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Ahmed Mudawi Musa

Ahmed Mudawi Musa
Institute of Endemic Diseases, University of Khartoum · Clinical Pathology & Immunology

MBBS, DTM&H, DLSHTM, MSc TM&IH, MRCPI, Ph D

About

125
Publications
24,771
Reads
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2,175
Citations
Additional affiliations
January 2011 - present
Director Institute of Endemic Diseases, University of Khartoum
Position
  • Head Department of Clinical Pathology & Immunology
January 2011 - October 2014
Director Institute of Endemic Diseases
Position
  • Managing Director
July 2000 - June 2015
University of Khartoum
Position
  • Managing Director

Publications

Publications (125)
Article
Full-text available
IntroductionIntramuscular paromomycin monotherapy to treat visceral leishmaniasis (VL) has been shown to be effective for Indian patients, while a similar regimen resulted in lower efficacy in Eastern Africa, which could be related to differences in paromomycin pharmacokinetics.Methods Pharmacokinetic data were available from two randomized control...
Article
Full-text available
Post kala azar dermal leishmaniasis (PKDL) is a chronic, stigmatising skin condition occurring frequently after apparent clinical cure from visceral leishmaniasis. Given an urgent need for new treatments, we conducted a Phase IIa safety and immunogenicity trial of ChAd63-KH vaccine in Sudanese patients with persistent PKDL. LEISH2a (NCT02894008) wa...
Article
Full-text available
Background: In order to expedite the development of new oral treatment regimens for visceral leishmaniasis (VL), there is a need for early markers to evaluate treatment response and predict long-term outcomes. Methods: Data from three clinical trials were combined in this study, where Eastern African VL patients received various antileishmanial...
Preprint
Full-text available
Post kala azar dermal leishmaniasis (PKDL) is a chronic, stigmatising skin condition occurring frequently after apparent clinical cure from visceral leishmaniasis. Given an urgent need for new treatments, we conducted a Phase IIa safety and immunogenicity trial of ChAd63-KH vaccine in Sudanese patients with persistent PKDL. LEISH2a ( NCT02894008 )...
Article
Full-text available
Background: Conventional miltefosine dosing (2.5 mg/kg/day) for treatment of visceral leishmaniasis (VL) is less effective in children than in adults. A higher allometric dose (median 3.2 mg/kg/day) was therefore investigated in paediatric VL patients in Eastern Africa. Results of this trial showed an unforeseen, lower than dose-proportional incre...
Article
Full-text available
Background: Tuberculosis (TB), an infectious disease caused by Mycobacterium Tuberculosis (MTB). Toll-like receptors (TLRs) are the beststudied class of PRRs, and they recognize specific pathogen-associated molecular patterns (PAMPs) from various microorganisms. Objectives: This study aimed to determine and measure cellular TLR2 and TLR4 in active...
Article
Full-text available
The risk of emergence and/or re-emergence of arthropod-borne viral (arboviral) infections is rapidly growing worldwide, particularly in Africa. The burden of arboviral infections and diseases is not well scrutinized because of the inefficient surveillance systems in endemic countries. Furthermore, the health systems are fully occupied by the burden...
Article
Full-text available
The risk of emergence and/or re-emergence of arthropod-borne viral (arboviral) infections is rapidly growing worldwide, particularly in Africa. The burden of arboviral infections and diseases is not well scrutinized because of the inefficient surveillance systems in endemic countries. Furthermore, the health systems are fully occupied by the burden...
Article
Full-text available
urposes: The study aimed to study the emergence of auto-immunity following secondary immune suppression caused by L. donovani infections. Methods: In a prospective case-controlled study and following informed consent, 155 individuals with visceral leishmaniasis (VL; n=62), post kala-azar dermal leishmaniasis (PKDL; n=31) and apparently healthy volu...
Article
Full-text available
Post-kala-azar dermal leishmaniasis may occur after successful treatment of visceral leishmaniasis and is characterized by macules, papules, or nodules in the skin, with varying size. The response to antileishmanial therapy remains difficult to assess because there are presently no reliable biomarkers. To date, skin lesions are clinically assessed...
Article
Full-text available
Background: In Sudan, neither mumps nor rubella vaccines are currently used and comprehensive data on the seroepidemiology of measles, mumps and rubella (M.M.R) as well as information about circulating mumps virus genotypes are lacking. Methods: In 2015/2016, dried blood spot samples were collected from 294 children, 153 adults from the general...
Article
Full-text available
Negative Duffy expression on the surface of human red blood cells was believed to be a barrier for Plasmodium vivax infection in most Africans. However, P. vivax has been demonstrated to infect Duffy-negative individuals in several Central and East African countries. In this study, we investigated the distribution of Duffy blood group phenotypes wi...
Article
Background The leishmaniases represent a complex of human diseases, with 350 million people at risk of infection worldwide. Although the potential benefits of vaccination have been well-recognised, no human vaccine is registered. Post-kala azar dermal leishmaniasis (PKDL) is a chronic skin disease often following treatment for visceral leishmaniasi...
Poster
Full-text available
