Ahmed Elattar

Ahmed Elattar
Newcastle University | NCL · Northern Institute for Cancer Research

Doctor of Medicine

About

41
Publications
6,087
Reads
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1,426
Citations
Introduction
Additional affiliations
November 2013 - present
Sandwell and West Birmingham Hospitals NHS Trust
Position
  • Consultant

Publications

Publications (41)
Article
Full-text available
Background: We present a systematic review and network meta-analysis (NMA) that is the precursor underpinning the Bayesian analyses that adjust for publication bias, presented in the same edition in AJT. The review assesses optimal cytoreduction for women undergoing primary advanced epithelial ovarian cancer (EOC) surgery. Areas of uncertainty:...
Article
Introduction/Background To ascertain the clinicopathological and treatment factors of recurrent ovarian adult-type granulosa cell tumours (AGCTO) and evaluate outcomes of women who underwent secondary and tertiary cytoreductive surgery (CRS) for recurrent AGCTO. Methodology This was a retrospective cohort study, spanning the period 2000–2022. Popu...
Article
ntroduction/Background To evaluate the long-term oncological outcomes in women with low-risk early-stage cervical cancer (CC) Methodology Retrospective population-based study of prospectively collected data, spanning the period 2008–2020. Eligibility criteria were: (1) FIGO 2018 IA2-IB1, (2) squamous cell carcinoma or grade 1–2 adenocarcinoma, (3)...
Article
Introduction/Background To compare post-operative morbidity and long-term survival outcomes of simple hysterectomy (SH) versus radical hysterectomy (RH) in FIGO 2018 stage IA2 cervical cancer (CC). Methodology Using the Pan-Birmingham Gynaecological Cancer Centre database, we identified women with stage IA2 CC between 2008 and 2020. Clinicopatholo...
Article
Background: Ovarian cancer is the seventh most common cancer among women and a leading cause of death from gynaecological malignancies. Epithelial ovarian cancer is the most common type, accounting for around 90% of all ovarian cancers. This specific type of ovarian cancer starts in the surface layer covering the ovary or lining of the fallopian t...
Article
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Background: Previous work has identified a strong association between the achievements of macroscopic cytoreduction and improved overall survival (OS) after primary surgical treatment of advanced epithelial ovarian cancer. Despite the use of contemporary methodology, resulting in the most comprehensive currently available evidence to date in this...
Article
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Objectives We consider expert opinion and its incorporation into a planned meta-analysis as a way of adjusting for anticipated publication bias. We conduct an elicitation exercise among eligible British Gynaecological Cancer Society (BGCS) members with expertise in gynaecology. Design Expert elicitation exercise. Setting BGCS. Participants Membe...
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Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. To assess the impact of residual disease after primary surgery on survival outcomes. In separate analyses, primary surgery will include both upfront debulking surgery followed by adjuvant chemotherapy (UDS) and neoadjuvant chemotherapy followed by inte...
Article
Background Surgery is the cornerstone of gynecological cancer management, but inpatient treatment may expose both patients and healthcare staff to COVID-19 infections. Plans to mitigate the impact of the COVID-19 pandemic have been implemented widely, but few studies have evaluated the effectiveness of these plans in maintaining safe surgical care...
Article
Objective To investigate the impact of serum albumin (at diagnosis and pre-operatively) on survival in patients undergoing cytoreductive surgery for advanced ovarian cancer(AOC) and whether improvement in albumin achieved following neoadjuvant chemotherapy (NACT) affects overall survival (OS). Methods Outcomes of 441 patients who underwent cytor...
Article
Outcomes of secondary cytoreduction surgery (SCS) were evaluated for morbidity, progression free survival (PFS) and overall survival (OS) and factors influencing results were explored. Retrospective analysis of all cases of SCS for epithelial ovarian cancer (EOC) was performed from October 2010 to December 2017. 62 patients were prospectively ident...
Conference Paper
Full-text available
Introduction/Background To investigate the impact of serum albumin (both at diagnosis and pre-operatively) on survival in patients undergoing cytoreductive surgery for AOC and whether any change in albumin achieved following Neoadjuvant chemotherapy (NACT) affects overall survival (OS). Pre-operative albumin is known to be a marker of survival in A...
