Ahmed Alhusban

Ahmed Alhusban
Jordan University of Science and Technology | Just · Department of Clinical Pharmacy

Pharm.D., Ph.D.

About

42
Publications
4,102
Reads
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642
Citations
Citations since 2017
24 Research Items
433 Citations
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
Additional affiliations
January 2018 - August 2019
Jordan University of Science and Technology
Position
  • Professor (Associate)
January 2011 - present
University of Georgia
August 2009 - August 2013
University of Georgia
Position
  • PhD Student

Publications

Publications (42)
Article
Full-text available
Background COVID-19 is a pandemic that has been widespread throughout the world. The disease and the measures employed to contain its spread have a detrimental effect on the mental health of individuals. Countries across the world have applied variable combinations of quarantine and social distancing measures to contain the spread of COVID-19. This...
Article
Full-text available
We assessed whether stroke severity, functional outcome, and mortality in patients with ischemic stroke differed between patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and those without. We conducted a prospective, single-center cohort study in Irbid, North Jordan. All patients diagnosed with ischemic stroke an...
Article
Objectives. Social media applications are widely used across different age groups and communities. Problematic use of social media (PMSU) is associated with depression among university students. There is a lack of data regarding the effect of studying pharmacy on the association between PMSU and depression as compared to other university discipline...
Article
Full-text available
This study aim to examine the hypothesis that repetitive painful stimuli during infancy will alter pain sensitivity and impair learning and memory during adulthood and that saccharin will prevent this through its analgesic effect. Naltrexone is used to examine if saccharin effect is mediated via the endogenous opioid system. Pain in rat pups was in...
Article
Full-text available
The COVID-19 pandemic is taking many lives every day. It affects literally all aspects of life and changes humanity communication tools, mobility, lifestyle, and feasibly their level of perceived stress and depression. The present study aims to investigate the psychological health status in terms of perceived stress and depression among the UAE pop...
Article
Full-text available
Hormone-dependent breast cancer is the most abundant molecular subtype of the disease. Despite the availability of endocrine treatments, the use of these drugs is limited by their serious adverse reactions and development of acquired resistance often mediated by growth factor receptors. The hepatocyte growth factor receptor, MET, is a receptor tyro...
Article
Aim The aim of the current work is to assess the role of proBDNF/BDNF in the interaction between brain microvascular endothelial cells and MDA-MB-231 breast cancer cell line that has been consistently reported to cause brain metastasis. Background Breast cancer brain metastasis (BM) is a significant health problem with limited therapeutic options....
Article
Introduction: Thrombspondin-1 (TSP-1) is a glycoprotein that has a variety of functions including suppression of angiogenesis and regulation of extracellular matrix deposition. These functions are central to the recovery process after stroke. Data regarding the association and predictive value of TSP-1 and stroke outcomes are limited. Patients an...
Article
Thirteen compounds were isolated from the methanolic extract of the leaves of Androcymbium palaestinum Baker (Colchicaceae). Of these, three were new, two were new natural products, and eight were known. The new isolated compounds were (+)-1-demethylandrocine (5), (−)-andropalaestine (8), and (+)-2-demethyl-β-lumicolchicone (10), while the new natu...
Article
Full-text available
Background Synthetic cannabinoids (SCs) are a group of newly-developed drugs that bind and activate endocannabinoid system receptors. Angiogenesis is a biological process in which new blood vessels are formed from preexistent blood vessels. It plays a vital role in tissue growth, wound healing, and embryogenesis. This study aims to investigate the...
Article
Full-text available
Purpose: To investigate the association between glycosylated hemoglobin A1c (HbA1c) with anthropometric measurements and clinicopathologic characteristics of breast cancer patients. Such data are lacking in Arabian countries. Patients and methods: A cross-sectional study was conducted at the Outpatient Oncology Unit at King Hussein Medical Cente...
Article
Management of neonatal pain is not only ethical but is also essential. Barriers to pain management in infants include lack of safe and effective medications and fear of adverse effects of conventional pain medications. Sweet solutions given intraorally have been shown to reduce pain behaviors and associated symptoms. Sucrose and other sweet solutio...
Conference Paper
Breast cancer is the most common malignancy among females and is a leading cause of cancer mortality. Brain metastasis is associated with poor prognosis and reduced survival among breast cancer patients. For brain metastasis to occur, cancer cells are required to remain in direct contact with endothelial cells that line brain blood vessels. Data re...
Conference Paper
Breast cancer is the most common malignancy among females and is a leading cause of cancer mortality. Brain metastasis is associated with poor prognosis and reduced survival among breast cancer patients. For brain metastasis to occur, cancer cells are required to remain in direct contact with endothelial cells that line brain blood vessels. Data re...
Poster
Full-text available
Background: Improvement in stroke management reduced stroke associated mortality. Despite this reduction, stroke is still the leading cause of long term disability worldwide. A number of factors have been suggested to predict recovery after stroke among different ethnic groups and geographic areas. Unfortunately, data from the Arab region is still...
Poster
Full-text available
Background: Thrombotic and embolic events have been considered as major causes of stroke. It has been demonstrated that the use of antiplatelets and anticoagulants after stroke reduces the risk of stroke recurrence. Data regarding the trend of antiplatelets and anticoagulants use in the Arab region is lacking. Aim: To evaluate the usage and sele...
Article
Full-text available
