Ahmed Madisch

Ahmed Madisch
Klinikum Region Hannover · Medical Department I

Professor, MD

About

207
Publications
12,839
Reads
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3,202
Citations
Additional affiliations
January 2009 - present
Klinikum Region Hannover
Position
  • Head of Department
January 2002 - December 2008
Technische Universität Dresden
Position
  • Professor (Associate)

Publications

Publications (207)
Article
Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple b...
Article
Objective and method: The treatment of patients with functional dyspepsia (irritable stomache syndrome) was recorded in a nationwide survey among family doctors. On a questionnaire, the physicians should provide information on the use of a combination preparation of gastric enzyme (pepsin) and amino acids, duration of use, therapy success and pati...
Article
Full-text available
The prokinetic cisapride, an important therapeutic option in functional gastrointestinal (GI) disorders, was withdrawn from the market 15 years ago due to rare severe side effects. Likewise in 2014, the use of metoclopramide (MCP) and domperidone in functional GI disorders (FGID) was restricted, consequently leaving a therapeutic gap in clinical pr...
Article
Objective: Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the...
Article
Eosinophilic esophagitis (EoE) is a clinicopathological condition of the esophagus that has become increasingly recognised over the last decade. EoE represents a chronic immune-mediated inflammatory disease of the esophagus. In adults dysphagia is the predominant symptom. Upper gastrointestinal endoscopy is required in order to take biopsies from t...
Article
Das Reizdarmsyndrom (RDS) gehört mit einer Prävalenz von 10–20 % zu den häufigsten funktionellen Krankheitsbildern und ist gekennzeichnet durch mehr als 3 Monate andauernde oder rezidivierende abdominelle Beschwerden ohne pathologische Veränderungen in den routinemäßig verfügbaren Untersuchungsverfahren Die Diagnosestellung erfolgt auf der Basis ei...
Article
Nach einer Clostridieninfektion haben Patienten ein erhöhtes Risiko für funktionelle Magen-Darm-Erkrankungen. Das gilt insbesondere für das Reizdarmsyndrom.
Article
Wer nachts unter gastroösophagealem Reflux leidet, braucht häufig ein Schläfchen am frühen Nachmittag. Das ist schlecht, denn dann tritt ein noch stärkeres Sodbrennen auf.
Article
Die chronische Obstipation ist ein häufig genanntes gastrointestinales Symptom, das unabhängig von den möglichen — zum Teil ernsten Komplikationen — zu einer deutlichen Einschränkung der Lebensqualität führt. „Verstopfung“ korreliert nicht nur mit der Stuhlgangsfrequenz. Lernen Sie hier, wie Obstipation genau definiert ist und wann Sie eingreifen s...
Conference Paper
Cisaprid, Metoclopramid (MCP) und Domperidon stehen wegen unerwünschter Wirkungen nicht mehr bzw. nur noch eingeschränkt zur Verfügung. Hierdurch wurde es notwendig, die klinischen Daten von möglichen therapeutischen Alternativen zu sichten, um Behandlungsoptionen mit vergleichbarer klinischer Wirksamkeit, aber einem günstigeren Sicherheitsprofil z...
Conference Paper
Full-text available
After the prokinetic cisaprid, an important therapeutic option in functional gastrointestinal (GI) diseases, had been withdrawn from the market due to rare severe side effects earlier, in 2014 metoclopramid (MCP) and domperidone have likewise been restricted from the use in these indication, so leaving a therapeutic gap. A systematic review was co...
Article
Full-text available
To investigate the efficacy and safety of two different budesonide formulations (effervescent tablet for orodispersible use (BET) and viscous suspension (BVS)) with different daily dosages for short-term treatment of eosinophilic oesophagitis (EoE). Adults with active EoE (n=76) randomly received 14 days' treatment with either BET 2×1 mg/day (BET1,...
Chapter
Der Singultus (lateinisch: Schluchzen, röcheln), im allgemeinen Sprachgebrauch auch Schluckauf genannt, ist ein meist kurzzeitiges Symptom ohne Krankheitswert. Dabei handelt es sich um reflektorische Einatembewegung bei gleichzeitigem Stimmlippenverschluss. Hält der Singultus über längere Zeit an, können neben der deutlichen Einschränkung der Leben...
Article
Background: Collagenous colitis (CC) and lymphocytic colitis (LC) are chronic disorders characterized by watery diarrhea. Aim: To evaluate prospectively the clinical features, response to treatment and outcomes in a large group of patients with CC and LC. Patients and Methods: Patients with histologically confirmed CC and LC were prospectively enro...
Article
Full-text available
Background & Aims Studies reporting that budesonide is effective for the treatment of collagenous colitis have been small and differed in efficacy measures. Mesalamine has been proposed as a treatment option for collagenous colitis, although its efficacy has never been investigated in placebo-controlled trials. We performed a phase 3, placebo-contr...
Article
Full-text available