The overall awareness towards the issue was moderately high, but the practice still persists also in high rates. It is not a revolution needed against consanguineous marriage in Sudan, rather we need more investigation and integration of public health genomics sector to build efficient community-based awareness programs.
Article
Full-text available
PP4.158 Metagenomic analysis of environmental samples from mycetoma endemic area in Sudan A. Ahmed1, S.M. Bakhiet2, N. Mahmood3, L.Y. Mohamed3, E.E. Siddig3, A.M. Musa 3, E.B. Khidir4, A.H. Fahal3 1Umm Al-Qura University, MAKKAH, Saudi Arabia 2University of Khartoum, Institute of Endemic Diseases, KHARTOUM, Sudan 3University of Khartoum, Mycetoma R...
Article
Full-text available
The Leishmania parasite resides and replicates within host macrophages during visceral leishmaniasis (VL). This study aimed to evaluate neopterin, a marker of macrophage activation, as possible pharmacodynamic biomarker to monitor VL treatment response and to predict long-term clinical relapse of VL. Following informed consent, 497 plasma samples w...
Data
Sudan map showing Sennar state and Wad Onsa and Wad El Nimear villages. (TIF)
Article
Full-text available
Mycetoma, one of the badly neglected tropical diseases, it is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep structures and bone resulting in mas...
Article
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BCR-ABL leukemic fusion gene types in chronic myeloid leukemia (CML) correlate with the disease clinical course and outcome. There is limited reported data regarding the frequency and types of BCR-ABL leukemic gene in the Sudan. This study aims to determine the frequency and types of BCR-ABL fusion transcripts and investigate their possible diagno...
Article
Full-text available
Background: Low efficacy of miltefosine in the treatment of visceral leishmaniasis was recently observed in Eastern Africa. Objectives: To describe the pharmacokinetics and establish a pharmacokinetic/pharmacodynamic relationship for miltefosine in Eastern African patients with visceral leishmaniasis, using a time-to-event approach to model rela...
Article
Full-text available
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. The majority of cases occur in the developed world. This prospective study aimed to correlate different human leukocyte antigens (HLA types; HLA DRB1 and DRB3) with the aggressiveness of CRC in Sudanese patients. Methods: Thirty-three patients with histopathologically co...
Article
Full-text available
Introduction: In 2010, WHO recommended a new first-line treatment for visceral leishmaniasis (VL) in Eastern Africa. The new treatment, a combination of intravenous (IV) or intramuscular (IM) sodium stibogluconate (SSG) and IM paromomycin (PM) was an improvement over SSG monotherapy, the previous first-line VL treatment in the region. To monitor t...
Article
Full-text available
A third of the world's population is latently infected with TB with an increased risk of developing active TB. Household contacts (HHCs) of pulmonary TB cases are at a greater risk of developing disease. Early identification and treatment of latent TB infected individuals may reduce progression to active TB. This study aimed to determine latent TB...
Article
BACKGROUND: SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization. Combination regimens including AmBisome and miltefosine are safe and effective in India, but there are no published data from trials of combination therapies including these drugs from Afr...
Article
Full-text available
Abstract Objectives: Seventy five patients with lymphadenopathy who were referred to the Clinic of Lymphadenopathy at the Institute of Endemic Diseases, University of Khartoum were enrolled in our study to detect gene mutation that associated with drug resistance to streptomycin and rifampicin. Materials and methods: Seventy five patients of lympha...
Article
Visceral leishmaniasis is a neglected tropical disease endemic in East Africa where improved patient-adapted treatments are needed. The Leishmaniasis East Africa Platform (LEAP) was created in 2003 to strengthen clinical research capacity, serve as a base for training, and evaluate and facilitate implementation of new treatments. Major infrastructu...
Technical Report
Full-text available
The Mycetoma Research Centre (MRC), University of Khartoum in collaboration with the Institute of Endemic Diseases (IEND), University of Khartoum and Sinner State Ministry of Health, had conducted the third medical and health field mission to Easter Sinner region which included Wad Onsa and Wad EL Nemir villages. Mission Objectives The main objecti...
Article
Full-text available
The study of families with epilepsy has unraveled several mysteries about the pathophysiology of the disease. However, the majority of those studies were conducted on non-African populations. Africa is strongly believed to be the origin of humans and thus the African genome must give a more comprehensive view of Mendelian diseases. In this review,...
Article
Full-text available
Viral hepatitis is an acute or chronic neglected disease that affects predominantly the liver. This study aimed to determine the sero prevalence and risk factors for viral hepatitis and HCV genotypes in urban areas of Yemen. In a prospective, cross-sectional, analytical and community-based study and following informed consent, 501 volunteers were r...
Article
Full-text available
Background: Post kala-azar dermal leishmaniasis (PKDL) is a recognized dermatologic complication of successfully treated visceral leishmaniasis (VL). PKDL lesions are suspected to be important reservoirs for VL transmission in Sudan. Prolonged treatment schedules, feeling of general well-being and the social stigmata of PKDL prevent most patient...
Article
Full-text available
