen succulent leaves. This species is distributed in the Mediterranean region of Egypt, Tunisia and Cyprus. The powdered aerial parts of the plant were extracted with methanol. The crude extract did not show any antimicrobial, antimalarial or anti-leishmanial activit...
Article
Full-text available
Panicum turgidum Forssk. (Poaceae) is a perennial desert grass from the Nile region of Egypt, Mediterranean coastal strip, Red sea coastal strip and oases. The geographical distribution of P. turgidum includes many arid sites within a belt of Africa and the Middle East extending between latitude 17 ° W and 88 ° E. The methanol extract of P. turgidu...
Article
Nerium oleander L. (Apocynaceae) is a poisonous plant rich in cardenolides. Many researchers investigated its aerial parts but little work has been carried out concerning the roots. The phytochemical investigation of different fractions of N. oleander roots resulted in isolation of 17 compounds. Strospeside (1) and 3β-O- (4-O- gentiobiosyl-D-digita...
Article
Full-text available
Corncobs could serve as a substrate for citric acid production using solid state fermentation technique. The culture optimization concerning substrate concentration, culture duration, pH, temperature and substrate hydrolysis was carried out for maximum productivity of citric acid. Under the optimized conditions, 48.4 g of citric acid was produced f...
Article
Full-text available
Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in Egyptian traditional medicine to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha mic...
Article
Full-text available
One of the leading causes of death worldwide is cardiovascular disease, hence searching for a cure is an important endeavor. The totally safe, edible, and inexpensive Boswellia plant exudate, known as olibanum or frankincense, is considered to possess diverse medicinal values in traditional medicine and from recent biological studies. Investigating...
Article
Full-text available
Two new cardenolide metabolites, 7β-OH-uzarigenin (1M) and 7β-OH-odoroside-H (2M) were obtained through the biotransformation of uzarigenin (1) and odoroside-H (2). Compounds 1 and 2 were isolated from the air-dried roots of Nerium oleander L. The plant, belonging to family Apocynaceae, was collected in October, 2010 from Mansoura university garden...
Article
Full-text available
This study investigated the effects of some plant extracts on the bacterial communication system, expressed as quorum sensing (QS) activity. Quorum sensing has a directly proportional effect on the amount of certain compounds, such as pigments, produced by the bacteria. Alcohol extracts of 23 ornamental and medicinal plants were tested for anti-QS...
Article
Full-text available
Two new compounds: 3-β,15-α,23,28-tetrahydroxyolean-12-en-3-O-arabinopyaranoside and 3-β,23,28-trihydroxy-olean-12-en-3-O-β-D-glucopyranoside were isolated from the aerial parts of Ammania auriculata along with the known compounds kaempferol, β-sitosterol-3-O-β- D-glucoside, 2-α,3-β,23-trihydroxyolean-12-en-28-oic acid-28-O-β-D-glucopyranoside, que...

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