Eosinophilic esophagitis (EoE) is a clinicopathological condition of the esophagus that has become increasingly recognised over the last decade. EoE represents a chronic immune-mediated inflammatory disease of the esophagus. In adults dysphagia is the predominant symptom. Upper gastrointestinal endoscopy is required in order to take biopsies from t...
Article
Oral budesonide has been proven effective in short- and long-term treatment of collagenous colitis; however, symptom relapse frequently occurs after drug withdrawal. The aim of this study was to identify the risk factors for symptom relapse in patients with collagenous colitis after withdrawal of short-term budesonide therapy. One hundred twenty-th...
Article
Microscopic colitis is an increasingly recognised chronic inflammatory bowel disease associated with watery, non-bloody diarrhoea. In addition, many patients suffer from abdominal pain, nocturnal diarrhoea, urgency and incontinence. The two traditional histological subtypes are collagenous colitis and lymphocytic colitis. A novel third subgroup is...
Article
Hintergrund: Die Diagnose der kollagenen Kolitis stutzt sich auf die histologische Untersuchung von Kolonbiopsien. Es ist nicht genau bekannt, wo und wieviele Biopsien entnommen werden mussen, um die Diagnose sicher zu stellen. Ziel: Bestimmung der topographischen Verteilung der fur die Diagnosestellung wichtigen Merkmale der kollagenen Kolitis Met...
Article
Eine 48-jährige Patientin unterzog sich einer laparoskopischen Cholezystektomie. Wegen einer begleitenden Cholezystitis erhielt sie prä- und postoperativ über zehn Tage ein Cephalosporin i.v. Schon während dieser Therapie hatte die Patientin eine erhöhte Stuhlfrequenz bei normaler Konsistenz. Zwei Wochen nach Absetzen des Antibiotikums begannen rez...
Article
Background: Pancreatitis is a potentially life-threatening condition frequently accompanied by peri-pancreatic fluid collections (PPFC), such as pseudocysts or pancreatic necrosis. Aspiration of PPFCs during EUS interventions for microbiologic analysis is still rarely performed in clinical routine. Objective: To evaluate the role of routine micr...
Article
Wenn das Schlucken zum Problem wird, droht mehr als nur eine deutliche Einschränkung der Lebensqualität. Aspirationspneumonien, Gewichtsverlust und Mangelernährung sind ernstzunehmende Komplikationen. Daher ist Gefahr im Verzug, was ein sofortiges, meist interdisziplinäres Eingreifen erforderlich macht.
Article
Gastrointestinale Symptome sind im höheren Alter ein häufiger Grund für Praxisbesuche und Klinikeinweisung. Sie führen unabhängig von möglichen organischen Komplikationen zu einer deutlichen Einschränkung der Lebensqualität. Die Kunst bei der diagnostischen Abklärung und Therapie besteht im Vermeiden überflüssiger Untersuchungen und dem gezielten E...
Article
Microscopic colitis (MC) is an inflammatory bowel disease presenting with chronic, non-bloody watery diarrhoea and few or no endoscopic abnormalities. The histological examination reveals mainly two subtypes of MC, lymphocytic or collagenous colitis. Despite the fact that the incidence in MC has been rising over the last decades, research has been...
Article
Triple therapy with a proton pump inhibitor, moxifloxacin, and amoxicillin has been proven effective in first-line treatment of Helicobacter pylori infection. To explore 1, the value of triple therapy with esomeprazole, moxifloxacin, and amoxicillin in second-line or rescue treatment of Caucasian patients and 2, the impact of treatment duration on...
Article
Collagenous colitis is a chronic inflammatory bowel disease of unknown origin characterized by a thickened subepithelial collagen layer. Differential expression of matrix-metalloproteinases (MMPs) have been implicated in the pathogenesis of collagenous colitis. The aim was to assess genetic polymorphisms of MMP-1, -7, and -9 in a case-control setti...
Article
Probe-based confocal laser endomicroscopy (pCLE) allows in-vivo assessment of the gastrointestinal mucosal architecture during ongoing endoscopy. We investigated the feasibility and safety of pCLE during double balloon enteroscopy (DBE). DBE was performed using the Fujinon EN-450P5. pCLE (Cellvizio-GI®, Mauna Kea Technologies) was performed after i...
Article
ZusammenfassungDie gastroösophageale Refluxkrankheit zählt zu den häufigsten internistischen Krankheitsbildern. Die möglichen klinischen Manifestationen betreffen sowohl ösophageale als auch extraösophageale Symptome. Etablierte extraösophageale Assoziationen sind Refluxhusten, Refluxlaryngitis, Refluxasthma, dentale Erosionen und Schlafstörungen....
Article
Generic omeprazole has been approved in many countries for the treatment of acid-related gastrointestinal disorders. However, clinical studies comparing generic to original proton pump inhibitors are limited. To compare the effect of generic omeprazole 20 mg/day with esomeprazole 20 mg/day on intragastric acidity and to investigate the influence of...
Article
Surveillance of Barrett's esophagus includes endoscopic inspection with biopsy of suspicious lesions followed by four-quadrant biopsy of the remaining mucosa. We assessed the ability of probe-based confocal laser endomicroscopy (pCLE) to replace biopsy in the endoscopic evaluation of patients with Barrett's esophagus in a prospective and controlled...