Ahmed Negida

• MBBCh, PhD
• Postdoctoral Scholar at Virginia Commonwealth University

Background Studies comparing subthalamus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) for the management of Parkinson’s disease in terms of neuropsychological performance are scarce and heterogeneous. Therefore, we performed a systematic review and metaanalysis to compare neuropsychological outcomes following STN DBS versus...

Background: Parkinson's disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies. Method and results: The literature suggests that caffeine plays multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk...

Objective: In our systematic review and meta-analysis, we aim to assess the effectiveness of cannabis and cannabinoids in the treatment of Tourette Syndrome Background: Tourette Syndrome is a neurodevelopmental and behavioral disorder that is characterized by motor and phonic tics. The condition’s prevalence is between 0.3 and 0.7% among children w...

Abstract Objective: To investigate the risk of developing multiple sclerosis in individuals with a history of head trauma. Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system with unclear etiology involving genetic, environmental, and immunological factors. The potential link between head trauma and MS is controve...

Abstract Objective: To evaluate the efficacy of crocin in alleviating depressive symptoms and its effective t in biomarkers in patients with multiple sclerosis (MS) through a meta-analysis of available clinical trials. Background: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease characterized by oxidative stress and infla...

Abstract Objective: This review aims to summarize the current evidence of reported myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS) overlap syndrome regarding clinical and laboratory features, diagnostic implications, management, outcomes, and comorbid conditions to raise awareness among healthcare providers and aid in proper care pro...

Objective: We aimed to compare the outcomes of Magnetic resonance-guided focused ultrasound (MRgFUS) versus sham procedure in patients with parkinson disease (PD) Background: Tremors are present in approximately half of PD patients. MRgFUS is a non-invasive method that may benefit tremor-dominant Parkinson’s patients who are resistant to medicati...

INTRODUCTION: Diabetes Mellitus (DM) often leads to diabetic neuropathy (DN), particularly Diabetic Peripheral Neuropathy (DPN), causing significant pain and discomfort. Despite available pharmacological treatments, many patients remain untreated or experience intolerable side effects. METHODS: A comprehensive search strategy was implemented thr...

Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. PD is diagnosed by a combination of motor symptoms including bradykinesia, resting tremors, rigidity and postural instability. Prodromal PD is the stage preceding the onset of class...

Background: Diabetes mellitus affects more than half a billion people globally, often leading to painful diabetic neuropathy (PDN). Spinal cord stimulation (SCS) has emerged as a promising treatment for PDN. Objective: This meta-analysis evaluated the efficacy of SCS compared with the best medical therapy (BMT) for PDN. Materials and Methods: Follo...

Introduction Several observational studies reported an association between Rheumatoid Arthritis (RA) and the subsequent risk of developing Parkinson’s disease (PD). However, whether the drugs commonly prescribed for RA contribute to this association remains controversial. Content We sought to summarize all the published evidence regarding the asso...

Background The discontinuation and non-publication of clinical studies in various medical fields undermine research efforts and may bias the medical evidence base. This study investigates the prevalence and factors associated with these issues in endovascular stroke studies. Methods Clinical Trials.gov was searched for all studies registered from i...

Background Cholinesterase inhibitors (ChEIs) are cornerstones in the symptomatic treatment of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) and are also prescribed for vascular dementia (VD). Despite their widespread use, patterns of prescribing ChEIs are not fully understood. Objective Examine the prevalence, timing, and types of C...

Background Lewy body dementia (LBD) is characterized by fluctuations in arousal and alertness, i.e., cognitive fluctuations (CF). Although CF significantly impacts quality of life, its neurophysiological basis remains poorly understood. This study's objective was to identify specific EEG features associated with cognitive fluctuations in patients w...

Background Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder, often leading to wheelchair dependence by age 13 with limited treatment options, largely relying on glucocorticosteroids. We assessed the efficacy and safety of vamorolone, a modified synthetic corticosteroid, for DMD. Methods We performed a systematic review and meta...

Objective This systematic review and meta-analysis aimed to compare the efficacy and safety of deep brain stimulation (DBS) targeting subthalamic nucleus (STN) versus the globus pallidus internus (GPI) in the treatment of dystonia. Methods A comprehensive search strategy was implemented up to July 2024, across five databases, identifying studies r...

Standard of care in glioma surgery involves maximal-safe resection. Intraoperative stimulation mapping can improve the extent of resection in eloquent area tumors. Resection is performed during awake craniotomy (AC) or under general anesthesia (GA). Considering the advances in glioma management, an updated meta-analysis is needed. We identified stu...