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Purpose Survival difference between socioeconomic groups with ovarian cancer has persisted in the United Kingdom despite efforts to reduce disparities in care. Our aim was to delineate critical episodes in the patient journey, where deprivation has most impact on survival. Methods A retrospective review of 834 patients with advanced ovarian cancer...
Article
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Objective: To determine which descriptors of cytoreductive surgical extent in advanced ovarian cancer(AOC) best predict post-operative morbidity. Design: Retrospective notes review. Setting: A gynaecological cancer centre in the United Kingdom. Population: 608 women operated on for AOC in 114 months at a tertiary cancer centre between 16/8/0...
Article
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To determine the pattern of disease recurrence in patients treated for advanced ovarian cancer (AOC). Materials and Methods:A retrospective review of the locations of recurrence in all patients treated for AOC between August 16, 2007 and February 3, 2014 who underwent cytoreductive surgery and platinum based chemotherapy achieving complete (R0) or...
Article
Objectives: To establish the positive predictive values of pre-operative identification with CT imaging of metastatic diaphragm disease in surgically managed cases of advanced ovarian cancer (AOC). Additionally, we have assessed the post-operative morbidity and survival following diaphragmatic surgical intervention in a large regional cancer centr...
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Objectives To assess the impact of 5 or more cycles of neoadjuvant chemotherapy (NACT) and cytoreductive outcomes on overall survival (OS) in patients undergoing interval debulking surgery (IDS) for advanced ovarian cancer. Methods A retrospective review of patients receiving NACT followed by IDS between 2007 and 2017. Patients were analysed accord...
Conference Paper
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INTRODUCTION: The impact of >5 cycles of NACT on survival, especially in association with modern cytoreductive targets, is poorly described. The SGO and ASCO recommends ≤4 cycles of NACT. Increasing to 6 cycles raises theoretical concerns relating to the development of chemo-resistance. Our aim was to assess the impact of the number of NACT cycles,...
Conference Paper
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INTRODUCTION: Despite the importance of surgery, up to 44% of patients with AOC do not receive optimum therapy. Limited data for these patients is recorded in national databases. In contrast, numerous reports exist regarding the efficacy of primary debulking surgery (PDS). In this latter group however, overall survival (OS) data is often presented...
Article
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The aim of this study was to determine whether the age-adjusted Charlston co-morbidity index (ACCI) can predict post-operative complications, adjuvant chemotherapy usage and overall survival (OS) in patients with advanced epithelial ovarian cancer (AOC) treated with neoadjuvant chemotherapy (NACT). A review was performed of all cytoreductive surger...
Article
Full-text available
Objective: Combined surgery and platinum-based chemotherapy is the internationally agreed standard therapy for advanced ovarian cancer (AOC). However international cancer registry datasets demonstrate a significant proportion of patients do not receive both or either therapies. Our objective was to evaluate the effect of total patient cohort data...
Conference Paper
Full-text available
Introduction The ACCI is a predictive model which uses 19 different medical conditions and age to predict mortality. A recent study of 567 patients who underwent primary surgery for advanced ovarian cancer (AOC) demonstrated that the ACCI was a significant predictor of progression free survival and overall survival (OS). The aim of our study was to...
Conference Paper
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Introduction Follow up regimes for patients treated for advanced ovarian cancer are controversial. We aimed to document the presentation and management of those with recurrent disease at the Pan-Birmingham Gynaecological Cancer Centre. Methods A retrospective review of all surgeries for stage 3/4 epithelial ovarian cancer performed between 16/8/07...
Conference Paper
Full-text available
Methods A retrospective review of all patients diagnosed with Stage 3/4 Epithelial ovarian cancer between 16/8/07 – 3/2/14 was performed as part of routine governance. Patients were identified from the Pan– Birmingham Gynaecological cancer centre MDT database and cross referenced with the surgical operating log. All notes were formally reviewed to...
Conference Paper
Full-text available
Objective To identify changing patterns of disease recurrence in patients who have received surgery for treatment of advanced ovarian cancer (AOC). Methods A retrospective review of all cytoreductive surgeries achieving complete (R0) or optimal (<1cm) (R1) cytoreduction and correlation of complexity of surgery with location(s) of recurrence. All o...