Diabetes mellitus (DM) is a major risk factor for cardiovascular disease. Additionally, it was found to induce a dysfunctional angiogenic response in the brain that was attributed to oxidative stress. Milk thistle seed extract (silymarin) has potent antioxidant properties, though its potential use in ameliorating diabetes-induced aberrant brain ang...
Article
Full-text available
Stroke is a leading cause of adult disability worldwide. Improving stroke outcome requires an orchestrated interplay that involves up regulation of pro-survival pathways and a concomitant suppression of pro-apoptotic mediators. In this investigation, we assessed the involvement of eNOS in the AT1 blocker-mediated protective and pro-recovery effects...
Article
Pain in neonates is associated with short and long-term adverse outcomes. Data demonstrated that long-term consequences of untreated pain are linked to the plasticity of the neonate's brain. Sucrose is effective and safe for reducing painful procedures from single events. However, the mechanism of sucrose-induced analgesia is not fully understood....
Article
Full-text available
Angiotensin type 1 receptor blockers (ARBs) have been shown to be neuroprotective and neurorestorative in experimental stroke. The mechanisms proposed include anti-inflammatory, antiapoptotic effects, as well as stimulation of endogenous trophic factors leading to angiogenesis and neuroplasticity. We aimed to investigate the involvement of the neur...
Article
Full-text available
Background: Blood flow restoration with fibrinolysis and thrombectomy is recommended to limit injury in stroke patients with proximal artery occlusion. Angiotensin receptor blockers have been shown to be neuroprotective in models of permanent and temporary occlusion, but the benefits on expression of trophic factors have been seen only when the ar...
Article
Preclinical stroke research has introduced a number of potential interventions that can be utilized to enhance recovery after stroke (Lo and Rosenberg, 2009). Many of these potential interventions targeted a single component of the neurovascular unit, but the majority of these interventions failed to prove effective in clinical studies. Additionall...
Article
Introduction: We and others have shown that the angiotensin type 2 (AT2) receptor agonist, compound 21 (C21), provides neuroprotection and enhances recovery in rodent stroke models yet the mechanism involved is not known. Moreover, C21 treatment is associated with an anti-inflammatory response. Here we tested the hypothesis that C21 mediates neurop...
Article
Introduction: Angiotensin II type 2 receptor (AT2R) stimulation is neuroprotective after experimental stroke. However, the therapeutic utility of AT2R stimulation has been hampered by the lack of a specific agonist with favourable bioavailability. Compound 21 (C21) - the first non-peptide AT2R agonist - offers a potential option to enhance stroke...
Article
Full-text available
Background and Purpose. Oxidative stress and matrix metalloproteinase (MMP) activity have been identified as key mediators of early vascular damage after ischemic stroke. Somewhat surprisingly, the angiotensin II type 1 receptor (AT1) blocker, candesartan, has been shown to acutely increase MMP activity while providing neurovascular protection. We...
Article
Full-text available
Angiotensin receptor blockers (ARBs), widely used anti-hypertensive drugs have also been investigated for their anti-cancer effects. The effect of ARBs on prostate cancer in experimental models compared to meta-analysis data from clinical trials is conflicting. Whereas this discrepancy might be due to the use of supra-therapeutic doses of ARBs in c...
Article
Full-text available
Exogenous administration of the anti-inflammatory cytokine, interleukin 10 (IL-10), is known to promote neuroprotection and mitigate neuroinflammation after ischemia. However, endogenous expression and localization of IL-10 and its receptor (IL-10R) in the post-ischemic brain are still to be elucidated. In this investigation we aimed at determining...
Article
Full-text available
This study aimedto assess general knowledge, beliefs and attitudes of people towards the use of antibiotics. Individuals referring to the outpatient pharmacies of 2 major teaching hospitals in the north of Jordan completed a self-administered, validated questionnaire. A total of 1091 individuals (56.8% males) participated in the study. Of these, 20...
Article
Full-text available
ABSTRACT This study aimed to assess general knowledge, beliefs and attitudes of people towards the use of antibiotics. Individuals referring to the outpatient pharmacies of 2 major teaching hospitals in the north of Jordan completed a self-administered, validated questionnaire. A total of 1091 individuals (56.8% males) participated in the study. Of...
Article
Full-text available
Candesartan is an angiotensin II type 1 receptor blocker (ARB) that has been to shown to limit ischemic stroke and improve stroke outcome. In experimental stroke, candesartan induces a proangiogenic effect that is partly due to vascular endothelial growth factor (VEGF). Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family...
Article
Full-text available
Hypertension and diabetes are known risk factors for retinal microvascular damage. However, the combined effects of diabetes with early and established stages of hypertension on retinal microvascular degeneration remain incompletely understood. Male spontaneously hypertensive rats (SHR) were compared to SHR with streptozotocin-induced diabetes (SHR...
Article
I t is now appreciated that emerging therapeutic strategies for recovery must include the cerebral vasculature and that induction of angiogenesis will stimulate endogenous recovery mechanisms, including neurogenesis, synaptogenesis, and neuronal and synaptic plasticity. These events are all involved in the long-term repair and restoration process o...
Article
Full-text available
We identified that the angiotensin receptor antagonist, candesartan, has profound neurovascular protective properties when administered after ischemic stroke and was associated with a proangiogenic state at least partly explained by vascular endothelial growth factor A (VEGFA). However, the spatial distribution of vascular endothelial growth factor...
Article
Stroke is a major health problem with significant impact on the affected individuals and the whole community. In light of stroke being the leading cause of disability, the ageing of the population and the high incidence of stroke among the elderly, highlight the importance of primary and secondary prevention interventions among this group. The elde...

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Projects

Projects (2)
Project
The current projects aims at identifying the how do hyperlipidemia and diabetes alters brain angiogenesis.