Despite the currently available treatment, one-third of epilepsy patients continue to experience seizures. Transcranial direct current stimulation (tDCS) has emerged as a potential neuromodulation approach for the non-invasive treatment of refrac-tory epilepsy. This study aims to provide a comprehensive investigation of the efficacy and safety of t...

Background Systematic review with meta-analysis integrates findings from multiple studies, offering robust conclusions on treatment effects and guiding evidence-based medicine. However, the process is often hampered by challenges such as inconsistent data reporting, complex calculations, and time constraints. Researchers must convert various statis...

Subtyping Parkinson’s disease with mild cognitive impairment (PD-MCI) could improve clinical trial design and personalized treatments. Cholinergic nucleus 4 (Ch4) volume has been linked to cognitive impairment severity and future decline in PD. This study investigates whether PD-MCI patients with MRI evidence of Ch4 degeneration have distinct clini...

BACKGROUND AND OBJECTIVES Access to neurosurgical care is limited in low-income and middle-income countries (LMICs) and in marginalized communities in high-income countries (HICs). International partnerships represent one possible means of addressing this issue. Insights from surgeons in HICs have been explored, but data from LMICs' counterparts ar...

Background Understanding the specific cognitive domains associated with activities of daily living (ADLs) impairment in Lewy body dementia (LBD) may help identify which targeted therapeutic interventions to pursue in future research. This study aimed to investigate the neuropsychological determinants of impairment in ADLs in LBD patients. Methods W...

Objective This systematic review and meta-analysis aimed to compare the efficacy and safety of deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) versus the globus pallidus internus (GPI) in the treatment of dystonia. Methods A comprehensive search strategy was implemented up to July 2024, across five databases, identifying studie...

Background Many observational studies have examined the association between statins and the incidence of Parkinson's disease (PD) in high‐risk populations. On the other hand, clinical trials as well as other observational studies investigated the safety and efficacy of statins in slowing disease progression in PD patients. However, the evidence has...

Background Identification of patients at high risk of surgical-site infections may allow surgeons to minimize associated morbidity. However, there are significant concerns regarding the methodological quality and transportability of models previously developed. The aim of this study was to develop a novel score to predict 30-day surgical-site infec...

Background & objectives Rigid ring and Flexible band are techniques used to repair tricuspid valve regurgitation. The comparison between both techniques' effectiveness is controversial in the literature. We conducted this systematic review and meta-analysis to compare the safety and efficacy of rigid ring versus flexible band for tricuspid valve re...

Objective: The goal of our study was to analyze the frequency and the determinants of cognitive impairment and other associated neurological impairment among COVID-19 recovered cases four weeks after being diagnosed with COVID-19 during the fourth wave of the pandemic Background: The fight against Coronavirus disease 2019 (COVID-19) appears to exte...

Objective: We evaluated the efficacy of applying repetitive transorbital alternating current stimulation (rTACS) to patients suffering from visual defects, especially homonymous hemianopia. Background: Visual functions are entangled with cortical areas responsible for transcoding the images we see each second. Moreover, cortical integrity is import...

Objective: This multicentric study aims to identify prevalence and characteristics of different types of headaches among medical students in Egypt and how it affects their daily activities. Background: Headaches are one of the most common neurological disorders, ranging in severity from a mild discomfort to a severe, debilitating condition. Headach...

Background Intrastriatal delivery of potential therapeutics in Huntington's disease (HD) requires sufficient caudate and putamen volumes. Currently, volumetric magnetic resonance imaging is rarely done in clinical practice, and these data are not available in large research cohorts such as Enroll‐HD. Objective The objective of this study was to in...

Introduction Several studies have reported iron accumulation in the basal ganglia to be associated with the development of Parkinson's Disease (PD). Recently, a few trials have examined the efficacy of using the iron‐chelating agent Deferiprone (DFP) for patients with PD. We conducted this meta‐analysis to summarize and synthesize evidence from pub...

Background SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2...

Background: Clinical trials have evaluated the efficacy of intravenous mesenchymal stem cells (MSCs) for acute and subacute ischemic stroke. Therefore, we conducted this meta-analysis to investigate the efficacy and safety of intravenous MSC treatments compared to placebo for acute and subacute ischemic stroke patients. Methods: We searched PubMed...

Background This systematic review and network meta-analysis aimed to evaluate the three different administration routes of vitamin B12: oral, intramuscular (IM), and sublingual (SL) routes. Methods We searched four electronic databases (PubMed, Scopus, Web of Science, and Cochrane CENTRAL Register of Controlled Trials). We included only comparative...