Conference Paper
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Introduction Residual disease following cytoreductive surgery in ovarian, peritoneal and tubal cancer has repeatedly been demonstrated to be the key modifiable determinant of survival. Although optimal (<1cm) cytoreduction carries a survival advantage in primary cytoreductive surgery the benefit in surgery after neoadjuvant chemotherapy is less wel...
Conference Paper
Full-text available
Objectives Survival in Epithelial ovarian cancer (EOC) following surgery is dependent on residual disease. The incidence of diaphragm involvement is high; when surgically managed, complete cytoreduction rates and 5-year survival significantly increase. This review analyses diaphragmatic surgical procedures performed at the Pan Birmingham Gynaecolog...
Article
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Background: Extensive (ultraradical) surgery may facilitate complete cytoreduction in ovarian cancer with potential survival benefit but with greater morbidity. Currently, patient-reported outcomes (PROs) from such surgery are unknown. We conducted the Surgery in Ovarian Cancer Quality of life Evaluation Research study (SOCQER 1), a prospective st...
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The use of cell lines or animal models has significant disadvantages when dealing with a set of heterogeneous diseases such as epithelial ovarian cancer. This has clinical relevance in that biomarkers developed using cell line or animal models are often not transferable to the clinical setting. In this study, we describe the development of a robust...
Article
Between March 2007 and December 2009, 38 patients underwent sentinel lymph node biopsy (SLNB) sampling, along with vulvectomy, in their management of vulval cancer. A review has been conducted to establish the reliability and accuracy of the new procedure compared with the traditional total inguinofemoral lymphadenectomy. We also aimed to establish...
Article
Background: The standard management of primary ovarian cancer is optimal cytoreductive surgery followed by platinum-based chemotherapy. Most women with primary ovarian cancer achieve remission on this combination therapy. For women achieving clinical remission after completion of initial treatment, most (60%) with advanced epithelial ovarian cance...
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Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination deficient (HRD) status on the clinicopathological features, chemotherapy response and survival outcomes of EOC patients. HR status was determined in primary cultures fro...
Article
Objectives: In the present study we explore the effects of androgens and anti-androgens on primary cultures of EOC cells. We also investigate the effects of chemotherapy on AR expression. Epithelial ovarian cancer (EOC) arises from ovarian surface epithelial cells (OSE), which express the androgen receptor (AR). Androgen stimulation of OSE cells r...
Article
Ovarian cancer is the sixth most common cancer among women. In addition to diagnosis and staging, primary surgery is performed to achieve optimal cytoreduction (surgical efforts aimed at removing the bulk of the tumour) as the amount of residual tumour is one of the most important prognostic factors for survival of women with epithelial ovarian can...
Article
Full-text available
Poly(ADP-ribose) polymerase (PARP) inhibitors selectively target homologous recombination (HR)-defective cells and show good clinical activity in hereditary breast and ovarian cancer associated with BRCA1 or BRCA2 mutations. A high proportion (up to 50%) of sporadic epithelial ovarian cancers (EOC) could be deficient in HR due to genetic or epigene...
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Epidemiological and in vitro data implicate androgens in the aetiology of ovarian cancer, but the mechanisms by which this is mediated are unclear. In this study, we wished to examine the effects of androgens on gene expression in ovarian cancer. The expression of androgen receptor (AR) in OVCAR3 and OSEC2 cells was confirmed using immunoblotting a...
Article
Summary: On average, the length of time women remain in hospital after giving birth in the UK has deceased in recent years but most women are nevertheless admitted to a postnatal ward after childbirth. In this unique, prospective, observational study, we drew upon the expertise of caregivers on postnatal wards to reveal a wide range of obstetric, m...
Article
On average, the length of time women remain in hospital after giving birth in the UK has deceased in recent years but most women are nevertheless admitted to a postnatal ward after childbirth. In this unique, prospective, observational study, we drew upon the expertise of caregivers on postnatal wards to reveal a wide range of obstetric, medical, n...

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