Oesophageal cancer is the eighth commonest form of cancer worldwide with variable incidence rates across different geographical regions. Squamous cell type is the commonest histological type in developing countries. This study aimed to determine the pathological subtypes of oesophageal cancer and the probable roles of some markers in the metastatic...
Article
Full-text available
Background: Post kala-azar dermal leishmaniasis (PKDL) is a recognized dermatologic complication of successfully treated visceral leishmaniasis (VL). PKDL lesions are suspected to be important reservoirs for VL transmission in Sudan. Prolonged treatment schedules, feeling of general well-being and the social stigmata of PKDL prevent most patients s...
Article
Full-text available
Background Little is known about the parasite/host factors that lead to Post Kala-azar Dermal Leishmaniasis (PKDL) in some visceral leishmaniasis (VL) patients after drug-cure. Studies in Sudan provide evidence for association between polymorphisms in the gene (IFNGR1) encoding the alpha chain of interferon-¿ receptor type I and risk of PKDL. This...
Article
Full-text available
Patients with cirrhotic ascites (PCA) are susceptible to spontaneous bacterial peritonitis (SBP) which has increased morbidity and mortality. Since some host defense aspects of peritoneal macrophages (PMф) from PCA are altered this study examined factors related to receptor-mediated phagocytosis. Twelve PCA were studied. PMɸ were isolated from asci...
Article
Full-text available
Background and objectives: Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In Sudan, VL is caused by L donovani. Most drugs used to treat VL, especially pentavalent antimony compounds (sodium stibogluconate, SSG), are potentially hepatotoxic. A number of fatal catastrophes happened because patients with VL...
Article
Full-text available
Anti-leishmanial drug regimens that include a single dose AmBisome® could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive design, was conducted to compare the efficacy and safety...
Article
Full-text available
Absract: Visceral Leishmaniasis (VL) is a protozoan disease caused by Leishmania donovani and transmitted by phlebotomus sand fly. The disease is endemic in Sudan and large area of tropics. It has been reported in eastern Sudan since the beginning of the twentieth century. This is a cross-sectional study conducted in Tabark Allah Village, eastern S...
Article
Full-text available
Most people exposed to M. tuberculosis show no evidence of clinical disease. Five to 10% of individuals with latent infection progress to develop overt disease during their life time. Identification of people with latent TB infection will increase case detection rates and may dictate new treatment policies to control tuberculosis. This study aimed...
Article
Full-text available
Visceral leishmaniasis (VL) is a neglected parasitic disease that is fatal if left untreated and is endemic in eastern Sudan. We estimated the direct and indirect costs of treatment of VL from the perspective of the provider and the household at three public hospitals in Gedaref State. The median total cost for one VL episode was estimated to be US...
Article
Latent TB infections (LTBI) constitute a pool fornew TB cases, ~5% of LTBI individuals progress to overt disease during their lifetime. Simple and cheap progression risk factors are needed to triage individuals for treatment. In aprospective case control study and following informed consent, apparently healthy 98 household contacts (HHCs) and 186 c...
Article
Full-text available
Background: Tuberculosis is a major health problem in developing countries. The distinction between tuberculous lymphadenitis, non-specific lymphadenitis and malignant lymph node enlargement has to be made at primary health care levels using easy, simple and cheap methods.Objective: To develop a reliable clinical algorithm for primary care settings...
Article
Full-text available
Post-kala-azar dermal leishmaniasis (PKDL) is a known complication of visceral leishmaniasis (VL) caused by L. donovani. It is rare in VL caused by L. infantum and L. chagasi. In Sudan, it occurs with a frequency of 58% among successfully treated VL patients. In the majority of cases, PKDL can be diagnosed on the basis of clinical appearance, distr...
Article
Full-text available
Hyperreactive Malarial Splenomegaly (HMS) is defined as a massive enlargement of the spleen resulting from abnormal immune responses after repeated exposure to the malaria parasites. This study was carried out in Khartoum, Sudan. Sudan is considered to be one of the countries where HMS is quite prevalent. The objective of the study was to determin...
Article
Full-text available
Visceral leishmaniasis (VL) is a parasitic disease characterized by immune suppression. Successful treatment is usually followed by immune reconstitution and a dermatosis called post-Kala-azar dermal leishmaniasis (PKDL). Recently, PKDL was described as one of the immune reconstitution syndromes (IRISs) in HIV/VL patients on HAART. This study aimed...
Article
Full-text available
Unlabelled: Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis that affects more than 50% of successfully treated visceral leishmaniasis (VL) patients in Sudan. PKDL is considered an important reservoir for the parasite and its treatment may help in the control of VL. Currently, treatment is mainly with sodium stibogluconate (SSG), an expe...
Chapter
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Data
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Cutaneous leishmaniasis in Sudan is caused by Leishmania major zymodeme LON1. Self-healing usually occurs within 1 year but occasionally its duration is prolonged and treatment is required. The clinical forms are ulcers, nodules and noduloulcerative lesions. Here we describe seven patients with uncommon lesions that were difficult to recognize as L...