The use of human amniotic membrane (HAM) has recently gained attention as a promising alternative option for duraplasty due to its superior tensile strength, elasticity, and anti-inflammatory and anti-fibrotic properties, offering greater durability and reliability compared to autologous grafts like the muscle fascia and pericranium. This systemati...

Defensive medicine refers to practices motivated mainly by legal rather than medical purposes. Increased healthcare costs, overutilization of medical services, and potential harm to patients from unnecessary procedures are among its drawbacks. We performed this study to assess the prevalence of defensive medicine practices in Egypt and their associ...

Background: Stroke is the second leading cause of both disability and death worldwide, with the highest burden of the disease shared by low- and middle-income countries. In 2022, there are over 101 million people currently living who have experienced stroke globally. Clinical studies in stroke are vulnerable to discontinuation and non-publication,...

Background: Traumatic brain injuries (TBIs), which account for a sizeable amount of the world's injury burden, are mostly brought on by accidents on the road and in falls. According to the Global Burden of Disease Research, TBI caused 69 million disability-adjusted life years (DALYs) in 2016. There were roughly 223,135 hospitalizations for TBI in 2...

Glioblastomas (GBM) are the most prevalent malignant CNS tumors globally, affecting about 3.19 per 100,000people. The standard of care of GBM management includes surgical resection followed by radiotherapy and/orchemotherapy owing to the high recurrent rates. Despite the advances in neurosurgical practice and brain cancerresearch, low- and middle-i...

Background: Research is pivotal to neurosurgical training and practice. The objectives of this study were to quantify neurosurgical research output by authors from low-income countries (LICs), using author affiliation as a proxy, and to understand the patterns of collaboration between LIC authors and their international partners. Methods: PubMed...

Objective: Long non-coding RNAs (IncRNAs) are regulatory RNA transcripts that have recently been associated with the onset of many neurodegenerative illnesses, including Alzheimer's disease (AD). Several IncRNAs have been found to be associated with AD pathophysiology, each with a distinct mechanism. In this review, we focused on the role of IncRN...

Introduction Scientific research has a direct, profound impact on healthcare systems worldwide. While an upward trend can be observed in the number of produced papers in the neurosurgical specialty, disparities still exist between African neurosurgeons on one side and between African neurosurgeons and neurosurgeons from high income countries, on th...

Background: Omega-3 long-chain polyunsaturated fatty acids (LCn-3 PUFA) is suspected to decrease cognitive decline. However, there is a conflict in the literature about its effectiveness. Methods: Five electronic databases were searched, only randomized clinical trials were included and global cognitive function was investigated by the mini-mental...

The field of global surgery has gained attention since the publication of the Lancet Commission landmark report in 2015. The authors estimated that 5 billion people worldwide do not have access to safe, affordable surgical and anesthesia services. The paper “Global Neurosurgery: The Unmet Need,” published in 2016, launched the modern global neurosu...

The Global Neurosurgery Committee (GNC) of the World Federation of Neurosurgical Societies (WFNS) launched the Global Action Plan during the 2016 Bogota Declaration on Global Neurosurgery in Colombia in order to coordinate efforts and bring neurosurgeons around the world to address unmet neurosurgical care. The Global Action Plan contains five obje...

The white paper published by the Lancet Commission put forward surgery as a global health priority. In that paper, their findings showed that 5 billion people in the world do not have access to 'safe, affordable surgical and anesthesia services when needed,' and this inequity is more evident in lower- and middle-income countries (LMICs). These defi...

Conference Abstract Presented at BIMCO, 2023 Ukraine Bukovinian state Medical University, Ukraine

We conducted this systematic review and meta-analysis to evaluate the existing evidence and to quantitatively synthesise evidence on the impact of therapeutic plasma exchange (TPE) on severe COVID-19 patients. This systematic review and meta-analysis protocol was prospectively registered on PROSPERO (CRD42022316331). We systemically searched six el...

Introduction: Stroke is a leading cause of morbidity and mortality worldwide, with limited effective treatment options. Fingolimod has been shown to have neuroprotective effects in previous studies and has been approved for use in multiple sclerosis. This systematic review aims to evaluate the current evidence regarding the efficacy of Fingolimod i...

Background: Since the advent of global COVID-19 vaccination, several studies reported cases of encephalitis with its various subtypes following COVID-19 vaccinations. In this regard, we conducted a systematic review to investigate and characterize the clinical settings of these reported cases to aid in physician awareness and proper care provision...